result 15714 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uka, Mayu| Iguchi, Toshihiro| Okawa, Nanako| Matsui, Yusuke| Tomita, Koji| Umakoshi, Noriyuki| Munetomo, Kazuaki| Gobara, Hideo| Araki, Motoo| Hiraki, Takao| |
| Keywords | Kidney neoplasms Cryosurgery Image-guided |
| Note | The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-022-01297-8| |
| Published Date | 2022-06-21 |
| Publication Title | Japanese Journal of Radiology |
| Volume | volume40 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1201 |
| End Page | 1209 |
| ISSN | 1867-1071 |
| NCID | AA12375935 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35727459 |
| DOI | 10.1007/s11604-022-01297-8 |
| Web of Science KeyUT | 000814035800002 |
| Related Url | isVersionOf https://doi.org/10.1007/s11604-022-01297-8 |
| FullText URL | fulltext20231114-03.pdf |
|---|---|
| Author | Matoba, Ryo| Morimoto, Noriko| Kawasaki, Ryo| Fujiwara, Miyuki| Kanenaga, Keisuke| Yamashita, Hidetoshi| Sakamoto, Taiji| Morizane, Yuki| |
| Keywords | Visual impairment Japan Certification criteria Survey Glaucoma |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10384-023-00986-9| This fulltext file will be available in Apr. 2024.| |
| Published Date | 2023-04-17 |
| Publication Title | Japanese Journal of Ophthalmology |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 346 |
| End Page | 352 |
| ISSN | 0021-5155 |
| NCID | AA00691177 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Japanese Ophthalmological Society 2023 |
| File Version | author |
| PubMed ID | 37067634 |
| DOI | 10.1007/s10384-023-00986-9 |
| Web of Science KeyUT | 000970743300001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10384-023-00986-9 |
| FullText URL | fulltext20231110-02.pdf |
|---|---|
| Author | Hasegawa, Kosei| Futagawa, Natsuko| Ago, Yuko| Miyahara, Hiroyuki| Harada, Daisuke| Miyazawa, Mari| Yoshimoto, Junko| Baba, Kenji| Moriwake, Tadashi| Tanaka, Hiroyuki| Tsukahara, Hirokazu| |
| Keywords | infant skeleton spine cartilage growth |
| Published Date | 2023 |
| Publication Title | Clinical Pediatric Endocrinology |
| Volume | volume32 |
| Issue | issue4 |
| Publisher | Japanese Society for Pediatric Endocrinology |
| Start Page | 221 |
| End Page | 227 |
| ISSN | 0918-5739 |
| NCID | AA11006467 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by The Japanese Society for Pediatric Endocrinology |
| File Version | publisher |
| PubMed ID | 37842142 |
| DOI | 10.1297/cpe.2023-0035 |
| Web of Science KeyUT | 001085272200003 |
| Related Url | isVersionOf https://doi.org/10.1297/cpe.2023-0035 |
| FullText URL | fulltext20231110-01.pdf |
|---|---|
| Author | Dansako, Hiromichi| Ikeda, Masanori| Ariumi, Yasuo| Togashi, Yosuke| Kato, Nobuyuki| |
| Keywords | double-stranded RNA hepatitis C virus innate immunity RIG-I-like receptor RNA virus |
| Note | This is the accepted version of the following article: Dansako, H., Ikeda, M., Ariumi, Y., Togashi, Y. and Kato, N. (2024), Hepatitis C virus NS5B triggers an MDA5-mediated innate immune response by producing dsRNA without the replication of viral genomes. FEBS J, 291: 1119-1130. https://doi.org/10.1111/febs.16980, which has been published in final form at https://doi.org/10.1111/febs.16980| This fulltext file will be available in Oct. 2024.| |
| Published Date | 2023-10-20 |
| Publication Title | The FEBS Journal |
| Volume | volume291 |
| Issue | issue6 |
| Publisher | Wiley |
| Start Page | 1119 |
| End Page | 1130 |
| ISSN | 1742-464X |
| NCID | AA11998513 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Federation of European Biochemical Societies. |
| File Version | author |
| PubMed ID | 37863517 |
| DOI | 10.1111/febs.16980 |
| Web of Science KeyUT | 001091349500001 |
| Related Url | isVersionOf https://doi.org/10.1111/febs.16980 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Choledochal cyst Congenital biliary dilatation Robot Surgical approach |
| Published Date | 2023-10 |
| Publication Title | Asian Journal of Surgery |
| Volume | volume46 |
| Issue | issue10 |
| Publisher | Elsevier |
| Start Page | 4399 |
