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JaLCDOI 10.18926/AMO/51067
FullText URL 67_4_227.pdf
Author Ryuko, Hiromasa| Otsuka, Fumio|
Abstract Primary care physicians often encounter patients with fever of unknown origin and without apparent causes. Recent advances in laboratory medicine have facilitated diagnostic procedures;however, it is still difficult to determine the critical febrile factor at an early stage. We reviewed the medical records of 174 patients who were admitted due to a chief complaint of fever (>37.5℃) to our hospital during the period from 2004 to 2010. The patients were categorized into patients with infection, inflammation, neoplasm and drug-induced fever. Based on the analysis done by category, it was revealed that the patient's age, body temperature and duration of fever were closely related to the final diagnosis. Serum CRP levels were significantly low in the nonbacterial infection group, while serum levels of sIL-2R were high in neoplasm and drug-induced cases. CRP level on admission was weakly but significantly correlated with body temperature, while duration of fever was inversely related to body temperature. The effectiveness of PET-CT and tissue biopsy for diagnosis was considerably high, particularly in the categories of neoplasm and nonspecific inflammation, respectively, though the effectiveness of bacterial culture was low. Thus, a careful review of physical and laboratory information including body temperature, CRP level, duration of fever, gender difference and history of medication is indispensable for diagnosis. Stepwise categorization and disease classification by comprehensive and systemic checkup are very helpful for determining the causes of fever.
Keywords computed tomography (CT) C-reactive protein (CRP) fluorodeoxyglucose positron emission tomography (FDG-PET) fever of unknown origin (FUO) soluble interleukin-2 receptor (sIL-2R)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-08
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 227
End Page 237
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970321
Web of Science KeyUT 000323470100004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/51947
JaLCDOI 10.18926/AMO/51066
FullText URL 67_4_219.pdf
Author Maruyama, Hidehiko| Nakamura, Makoto| Yonemoto, Naohiro| Kageyama, Misao|
Abstract Cholestasis and thrombocytopenia are complications that affect infants born small for gestational age (SGA). In SGA infants, other vital organs develop at the expense of the liver, and the thrombopoietin produced by the liver is low, often resulting in cholestasis. We hypothesized that thrombocytopenia at birth can be used to predict cholestasis in very-low-birth-weight infants (VLBWIs) with SGA. This retrospective cohort study enrolled VLBWIs with SGA admitted to a tertiary neonatal intensive care unit. A platelet cutoff value predictive of cholestasis was determined using receiver operating characteristic analysis. Multivariate logistic regression analysis was performed to evaluate the platelet cutoff value, and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Regarding the onset of cholestasis, survival analysis was performed by calculating the adjusted hazard ratios (HRs) and 95% CIs. A total of 87 infants were evaluated, and the platelet cutoff value was determined as 88×10(3) cells/μl. The adjusted OR for this platelet cutoff value was 10.52 (95% CI 2.26-55.93, p=0.003), and the adjusted HR was 7.76 (95% CI 2.51-23.50, p=0.0006). Thrombocytopenia is a useful predictor for cholestasis in VLBWIs with SGA.
Keywords cholestasis platelet small for gestational age thrombocytopenia very low birth weight
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-08
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 225
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970320
Web of Science KeyUT 000323470100003
JaLCDOI 10.18926/AMO/51065
FullText URL 67_4_213.pdf
Author Kawahara, Michiko| Sato, Shuhei| Ida, Yukiko| Watanabe, Masao| Fujishima, Mamoru| Ishii, Hiroaki| Hori, Keisuke| Kanazawa, Susumu|
Abstract A relatively large number of women in their 40s with high-density breasts, in which it can be difficult to detect lesions, are encountered in mammography cancer screenings in Japan. Here, we retrospectively investigated factors related to breast density. Two hundred women (40-49 years old) were examined at the screening center in our hospital. Multivariate analysis showed that factors such as small abdominal circumference, high HDL cholesterol, and no history of childbirth were related to high breast density in women in their 40s undergoing mammography. Other non-mammographic screening methods should be considered in women with abdominal circumferences <76cm, HDL-C >53mg/dl, and no history of childbirth, as there is a strong possibility of these women having high-density breasts that can make lesion detection difficult.
