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Author Nakagawa, Tomoyuki| Mitsui, Ryoji| Tani, Akio| Sasa, Kentaro| Tashiro, Shinya| Iwama, Tomonori| Hayakawa, Takashi| Kawai, Keiichi|
Published Date 2013-03-22
Publication Title PLOS ONE
Volume volume7
Issue issue11
Content Type Journal Article
Author Oshima, Kenshiro| Hattori, Masahira| Shimizu, Hitomi| Fukuda, Koji| Nemoto, Michiko| Inagaki, Kenji| Tamura, Takashi|
Published Date 2015-07-09
Publication Title Genome Announcements
Volume volume3
Issue issue4
Content Type Journal Article
Author Dansako, Hiromichi| Ueda, Youki| Okumura, Nobuaki| Satoh, Shinya| Sugiyama, Masaya| Mizokami, Masashi| Ikeda, Masanori| Kato, Nobuyuki|
Published Date 2015
Publication Title The FEBS journal
Content Type Journal Article
Author Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao|
Published Date 2013-04-15
Publication Title SpringerPlus
Volume volume2
Content Type Journal Article
FullText URL K0005089 abstract_review.pdf K0005089_fulltext.pdf K0005089_summary.pdf
Author Furuta, Ryohei|
Published Date 2015-03-25
Content Type Thesis or Dissertation
Grant Number 甲第5089号
Granted Date 2015-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Title Alternative The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize)
FullText URL 126_187.pdf
Author Yamamoto, Hiromasa|
Abstract 受賞対象論文: Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S:Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst (2014) 106, djt338
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Start Page 187
End Page 190
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.187
NAID 130004903235
Author Monden, Yuki| Yamamoto, Ayaka| Shindo, Akiko| Tahara, Makoto|
Published Date 2014-06-16
Publication Title DNA Research
Content Type Journal Article
Author Monden, Yuki| Fujii, Nobuyuki| Yamaguchi, Kentaro| Ikeo, Kazuho| Nakazawa, Yoshiko| Waki, Takamitsu| Hirashima, Keita| Uchimura, Yosuke| Tahara, Makoto|
Published Date 2014-06-25
Publication Title Genome
Volume volume57
Issue issue5
Content Type Journal Article
Author Monden, Yuki| Takasaki, Kazuto| Futo, Satoshi| Niwa, Kousuke| Kawase, Mitsuo| Akitake, Hiroto| Tahara, Makoto|
Published Date 2014-09-20
Publication Title Journal of Biotechnology
Volume volume185
Content Type Journal Article
JaLCDOI 10.18926/AMO/52785
FullText URL 68_4_191.pdf
Author Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi|
Abstract Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance.
Keywords non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2014-08
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 191
End Page 200
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145405
Web of Science KeyUT 000340687500001
FullText URL K0004983_abstract_review.pdf K0004983_fulltext.pdf
Author Lakha Salaipeth|
Published Date 2014-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4983号
Granted Date 2014-03-25
Thesis Type Doctor of Philosophy in Agriculture
Grantor 岡山大学
language Japanese English
Author Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide|
Published Date 2011-10-21
Publication Title BMC Cancer
Volume volume11
Content Type Journal Article
Author Sato, Kazuhiro| Motoi, Yuka| Yamaji, Nami| Yoshida, Hideya|
Published Date 2011-05-19
Publication Title BMC Genomics
Volume volume12
Content Type Journal Article
Author Close, Timothy J.| Bhat, Prasanna R.| Lonardi, Stefano| Wu, Yonghui| Rostoks, Nils| Ramsay, Luke| Druka, Arnis| Stein, Nils| Svensson, Jan T.| Wanamaker, Steve| Bozdag, Serdar| Roose, Mikeal L.| Moscou, Matthew J.| Chao, Shiaoman| Varshney, Rajeev K.| Szuecs, Peter| Sato, Kazuhiro| Hayes, Patrick M.| Matthews, David E.| Kleinhofs, Andris| Muehlbauer, Gary J.| DeYoung, Joseph| Marshall, David F.| Madishetty, Kavitha| Fenton, Raymond D.| Condamine, Pascal| Graner, Andreas| Waugh, Robbie|
Published Date 2009-12-04
Publication Title BMC Genomics
Volume volume10
Content Type Journal Article
Author Kurata, Nori| Satoh, Hikaru| Kitano, Hidemi| Nagato, Yasuo| Endo, Takashi| Sato, Kazuhiro| Akashi, Ryo| Ezura, Hiroshi| Kusaba, Makoto| Kobayashi, Masatomo| Nitasaka, Eiji| Kasai, Fumie| Yamazaki, Yukiko| Yoshimura, Atsushi|
Published Date 2010-12
Publication Title Breeding Science
Volume volume60
Issue issue5
Content Type Journal Article
Author Shahinnia, Fahimeh| Sayed-Tabatabaei, Badraldin Ebrahim| Sato, Kazuhiro| Pourkheirandish, Mohammad| Komatsuda, Takao|
Published Date 2009-12
Publication Title Breeding Science
Volume volume59
Issue issue4
Content Type Journal Article
Author Chen, Guoxiong| Komatsudu, Takao| Pourkheirandish, Mohammad| Sameri, Mohammad| Sato, Kazuhiro| Krugman, Tamar| Fahima, Tzion| Korol, Abraham B.| Nevo, Eviatar|
Published Date 2009-03
Publication Title Breeding Science
Volume volume59
Issue issue1
Content Type Journal Article
Author Iehisa, Julio Cesar Masaru| Shimizu, Akifumi| Sato, Kazuhiro| Nasuda, Shuhei| Takumi, Shigeo|
Published Date 2012-12
Publication Title DNA Research
Volume volume19
Issue issue6
Content Type Journal Article
Author Sato, Kazuhiro| Shin-I, Tadasu| Seki, Motoaki| Shinozaki, Kazuo| Yoshida, Hideya| Takeda, Kazuyoshi| Yamazaki, Yukiko| Conte, Matthieu| Kohara, Yuji|
Published Date 2009-04
Publication Title DNA Research
Volume volume16
Issue issue2
Content Type Journal Article
Author Monden, Yuki| Takai, Takeru| Tahara, Makoto|
Published Date 2014-02-01
Publication Title 岡山大学農学部学術報告
Volume volume103
Content Type Departmental Bulletin Paper