result 1261 件
JaLCDOI | 10.18926/AMO/61213 |
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FullText URL | 74_6_531.pdf |
Author | Hashimoto, Kazuhiko| Nishimura, Shunji| Chikugo, Takaaki| Kakinoki, Ryosuke| Akagi, Masao| |
Abstract | Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma. |
Keywords | soft tissue myoepithelioma unplanned resection shoulder |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 531 |
End Page | 535 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361874 |
Web of Science KeyUT | 000601203600010 |
NAID | 120006948952 |
JaLCDOI | 10.18926/AMO/61209 |
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FullText URL | 74_6_495.pdf |
Author | Calliope, Simba Akintije| Yorifuji, Takashi| Wada, Takayuki| Mukakarake, Marie Goret| Mutesa, Leon| Yamamoto, Taro| |
Abstract | In many economically developing countries, and especially in the rural regions of sub-Saharan African coun-tries, there have been only limited investigations into the association between antenatal care (ANC) and adverse pregnancy outcomes. We obtained information on ANC and pregnancy outcomes between 2011 and 2016 from hospital files of pregnant women (n = 4,960) served at a rural hospital in Rwanda, and we examined the associa-tions between their ANC visits and the adverse pregnancy and neonatal outcomes by using univariate and mul-tivariate logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Most of the pregnant women had ≥ 4 ANC visits, but 39% (n = 1,911) did not have ≥ 3 visits before delivery. The prev-alence of low birth weight (LBW) and that of preterm birth (PTB) were 12% and 9.9%, respectively. Compared to the women who attended only one ANC visit, those who attended ≥ 4 ANC visits had lower risks of LBW (OR 0.20; 95%CI: 0.11-0.36) and PTB (OR 0.28; 95%CI: 0.11-0.76). Frequent ANC visits were also associ-ated with better postnatal outcomes of the newborns. Encouraging women to attend ANC visits before delivery can markedly reduce PTB-related and LBW-related complications, especially in resource-limited settings. |
Keywords | antenatal care epidemiology low birth weight preterm birth rural |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 495 |
End Page | 503 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361869 |
Web of Science KeyUT | 000601203600005 |
NAID | 120006948958 |
JaLCDOI | 10.18926/AMO/61207 |
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FullText URL | 74_6_483.pdf |
Author | Miyagi, Yasunari| Miyake, Takahito| |
Abstract | We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese fetuses based on the gestational weeks and the bi-parietal diameter, abdominal circumference, and femur length. The AI comprised of neural network architecture was trained by deep learning with a dataset that consists of ± 2 standard devia-tion (SD), ± 1.5SD, and ± 0SD categories of the approved standard values of ultrasonic measurements of the fetal weights of Japanese fetuses (Japan Society of Ultrasonics in Medicine [JSUM] data). We investigated the residuals and compared 2 other regression formulae for estimating the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI for the test dataset that was 12.5% of the JSUM data were 6.4 ± 2.6, −3.8 ± 8.6, and −0.32 ± 6.3 (g) at −2SD, +2SD, and all categories, respectively. The residu-als of another AI method created with all of the JSUM data, of which 20% were randomized validation data, were −1.5 ± 9.4, −2.5 ± 7.3, and −1.1 ± 6.7 (g) for −2SD, +2SD, and all categories, respectively. The residuals of this AI were not different from zero, whereas those of the published formulae differed from zero. Though vali-dation is required, the AI demonstrated potential for generating fetal weights accurately, especially for extreme fetal weights. |
Keywords | deep learning artificial intelligence fetal weight neural network ultrasound biometry |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 483 |
End Page | 493 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361868 |
Web of Science KeyUT | 000601203600004 |
NAID | 120006948957 |
JaLCDOI | 10.18926/AMO/61204 |
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FullText URL | 74_6_461.pdf |