Keywords high-density breasts abdominal circumference high-density lipoprotein cholesterol childbirth mammography
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-08
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 213
End Page 217
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970319
Web of Science KeyUT 000323470100002
JaLCDOI 10.18926/AMO/51064
FullText URL 67_4_203.pdf
Author Ohuchi, Hideyo|
Abstract A central issue of evolutionary developmental biology is how the eye is diverged morphologically and functionally. However, the unifying mechanisms or schemes that govern eye diversification remain unsolved. In this review, I first introduce the concept of evolutionary developmental biology of the eye with a focus on photoreception, the fundamental property of retinal cells. Second, I summarize the early development of vertebrate eyes and the role of a homeobox gene, Lhx1, in subdivision of the retina into 2 domains, the neural retina and retinal pigmented epithelium of the optic primordium. The 2 retinal domains are essential components of the eye as they are found in such prototypic eyes as the extant planarian eye. Finally, I propose the presence of novel retinal cell subtypes with photosensory functions based on our recent work on atypical photopigments (opsins) in vertebrates. Since human diseases are attributable to the aberration of various types of cells due to alterations in gene expression, understanding the precise mechanisms of cellular diversification and unraveling the molecular profiles of cellular subtypes are essential to future regenerative medicine.
Keywords eye development evolution opsin photoreceptor
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2013-08
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 203
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970318
Web of Science KeyUT 000323470100001
FullText URL K0004799.pdf K0004799_honbun.pdf
Author Ueno, Hiroshi|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4799号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Health Sciences
Grantor 岡山大学
language Japanese English
FullText URL K0004710.pdf K0004710_honbun.pdf
Author Ika, Katsuhiko|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4710号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
FullText URL K0004706.pdf K0004706_honbun.pdf
Author Arafato, Arukin|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4706号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
FullText URL K0004701.pdf K0004701_honbun.pdf
Author Yamamoto, Masanao|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4701号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
FullText URL K0004674.pdf K0004674_honbun.pdf
Author Watanabe, Masutaka|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4674号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
FullText URL K0004673.pdf K0004673_honbun.pdf
Author Ishihara, Setsuko|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4673号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
FullText URL K0004671.pdf K0004671_honbun.pdf
Author Mikawa, Yasuhito|
Published Date 2013-03-25
Content Type Thesis or Dissertation
Grant Number 甲第4671号
Granted Date 2013-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
JaLCDOI 10.18926/AMO/50414
FullText URL 67_3_197.pdf
Author Yasuhara, Takao| Takahashi, Yuichi| Kumamoto, Shinji| Nakahara, Masayuki| Yoneda, Kotaro| Niimura, Tatsuomi| Tanoue, Takashi| Kusumegi, Akira| Sennari, Takashi| Hijikata, Yasukazu| Manabe, Hiroaki| Miyoshi, Yasuyuki| Date, Isao| Ogawa, Koichi| Nishida, Kenki|
Abstract Some cases with lumbar degenerative diseases require multi-level fusion surgeries. At our institute, 27 and 4 procedures of 3- and 4-level fusion were performed out of a total 672 posterior lumbar interfusions (PLIFs) on patients with lumbar degenerative disease from 2005 to 2010. We present 2 osteoporotic patients who developed proximal vertebral body fracture after 4-level fusion. Both cases presented with gait disability for leg pain by degenerative lumbar scoliosis and canal stenosis at the levels of L1/2-4/5. After 4-level fusion using L1 as the upper instrumented vertebra, proximal vertebral body fractures were found along with the right pedicle fractures of L1 in both cases. One of these patients, aged 82 years, was treated as an outpatient using a hard corset for 24 months, but the fractures were exacerbated over time. In the other patient, posterolateral fusion was extended from Th10 to L5. Both patients can walk alone and have been thoroughly followed up. In both cases, the fracture of the right L1 pedicle might be related to the subsequent fractures and fusion failure. In consideration of multi-level fusion, L1 should be avoided as an upper instrumented vertebra to prevent junctional kyphosis, especially in cases with osteoporosis and flat back posture.
