result 1235 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohata, Miyu| Fukui, Ryohei| Morimitsu, Yusuke| Kobayashi, Daichi| Yamauchi, Takatsugu| Akagi, Noriaki| Honda, Mitsugi| Hayashi, Aiko| Hasegawa, Koshi| Kida, Katsuhiro| Goto, Sachiko| Hiraki, Takao| |
| Keywords | Image quality photon-counting computed tomography quantum iterative reconstruction radiomics renal cell carcinoma |
| Published Date | 2025-01 |
| Publication Title | Journal of Medical Physics |
| Volume | volume50 |
| Issue | issue1 |
| Publisher | Medknow Publications |
| Start Page | 100 |
| End Page | 107 |
| ISSN | 0971-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Journal of Medical Physics |
| File Version | publisher |
| DOI | 10.4103/jmp.jmp_114_24 |
| Web of Science KeyUT | 001452585400015 |
| Related Url | isVersionOf https://doi.org/10.4103/jmp.jmp_114_24 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishii, Naoko| Kawai, Tomoko| Yasuoka, Hiroki| Abe, Tadashi| Tatsumi, Nanami| Harada, Yuika| Miyaji, Takaaki| Li, Shunai| Tsukano, Moemi| Watanabe, Masami| Ogawa, Daisuke| Wada, Jun| Takei, Kohji| Yamada, Hiroshi| |
| Keywords | VGLUT3 glutamate podocyte glutamatergic transmission |
| Published Date | 2025-03-11 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 2485 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40141129 |
| DOI | 10.3390/ijms26062485 |
| Web of Science KeyUT | 001452693900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26062485 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakama, Masaki| Noji, Tomoyasu| Kojima, Keiichi| Yoshizawa, Susumu| Ishikita, Hiroshi| Sudo, Yuki| |
| Keywords | microbial rhodopsin anion transport retinal membrane protein photobiology |
| Published Date | 2025-04 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume301 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 108334 |
| ISSN | 1083-351X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 39984052 |
| DOI | 10.1016/j.jbc.2025.108334 |
| Web of Science KeyUT | 001450594900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jbc.2025.108334 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshida, Suzuka| Kuroda, Masahiro| Nakamura, Yoshihide| Fukumura, Yuka| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Kuroda, Kazuhiro| Shimizu, Yudai| Tanabe, Yoshinori| Oita, Masataka| Sugianto, Irfan| Barham, Majd| Tekiki, Nouha| Kamaruddin, Nurul N.| Hisatomi, Miki| Yanagi, Yoshinobu| Asaumi, Junichi| |
| Keywords | head and neck tumors mean kurtosis simple diffusion kurtosis imaging magnetic resonance imaging apparent diffusion coefficient value diffusion kurtosis imaging machine learning bi-parameter analysis gradient boosting differential diagnosis of benign and malignant |
| Published Date | 2025-03-20 |
| Publication Title | Diagnostics |
| Volume | volume15 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 790 |
| ISSN | 2075-4418 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40150132 |
| DOI | 10.3390/diagnostics15060790 |
| Web of Science KeyUT | 001452274300001 |
| Related Url | isVersionOf https://doi.org/10.3390/diagnostics15060790 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyai, Hisataka| Tomofuji, Takaaki| Mizuno, Hirofumi| Morita, Manabu| Nakahara, Momoko| Kataoka, Kota| Sumita, Ichiro| Uchida, Yurika| Toyama, Naoki| Yokoi, Aya| Yamanaka-Kohno, Reiko| Takeuchi, Noriko| Maruyama, Takayuki| Ekuni, Daisuke| |
| Keywords | halitosis trehalose oral dryness cross-over study randomized trial |
| Published Date | 2025-03-13 |
| Publication Title | Healthcare |
| Volume | volume13 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 619 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40150469 |
| DOI | 10.3390/healthcare13060619 |
| Web of Science KeyUT | 001452703300001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare13060619 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujii, Yuki| Matsumoto, Kazuyuki| Ochi, Kiyoaki| Himei, Hitomi| Sakakihara, Ichiro| Ueta, Eijiro| Toyokawa, Tatsuya| Harada, Ryo| Ogawa, Taiji| Tomoda, Takeshi| Kato, Hironari| Sato, Ryosuke| Obata, Taisuke| Matsumi, Akihiro| Miyamoto, Kazuya| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Otsuka, Motoyuki| |
| Keywords | clipping closure delayed bleeding endoscopic papillectomy |
| Published Date | 2025 |
| Publication Title | Therapeutic Advances in Gastroenterology |
| Volume | volume18 |
| Publisher | SAGE Publications |
| ISSN | 1756-2848 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), 2025. |
| File Version | publisher |
| PubMed ID | 40104325 |