Author | Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
Abstract | Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted. |
Keywords | gastric cancer young patients Helicobacter pylori |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 461 |
End Page | 466 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361865 |
Web of Science KeyUT | 000601203600001 |
NAID | 120006948954 |
FullText URL | K0006240_abstract_review.pdf K0006240_summary.pdf K0006240_fulltext.pdf |
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Author | Kanzaki, Yuki| |
Published Date | 2020-09-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第6240号 |
Granted Date | 2020-09-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
JaLCDOI | 10.18926/AMO/60880 |
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FullText URL | 74_6_505.pdf |
Author | Ohara, Toshiaki| Sakurama, Kazufumi| Hiramatsu, Satoshi| |
Abstract | Vascular-access interventions are necessary for the continuation of hemodialysis, and they are performed under X-ray guidance. During interventions, patients’ accidental falls from the bed are a serious problem, and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking. We developed a new fixation plate made of polypropylene homopolymer and tested its ability to prevent such falls retrospectively. This plate, which we named the ‘vascular-access intervention assistance plate,’ offers functional features such as the concurrent fixation of the body and either arm and an arm space with serrations for fixing a forearm strap. We performed computer simulations to examine the strength of the plate, and we evaluated the efficacy of fall prevention by reviewing patients’ medical records. The results demonstrated that the functional design of the plate provides good operability via accurate concurrent fixations of the body and arm. The com-puter simulation analysis results indicated the plate’s sufficient strength. The medical records analysis revealed three accidental falls before the plate’s introduction (401 patients, 1,437 interventions), and none after plate introduction (683 patients, 1,872 interventions). Accidental falls were significantly prevented by use of the plate (p < 0.05). The dementia rate and type of procedure were not significantly different between the patients who fell and those who did not. This vascular-access intervention assisted plate provides good operability and safety by preventing accidental falls among hemodialysis patients. |
Keywords | hemodialysis fall accident incident vascular access |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 505 |
End Page | 511 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361870 |
Web of Science KeyUT | 000601203600006 |
NAID | 120006948959 |
FullText URL | fulltext.pdf |
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Author | Oyama, Takanori| Noda, Takuo| Washio, Kana| Shimada, Akira| |
Keywords | growing teratoma syndrome immature teratoma ovarian tumor pediatric |
Published Date | 2020-09-18 |
Publication Title | Medicine |
Volume | volume99 |
Issue | issue38 |
Publisher | Lippincott, Williams & Wilkins |
Start Page | e22297 |
ISSN | 0025-7974 |
NCID | AA00728867 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 the Author(s). |
File Version | publisher |
PubMed ID | 32957389 |
DOI | 10.1097/MD.0000000000022297 |
Web of Science KeyUT | 000579298600086 |
Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000022297 |
FullText URL | fulltext.pdf |
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Author | Satouchi, Miyako| Nosaki, Kaname| Takahashi, Toshiaki| Nakagawa, Kazuhiko| Aoe, Keisuke| Kurata, Takayasu| Sekine, Akimasa| Horiike, Atsushi| Fukuhara, Tatsuro| Sugawara, Shunichi| Umemura, Shigeki| Saka, Hideo| Okamoto, Isamu| Yamamoto, Nobuyuki| Sakai, Hiroshi| Kishi, Kazuma| Katakami, Nobuyuki| Horinouchi, Hidehito| Hida, Toyoaki| Okamoto, Hiroaki| Atagi, Shinji| Ohira, Tatsuo| Han, Shi Rong| Noguchi, Kazuo| Ebiana, Victoria| Hotta, Katsuyuki| |
Keywords | Japan non-small-cell lung carcinoma PD-L1 protein pembrolizumab treatment outcome |
Published Date | 2020-09-14 |
Publication Title | Cancer Science |
