result 3869 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okatani, Takeshi| Nishimura, Midori Filiz| Egusa, Yuria| Yoshida, Sayako| Nishimura, Yoshito| Nishikori, Asami| Yoshino, Tadashi| Yamamoto, Hidetaka| Sato, Yasuharu| |
| Keywords | methotrexate-associated lymphoproliferative disorders other iatrogenic immunodeficiency-associated lymphoproliferative disorders lymphoproliferative disorders arising in immune deficiency/dysregulation NOTCH1 |
| Published Date | 2024 |
| Publication Title | Journal of Clinical and Experimental Hematopathology |
| Volume | volume64 |
| Issue | issue1 |
| Publisher | Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 1 |
| End Page | 9 |
| ISSN | 1346-4280 |
| NCID | AA11556796 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 38281745 |
| DOI | 10.3960/jslrt.23038 |
| Web of Science KeyUT | 001155420800001 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.23038 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yang, Chen| Shitamukai, Atsunori| Yang, Shucai| Kawaguchi, Ayano| |
| Keywords | in vivo electroporation in utero electroporation genome editing IUE iON TEMPO iGONAD |
| Published Date | 2023-09-15 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume24 |
| Issue | issue18 |
| Publisher | MDPI |
| Start Page | 14128 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37762431 |
| DOI | 10.3390/ijms241814128 |
| Web of Science KeyUT | 001145294000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms241814128 |
| FullText URL | fulltext20240129-01.pdf |
|---|---|
| Author | Suzuki, Shintaro| Barrientos, Tomás| Mejía, Héctor| Price, T. Douglas| |
| Note | © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Dec. 2025.| |
| Published Date | 2024-02 |
| Publication Title | Journal of Archaeological Science: Reports |
| Volume | volume53 |
| Publisher | Elsevier BV |
| Start Page | 104348 |
| ISSN | 2352-409X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Ltd. |
| File Version | author |
| DOI | 10.1016/j.jasrep.2023.104348 |
| Web of Science KeyUT | 001143409600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jasrep.2023.104348 |
| JaLCDOI | 10.18926/66519 |
|---|---|
| Title Alternative | Context Development Function of the Conjunction "de" in Conversation |
| FullText URL | hss_056_089.pdf |
| Author | LIU, YANG| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2023-12-28 |
| Volume | volume56 |
| Start Page | 89 |
| End Page | 106 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2023 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kato, Yusuke| Kuroda, Hiroshi| Ozawa, Shin-Ichiro| Saito, Keisuke| Dogra, Vivek| Scholz, Martin| Zhang, Guoxian| de Vitry, Catherine| Ishikita, Hiroshi| Kim, Chanhong| Hippler, Michael| Takahashi, Yuichiro| Sakamoto, Wataru| |
| Keywords | post-translational modification Arabidopsis thaliana protein degradation photosystem II photo-oxidative damage tryptophan oxidation Chlamydomonas reinhardtii |
| Published Date | 2023-11-21 |
| Publication Title | eLife |
| Volume | volume12 |
| Publisher | eLife Sciences Publications |
| Start Page | RP88822 |
| ISSN | 2050-084X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Kato, Kuroda, Ozawa et al. |
| File Version | publisher |
| PubMed ID | 37986577 |
| DOI | 10.7554/eLife.88822 |
| Web of Science KeyUT | 001134641800001 |
| Related Url | isVersionOf https://doi.org/10.7554/eLife.88822 |
| JaLCDOI | 10.18926/AMO/66160 |
|---|---|
| FullText URL | 77_6_665.pdf |
| Author | Sakurai, Atsunobu| Uka, Mayu| Iguchi, Toshihiro| Tomita, Koji| Matsui, Yusuke| Kakiuchi, Yoshihiko| Kuroda, Shinji| Fujiwara, Toshiyoshi| Hiraki, Takao| |
| Abstract | We report the case details of a 65-year-old Japanese man with an omental abscess that was discovered 43 days after he underwent a laparoscopic proximal gastrectomy for gastric cancer. His chief complaint was mild abdominal pain that had persisted for several days. The abscess was diagnosed as a rare postoperative complication. We hesitated to perform a reoperation given the invasiveness of general anesthesia and surgery, plus the possibility of postoperative adhesions and because the patient’s general condition was stable and he had only mild abdominal pain. Percutaneous drainage using a 10.2-F catheter was performed with the patient under conscious sedation and computed tomography–fluoroscopy guidance, with no complications. After the procedure, the size of the abscess cavity was remarkably reduced, and 23 days later the catheter was withdrawn. |