| End Page | 4402 |
| ISSN | 1015-9584 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. |
| File Version | publisher |
| PubMed ID | 36801184 |
| DOI | 10.1016/j.asjsur.2023.02.021 |
| Web of Science KeyUT | 001088748000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.asjsur.2023.02.021 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Otani, Yusuke| Yoshikawa, Soichiro| Nagao, Kei| Tanaka, Takehiro| Toyooka, Shinichi| Fujimura, Atsushi| |
| Keywords | Mast cells Connective tissue mast cells Noradrenaline Immunoelectron microscopy SLC22A3 |
| Note | The version of record of this article, first published in The Journal of Physiological Sciences, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12576-023-00883-3| |
| Published Date | 2023-10-12 |
| Publication Title | The Journal of Physiological Sciences |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 24 |
| ISSN | 1880-6546 |
| NCID | AA12129145 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37828465 |
| DOI | 10.1186/s12576-023-00883-3 |
| Web of Science KeyUT | 001089236900002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12576-023-00883-3 |
| FullText URL | mjou_066_103_113.pdf |
|---|---|
| Author | Puthenpurakal, Tony J.| |
| Abstract | Let (A,m) be an excellent Henselian Cohen-Macaulay local ring of finite representation type. If the AR-quiver of A is known then by a result of Auslander and Reiten one can explicity compute G(A) the Grothendieck group of finitely generated A-modules. If the AR-quiver is not known then in this paper we give estimates of G(A)Q = G(A) ⊗Z Q when k = A/m is perfect. As an application we prove that if A is an excellent equi-characteristic Henselian Gornstein local ring of positive even dimension with char A/m ≠ 2, 3, 5 (and A/m perfect) then G(A)Q ≅ Q. |
| Keywords | Grothendieck group finite representation type AR sequence |
| Published Date | 2024-01 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Department of Mathematics, Faculty of Science, Okayama University |
| Start Page | 103 |
| End Page | 113 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright ©2024 by the Editorial Board of Mathematical Journal of Okayama University |
| FullText URL | mjou_066_045_061.pdf |
|---|---|
| Author | Nakamura, Tomoya| |
| Abstract | We define Dirac pairs on Jacobi algebroids, which is a generalization of Dirac pairs on Lie algebroids introduced by Kosmann-Schwarzbach. We show the relationship between Dirac pairs on Lie and on Jacobi algebroids, and that Dirac pairs on Jacobi algebroids characterize several compatible structures on Jacobi algebroids. |
| Keywords | Dirac pair Dirac structure Jacobi algebroid Lie algebroid |
| Published Date | 2024-01 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Department of Mathematics, Faculty of Science, Okayama University |
| Start Page | 45 |
| End Page | 61 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright ©2024 by the Editorial Board of Mathematical Journal of Okayama University |
| FullText URL | fulltext20231101-01.pdf |
|---|---|
| Author | Ren, Jianchao| Danchana, Kaewta| Sasaki, Keiko| Kaneta, Takashi| |
| Keywords | Laccase Mushroom Fluorometry 2,2'-Azinobis(3-ethylbenzthiazolin-6-sulfonic acid) N-Benzoyl leucomethylene blue |
| Note | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Aug. 2024.| |
| Published Date | 2023-10 |
| Publication Title | Journal of Food Composition and Analysis |
| Volume | volume123 |
| Publisher | Elsevier BV |
| Start Page | 105627 |
| ISSN | 0889-1575 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Inc. |
| File Version | author |
| DOI | 10.1016/j.jfca.2023.105627 |
| Web of Science KeyUT | 001068657200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jfca.2023.105627 |
| FullText URL | fulltext20231025-01.pdf |
|---|---|
| Author | Tsunata, Ren| Takemoto, Masatsugu| Imai, Jun| Saito, Tatsuya| Ueno, Tomoyuki| |
| Keywords | Aspect ratio axial-flux machine axial-gap motor cooling high efficiency mass production PMSM radial-flux machine soft magnetic composite thermal characteristic |
