result 358 件
| JaLCDOI | 10.18926/AMO/61217 |
|---|---|
| FullText URL | 74_6_557.pdf |
| Author | Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki| |
| Abstract | A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively. |
| Keywords | 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 557 |
| End Page | 562 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361878 |
| Web of Science KeyUT | 000601203600014 |
| NAID | 120006948944 |
| JaLCDOI | 10.18926/AMO/60808 |
|---|---|
| FullText URL | 74_5_455.pdf |
| Author | Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Kanetaka, Kengo| Nagayasu, Takeshi| Eguchi, Susumu| |
| Abstract | Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients’ records until 3 weeks after the fourth docetaxel administration. This study’s results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients. |
| Keywords | breast cancer docetaxel neuropathy compression |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 455 |
| End Page | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106704 |
| Web of Science KeyUT | 000581970100013 |
| NAID | 120006892934 |
| JaLCDOI | 10.18926/AMO/60805 |
|---|---|
| FullText URL | 74_5_435.pdf |
| Author | Fujishita, Keigo| Oka, Satoshi| Kamei, Katsuhiko| Tani, Katsuma| Fujisawa, Yuka| Kitamura, Wataru| Machida, Takuya| Imai, Toshi| |
| Abstract | A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring normal hematopoiesis is important in the treatment of fusariosis, HSCT might be considered for patients with persistent pancytopenia. |
| Keywords | disseminated fusariosis Fusarium fujikuroi species complex allogeneic hematopoietic stem cell transplantation acute myeloid leukemia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 435 |
| End Page | 441 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106701 |
| Web of Science KeyUT | 000581970100010 |
| NAID | 120006892931 |
| JaLCDOI | 10.18926/AMO/60798 |
|---|---|
| FullText URL | 74_5_391.pdf |
| Author | Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakaif, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Shimada, Hayato| Dohmae, Yoichiro| Endo, Naoto| |
| Abstract | Indexes for objectively evaluating abnormal gait in hip osteoarthritis (OA) patients and determining effective interventions are unclear. We analyzed the abnormal gait of hip OA patients by focusing on movements of the trunk and pelvis to establish an effective evaluation index for each direction of motion. We studied 28 patients with secondary hip OA due to developmental dysplasia of the hip and 16 controls. The trunk and pelvic movements during gait were measured in the medial-lateral (x), vertical (y), and back-and-forth (z) directions by a triaxial angular accelerometer. Gait speed, steps, step length, muscle strength, range of motion, and timed up-and-go (TUG) test performance were measured. We determined the correlations between physical function and the index of abnormal gait in the hip OA patients. Movements other than trunk and pelvic motions in the y-direction indicated abnormal gait in the patients. Significant correlations were found between abnormal gait and range of motions (extension, internal rotation), TUG score, stride length, and steps. The TUG test, stride length and steps were important for evaluating abnormal gait in hip OA patients. Individual interventions for each movement direction are required. |
| Keywords | hip osteoarthritis three-dimensional gait analysis abnormal gait timed up and go test range of motion |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 399 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106694 |
| Web of Science KeyUT | 000581970100003 |
| NAID | 120006892924 |
| FullText URL | EJSO_2020.05.025.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Kaneuchi, Yoichi| Stevenson, Jonathan| Parry, Michael| Kurisunkal, Vineet| Clark, Rhys| Tsuda, Yusuke| Laitinen, Minna| Grimer, Robert| Jeys, Lee| |
| Keywords | Chondrosarcoma Pelvis Surgery Navigation |
| Note | This fulltext is available in Jul. 2021.| |
| Published Date | 2020-07-03 |
| Publication Title | EJSO - European Journal of Surgical Oncology |
| Volume | volume47 |
| Issue | issue2 |
| Publisher | European Society of Surgical Oncology |
| Start Page | 416 |
| End Page | 423 |
| ISSN | 0748-7983 |
| NCID | AA10516435 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32788097 |