Keywords degenerative lumbar scoliosis osteoporosis pedicle fracture posterior lumbar interbody fusion vertebral body fracture
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 197
End Page 202
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804144
Web of Science KeyUT 000320747900010
JaLCDOI 10.18926/AMO/50413
FullText URL 67_3_191.pdf
Author Binti Md Nor, Nurliza| Kusumoto, Tomoyuki| Inoue, Seiji| Nakamura, Keiichiro| Seki, Noriko| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji|
Abstract Struma ovarii is a rare neoplasm that accounts for approximately 0.3オ of ovarian tumors. Due to its ultrasound morphology, which is quite similar to that of malignant ovarian carcinoma, most struma ovarii cases are open operated with laparotomy rather than laparoscopy. We present 3 cases of struma ovarii, which were diagnosed preoperatively by imaging studies and removed by laparoscopic surgery. All patients were premenopausal women between ages 31‒50. The magnetic resonance imaging (MRI) findings were complex masses composed of multiple cysts and solid components with T2-hypointense regions as well as multiple T1-hyperintense cystic areas, findings that are typical for struma ovarii. A combination of plain computed tomography (CT), positron emission tomography (PET)-CT, and scintigraphy was useful for diagnosis. Laboratory examination revealed elevated serum thyroglobulin, which led to the diagnosis of struma ovarii. Laparoscopic surgeries were performed without rupturing the tumors. Although it has been difficult to differentiate between struma ovarii and malignant tumors by conventional methods, recently MRI techniques appear make it possible to diagnose struma ovarii preoperatively from the abovementioned imaging characteristic, together with laboratory data. As for treatment, we think laparoscopy could be successful for struma ovarii, but the surgeon must be careful not to rupture the tumor intra-abdominally in order to prevent dissemination, which could lead to malignancy.
Keywords struma ovarii ovarian neoplasms MRI laparoscopic surgery
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 195
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804143
Web of Science KeyUT 000320747900009
JaLCDOI 10.18926/AMO/50412
FullText URL 67_3_185.pdf
Author Misawa, Haruo| Tanaka, Masato| Sugimoto, Yoshihisa| Koshimune, Kouichiro| Ozaki, Toshifumi|
Abstract Cervical misalignment after upper cervical fusion including the occipital bone may cause trismus or dysphagia, because the occipito-atlanto joint is associated with most of the flex and extended motion of the cervical spine. There are no reports of dysphagia and trismus after C1-2 fusion. The purpose of this paper is to demonstrate the potential risk of dysphagia and trismus even after upper cervical short fusion without the occipital bone. The patient was a 69-year-old man with myelopathy caused by os odontoideum and Klippel-Feil syndrome, who developed dysphagia and trismus immediately after C1-2 fusion and C3-6 laminoplasty. Radiographs and CT revealed that his neck posture was extended, but his symptoms still existed a week after surgery. The fixation angle was hyperextended 12 days after the first surgery. His symptoms disappeared immediately after revision surgery. The fixation in the neck-flexed position is thought to be the main cause of the patientʼs post-operative dysphagia and trismus. Dysphagia and trismus may occur even after short upper cervical fusion without the occipital bone or cervical fusion in the neck-extended position. The pre-operative cervical alignment and range of motion of each segment should be thoroughly evaluated.
Keywords dysphagia trismus os odontoid Klippel-Feil syndrome atlantoaxial posterior fusion
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 185
End Page 190
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804142
Web of Science KeyUT 000320747900008
JaLCDOI 10.18926/AMO/50411
FullText URL 67_3_177.pdf
Author Matsuo, Toshihiko| Yamasaki, Hanako| Yasuhara, Hirotaka| Hasebe, Kayoko|
Abstract To test the effect of double vision on postural stability, we measured postural stability by electric stabilometry before prism-wearing and immediately, 15, 30, and 60min after continuous prism-wearing with 6 prism diopters in total (a 3-prism-diopter prism placed with the base up in front of one eye and with the base down in front of the other eye) in 20 normal adult individuals with their eyes open or closed. Changes in stabilometric parameters in the time course of 60min were analyzed statistically by repeated-measure analysis of variance. When subjectsセ eyes were closed, the total linear length (cm) and the unit-time length (cm/sec) of the sway path were significantly shortened during the 60-minute prism-wearing (p<0.05). No significant change was noted in any stabilometric parameters obtained with the eyes open during the time course. In conclusion, postural stability did not change with the eyes open in the condition of large vertical diplopia, induced by prism-wearing for 60min, while the stability became better when measured with the eyes closed. A postural control mechanism other than that derived from visual input might be reinforced under abnormal visual input such as non-fusionable diplopia.
Keywords body sway postural stability (postural control) stabilometry prism vertical diplopia
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 177
End Page 183
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804141
Web of Science KeyUT 000320747900007
JaLCDOI 10.18926/AMO/50410
FullText URL 67_3_171.pdf
Author Hashimoto, Atsunori| Ueda, Takahiro| Kuboyama, Kazutoshi| Yamada, Taihei| Terashima, Mariko| Miyawaki, Atsushi| Nakao, Atsunori| Kotani, Joji|
Abstract On April 25, 2005, a Japanese express train derailed into a building, resulting in 107 deaths and 549 injuries. We used “First Impression Triage (FIT)”, our new triage strategy based on general inspection and palpation without counting pulse/respiratory rates, and determined the feasibility of FIT in the chaotic situation of treating a large number of injured people in a brief time period. The subjects included 39 patients who required hospitalization among 113 victims transferred to our hospital. After initial assessment with FIT by an emergency physician, patients were retrospectively reassessed with the preexisting the modified Simple Triage and Rapid Treatment (START) methodology, based on Injury Severity Score, probability of survival, and ICU stay. FIT resulted in shorter waiting time for triage. FIT designations comprised 11 red (immediate), 28 yellow (delayed), while START assigned six to red and 32 to yellow. There were no statistical differences between FIT and START in the accuracy rate calculated by means of probability of survival and ICU stay. Overall validity and reliability of FIT determined by outcome assessment were similar to those of START. FIT would be a simple and accurate technique to quickly triage a large number of patients.