| Keywords | drainage omental abscess omental infarction proximal gastrectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 665 |
| End Page | 669 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145942 |
| Web of Science KeyUT | 001164631200013 |
| JaLCDOI | 10.18926/AMO/66157 |
|---|---|
| FullText URL | 77_6_647.pdf |
| Author | Kojima, Katsuhide| Takahashi, Yuka| Sugiyama, Soichi| Asano, Yudai| Okawa, Nanako| Makimoto, Satoko| Higaki, Fumiyo| Iguchi, Toshihiro| Hiraki, Takao| |
| Abstract | A 67-year-old man was referred to our hospital for the diagnosis and treatment of prostate cancer. Multidisciplinary discussion led to intensity-modulated radiotherapy preceded by hormone therapy. Before radiotherapy, a biodegradable hydrogel spacer (HS) was placed between the prostate and rectum to reduce radiation injury risk. Three weeks postplacement, pelvic magnetic resonance imaging revealed HS migration into the pelvic vein. Subsequent whole-body contrast-enhanced computed tomography (CECT) revealed HS migration into the pulmonary artery. The patient showed no symptoms or clinical signs. Radiotherapy was completed uneventfully. Complete absorption of the migrated HS was confirmed using CECT images 5 months postplacement. |
| Keywords | hydrogel spacer prostate cancer radiotherapy pulmonary embolism |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 647 |
| End Page | 650 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145939 |
| Web of Science KeyUT | 001164631200010 |
| JaLCDOI | 10.18926/AMO/66155 |
|---|---|
| FullText URL | 77_6_627.pdf |
| Author | Hibino, Yumi| Okazawa-Sakai, Mika| Yokoyama, Takanori| Fujimoto, Etsuko| Okame, Shinichi| Teramoto, Norihiro| Takehara, Kazuhiro| |
| Abstract | To explore the incidence of abnormal vaginal cytology after total laparoscopic hysterectomy for the treatment of cervical intraepithelial neoplasia 3, we retrospectively analyzed the medical records of patients treated at NHO Shikoku Cancer Center (Japan) in 2014-2019. The cases of 99 patients who underwent a laparoscopic (n=36) or open (n=63) hysterectomy and postoperative follow-up were examined. Abnormal vaginal cytology was detected in 13.9% (5/36) of the laparoscopic-surgery (LS) group and 14.3% (9/63) of the open-surgery (OS) group. A vaginal biopsy was performed at the physicians’ discretion; one LS patient and six OS patients were diagnosed with vaginal intraepithelial neoplasia. The cumulative incidence of abnormal vaginal cytology at 3 years post-hysterectomy was 21.4% (LS group) and 20.5% (OS group), a nonsignificant difference. A multivariate analysis showed that age > 50 years was the only independent risk factor for abnormal vaginal cytology among the covariates examined including age; body mass index; histories of vaginal delivery, abdominal surgery, and smoking; and surgical approach (hazard ratio 8.11; 95% confidence interval 1.73-37.98; p=0.01). These results suggest that the occurrence of abnormal vaginal cytology after a hysterectomy may not be influenced by the laparoscopic procedure but is associated with older age. |
| Keywords | total laparoscopic hysterectomy vaginal intraepithelial neoplasia cervical intraepithelial neoplasia vaginal cytology risk factor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 627 |
| End Page | 634 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145937 |
| Web of Science KeyUT | 001164631200008 |
| JaLCDOI | 10.18926/AMO/66150 |
|---|---|
| FullText URL | 77_6_589.pdf |
| Author | Omichi, Ryotaro| Kariya, Shin| Maeda, Yukihide| Fukushima, Kunihiro| Kataoka, Yuko| Sugaya, Akiko| Nishizaki, Kazunori| Ando, Mizuo| |