| DOI | 10.1016/j.ejso.2020.05.025 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejso.2020.05.025 |
| JaLCDOI | 10.18926/AMO/60376 |
|---|---|
| FullText URL | 74_4_365.pdf |
| Author | Chuma, Masayuki| Kondo, Masateru| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Okada, Naoto| Shibata, Akitomo| Asada, Mizuho| Oto, Jun| Yanagawa, Hiroaki| Ishizawa, Keisuke| |
| Abstract | Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function. |
| Keywords | vancomycin, therapeutic drug monitoring cystatin C bacterial meningitis sepsis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 365 |
| End Page | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843769 |
| Web of Science KeyUT | 000562508700013 |
| NAID | 120006880215 |
| JaLCDOI | 10.18926/AMO/60365 |
|---|---|
| FullText URL | 74_4_285.pdf |
| Author | Tsukahara, Kohei| Naitou, Hiromichi| Yorifuji, Takashi| Nosaka, Nobuyuki| Yamamoto, Hirotsugu| Osako, Takaaki| Nakao, Atsunori| the JaRPAC Study Group| |
| Abstract | The importance of centralizing treatment services for severely ill children has been well established, but such entralization remains difficult in Japan. We aimed to compare the trauma and illness severity and mortality of children admitted to two common types of ICUs for children. According to the type of management and disposition of the medical provider, we classified ICUs as pediatric ICUs [PICUs] or general ICUs, and analyzed differences in endogenous and exogenous illness settings between them. Overall, 1,333 pediatric patients were included, with 1,143 patients admitted to PICUs and 190 patients to general ICUs. The Pediatric Cerebral Performance Category score (PCPC) at discharge was significantly lower in the PICU group (adjusted OR: 0.45; 95%CI: 0.23-0.88). Death and unfavorable neurological outcomes occurred less often in the PICU group (adjusted OR: 0.29; 95%CI: 0.14-0.60). However, when limited to exogenous illness, PCPC scores (adjusted OR: 0.38; 95%CI: 0.07-1.99) or death/unfavorable outcomes (adjusted OR: 0.72; 95%CI: 0.08-6.34) did not differ between the groups. PCPC deterioration and overall sequelae/death rates were lower in PICUs for children with endogenous illnesses, although the outcomes of exogenous illness were similar between the 2 unit types. Further studies on the necessity of centralization are warranted. |
| Keywords | kids critical care mortality morbidity centralization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 291 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843759 |
| Web of Science KeyUT | 000562508700003 |
| NAID | 120006880204 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Shumpei| Onishi, Hideki| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Keywords | Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin |
| Published Date | 2020-04-21 |
| Publication Title | Gastrointestinal Tumors |
| Volume | volume7 |
| Issue | issue3 |
| Publisher | Karger |
| Start Page | 83 |
| End Page | 92 |
| ISSN | 2296-3774 |
| NCID | AA12665877 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s) |
| File Version | publisher |
| DOI | 10.1159/000506941 |
| Web of Science KeyUT | 000551254300003 |
| Related Url | isVersionOf https://doi.org/10.1159/000506941 |
| FullText URL | Knee_27_3_899_905_Fulltext.pdf Knee_27_3_899_905_Figures.pptx |
|---|---|
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Miyazawa, Shinichi| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Kodama, Yuya| Ozaki, Toshifumi| |
| Keywords | Medial meniscus posterior root tear Pullout repair Tibial tunnel Meniscal healing |
| Note | This fulltext is available in Apr. 2021.| |
| Published Date | 2020-04-02 |
| Publication Title | The Knee |
| Volume | volume27 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 899 |
| End Page | 905 |
| ISSN | 0968-0160 |
| NCID | AA10996272 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Elsevier B.V. |
| File Version | author |
| PubMed ID | 32249020 |
| DOI | 10.1016/j.knee.2020.02.025 |
| Web of Science KeyUT | 000542165100038 |
| Related Url | isVersionOf https://doi.org/10.1016/j.knee.2020.02.025 |
| JaLCDOI | 10.18926/AMO/58273 |
|---|---|
| FullText URL | 74_2_145.pdf |
| Author | Otsuki, Hideo| Yamasaki, Tomoya| Hori, Shunsuke| Aoki, Hiroshi| Kosaka, Takeo| Uehara, Shinya| Fujio, Kei| |
| Abstract | To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent. |
