result 3863 件
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Nicolussi, Paola| Pilo, Giovannantonio| Cancedda, Maria Giovanna| Peng, Guotao| Chau, Ngoc Do Quyen| De la Cadena, Alejandro| Vanna, Renzo| Samad, Yarjan Abdul| Ahmed, Tanweer| Marcellino, Jeremia| Tedde, Giuseppe| Giro, Linda| Ylmazer, Acelya| Loi, Federica| Carta, Gavina| Secchi, Loredana| Dei Giudici, Silvia| Macciocu, Simona| Polli, Dario| Nishina, Yuta| Ligios, Ciriaco| Cerullo, Giulio| Ferrari, Andrea| Bianco, Alberto| Fadeel, Bengt| Franzoni, Giulia| Delogu, Lucia Gemma| |
| Keywords | 2D materials biocompatibility immune system porcine model toxicity |
| Published Date | 2024-10-10 |
| Publication Title | Advanced Healthcare Materials |
| Volume | volume14 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 2401783 |
| ISSN | 2192-2640 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39385652 |
| DOI | 10.1002/adhm.202401783 |
| Web of Science KeyUT | 001329514700001 |
| Related Url | isVersionOf https://doi.org/10.1002/adhm.202401783 |
| FullText URL | fulltext.pdf suppl.pdf |
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| Author | Ferreras, Andrea| Matesanz, Ana| Mendizabal, Jabier| Artola, Koldo| Nishina, Yuta| Acedo, Pablo| Jorcano, José L.| Ruiz, Amalia| Reina, Giacomo| Martín, Cristina| |
| Keywords | photothermal therapy graphene derivatives 4D bioprinting alginate tissue engineering |
| Published Date | 2024-06-07 |
| Publication Title | ACS Nanoscience Au |
| Volume | volume4 |
| Issue | issue4 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 263 |
| End Page | 272 |
| ISSN | 2694-2496 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 39184835 |
| DOI | 10.1021/acsnanoscienceau.4c00006 |
| Web of Science KeyUT | 001242680500001 |
| Related Url | isVersionOf https://doi.org/10.1021/acsnanoscienceau.4c00006 |
| FullText URL | fulltext.pdf suppl1.pdf suppl4.xlsx suppl5.xlsx |
|---|---|
| Author | Tsukahara, Sayuri| Bousios, Alexandros| Perez-Roman, Estela| Yamaguchi, Sota| Leduque, Basile| Nakano, Aimi| Naish, Matthew| Osakabe, Akihisa| Toyoda, Atsushi| Ito, Hidetaka| Edera, Alejandro| Tominaga, Sayaka| Juliarni| Kato, Kae| Oda, Shoko| Inagaki, Soichi| Lorković, Zdravko| Nagaki, Kiyotaka| Berger, Frédéric| Kawabe, Akira| Quadrana, Leandro| Henderson, Ian| Kakutani, Tetsuji| |
| Published Date | 2025-01-01 |
| Publication Title | Nature |
| Volume | volume637 |
| Issue | issue8046 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 744 |
| End Page | 748 |
| ISSN | 0028-0836 |
| NCID | AA00752384 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 39743586 |
| DOI | 10.1038/s41586-024-08319-7 |
| Web of Science KeyUT | 001386539900001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41586-024-08319-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mitsutake, Akihiko| Matsukawa, Takashi| Naito, Tatsuhiko| Ishiura, Hiroyuki| Mitsui, Jun| Harada, Hiroaki| Fujio, Keishi| Fujishiro, Jun| Mori, Harushi| Morishita, Shinichi| Tsuji, Shoji| Toda, Tatsushi| |
| Keywords | epileptic encephalopathy whole-exome sequencing KCNH5 de novo variant |
| Published Date | 2025-03-01 |
| Publication Title | Internal Medicine |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 759 |
| End Page | 762 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 39085070 |
| DOI | 10.2169/internalmedicine.3999-24 |
| Web of Science KeyUT | 001447558300019 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.3999-24 |
| FullText URL | K0007196_abstract_review.pdf K0007196_fulltext.pdf K0007196_summary.pdf |
|---|---|
| Author | ZHAO, PENGFEI| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7196号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2024 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
| JaLCDOI | 10.18926/AMO/68729 |
|---|---|
| FullText URL | 79_3_209.pdf |
| Author | Taguchi, Kenichi| Nishii, Kazuya| Hata, Sakura| Kuyama, Shoichi| Tanaka, Shoichi| |