| Abstract | Choosing the optimal side for cochlear implantation (CI) remains a major challenge because of the lack of evidence. We investigated the choice of the surgery side for CI (i.e., the better- or poorer-hearing ear) in patients with asymmetric hearing. Audiological records of 74 adults with a unilateral hearing aid who had undergone surgery at Okayama University Hospital were reviewed. The definition of ‘better-hearing ear’ was the aided ear, and the unaided ear was considered the poorer-hearing ear. We performed a multiple regression analysis to identify potential predictors of speech recognition performance after unilateral CI in the patients. Fifty-two patients underwent CI in the poorer-hearing ear. The post-Ci bimodal hearing rate was far higher in the poorer-ear group (77.8% vs. 22.2%). A multivariate analysis revealed that prelingual hearing loss and the patient’s age at CI significantly affected the speech recognition outcome (beta coefficients: 24.6 and −0.33, 95% confidence intervals [11.75-37.45] and [−0.58 to −0.09], respectively), but the CI surgery side did not (−6.76, [−14.92-1.39]). Unilateral CI in the poorer-hearing ear may therefore be a reasonable choice for adult patients with postlingual severe hearing loss, providing a greater opportunity for postoperative bimodal hearing. |
| Keywords | cochlear implantation poorer hearing ear better hearing ear hearing aids speech recognition |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 589 |
| End Page | 593 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145932 |
| Web of Science KeyUT | 001164631200003 |
| JaLCDOI | 10.18926/AMO/66149 |
|---|---|
| FullText URL | 77_6_577.pdf |
| Author | Liu, Siyu| Athurupana, Rukmali| Han, Hongmei| Yang, Titi| Nakatsuka, Mikiya| |
| Abstract | Bereavement care is conducted to meet the emotional needs of grieving couples who are devastated by the experience of a miscarriage or stillbirth. From January to April 2022, we distributed a questionnaire that assessed the knowledge and attitudes of Japanese nursing staff (nurses and midwives) in Japan’s Chugoku-Shikoku region toward bereavement care for couples with miscarriage/stillbirth. The 370 survey respondents’ answers revealed that the nursing staff’s knowledge regarding recurrent pregnancy loss and subsequent bereavement care was insufficient. About 41.1% and 64.1% of the respondents had received school and on-the-job education in bereavement care, respectively, and 79.2% expressed willingness to provide such care. Our analyses revealed that the following factors were associated with the nursing staff’s knowledge level: parent status, age, reproductive history, midwifery license, work experience and environment, and on-the-job education. The following were correlated with the staff’s willingness to provide bereavement care: work environment, midwifery license, bereavement care knowledge, and on-the-job education. Together our findings indicate that education plays a significant role in equipping caregivers to provide effective bereavement care for couples who have experienced a miscarriage or stillbirth. |
| Keywords | midwife nurse miscarriage bereavement knowledge |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 577 |
| End Page | 587 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145931 |
| Web of Science KeyUT | 001164631200002 |
| JaLCDOI | 10.18926/AMO/66148 |
|---|---|
| FullText URL | 77_6_567.pdf |
| Author | Matsumoto, Naomi| Higuchi, Chigusa| Miyaji, Chikara| Mitsuhashi, Toshiharu| Hagiya, Hideharu| Takao, Soshi| Yorifuji, Takashi| |
| Abstract | This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic. |
| Keywords | coronavirus disease 2019 adverse reactions mRNA vaccine antibody titers young adults |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 567 |
| End Page | 575 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145930 |
| Web of Science KeyUT | 001164631200001 |
| JaLCDOI | 10.18926/OER/66035 |
|---|---|
| Title Alternative | Die Grundlagen der wirtschaftlichen Entwicklung des Königreichs Sachsen（3） |
| FullText URL | oer_055_2_033_052.pdf |
| Author | Matsuo, Nobushige| |
| Publication Title | Okayama Economic Review |
| Published Date | 2023-11-24 |
| Volume | volume55 |
| Issue | issue2 |
| Start Page | 33 |
| End Page | 52 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2023 岡山大学経済学会 |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/65979 |
|---|---|
| FullText URL | 77_5_553.pdf |