| Keywords | stent-related symptoms overactive bladder mirabegron ureterorenoscopic lithotripsy ureteral stent |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 150 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341589 |
| Web of Science KeyUT | 000528278500008 |
| NAID | 120006839452 |
| JaLCDOI | 10.18926/AMO/58270 |
|---|---|
| FullText URL | 74_2_123.pdf |
| Author | Fukuhara, Ryuichiro| Shinya, Takayoshi| Fukuma, Shogo| Ogawa, Nanako| Masaoka, Yoshihisa| Tanaka, Takehiro| Marunaka, Hidenori| Arioka, Tadashi| Hiraki, Takao| Kaji, Mitsumasa| Kanazawa, Susumu| |
| Abstract | The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly. |
| Keywords | 18F-fluorodeoxyglucose positron emission tomography/computed tomography extranodular spread metastasis oral squamous cell carcinoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 128 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341586 |
| Web of Science KeyUT | 000528278500005 |
| NAID | 120006839449 |
| JaLCDOI | 10.18926/AMO/58268 |
|---|---|
| FullText URL | 74_2_109.pdf |
| Author | Ogawa, Chikako| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Masuyama, Hisashi| |
| Abstract | This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients. |
| Keywords | second primary cancer gynecologic cancer prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 114 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341584 |
| Web of Science KeyUT | 000528278500003 |
| NAID | 120006839447 |
| JaLCDOI | 10.18926/AMO/57953 |
|---|---|
| FullText URL | 74_1_53.pdf |
| Author | Kubota, Risa| Araki, Motoo| Wada, Koichiro| Kawamura, Kasumi| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Ariyoshi, Yuichi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Kano, Yuzuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hitoshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | We investigated the feasibility of robotic renal autotransplantation (RAT) in a porcine model to reduce invasiveness of RAT. Five pigs underwent robotic RAT using the da Vinci® robotic system. A robotic left nephrectomy was performed in all cases. Robotic RAT was performed on the left side in all but one case. Four ports were used. In 3 cases, the kidney was taken out through the GelPort® and irrigated on ice with Ringer’s solution. In 2 cases, a complete intracorporeal robotic RAT was performed. An end-to-side anastomosis was performed between the renal vein and the external iliac vein and between the renal artery and the external iliac artery. Ureteroneocystostomy was also performed in 2 cases. All cases were performed robotically without open conversion. The median (IQR) console time was 3.1 (0.7) h, and the operative time was 3.8 (1.1) h. The estimated blood loss was 30 (0) ml. The warm ischemia time was 4.0 (0.2) min, and the cold ischemia time was 97 (17) min. Intracorporeal transarterial hypothermic renal perfusion was feasible in the 2 complete intracorporeal robotic RAT cases by using a perfusion catheter through a laparoscopic port. Robotic RAT has the potential to be a new minimally invasive substitute for conventional open surgery. |
| Keywords | renal autotransplantation robotic porcine model transplantation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099249 |
| Web of Science KeyUT | 000516606200008 |
| NAID | 120006795620 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
| JaLCDOI | 10.18926/AMO/57720 |
|---|---|
| FullText URL | 73_6_537.pdf |
| Author | Takahara, Yasuhiro| Nishida, Keiichiro| Nakashima, Hirotaka| Ochi, Nobuaki| Uchida, Yoichiro| Kato, Hisayoshi| Itani, Satoru| Nakamura, Makoto| Iwasaki, Yuichi| Tsujimura, Yoshitaka| |
| Abstract | High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty. |
| Keywords | high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-12 |
| Volume | volume73 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 537 |
| End Page | 542 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31871338 |
| Web of Science KeyUT | 000503431400011 |
| JaLCDOI | 10.18926/AMO/57715 |
|---|---|
| FullText URL | 73_6_511.pdf |
| Author | Takahara, Yasuhiro| Furumatsu, Takayuki| Nakashima, Hirotaka| Itani, Satoru| Nakamura, Makoto| Uchida, Yoichiro| Kato, Hisayoshi| Tsujimura, Yoshitaka| Iwasaki, Yuichi| Ochi, Nobuaki| |