| Abstract | A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered. |
| Keywords | methemoglobinemia aniline methylene blue cyanosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 209 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574260 |
| Web of Science KeyUT | 001524768800008 |
| JaLCDOI | 10.18926/AMO/68727 |
|---|---|
| FullText URL | 79_3_197.pdf |
| Author | Kondo, Naoki| Kakutani, Rika| Mochizuki, Tomoharu| Wakui, Junichi | Hao, Nariaki| Kinoshita, Eiji| Kawashima, Hiroyuki| |
| Abstract | A 67-year-old woman with rheumatoid arthritis presented with an untriggered hematoma in the right shoulder joint. Radiographic findings showed humeral head collapse and destruction of the glenoid fossa with ectopic calcification. Calcium pyrophosphate deposition (CPPD) in the synovial fluid was observed using a polarizing microscope. Histopathological findings revealed chronic inflammatory cell infiltration and giant cells surrounded by CPPD. The patient was diagnosed with rapid destructive arthropathy (RDA). Endoscopic shoulder joint debridement was performed. Postoperatively, active flexion improved from 40 to 75 degrees. This case highlights that CPPD can cause RDA in the shoulder, detectable with detailed histopathology. |
| Keywords | rheumatoid arthritis calcium pyrophosphate deposition rapid destructive arthropathy case report |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 203 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574258 |
| Web of Science KeyUT | 001524768800006 |
| JaLCDOI | 10.18926/AMO/68726 |
|---|---|
| FullText URL | 79_3_185.pdf |
| Author | Yoshikawa, Ayumi| Taira, Naruto| Okanaga, Mayumi| Saito, Shinya| |
| Abstract | We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners. |
| Keywords | breast cancer patient young patient single partners relationships |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574257 |
| Web of Science KeyUT | 001524768800005 |
| JaLCDOI | 10.18926/AMO/68724 |
|---|---|
| FullText URL | 79_3_167.pdf |
| Author | Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator| |
| Abstract | This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy. |
| Keywords | non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574255 |
| Web of Science KeyUT | 001524768800003 |
| JaLCDOI | 10.18926/AMO/68723 |
|---|---|
| FullText URL | 79_3_157.pdf |
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
| Abstract | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
| Keywords | advanced glycation end product aging cartilage collagen aggrecan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 157 |
| End Page | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574254 |
| Web of Science KeyUT | 001524768800002 |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574253 |
| Web of Science KeyUT | 001524768800001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takatori, S.| Pimon, M.| Pollitt, S.| Bartokos, M.| Beeks, K.| Grueneis, A.| Hiraki, T.| Honma, T.| Hosseini, N.| Leitner, A.| Masuda, T.| Morawetz, I| Nitta, K.| Okai, K.| Riebner, T.| Schaden, F.| Schumm, T.| Sekizawa, O.| Sikorsky, T.| Takahashi, Y.| De Col, Col, L. Toscani| Yamamoto, R.| Yomogida, T.| Yoshimi, A.| Yoshimura, K.| |
| Keywords | solid-state nuclear clock thorium-229 XAFS |
| Published Date | 2025-04-28 |
| Publication Title | New Journal of Physics |
| Volume | volume27 |
| Issue | issue4 |
| Publisher | IOP Publishing |
| Start Page | 043024 |
| ISSN | 1367-2630 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| DOI | 10.1088/1367-2630/adce22 |
| Web of Science KeyUT | 001477975100001 |
| Related Url | isVersionOf https://doi.org/10.1088/1367-2630/adce22 |
| JaLCDOI | 10.18926/AMO/68649 |
|---|---|
| FullText URL | 79_2_109.pdf |
| Author | Awai, Kyoko| Nakatsuka, Mikiya| |