| Author | Murokawa, Takahiro| Sakamoto, Shinya| Tabuchi, Motoyasu| Sui, Kenta| Ozaki, Kazuhide| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| Yoshida, Hiroshi| |
| Abstract | Gastric cancer with peritoneal metastases is typically a devastating diagnosis. Ligamentum teres hepatis (LTH) metastasis is an extremely rare presentation with only four known cases. Herein, we report salvage surgery of successive metastases to the abdominal wall and LTH in a patient originally presenting with advanced gastric cancer with peritoneal metastasis, leading to long-term survival. A 72-year-old man with advanced gastric cancer underwent curative-intent distal gastrectomy with D2 lymph node dissection for gastric outlet obstruction. During this procedure, three small peritoneal metastases were detected in the lesser omentum, the small mesentery, and the mesocolon; however, intraoperative abdominal lavage cytology was negative. We added cytoreductive surgery for peritoneal metastasis. The pathological diagnosis of the gastric cancer was tubular adenocarcinoma with pT4aN1pM1(PER/P1b)CY0 stage IV (Japanese classification of gastric carcinoma/JCGC 15th), or T4N1M1b stage IV (UICC 7th). Post-operative adjuvant chemotherapy with S-1 (TS-1)+cisplatin (CDDP) was administered for 8 months followed by S-1 monotherapy for 4 months. At 28 months after the initial surgery, a follow-up computed tomography (CT) detected a small mass beneath the upper abdominal wall. The ass showed mild avidity on 18F-fluorodeoxyglucose positron-emission (FDG-PET) CT. Salvage resection was performed for diagnosis and treatment, and pathological findings were consistent with primary gastric cancer metastasis. At 49 months after the initial gastrectomy, a new lesion was detected in the LTH with a similar level of avidity on FDG-PET CT as the abdominal wall metastatic lesion. We performed a second salvage surgery for the LTH tumor, which also showed pathology of gastric cancer metastasis. There has been no recurrence up to 1 year after the LTH surgery. With multidisciplinary treatment the patient has survived almost 5 years after the initial gastrectomy. Curative-intent gastrectomy with cytoreductive surgery followed by adjuvant chemotherapy for advanced gastric cancer with localized peritoneal metastasis might have had a survival benefit in our patient. Successive salvage surgeries for oligometastatic lesions in the abdominal wall and the LTH also yielded favorable outcomes. |
| Keywords | gastric cancer peritoneal metastasis ligamentum teres hepatis oligometastasis salvage surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 553 |
| End Page | 559 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899267 |
| Web of Science KeyUT | 001110832700001 |
| JaLCDOI | 10.18926/AMO/65978 |
|---|---|
| FullText URL | 77_5_545.pdf |
| Author | Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki| |
| Abstract | To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant. |
| Keywords | esophagogastroduodenoscopy gastric lesion amyloidosis light chain |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 545 |
| End Page | 552 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899266 |
| Web of Science KeyUT | 001094245100001 |
| JaLCDOI | 10.18926/AMO/65974 |
|---|---|
| FullText URL | 77_5_517.pdf |
| Author | Horiguchi, Shigeru| Matsumoto, Kazuyuki| Morimoto, Kosaku| Matsumi, Akihiro| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Kato, Hironari| |
| Abstract | We investigated the effect of modified FOLFIRINOX (mFFX) in unresectable pancreatic cancer by retrospectively analyzing the cases of 43 patients who underwent BRCA testing (germline, n=11; somatic, n=26; both germline and somatic, n=6). The association between BRCA mutations and therapeutic effect was clarified. Six patients tested positive for germline pathogenic variants. Familial pancreatic cancer (33% vs. 3%, p=0.006) and peritoneal disseminated lesions (66% vs. 8%, p<0.001) were significantly more common in patients with germline pathogenic variants. The partial response (PR) rate was 100% in the germline BRCA-positive patients, and 27% in the germline BRCA-negative patients (p<0.001). The median progression-free survival (PFS) was not reached for any germline BRCA-positive patients but was 9.0 months for the germline BRCA-negative patients (p=0.042). Patients with stage IV BRCA-associated pancreatic cancer had better overall survival than those with non-BRCA-associated pancreatic cancer, although the difference was nonsignificant (not reached vs. 655 days, p=0.061). Our results demonstrate that a PR and prolonged PFS can be expected in germline BRCA-positive patients after treatment with mFFX. Our findings also suggest that germline BRCA pathogenic variants may be useful as biomarkers for the therapeutic effect of mFFX in patients with pancreatic cancer. |