| Note | © 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.| This fulltext file will be available in Mar. 2025.| |
| Published Date | 2023-03-13 |
| Publication Title | IEEE Transactions on Industry Applications |
| Volume | volume59 |
| Issue | issue3 |
| Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| Start Page | 3353 |
| End Page | 3367 |
| ISSN | 0093-9994 |
| NCID | AA00667900 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 IEEE. |
| File Version | author |
| DOI | 10.1109/tia.2023.3255845 |
| Web of Science KeyUT | 001061319100099 |
| Related Url | isVersionOf https://doi.org/10.1109/tia.2023.3255845 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takao, Tomoka| Yamada, Daisuke| Takarada, Takeshi| |
| Published Date | 2022-12-16 |
| Publication Title | STAR Protocols |
| Volume | volume3 |
| Issue | issue4 |
| Publisher | Cell Press |
| Start Page | 101786 |
| ISSN | 2666-1667 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36317170 |
| DOI | 10.1016/j.xpro.2022.101786 |
| Web of Science KeyUT | 001059369400011 |
| Related Url | isVersionOf https://doi.org/10.1016/j.xpro.2022.101786 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sano, Takehiro| Migita, Tsuyoshi| Takahashi, Norikazu| |
| Keywords | Nonnegative matrix factorization Hierarchical alternating least squares algorithm Global convergence |
| Note | The version of record of this article, first published in Journal of Global Optimization, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10898-022-01167-7| |
| Published Date | 2022-04-30 |
| Publication Title | Journal of Global Optimization |
| Volume | volume84 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 755 |
| End Page | 781 |
| ISSN | 0925-5001 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| DOI | 10.1007/s10898-022-01167-7 |
| Web of Science KeyUT | 000788940200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10898-022-01167-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | TAKAGI, KOSEI| KUMANO, KENJIRO| UMEDA, YUZO| YOSHIDA, RYUICHI| FUJI, TOMOKAZU| YASUI, KAZUYA| YAGI, TAKAHITO| FUJIWARA, TOSHIYOSHI| |
| Keywords | Robot distal pancreatectomy surgical approach splenic artery pancreatic cancer |
| Published Date | 2022-08-23 |
| Publication Title | Anticancer Research |
| Volume | volume42 |
| Issue | issue9 |
| Publisher | Anticancer Research USA Inc. |
| Start Page | 4471 |
| End Page | 4476 |
| ISSN | 0250-7005 |
| NCID | AA10625860 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios) |
| File Version | publisher |
| PubMed ID | 36039441 |
| DOI | 10.21873/anticanres.15947 |
| Web of Science KeyUT | 000848585700012 |
| Related Url | isVersionOf https://doi.org/10.21873/anticanres.15947 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shan, Qiusheng| Takabatake, Kiyofumi| Omori, Haruka| Kawai, Hotaka| Oo, May Wathone| Sukegawa, Shintaro| Fujii, Masae| Inada, Yasunori| Sano, Sho| Nakano, Keisuke| Nagatsuka, Hitoshi| |
| Keywords | oral squamous cell carcinoma bone invasion gingival ligament tissue‑derived stromal cell periodontal ligament tissue‑derived stromal cell xenograft model microarray |
| Published Date | 2022-09-13 |
| Publication Title | Oncology Letters |
| Volume | volume24 |
| Issue | issue5 |
| Publisher | Spandidos Publications |
| Start Page | 382 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Shan et al. |
| File Version | publisher |
| PubMed ID | 36238359 |
| DOI | 10.3892/ol.2022.13502 |
| Web of Science KeyUT | 000859364100001 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2022.13502 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shan, Qiusheng| Takabatake, Kiyofumi| Kawai, Hotaka| Oo, May Wathone| Inada, Yasunori| Sukegawa, Shintaro| Fushimi, Shigeko| Nakano, Keisuke| Nagatsuka, Hitoshi| |
| Keywords | oral squamous cell carcinoma bone invasion osteoclast receptor activator of NF‑κB ligand parathyroid hormone‑related peptide microarray cancer‑associated stromal cells |
| Published Date | 2022-02-24 |
| Publication Title | Oncology Reports |
| Volume | volume47 |
| Issue | issue4 |