Keywords simple triage and rapid treatment injury severity score probability of survival
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 171
End Page 176
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804140
Web of Science KeyUT 000320747900006
JaLCDOI 10.18926/AMO/50409
FullText URL 67_3_165.pdf
Author Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro|
Abstract While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p=0.045) and histological grade 3 (p=0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.
Keywords breast cancer neoadjuvant chemotherapy predictors
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 165
End Page 170
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804139
Web of Science KeyUT Pretreatment Specimen Predicts
JaLCDOI 10.18926/AMO/50408
FullText URL 67_3_153.pdf
Author Yamamoto, Masanao| Fujita, Hirofumi| Katase, Naoki| Inoue, Keiji| Nagatsuka, Hitoshi| Utsumi, Kozo| Sasaki, Junzo| Ohuchi, Hideyo|
Abstract Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum.
Keywords 5-aminolevulinic acid protoporphyrin IX oncology photodynamic therapy apoptosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 153
End Page 164
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804138
Web of Science KeyUT 000320747900004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/50681
JaLCDOI 10.18926/AMO/50407
FullText URL 67_3_145.pdf
Author Ishihara, Setsuko| Taira, Naruto| Kawasaki, Kensuke| Ishibe, Youichi| Mizoo, Taeko| Nishiyama, Keiko| Iwamoto, Takayuki| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| Komoike, Yoshifumi| Sato, Shuhei| Kanazawa, Susumu|
Abstract A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been performed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, -0.403;p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, -0.196;p value, 0.0143) and number of deliveries (parameter estimate, -0.388;p value, 0.0186) were significant factors determining breast density;breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely correlated with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s.
Keywords breast cancer mammographic breast density life style body mass index
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 151
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804137
Web of Science KeyUT 000320747900003
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/50646
JaLCDOI 10.18926/AMO/50406
FullText URL 67_3_135.pdf
Author Ueno, Hiroshi| Shoshi, Chikafumi| Suemitsu, Shunsuke| Usui, Shinichi| Sujiura, Hiroko| Okamoto, Motoi|
Abstract In the phenomenon known as cross-modal plasticity, the loss of one sensory system is followed by improved functioning of other intact sensory systems. MRI and functional MRI studies suggested a role of the prefrontal cortex and the temporal lobe in cross-modal plasticity. We used a mouse model to examine the effects of sensory deprivation achieved by whisker trimming and visual deprivation achieved by dark rearing in neonatal mice on the appearance of parvalbumin (PV) neurons and the formation of glutamic acid decarboxylase 67 (GAD67)-positive puncta around pyramidal neurons in the prefrontal cortex and hippocampus. Whisker trimming, but not dark rearing, decreased the density of PV neurons in the hippocampus at postnatal day 28 (P28). In the prefrontal cortex, whisker trimming and dark rearing decreased the density of PV neurons in layer 5/6 (L5/6) at P28 and in L2/3 at P56, respectively, whereas dark rearing increased the density of PV neurons in L5/6 at P56. Whisker trimming decreased the density of GAD67-positive puncta in CA1 of the hippocampus at both P28 and P56 and in L5/6 of the prefrontal cortex at P28. Dark rearing decreased the density of GAD67-positive puncta in CA1 of the hippocampus and in both L2/3 and L5/6 of the prefrontal cortex at P28, and in L2/3 of the prefrontal cortex at P56. These results demonstrate that somatosensory or visual deprivation causes changes in the PV-interneuronal network in the mouse prefrontal cortex and hippocampus. The results also suggest that the alteration of the PV-interneuronal network, especially in the prefrontal cortex, may contribute to cross-modal plasticity.
Keywords sensory deprivation parvalbumin glutamate decarboxylase (GAD67) prefrontal cortex hippocampus
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-06
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 135
End Page 143
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804136
Web of Science KeyUT 000320747900002
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/50870