| DOI | 10.1177/17562848251326450 |
| Web of Science KeyUT | 001447404800001 |
| Related Url | isVersionOf https://doi.org/10.1177/17562848251326450 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sato, Asuka| Omichi, Ryotaro| Maeda, Yukihide| Ando, Mizuo| |
| Keywords | The organ of Corti Acoustic trauma RNA sequencing 51-Da FK506-binding protein Mitogen-activated protein kinase signaling Tumor necrosis factor signaling |
| Published Date | 2025-03-03 |
| Publication Title | Scientific Reports |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 7506 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40033010 |
| DOI | 10.1038/s41598-025-92400-2 |
| Web of Science KeyUT | 001437310100016 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-025-92400-2 |
| FullText URL | fulltext20250324-01.pdf |
|---|---|
| Author | Eguchi, Takanori| Calderwood, Stuart K.| |
| Keywords | Myeloid zinc finger 1 MZF1 Nuclear body PML Sumoylation SCAN domain protein |
| Note | © 2025 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2026.| |
| Published Date | 2025-03-08 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume752 |
| Publisher | Elsevier BV |
| Start Page | 151481 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Published by Elsevier Inc. |
| File Version | author |
| PubMed ID | 39954358 |
| DOI | 10.1016/j.bbrc.2025.151481 |
| Web of Science KeyUT | 001428196800001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2025.151481 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Maruyama, Takayuki| Takayama, Eiji| Tokuno, Shinichi| Morita, Manabu| Ekuni, Daisuke| |
| Keywords | periodontal disease oxidative stress hydrogen randomized controlled trial |
| Published Date | 2025-03-06 |
| Publication Title | Healthcare |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 577 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40077138 |
| DOI | 10.3390/healthcare13050577 |
| Web of Science KeyUT | 001442551300001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare13050577 |
| FullText URL | fulltext20250311-01.pdf fig20250311-01.pdf table20250311-01.pdf suppl20250311-01.pdf |
|---|---|
| Author | Hagiya, Hideharu| Fujita, Yasushi| Kiguchi, Takashi| Manabe, Yohei| |
| Keywords | COVID-19 Immunization Reimbursement Healthcare workers Financial support |
| Note | © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2026.| |
| Published Date | 2025-03 |
| Publication Title | Journal of Infection and Chemotherapy |
| Volume | volume31 |
| Issue | issue3 |
| Publisher | Elsevier BV |
| Start Page | 102660 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. |
| File Version | author |
| PubMed ID | 39956368 |
| DOI | 10.1016/j.jiac.2025.102660 |
| Web of Science KeyUT | 001428904200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2025.102660 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kanai, Takenori| Osawa, Kyoko| Kajiwara, Koichiro| Sato, Yoshiaki| Sawa, Yoshihiko| |
| Keywords | podoplanin cKO osteocyte bone remodeling |
| Published Date | 2025-01-29 |
| Publication Title | Dentistry Journal |
| Volume | volume13 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 61 |
| ISSN | 2304-6767 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39996935 |
| DOI | 10.3390/dj13020061 |
| Web of Science KeyUT | 001433216400001 |
| Related Url | isVersionOf https://doi.org/10.3390/dj13020061 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Okada, Hiroyuki| Otsuka, Motoyuki| |
| Keywords | esophagogastroduodenoscopy gastric lesions gastrointestinal stromal tumor subepithelial lesion submucosal tumor |
| Published Date | 2025-02-07 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume14 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 1055 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 40004584 |
| DOI | 10.3390/jcm14041055 |
| Web of Science KeyUT | 001430791000001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm14041055 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yunoki, Kei| Matsumi, Hiroaki| Miyoshi, Toru| Kubo, Motoki| Hata, Yoshiki| Yuasa, Shinsuke| |
| Keywords | coronary artery disease endothelial function eicosapentaenoic acid residual risk factor |
| Published Date | 2025-02-05 |
| Publication Title | Journal of Cardiovascular Development and Disease |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 60 |
| ISSN | 2308-3425 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39997494 |
| DOI | 10.3390/jcdd12020060 |
| Web of Science KeyUT | 001430669800001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcdd12020060 |