| Publisher | Spandidos Publications |
| Start Page | 81 |
| ISSN | 1021-335X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Shan et al. |
| File Version | publisher |
| PubMed ID | 35211756 |
| DOI | 10.3892/or.2022.8292 |
| Web of Science KeyUT | 000764236000001 |
| Related Url | isVersionOf https://doi.org/10.3892/or.2022.8292 |
| JaLCDOI | 10.18926/AMO/65979 |
|---|---|
| FullText URL | 77_5_553.pdf |
| Author | Murokawa, Takahiro| Sakamoto, Shinya| Tabuchi, Motoyasu| Sui, Kenta| Ozaki, Kazuhide| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| Yoshida, Hiroshi| |
| Abstract | Gastric cancer with peritoneal metastases is typically a devastating diagnosis. Ligamentum teres hepatis (LTH) metastasis is an extremely rare presentation with only four known cases. Herein, we report salvage surgery of successive metastases to the abdominal wall and LTH in a patient originally presenting with advanced gastric cancer with peritoneal metastasis, leading to long-term survival. A 72-year-old man with advanced gastric cancer underwent curative-intent distal gastrectomy with D2 lymph node dissection for gastric outlet obstruction. During this procedure, three small peritoneal metastases were detected in the lesser omentum, the small mesentery, and the mesocolon; however, intraoperative abdominal lavage cytology was negative. We added cytoreductive surgery for peritoneal metastasis. The pathological diagnosis of the gastric cancer was tubular adenocarcinoma with pT4aN1pM1(PER/P1b)CY0 stage IV (Japanese classification of gastric carcinoma/JCGC 15th), or T4N1M1b stage IV (UICC 7th). Post-operative adjuvant chemotherapy with S-1 (TS-1)+cisplatin (CDDP) was administered for 8 months followed by S-1 monotherapy for 4 months. At 28 months after the initial surgery, a follow-up computed tomography (CT) detected a small mass beneath the upper abdominal wall. The ass showed mild avidity on 18F-fluorodeoxyglucose positron-emission (FDG-PET) CT. Salvage resection was performed for diagnosis and treatment, and pathological findings were consistent with primary gastric cancer metastasis. At 49 months after the initial gastrectomy, a new lesion was detected in the LTH with a similar level of avidity on FDG-PET CT as the abdominal wall metastatic lesion. We performed a second salvage surgery for the LTH tumor, which also showed pathology of gastric cancer metastasis. There has been no recurrence up to 1 year after the LTH surgery. With multidisciplinary treatment the patient has survived almost 5 years after the initial gastrectomy. Curative-intent gastrectomy with cytoreductive surgery followed by adjuvant chemotherapy for advanced gastric cancer with localized peritoneal metastasis might have had a survival benefit in our patient. Successive salvage surgeries for oligometastatic lesions in the abdominal wall and the LTH also yielded favorable outcomes. |
| Keywords | gastric cancer peritoneal metastasis ligamentum teres hepatis oligometastasis salvage surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 553 |
| End Page | 559 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899267 |
| Web of Science KeyUT | 001110832700001 |
| JaLCDOI | 10.18926/AMO/65978 |
|---|---|
| FullText URL | 77_5_545.pdf |
| Author | Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki| |
| Abstract | To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant. |
| Keywords | esophagogastroduodenoscopy gastric lesion amyloidosis light chain |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 545 |
| End Page | 552 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899266 |
| Web of Science KeyUT | 001094245100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shan, Qiusheng| Takabatake, Kiyofumi| Kawai, Hotaka| Oo, May Wathone| Sukegawa, Shintaro| Fujii, Masae| Nakano, Keisuke| Nagatsuka, Hitoshi| |
| Keywords | oral squamous cell carcinoma tumor-associated macrophages cancer stroma tumor microenvironment microvessel density microarray |
| Published Date | 2022-05-06 |
| Publication Title | International Journal of Oncology |
| Volume | volume60 |