Volume | volume111 |
Issue | issue12 |
Publisher | Wiley |
Start Page | 4480 |
End Page | 4489 |
ISSN | 1347-9032 |
NCID | AA11808050 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 32926507 |
DOI | 10.1111/cas.14647 |
Web of Science KeyUT | 000577975700001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.14647 |
FullText URL | fulltext.pdf |
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Author | Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki| |
Keywords | IPMN PJC LBC BD SurePath |
Published Date | 2020-09-29 |
Publication Title | BMC Gastroenterology |
Volume | volume20 |
Issue | issue1 |
Publisher | BMC |
Start Page | 319 |
ISSN | 1471-230X |
NCID | AA12034934 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s). 2020 |
File Version | publisher |
PubMed ID | 32993498 |
DOI | 10.1186/s12876-020-01465-y |
Web of Science KeyUT | 000576989100004 |
Related Url | isVersionOf https://doi.org/10.1186/s12876-020-01465-y |
FullText URL | J_Invest_Med_HIgh_Inpact_Case_Rep_8.pdf |
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Author | Matsuo, Toshihiko| Shimizu, Takehiro| Tanaka, Takehiro| Yamamoto, Akira| Takasuka, Hiroki| |
Keywords | adult T-cell leukemia/lymphoma vitreous opacity vitrectomy aqueous hypopyon aqueous tap cytology pathology Japanese literature review immunostaining |
Published Date | 2020-10-20 |
Publication Title | Journal of Investigative Medicine High Impact Case Reports |
Volume | volume8 |
Publisher | SAGE Publications |
Start Page | 2324709620966843 |
ISSN | 2324-7096 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 American Federation for Medical Research |
File Version | publisher |
DOI | 10.1177/2324709620966843 |
Related Url | isVersionOf https://doi.org/10.1177/2324709620966843 |
JaLCDOI | 10.18926/AMO/60806 |
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FullText URL | 74_5_443.pdf |
Author | Sekito, Takanori| Araki, Motoo| Hiraki, Takao| Uka, Mayu| Komaki, Toshiyuki| Matsui, Yusuke| Iguchi, Toshihiro| Katayama, Satoshi| Yoshinaga, Kasumi| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Kubota, Risa| Sadahira, Takuya| Nishimura, Shingo| Wada, Koichiro| Takamoto, Atsushi| Edamura, Kohei| Sako, Tomoko| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Kanazawa, Susumu| Nasu, Yasutomo| |
Abstract | We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. |
Keywords | laparoscopic cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma von Hippel-Lindau disease |
Amo Type | Case Report |
Note | Fig. 1B is replaced on Dec. 23, 2020.| |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 443 |
End Page | 448 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106702 |
Web of Science KeyUT | 000581970100011 |
NAID | 120006892932 |
JaLCDOI | 10.18926/AMO/60801 |
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FullText URL | 74_5_415.pdf |
Author | Narihiro, Naomasa| Oita, Masataka| Takeda, Yoshihiro| |
Abstract | During radiation therapy, incident radiation oblique to the skin surface is high and may cause severe skin damage. Understanding the dose of radiation absorbed by the skin is important for predicting skin damage due to radiation. In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new equation in which the oblique surface dose can be calculated within the error range of −7.7-5.1%. |
Keywords | optically stimulated luminescent dosimeter radiotherapy oblique surface dose high-energy X-ray therapy angular dependence |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 415 |
End Page | 422 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106697 |
Web of Science KeyUT | 000581970100006 |
NAID | 120006892927 |
JaLCDOI | 10.18926/AMO/60797 |
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FullText URL | 74_5_381.pdf |
Author | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
Abstract | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
Keywords | hormones hyperprolactinemia inflammation pituitary prolactin |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 381 |
End Page | 389 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106693 |
Web of Science KeyUT | 000581970100002 |
NAID | 120006892923 |