| FullText URL | fulltext20250304-01.pdf |
|---|---|
| Author | Nishimura, Yoshito| Fajgenbaum, David C.| Pierson, Sheila K.| Iwaki, Noriko| Nishikori, Asami| Kawano, Mitsuhiro| Nakamura, Naoya| Izutsu, Koji| Takeuchi, Kengo| Nishimura, Midori Filiz| Maeda, Yoshinobu| Otsuka, Fumio| Yoshizaki, Kazuyuki| Oksenhendler, Eric| van Rhee, Frits| Sato, Yasuharu| |
| Note | This is the peer reviewed version of the following article: [Nishimura Y, Fajgenbaum DC, Pierson SK, et al. Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease. Am J Hematol. 2021; 96(10): 1241-1252. https://doi.org/10.1002/ajh.26292], which has been published in final form at [https://doi.org/10.1002/ajh.26292]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2021-07-28 |
| Publication Title | American Journal of Hematology |
| Volume | volume96 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 1241 |
| End Page | 1252 |
| ISSN | 0361-8609 |
| NCID | AA00520673 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Wiley Periodicals LLC. |
| File Version | author |
| PubMed ID | 34265103 |
| DOI | 10.1002/ajh.26292 |
| Web of Science KeyUT | 000678183100001 |
| Related Url | isVersionOf https://doi.org/10.1002/ajh.26292 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naniwa, Shuichi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Ohtsuki, Takashi| Hotta, Yoshifumi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Otsuka, Noriaki| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress LRP4 Agrin β-catenin SOX9 |
| Published Date | 2025-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1007 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39940775 |
| DOI | 10.3390/ijms26031007 |
| Web of Science KeyUT | 001418599900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26031007 |
| JaLCDOI | 10.18926/AMO/68362 |
|---|---|
| FullText URL | 79_1_051.pdf |
| Author | Miura, Taro| Kawasaki, Yoichi| Hamano, Hirofumi| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected in human serum. Here, we investigated the histamine-producing effects in HMC-1 cells and the inflammatory cytokine release effects in RAW264 cells for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; and 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All four promoted histamine production in HMC-1 cells; however, they did not significantly affect the release of inflammatory cytokines in RAW264 cells. These findings suggest that these four photoinitiators induce inflammatory cytokine-independent histamine production, potentially contributing to histamine-mediated chronic inflammation in vitro. |
| Keywords | photoinitiator ink injection histamine inflammation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 51 |
| End Page | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012160 |
| Web of Science KeyUT | 001440463800007 |
| JaLCDOI | 10.18926/AMO/68360 |
|---|---|
| FullText URL | 79_1_039.pdf |
| Author | Takao, Shinichiro| Uotani, Koji| Misawa, Haruo| Tetsunaga, Tomoko| Shinohara, Kensuke| Yamane, Kentaro| Oda, Yoshiaki| Tsuji, Hironori| Kajiki, Yuya| Ozaki, Toshifumi| |
| Abstract | Evaluating vertebral bone mass and quality in the elderly poses challenges due to degenerative changes. This study aims to elucidate the usefulness of the trabecular bone score (TBS) by examining the relationship between bone mineral density (BMD), TBS, and Hounsfield unit (HU) values. A retrospective analysis of 599 vertebrae from 152 patients (mean age 69.0 years; range 44-89; 74 males and 78 females) undergoing dual-energy X-ray absorptiometry (DXA) and CT scans was conducted. Vertebrae were categorized into three grades based on the degree of degeneration. The TBS was calculated from DXA images, and the HU value was measured by placing a region of interest on an axial image of the vertebral mid-body. One-way analysis of variance and Pearson’s correlation tests were employed to investigate the relationship between BMD and TBS or HU values. While lumbar BMD significantly increased (p<0.01) with degenerative changes, TBS and HU values showed no significant differences. The correlations between lumbar BMD and TBS values, and between BMD and HU values, were stronger without degenerative changes than with degenerative changes. Significantly different HU values were observed between the right and left sides of severely degenerated vertebrae. Severe degenerative changes, particularly those associated with sclerosis, may impact HU values. TBS exhibits greater potential than HU values as a complementary tool. |
