result 3251 件
| Author | 刘 文涛| |
|---|---|
| Published Date | 2014-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004908_abstract_review.pdf K0004908_fulltext.pdf |
|---|---|
| Author | Sato, Kota| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4908号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0004892_abstract_review.pdf K0004892_fulltext.pdf |
|---|---|
| Author | Hayakawa, Hiromi| |
| Published Date | 2014-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4892号 |
| Granted Date | 2014-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Sato, Katsunori| |
|---|---|
| Published Date | 2014-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume30 |
| Content Type | Others |
| Author | Saito, Noboru| |
|---|---|
| Published Date | 2014-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume30 |
| Content Type | Others |
| Author | Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | International Orthopaedics |
| Volume | volume37 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52406 |
|---|---|
| FullText URL | 68_2_101.pdf |
| Author | Izutsu, Masato| Suzuki, Etsuji| Izutsu, Yukako| Doi, Hiroyuki| |
| Abstract | The aim of this study was to examine trends in the geographic distribution of nursing staff in Japan from 2000 to 2010. We examined time trends in the rates of nursing staff per 100,000 population across 349 secondary health service areas. Using the Gini coefficient as a measure of inequality, we separately analyzed the data of 4 nursing staff types:public health nurses (PHN), midwives (MW), nurses (NS), and associate nurses (AN). Then, using multilevel Poisson regression models, we calculated the rate ratios (RRs) and their 95% confidence intervals (CIs) for each type of nursing staff per 1-year change. Overall, the distribution of PHN, MW, and NS improved slightly in terms of the Gini coefficient. After adjusting for prefectural capital and population density, PHN, MW, and NS significantly increased;the RRs per 1-year increment were 1.022 (95% CI:1.020-1.023), 1.021 (95% CI:1.019-1.022), and 1.037 (95% CI:1.037-1.038), respectively. In contrast, AN significantly decreased;the RR per 1-year increment was 0.993 (95% CI:0.993-0.994). Despite the considerable increase in the absolute number of nursing staff in Japan (excluding AN), this increase did not lead to a sufficient improvement in distribution over the last decade. |
| Keywords | health policy inequality Japan multilevel Poisson model nursing staff |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 101 |
| End Page | 110 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743785 |
| Web of Science KeyUT | 000334652700005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52523 |
| JaLCDOI | 10.18926/AMO/52403 |
|---|---|
| FullText URL | 68_2_63.pdf |
| Author | Fujii, Yasuyuki| Hoshino, Tyuji| Kumon, Hiromi| |
| Abstract | Dickkopf (DKK) proteins interact with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to modulate WNT signaling. The interaction is mediated by a cysteine-rich domain (C2) in the DKK protein and β-propeller domains (PD) of LRP5/6. However, the third member of the DKK family (DKK3) does not bind to LRP5/6. To determine why DKK3 does not bind to the receptor domains, we performed a molecular modeling simulation study including homology modeling, protein-protein docking and molecular dynamics (MD). The computed affinities (ΔGbinding) between the C2 and PD models were consistent with the previously reported experimental results. The C2 model of DKK3 showed the lowest affinity for PD models. Multiple sequence alignment of C2 domains revealed that the DKK3 genes have a unique 7-amino-acid insertion (L249-E255 in human DKK3) and P258 in a finger loop 1 (FL1). Interestingly, the insertion sequence is evolutionally conserved. MD simulations of high-affinity complex models of C2 and PD showed that FL1 directly interacts with the PD models and stabilizes the complex models. We also built a 7-amino-acid-deletion/P258G mutant model of DKK3C2 and estimated its affinities for the PD models. The affinity for human LRP5PD2 was increased by the substitution (ΔGbinding＝－48.9kcal/mol) and the affinity was compatible with that of high-affinity ligands. The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. The sequence differences thus suggest an explanation for this unique property of DKK3. |
| Keywords | DKK3 molecular modeling protein-protein docking LRP5/6 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743782 |
| Web of Science KeyUT | 000334652700002 |
| JaLCDOI | 10.18926/52378 |
|---|---|
| Title Alternative | Cross Cultural Adjustment of Foreign Care Workers in Japan －Analyzing the Longitudinal Cases Based on A Three-Layered Structural Model－ |
| FullText URL | hss_037_067_076.pdf |
| Author | Hatanaka, Kaori| Tanaka, Tomoko| Mithuyoshi, Jinya| |
| Publication Title | 岡山大学大学院社会文化科学研究科紀要 |
| Published Date | 2014-03-25 |
| Volume | volume37 |
| Start Page | 67 |
| End Page | 76 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120005418222 |
| Author | Kurimoto, Etsuko| Miyahara, Nobuaki| Kanehiro, Arihiko| Waseda, Koichi| Taniguchi, Akihiko| Ikeda, Genyo| Koga, Hikari| Nishimori, Hisakazu| Tanimoto, Yasushi| Kataoka, Mikio| Iwakura, Yoichiro| Gelfand, Erwin W.| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2013-01-20 |
| Publication Title | Respiratory Research |
| Volume | volume14 |
| Content Type | Journal Article |
| Author | Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02-19 |
| Publication Title | PLoS ONE |
| Volume | volume8 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Morimoto, Nobutoshi| Abe, Koji| |
|---|---|
| Published Date | 2014-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume126 |
| Issue | issue1 |
| Content Type | Journal Article |
| Title Alternative | Molecular targeted therapies in leukemia |
|---|---|
| FullText URL | 126_49.pdf |
| Author | Maeda, Yoshinobu| Tanimoto, Mitsune| |