| Abstract | The status of postpartum depression was elucidated herein with the use of the Edinburgh Postnatal Depression Scale (EPDS) in women in Shikoku, Japan who became pregnant and gave birth after undergoing infertility treatment, including assisted reproductive technology (ART). The assessment was performed during their children’s 4-month health examination. The relationships between postpartum depression and the mothers’ background factors and scores on the Big Five personality traits scale were also examined. Of the Big Five personality traits, the scores for neuroticism were significantly higher in the ART group (n=71) than in the general infertility treatment (n=118) and natural pregnancy (n=872) groups. No significant differences in EPDS scores were seen among these three groups. A logistic regression analysis showed that neuroticism was associated with an EPDS score ≧9 points, (which is suggestive of postpartum depression, ) in all groups. Moreover, although a long-standing marriage had an inhibitory effect on postpartum depression in the natural pregnancy group, no such trend was seen in the ART group, which included many women with long-standing marriages. Particularly for women who become pregnant by ART, an individualized response that pays close attention to the woman’s personality traits is needed. |
| Keywords | infertility treatment assisted reproductive technology postpartum postpartum depression personality trait |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 116 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302282 |
| Web of Science KeyUT | 001485544200006 |
| JaLCDOI | 10.18926/AMO/68648 |
|---|---|
| FullText URL | 79_2_101.pdf |
| Author | Isozaki, Hiroshi| Matsumoto, Sasau| Takama, Takehiro| Isozaki, Yuka| |
| Abstract | To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes. |
| Keywords | breast cancer postoperative irradiation radiation therapy sentinel lymph nodes recurrence |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 101 |
| End Page | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302281 |
| Web of Science KeyUT | 001485544200005 |
| JaLCDOI | 10.18926/AMO/68646 |
|---|---|
| FullText URL | 79_2_081.pdf |
| Author | Kawada, Tatsushi| Kobayashi, Yasuyuki| Tsugawa, Takuji| Tsuboi, Kazuma| Katayama, Satoshi| Iwata, Takehiro| Bekku, Kensuke| Kobayashi, Tomoko| Edamura, Kohei| Ebara, Shin| Araki, Motoo| |
| Abstract | We retrospectively evaluated the oncologic outcomes of paclitaxel, cisplatin, and gemcitabine (PCG) with those of gemcitabine and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients. The primary outcome was efficacy: pathological complete response (pCR), ypT0N0; and pathological objective response (pOR), ypT0N0, ≤ ypT1N0, or ypT0N1. Secondary outcomes included overall survival (OS), recurrence-free survival (RFS), predictive factors for pOR, OS, and RFS, and hematologic adverse events (AEs). Among 113 patients treated (PCG, n=28; GC, n=85), similar pOR and pCR rates were achieved by the groups (pOR: PCG, 57.1% vs. GC, 49. 4%; p=0.52; pCR: PCG, 39.3% vs. GC, 29.4%; p=0.36). No significant differences were observed in OS (p=1.0) or RFS (p=0.20). Multivariate logistic regression analysis showed that hydronephrosis (odds ratio [OR] 0.32, 95%CI: 0.11-0.92) and clinical node-positive status (cN+) (OR 0.22, 95%CI: 0.050-0.99) were significantly associated with a decreased probability of pOR. On multivariate Cox regression analyses, pOR achievement was associated with improved OS (hazard ratio [HR] 0.23, 95%CI: 0.10-0.56) and RFS (HR 0.30, 95%CI: 0.13-0.67). There were no significant between-group differences in the incidence of grade ≥ 3 hematologic AEs or dose-reduction required, but the PCG group had a higher incidence of grade 4 neutropenia. |
| Keywords | urothelial carcinoma paclitaxel cisplatin gemcitabine neoadjuvant |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 81 |
| End Page | 92 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302279 |