| Keywords | trabecular bone score computed tomography Hounsfield unit lumbar degenerative change radiodensity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 39 |
| End Page | 45 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012158 |
| Web of Science KeyUT | 001440463800005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ooba, Hikaru| Maki, Jota| Masuyama, Hisashi| |
| Keywords | Perinatal mental disorders Voice analysis Machine learning Screening Pregnant women |
| Published Date | 2025-02-08 |
| Publication Title | Discover Mental Health |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 12 |
| ISSN | 2731-4383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 39920468 |
| DOI | 10.1007/s44192-025-00138-0 |
| Web of Science KeyUT | 001415532800001 |
| Related Url | isVersionOf https://doi.org/10.1007/s44192-025-00138-0 |
| JaLCDOI | 10.18926/AMO/68356 |
|---|---|
| FullText URL | 79_1_031.pdf |
| Author | Maeda, Shigeru| Pimkhaokham, Atiphan| Yoshida, Michihiro| Hosoi, Hiroki| Ohshima, Ayako| Kurisu, Ryoko| Utsumi, Nozomi| Higuchi, Hitoshi| Miyawaki, Takuya| |
| Abstract | We retrospectively analyzed the safety of the use of articaine, an amide-type local anesthetic, in Japanese dental patients (n=300) treated in Thailand in 2015-2017. The dosage, adverse events (AEs) caused by local anesthesia, and treatment efficacy were examined. Articaine, which is safe for patients with liver impairments due to its unique metabolism, has not been thoroughly tested in Japan for doses above 5.1 mL. Eighty of the present patients had undergone root canal treatment (RCT), 71 underwent tooth extraction, and 149 underwent implant-related surgery. More than three articaine cartridges were used in 41 patients, and no AEs occurred in these cases. The only AE occurred in a 52-year-old woman who was treated with three cartridges and presented with what appeared to be hyperventilation syndrome; she later recovered and received her dental treatment as scheduled. Most treatments were completed with three or fewer cartridges, suggesting that this number is generally sufficient. Our findings, particularly the low AE risk even with doses exceeding three cartridges, support the potential applicability of the overseas recommended maximum dose of articaine (7 mg/kg) in Japanese patients. This conclusion is significant for advancing dental anesthetic practices and ensuring patient safety and treatment efficacy in Japan. |
| Keywords | dental anesthesia local anesthesia drug-related side effect adverse reaction |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012157 |
| Web of Science KeyUT | 001440463800004 |
| JaLCDOI | 10.18926/AMO/68355 |
|---|---|
| FullText URL | 79_1_021.pdf |
| Author | Yamamoto, Yasuhiro| Haraguchi, Takafumi| Matsuda, Kaori| Okazaki, Yoshio| Kimoto, Shin| Tanji, Nozomu| Matsumoto, Atsushi| Kobayashi, Yasuyuki| Mimura, Hidefumi| Hiraki, Takao| |
| Abstract | We developed a machine learning model for predicting prostate cancer (PCa) grades using radiomic features of magnetic resonance imaging. 112 patients diagnosed with PCa based on prostate biopsy between January 2014 and December 2021 were evaluated. Logistic regression was used to construct two prediction models, one using radiomic features and prostate-specific antigen (PSA) values (Radiomics model) and the other Prostate Imaging-Reporting and Data System (PI-RADS) scores and PSA values (PI-RADS model), to differentiate high-grade (Gleason score [GS] ≥ 8) from intermediate or low-grade (GS < 8) PCa. Five imaging features were selected for the Radiomics model using the Gini coefficient. Model performance was evaluated using AUC, sensitivity, and specificity. The models were compared by leave-one-out cross-validation with Ridge regularization. Furthermore, the Radiomics model was evaluated using the holdout method and represented by a nomogram. The AUC of the Radiomics and PI-RADS models differed significantly (0.799, 95% CI: 0.712-0.869; and 0.710, 95% CI: 0.617-0.792, respectively). Using holdout method, the Radiomics model yielded AUC of 0.778 (95% CI: 0.552-0.925), sensitivity of 0.769, and specificity of 0.778. It outperformed the PI-RADS model and could be useful in predicting PCa grades, potentially aiding in determining appropriate treatment approaches in PCa patients. |
| Keywords | prostate cancer machine learning prostate Imaging-Reporting and Data System radiomics Gleason score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 21 |
| End Page | 30 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012156 |
| Web of Science KeyUT | 001440463800003 |