| Issue | issue6 |
| Publisher | Spandidos Publications |
| Start Page | 78 |
| ISSN | 1019-6439 |
| NCID | AA10992511 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Shan et al. |
| File Version | publisher |
| PubMed ID | 35514301 |
| DOI | 10.3892/ijo.2022.5368 |
| Web of Science KeyUT | 000795124900001 |
| Related Url | isVersionOf https://doi.org/10.3892/ijo.2022.5368 |
| JaLCDOI | 10.18926/AMO/65976 |
|---|---|
| FullText URL | 77_5_537.pdf |
| Author | Song, Qingqing| Pan, Yu| Kanazawa, Tomoyuki| Morimatsu, Hiroshi| |
| Abstract | Elderly patients are at higher risk of postoperative hypoxemia due to their decreased respiratory function. The aim of this study was to investigate the relationship of intraoperative oxygen saturation (SpO2) and end-expiratory carbon dioxide (ETCO2) values with postoperative hypoxemia in elderly patients. The inclusion criteria were: 1) patients aged≥75 years; 2) underwent general anesthesia in non-cardiac surgery; 3) operative time longer than two hours; and 4) admission to the intensive care unit (ICU) following surgery performed between January and December 2019. Intraoperative SpO2 and ETCO2 values were collected every minute for the first two hours during surgery. The 253 patients were divided into two groups: SpO2≥92% and SpO2<92%. The time-weighted averages of intraoperative SpO2 and ETCO2 were used to compare differences between the two groups. The incidence of postoperative hypoxemia was 22.5%. For similar ventilator settings, patients with postoperative hypoxemia had lower intraoperative SpO2 and higher ETCO2 values. Sex, ASA classification, and intraoperative SpO2 were independent risk factors for postoperative hypoxemia. In conclusion, postoperative SpO2<92% was a frequent occurrence (> 20%) in elderly patients who underwent major non-cardiac surgery. Postoperative hypoxemia was associated with low intraoperative SpO2 and relatively higher ETCO2. |
| Keywords | oxygen saturation end-expiratory carbon dioxide postoperative hypoxemia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 537 |
| End Page | 543 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899265 |
| Web of Science KeyUT | 001108661600011 |
| JaLCDOI | 10.18926/AMO/65974 |
|---|---|
| FullText URL | 77_5_517.pdf |
| Author | Horiguchi, Shigeru| Matsumoto, Kazuyuki| Morimoto, Kosaku| Matsumi, Akihiro| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Kato, Hironari| |
| Abstract | We investigated the effect of modified FOLFIRINOX (mFFX) in unresectable pancreatic cancer by retrospectively analyzing the cases of 43 patients who underwent BRCA testing (germline, n=11; somatic, n=26; both germline and somatic, n=6). The association between BRCA mutations and therapeutic effect was clarified. Six patients tested positive for germline pathogenic variants. Familial pancreatic cancer (33% vs. 3%, p=0.006) and peritoneal disseminated lesions (66% vs. 8%, p<0.001) were significantly more common in patients with germline pathogenic variants. The partial response (PR) rate was 100% in the germline BRCA-positive patients, and 27% in the germline BRCA-negative patients (p<0.001). The median progression-free survival (PFS) was not reached for any germline BRCA-positive patients but was 9.0 months for the germline BRCA-negative patients (p=0.042). Patients with stage IV BRCA-associated pancreatic cancer had better overall survival than those with non-BRCA-associated pancreatic cancer, although the difference was nonsignificant (not reached vs. 655 days, p=0.061). Our results demonstrate that a PR and prolonged PFS can be expected in germline BRCA-positive patients after treatment with mFFX. Our findings also suggest that germline BRCA pathogenic variants may be useful as biomarkers for the therapeutic effect of mFFX in patients with pancreatic cancer. |
| Keywords | BRCA FOLFIRINOX pancreatic cancer progression-free survival pathogenic variant |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 517 |
| End Page | 525 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899263 |
| Web of Science KeyUT | 001108661600009 |