| Abstract | Medial open- and lateral closed-wedge high tibial osteotomy (hybrid CWHTO) can overcome the limitations of conventional CWHTO and open-wedge HTO (OWHTO) for medial compartmental osteoarthritis (OA) of the knee. Hybrid CWHTO increases stability by using a rigid locking plate and allows early full weight-bearing. However, the literature contains no information about time to bone union after this new procedure. The aim of this study is to evaluate the time to bone union after hybrid CWHTO. We reviewed 44 knees treated with hybrid CWHTO. Patients were able to stand on both legs on the day after surgery and walked with full weight-bearing within 4 weeks of the procedure. The time to achievement of bone union at the osteotomy site was defined as the number of months until bone union was confirmed on radiographic imaging. The mean time to radiographic confirmation of bone union was 4.5±1.5 months after surgery. Eleven knees (25.0%) required 6 months or more. Radiographic analysis and JOA score improved significantly between before and 1 year after surgery (p<0.01). Hybrid CWHTO is a very useful method for treating medial OA, but radiographic bone union requires 4.5 months on average. We must be aware of bone union after hybrid CWHTO. |
| Keywords | bone union hybrid closed-wedge high tibial osteotomy osteoarthritis |
| Amo Type | Original Article |
| Note | ,| |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-12 |
| Volume | volume73 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 511 |
| End Page | 516 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31871333 |
| Web of Science KeyUT | 000503431400006 |
| JaLCDOI | 10.18926/AMO/57711 |
|---|---|
| FullText URL | 73_6_479.pdf |
| Author | Suganami, Yu| Oka, Kosuke| Hanayama, Yoshihisa| Honda, Hiroyuki| Hamahara, Jun| Obika, Mikako| Kariyama, Kazuya| Kishida, Masayuki| Otsuka, Fumio| |
| Abstract | To clarify the potential relevance of patients’ chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), orthopedic and skin (10%), and systemic (22%) symptoms. The SDS score tended to be higher in females and younger patients. The FSSG score did not differ by gender but was higher in younger patients. The patients receiving social welfare had higher SDS and FSSG scores. A close inter-relationship between the FSSG (including both degrees of reflux and dysmotility) and SDS was observed in all patients. Although the averages of the SDS and FSSG scores were not significantly different among the symptom-based categories, we observed significantly positive correlations between the FSSG and SDS in each category, suggesting that depressive status may be closely related to GERD-related symptoms regardless of the patients’ chief complaints. An initial checkup of patients’ psychological condition and/or GERD-like symptoms could help screen for latent disorders in outpatients with uncertain complaints. |
| Keywords | chief complaints frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) self-rating depression scale (SDS) welfare |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-12 |
| Volume | volume73 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 486 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31871329 |
| Web of Science KeyUT | 000503431400002 |
| JaLCDOI | 10.18926/AMO/57374 |
|---|---|
| FullText URL | 73_5_433.pdf |
| Author | Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia. |
| Keywords | preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 433 |
| End Page | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649370 |
| Web of Science KeyUT | 000491886600009 |
| JaLCDOI | 10.18926/AMO/57372 |
|---|---|
| FullText URL | 73_5_419.pdf |
| Author | Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo| |
| Abstract | We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis. |
| Keywords | sedentary behavior hemodialysis mortality physical activity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 419 |
| End Page | 425 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649368 |
| Web of Science KeyUT | 000491886600007 |
| JaLCDOI | 10.18926/AMO/57369 |
|---|---|
| FullText URL | 73_5_393.pdf |
| Author | Yi Yi Cho Thein| Win, Myitzu| Thuzara, Moe| Matsumoto, Hiroshi| Yamada, Kiyoshi| Kimata, Yoshihiro| Leung, Michael| |
| Abstract | Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation. |
| Keywords | microsurgery educational programs challenges of microsurgical free flaps reoperation flap salvageable rate |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 393 |
| End Page | 401 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649365 |
| Web of Science KeyUT | 000491886600004 |