FullText URL | fulltext.pdf |
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Author | Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Tomoda, Takeshi| Matsumi, Akihiro| Ishihara, Yuki| Saragai, Yosuke| Takada, Saimon| Muro, Shinichiro| Uchida, Daisuke| Okada, Hiroyuki| |
Keywords | Endoscopic ultrasound-guided fine needle aspiration Pancreaticobiliary cancer Neoplasm recurrence |
Published Date | 2020 |
Publication Title | Gut and Liver |
Volume | volume14 |
Issue | issue5 |
Publisher | Gut and Liver |
Start Page | 652 |
End Page | 658 |
ISSN | 1976-2283 |
NCID | AA12329814 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 31818050 |
NAID | 120006891207 |
DOI | 10.5009/gnl19200 |
Web of Science KeyUT | 000569359000016 |
Related Url | isVersionOf https://doi.org/10.5009/gnl19200 |
FullText URL | fulltext.pdf |
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Author | Matsuo, Toshihiko| matsuo, Chie| Uchida, Tetsuya| Yamashita, Koichiro| Tanaka, Tenu| Kawakami, Yusuke| Hitomi, Toshiya| Taga, Kanji| Sanada, Tatsuya| Yamashita, Yusuke| |
Keywords | Dye-coupled thin film retinal prosthesis Curved-tip injector Photoelectric dye Rabbit 25G vitrectomy |
Published Date | 2020-09-23 |
Publication Title | Journal of Surgical Techniques and Procedures |
Volume | volume4 |
Issue | issue3 |
Publisher | Remedy |
Start Page | 1040 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Toshihiko Matsuo |
File Version | publisher |
Official Url | http://www.remedypublications.com/journal-of-surgical-techniques-and-procedures-home.php| |
Related Url | isVersionOf http://www.remedypublications.com/journal-of-surgical-techniques-and-procedures-articles.php?vol=4&&iss=3 |
JaLCDOI | 10.18926/okadaironkou/60691 |
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FullText URL | okadaironkou_8_28_38.pdf |
Author | 亀池 峰子| |
Publication Title | 岡大国文論稿 |
Published Date | 1980-03-01 |
Issue | issue8 |
Start Page | 28 |
End Page | 38 |
ISSN | 0386-3123 |
language | Japanese |
File Version | publisher |
JaLCDOI | 10.18926/okadaironkou/60623 |
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FullText URL | okadaironkou_11_27_38.pdf |
Author | 赤羽 学| |
Publication Title | 岡大国文論稿 |
Published Date | 1983-03-31 |
Issue | issue11 |
Start Page | 27 |
End Page | 38 |
ISSN | 0386-3123 |
language | Japanese |
File Version | publisher |
JaLCDOI | 10.18926/okadaironkou/60548 |
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FullText URL | okadaironkou_13_38_49.pdf |
Author | 越智 悦子| |
Publication Title | 岡大国文論稿 |
Published Date | 1985-03-31 |
Issue | issue13 |
Start Page | 38 |
End Page | 49 |
ISSN | 0386-3123 |
language | Japanese |
File Version | publisher |
FullText URL | Surgical_oncology_35_303.pdf |
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Author | Fujiwara, Tomohiro| Kaneuchi, Yoichi| Tsuda, Yusuke| Stevenson, Jonathan| Parry, Michael| Jeys, Lee| |
Keywords | Soft-tissue sarcoma Low-grade Surgery Margin Local control |
Note | This is an Accepted Manuscript of an article published by Elsevier.| |
Published Date | 2020-08-26 |
Publication Title | Surgical Oncology |
Volume | volume35 |
Publisher | Elsevier |
Start Page | 303 |
End Page | 308 |
ISSN | 0960-7404 |
NCID | AA10850448 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32961431 |
DOI | 10.1016/j.suronc.2020.08.022 |
Related Url | isVersionOf https://doi.org/10.1016/j.suronc.2020.08.022 |
JaLCDOI | 10.18926/AMO/60376 |
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FullText URL | 74_4_365.pdf |
Author | Chuma, Masayuki| Kondo, Masateru| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Okada, Naoto| Shibata, Akitomo| Asada, Mizuho| Oto, Jun| Yanagawa, Hiroaki| Ishizawa, Keisuke| |
Abstract | Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function. |
Keywords | vancomycin, therapeutic drug monitoring cystatin C bacterial meningitis sepsis |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2020-08 |
Volume | volume74 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 365 |
End Page | 370 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 32843769 |
Web of Science KeyUT | 000562508700013 |
NAID | 120006880215 |