| Keywords | BRCA FOLFIRINOX pancreatic cancer progression-free survival pathogenic variant |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 517 |
| End Page | 525 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899263 |
| Web of Science KeyUT | 001108661600009 |
| JaLCDOI | 10.18926/AMO/65973 |
|---|---|
| FullText URL | 77_5_511.pdf |
| Author | Sato, Kohei| Tsuji, Hironori| Yorimitsu, Masanori| Uehara, Takenori| Okazaki, Yuki| Takao, Shinichiro| Hata, Toshiaki| Fukuoka, Shiro| Noda, Tomoyuki| Kanda, Hideyuki| Ozaki, Toshifumi| |
| Abstract | Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either “gait disturbance” or “independent gait”. Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required. |
| Keywords | sarcopenia nutrition geriatric hip fracture psoas muscle index controlling nutritional status score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 511 |
| End Page | 516 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899262 |
| Web of Science KeyUT | 001108661600008 |
| FullText URL | fulltext20231011-03.pdf |
|---|---|
| Author | Kurihara, Marie| Thiel, Vera| Takahashi, Hirona| Kojima, Keiichi| Ward, David M.| Bryant, Donald A.| Sakai, Makoto| Yoshizawa, Susumu| Sudo, Yuki| |
| Keywords | rhodopsin ion transport retinal isomerization optogenetics |
| Published Date | 2023-02-01 |
| Publication Title | Chemical and Pharmaceutical Bulletin |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Pharmaceutical Society of Japan |
| Start Page | 154 |
| End Page | 164 |
| ISSN | 0009-2363 |
| NCID | AA00602100 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Pharmaceutical Society of Japan |
| File Version | publisher |
| PubMed ID | 36724978 |
| DOI | 10.1248/cpb.c22-00774 |
| Web of Science KeyUT | 000964953300013 |
| Related Url | isVersionOf https://doi.org/10.1248/cpb.c22-00774 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Akıl, Caner| Ali, Samson| Tran, Linh T.| Gaillard, Jérémie| Li, Wenfei| Hayashida, Kenichi| Hirose, Mika| Kato, Takayuki| Oshima, Atsunori| Fujishima, Kosuke| Blanchoin, Laurent| Narita, Akihiro| Robinson, Robert C.| |
| Published Date | 2022-03-25 |
| Publication Title | Science Advances |
| Volume | volume8 |
| Issue | issue12 |
| Publisher | American Association for the Advancement of Science (AAAS) |
| Start Page | eabm2225 |
| ISSN | 2375-2548 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors |
| File Version | publisher |
| PubMed ID | 35333570 |
| DOI | 10.1126/sciadv.abm2225 |
| Web of Science KeyUT | 000800334900012 |
| Related Url | isVersionOf https://doi.org/10.1126/sciadv.abm2225 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Satoshi| Heerspink, Hiddo J. L.| de Zeeuw, Dick| Toyoda, Masao| Suzuki, Daisuke| Hatanaka, Takashi| Nakamura, Tohru| Kamei, Shinji| Murao, Satoshi| Hida, Kazuyuki| Ando, Shinichiro| Akai, Hiroaki| Takahashi, Yasushi| Koya, Daisuke| Kitada, Munehiro| Sugano, Hisashi| Nunoue, Tomokazu| Nakamura, Akihiko| Sasaki, Motofumi| Nakatou, Tatsuaki| Fujimoto, Kei| Kawanami, Daiji| Wada, Takashi| Miyatake, Nobuyuki| Yoshida, Michihiro| Shikata, Kenichi| the CANPIONE study Investigators| |
| Keywords | canagliflozin CANPIONE study diabetic kidney disease eGFR slope SGLT2 inhibitor urinary albumin-to-creatinine ratio |
| Published Date | 2022-05-18 |
| Publication Title | Diabetes, Obesity and Metabolism |
| Volume | volume24 |
| Issue | issue8 |
| Publisher | Wiley |
| Start Page | 1429 |
| End Page | 1438 |
| ISSN | 1462-8902 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35491532 |
| DOI | 10.1111/dom.14731 |
| Web of Science KeyUT | 000822653700001 |
| Related Url | isVersionOf https://doi.org/10.1111/dom.14731 |
