result 465 件
Author | Nakagawa, Tomoyuki| Mitsui, Ryoji| Tani, Akio| Sasa, Kentaro| Tashiro, Shinya| Iwama, Tomonori| Hayakawa, Takashi| Kawai, Keiichi| |
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Published Date | 2013-03-22 |
Publication Title | PLOS ONE |
Volume | volume7 |
Issue | issue11 |
Content Type | Journal Article |
Author | Oshima, Kenshiro| Hattori, Masahira| Shimizu, Hitomi| Fukuda, Koji| Nemoto, Michiko| Inagaki, Kenji| Tamura, Takashi| |
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Published Date | 2015-07-09 |
Publication Title | Genome Announcements |
Volume | volume3 |
Issue | issue4 |
Content Type | Journal Article |
Author | Dansako, Hiromichi| Ueda, Youki| Okumura, Nobuaki| Satoh, Shinya| Sugiyama, Masaya| Mizokami, Masashi| Ikeda, Masanori| Kato, Nobuyuki| |
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Published Date | 2015 |
Publication Title | The FEBS journal |
Content Type | Journal Article |
Author | Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao| |
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Published Date | 2013-04-15 |
Publication Title | SpringerPlus |
Volume | volume2 |
Content Type | Journal Article |
FullText URL | K0005089 abstract_review.pdf K0005089_fulltext.pdf K0005089_summary.pdf |
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Author | Furuta, Ryohei| |
Published Date | 2015-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5089号 |
Granted Date | 2015-03-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize) |
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FullText URL | 126_187.pdf |
Author | Yamamoto, Hiromasa| |
Abstract | 受賞対象論文: Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S:Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst (2014) 106, djt338 |
Publication Title | 岡山医学会雑誌 |
Published Date | 2014-12-01 |
Volume | volume126 |
Issue | issue3 |
Start Page | 187 |
End Page | 190 |
ISSN | 0030-1558 |
language | Japanese |
Copyright Holders | Copyright (c) 2014 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.126.187 |
NAID | 130004903235 |
Author | Monden, Yuki| Yamamoto, Ayaka| Shindo, Akiko| Tahara, Makoto| |
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Published Date | 2014-06-16 |
Publication Title | DNA Research |
Content Type | Journal Article |
Author | Monden, Yuki| Fujii, Nobuyuki| Yamaguchi, Kentaro| Ikeo, Kazuho| Nakazawa, Yoshiko| Waki, Takamitsu| Hirashima, Keita| Uchimura, Yosuke| Tahara, Makoto| |
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Published Date | 2014-06-25 |
Publication Title | Genome |
Volume | volume57 |
Issue | issue5 |
Content Type | Journal Article |
Author | Monden, Yuki| Takasaki, Kazuto| Futo, Satoshi| Niwa, Kousuke| Kawase, Mitsuo| Akitake, Hiroto| Tahara, Makoto| |
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Published Date | 2014-09-20 |
Publication Title | Journal of Biotechnology |
Volume | volume185 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/52785 |
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FullText URL | 68_4_191.pdf |
Author | Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi| |
Abstract | Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance. |
Keywords | non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2014-08 |
Volume | volume68 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 191 |
End Page | 200 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25145405 |
Web of Science KeyUT | 000340687500001 |
FullText URL | K0004983_abstract_review.pdf K0004983_fulltext.pdf |
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Author | Lakha Salaipeth| |
Published Date | 2014-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第4983号 |
Granted Date | 2014-03-25 |
Thesis Type | Doctor of Philosophy in Agriculture |
Grantor | 岡山大学 |
language | Japanese English |
Author | Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide| |
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Published Date | 2011-10-21 |
Publication Title | BMC Cancer |
Volume | volume11 |
Content Type | Journal Article |
Author | Sato, Kazuhiro| Motoi, Yuka| Yamaji, Nami| Yoshida, Hideya| |
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Published Date | 2011-05-19 |
Publication Title | BMC Genomics |
Volume | volume12 |
Content Type | Journal Article |
Author | Close, Timothy J.| Bhat, Prasanna R.| Lonardi, Stefano| Wu, Yonghui| Rostoks, Nils| Ramsay, Luke| Druka, Arnis| Stein, Nils| Svensson, Jan T.| Wanamaker, Steve| Bozdag, Serdar| Roose, Mikeal L.| Moscou, Matthew J.| Chao, Shiaoman| Varshney, Rajeev K.| Szuecs, Peter| Sato, Kazuhiro| Hayes, Patrick M.| Matthews, David E.| Kleinhofs, Andris| Muehlbauer, Gary J.| DeYoung, Joseph| Marshall, David F.| Madishetty, Kavitha| Fenton, Raymond D.| Condamine, Pascal| Graner, Andreas| Waugh, Robbie| |
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Published Date | 2009-12-04 |
Publication Title | BMC Genomics |
Volume | volume10 |
Content Type | Journal Article |
Author | Kurata, Nori| Satoh, Hikaru| Kitano, Hidemi| Nagato, Yasuo| Endo, Takashi| Sato, Kazuhiro| Akashi, Ryo| Ezura, Hiroshi| Kusaba, Makoto| Kobayashi, Masatomo| Nitasaka, Eiji| Kasai, Fumie| Yamazaki, Yukiko| Yoshimura, Atsushi| |
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Published Date | 2010-12 |
Publication Title | Breeding Science |
Volume | volume60 |
Issue | issue5 |
Content Type | Journal Article |
Author | Shahinnia, Fahimeh| Sayed-Tabatabaei, Badraldin Ebrahim| Sato, Kazuhiro| Pourkheirandish, Mohammad| Komatsuda, Takao| |
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Published Date | 2009-12 |
Publication Title | Breeding Science |
Volume | volume59 |
Issue | issue4 |
Content Type | Journal Article |
Author | Chen, Guoxiong| Komatsudu, Takao| Pourkheirandish, Mohammad| Sameri, Mohammad| Sato, Kazuhiro| Krugman, Tamar| Fahima, Tzion| Korol, Abraham B.| Nevo, Eviatar| |
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Published Date | 2009-03 |
Publication Title | Breeding Science |
Volume | volume59 |
Issue | issue1 |
Content Type | Journal Article |
Author | Iehisa, Julio Cesar Masaru| Shimizu, Akifumi| Sato, Kazuhiro| Nasuda, Shuhei| Takumi, Shigeo| |
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Published Date | 2012-12 |
Publication Title | DNA Research |
Volume | volume19 |
Issue | issue6 |
Content Type | Journal Article |
Author | Sato, Kazuhiro| Shin-I, Tadasu| Seki, Motoaki| Shinozaki, Kazuo| Yoshida, Hideya| Takeda, Kazuyoshi| Yamazaki, Yukiko| Conte, Matthieu| Kohara, Yuji| |
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Published Date | 2009-04 |
Publication Title | DNA Research |
Volume | volume16 |
Issue | issue2 |
Content Type | Journal Article |
Author | Monden, Yuki| Takai, Takeru| Tahara, Makoto| |
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Published Date | 2014-02-01 |
Publication Title | 岡山大学農学部学術報告 |
Volume | volume103 |
Content Type | Departmental Bulletin Paper |