| Keywords | 白血病 分子標的薬 チロシンキナーゼ阻害薬 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 49 |
| End Page | 54 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.49 |
| Title Alternative | Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer |
|---|---|
| FullText URL | 126_25.pdf |
| Author | Mizoo, Taeko| Shien, Tadahiko| Ito, Maiko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| |
| Abstract | Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery. |
| Keywords | OSNA法（OSNA method） センチネルリンパ節（sentinel lymph node） micrometastases CK-19 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 25 |
| End Page | 30 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.25 |
| JaLCDOI | 10.18926/OER/52264 |
|---|---|
| Title Alternative | Clues on Building Trust at Start-ups: A Case of Market Business Model |
| FullText URL | oer_045_4_001_016.pdf |
| Author | Kita, Masanobu| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-03-11 |
| Volume | volume45 |
| Issue | issue4 |
| Start Page | 1 |
| End Page | 16 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005398231 |
| JaLCDOI | 10.18926/fest/52229 |
|---|---|
| Title Alternative | Material design for the ceramics coating with high mold releasability by using molecular orbital calculations |
| FullText URL | fest_019_022_025.pdf |
| Author | Nanba, Tokuro| Fujihara, Jiro| Sakida, Shinichi| Benino, Yasuhiko| |
| Abstract | To explore the ceramic materials appropriate for the coatings with high mold releasability, molecular orbital (MO) calculations have been applied to the ceramics with NaCl structure, such as TiN, TiC, CrN, etc. Chemical bonding characters were evaluated based on the MO calculations, which were correlated to the experimental surface free energy. The dispersion and polar components of surface free energy indicated high correlation with the bond overlap population of the surface bonds and the net charge of inside atoms of the cluster models, respectively. Among the ceramic materials investigated, MoN had the lowest surface free energy, being expected to be most suitable as the ceramic coating material with high releasability |
| Keywords | Material design Ceramic coating Releasability Molecular orbital calculation |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Published Date | 2014-03 |
| Volume | volume19 |
| Issue | issue1 |
| Start Page | 22 |
| End Page | 25 |
| ISSN | 2187-6940 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394644 |
| JaLCDOI | 10.18926/fest/52227 |
|---|---|
| Title Alternative | Numerical Evaluation of the Approximation by an Influence Function |
| FullText URL | fest_019_001_007.pdf |
| Author | Bao, Hong Mei| Fueda, Kaoru| |
| Abstract | For evaluating statistical models one of the most effective criteria is cross-validation. But it requires a large amount of computation. Various alternative schemes are considered to reduce its computation. Modified generalized information criterion is one of those alternative schemes. In this criterion an influence function is used to estimate the parameters of the models. By the numerical simulation we studied the effect of an influence function. Surveying data of the lake depth are used as the sample data. We estimate the shape of lake bottom as spline surface. The estimated parameters and the estimated depths obtained by two criteria are compared and the effect of an information function is analysed. |
| Keywords | influence function information criteria CV mGIC B-spline |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Published Date | 2014-03 |
| Volume | volume19 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 2187-6940 |
| language | English |
| File Version | publisher |
| NAID | 120005394642 |
| JaLCDOI | 10.18926/52199 |
|---|---|
| FullText URL | bhe_009_155_168.pdf |
| Author | Nakamura, Ian| |
| Abstract | This exploratory study will begin with a review of cinematic portrayals of teachers and their situations by establishing three categories: thought-provoking stories of teachers and students trying to overcome social barriers, entertainment first productions with an uplifting resolution of conflict, and documentaries that track the real-life struggles and successes of educational practitioners and their students through projectbased training and performance. Then I will use forms of reflective practice and discourse analysis to delve deeper into the details of teaching and context. This working paper will conclude with some thoughts on what ‘good’ teachers do. |
| Keywords | films reflection teachers students professional development |
| Publication Title | 大学教育研究紀要 |
| Published Date | 2013-12-30 |
| Volume | volume9 |
| Start Page | 155 |
| End Page | 168 |
| ISSN | 1881-5952 |
| language | English |
| File Version | publisher |
| NAID | 120005394634 |
| JaLCDOI | 10.18926/bgeou/52172 |
|---|---|
| Title Alternative | Utilizing Video Self-Modeling and Video Hero Modeling to Increase Task Engagement of an Elementary-Aged Student with Autism Spectrum Disorder. |
| FullText URL | bgeou_155_013_022.pdf |
| Author | Ohtaka, Yoshihisa| Takahashi, Ayaka| Takeuchi, Ai| Watanabe, Kentaro| Hamada, Toshiko| |
| Abstract | 本研究では，集中して着替えに取り組むことが難しい一人の知的障害のある自閉症スペクトラム障害児に対して，３種類のビデオモデリング技法を順次適用し，どの技法がもっとも着替え従事率の上昇をもたらすかを検討した。用いられた技法は，①本人が着替えに取り組 むビデオを着替えに先立ち視聴させる技法，②本人が着替えの競争でヒーローに勝つビデオを着替えに先立ち視聴させる技法，③ヒーローが着替えに取り組むビデオを着替えの最中に視聴させる技法の３つであった。ABACADA デザインを用いてこれら３つの介入効果を比 較した結果，③の技法のみに効果が確認された。 |
| Keywords | 自閉症スペクトラム障害 日常生活の指導 ビデオセルフモデリング ビデオヒーローモデリング |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 13 |
| End Page | 22 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394597 |
| JaLCDOI | 10.18926/AMO/52138 |
|---|---|
| FullText URL | 68_1_7.pdf |
| Author | Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi| |
| Abstract | Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration. |
| Keywords | cell biology immunosuppression stem cells |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553483 |
| Web of Science KeyUT | 000331592800002 |