| Web of Science KeyUT | 001485544200003 |
| JaLCDOI | 10.18926/AMO/68645 |
|---|---|
| FullText URL | 79_2_075.pdf |
| Author | Higaki, Fumiyo| Morimitsu, Yusuke| Iguchi, Toshihiro| Hwang, Sung Il| Kitayama, Takahiro| Takahashi, Yuka| Uka, Mayu| Akagi, Noriaki| Sugaya, Akiko| Mitsuhashi, Toshiharu| Matsui, Yusuke| Hiraki, Takao| |
| Abstract | Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%. |
| Keywords | computed tomography photon-counting detector computed tomography ear ossicle energy-integrating detector computed tomography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 75 |
| End Page | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302278 |
| Web of Science KeyUT | 001485544200002 |
| JaLCDOI | 10.18926/AMO/68644 |
|---|---|
| FullText URL | 79_2_065.pdf |
| Author | Maki, Masatoshi| Takada, Ryo| Ishigo, Tomoyuki| Fujiwara, Miki| Takahashi, Yoko| Otsuka, Shinya| Tamura, Koji| Hamaoka, Terutaka| |
| Abstract | Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy. |
| Keywords | anamorelin cancer-associated cachexia body mass index albumin efficacy rate |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 73 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302277 |
| Web of Science KeyUT | 001485544200001 |
| JaLCDOI | 10.18926/bgeou/68588 |
|---|---|
| Title Alternative | Daily Social Support among Canberra Residents |
| FullText URL | bgeou_087_063_083.pdf |
| Author | NOBE, MASAO| |
| Abstract | This paper reports a study that investigated perceived sources of daily support. To gather empirical evidence, a sample survey of women in four study areas of Canberra was conducted in 1986-1987. Three hundred and ninety-four women who were under 55 years of age and who were married or in a de facto relationship were interviewed. They responded to six hypothetical difficult situations by identifying the first source from which they would seek support. Analysis of the data has revealed the following ; (1) When respondents had their relatives in Canberra, they regarded their relatives as the chief source of daily support. However, there were many residents without local relatives in Canberra. For such respondents, their relatives were not so helpful in daily support. Incidentally, workmates were thought of as much less important providers of support than relatives, neighbours or friends. (2) Social networks were differentiated in that respondents tended to depend on types of people appropriate to individual difficult situations. (3) Dependable friends and workmates tended to live closer than dependable relatives. (4) Dependable relatives were usually limited to immediate family, such as parents (-in-law), brothers (-in-law) or sisters (-in-law). |
| Publication Title | Bulletin of Faculty of Education,Okayama University |
| Published Date | 1991-07-15 |
| Volume | volume87 |
| Start Page | 63 |
| End Page | 83 |
| ISSN | 0471-4008 |
| language | Japanese |
| File Version | publisher |
| Title Alternative | Les extinctions des droits réels grevés sur l’immeuble qui est acquis par usucapion : La recherche historique sur la jurisprudence au XIXe siècle. |
|---|---|
| FullText URL | olj_74_3-4_189_252.pdf |
| Author | Shimazu, G. | |
| Publication Title | Okayama Law Journal |
| Published Date | 2025-03-24 |
| Volume | volume74 |
| Issue | issue3-4 |
| Start Page | 189 |
| End Page | 252 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/OER/68447 |
|---|---|
| Title Alternative | Die Grundlagen der wirtschaftlichen Entwicklung des Königreichs Sachsen（ 7 und Schluß） |
| FullText URL | oer_056_3_065_086.pdf |
| Author | Matsuo, Nobushige| |
| Publication Title | Okayama Economic Review |
| Published Date | 2025-03-21 |
| Volume | volume56 |
| Issue | issue3 |
| Start Page | 65 |
| End Page | 86 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2025 岡山大学経済学会 |
| File Version | publisher |
