result 463 件
| Author | Okumura, Kazutoshi| |
|---|---|
| Published Date | 1959-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue7-1 |
| Content Type | Journal Article |
| Author | Okumura, Kazutoshi| |
|---|---|
| Published Date | 1959-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue7-1 |
| Content Type | Journal Article |
| Author | Okumura, Kazutoshi| |
|---|---|
| Published Date | 1959-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue7-1 |
| Content Type | Journal Article |
| Author | Hanaoka, Atsumi| |
|---|---|
| Published Date | 1959-05-15 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume71 |
| Issue | issue6-2 |
| Content Type | Journal Article |
| Author | Hatano, Makoto| |
|---|---|
| Published Date | 1989-10 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume101 |
| Issue | issue9-10 |
| Content Type | Journal Article |
| Author | Fujiwara, Kanta| |
|---|---|
| Published Date | 1989-08-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume101 |
| Issue | issue7-8 |
| Content Type | Journal Article |
| Author | Fujiwara, Kanta| |
|---|---|
| Published Date | 1989-08-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume101 |
| Issue | issue7-8 |
| Content Type | Journal Article |
| Author | Kawakami, Yunosuke| |
|---|---|
| Published Date | 1990-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume102 |
| Issue | issue3-4 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/40502 |
|---|---|
| FullText URL | 64_5_277.pdf |
| Author | Kumase, Fumiaki| Morizane, Yuki| Mohri, Satoshi| Takasu, Ippei| Ohtsuka, Aiji| Ohtsuki, Hiroshi| |
| Abstract | Endothelial glycocalyx (GCX) has been reported as a protective factor for vascular endothelial cells (VEC) in diabetes and hypertension. However, the involvement of GCX impairment in ocular vasculopathy remains unclear. We evaluated the changes in the GCX thicknesses of the retinal and choroidal capillaries in rats with diabetes and hypertension by cationic colloidal iron staining using a transmission electron microscope. In the control group, the mean (standard error of the mean) thicknesses of retinal and choroidal GCX were 60.2 (1.5) nm and 84.3 (3.1) nm, respectively. The diabetic rats showed a significant decrease of GCX thickness in the retina, but not in the choroid, compared to controls (28.3 (0.3) nm, p＜0.01 and 77.8 (1.4) nm, respectively). In the hypertensive rats, both retinal and choroidal GCX were significantly decreased compared to the control values (10.9 (0.4) nm and 13.2 (1.0) nm, respectively, both p＜0.01). Moreover, we could visualize the adhesion of leukocytes and platelets on the luminal surface of VEC, at the site where the GCX was markedly degraded. These findings suggest that the GCX prevents adhesion of leukocytes and platelets to the VEC surface, and this impairment may lead to ocular vasculopathy in diabetes and hypertension. |
| Keywords | glycocalyx retina choroid diabetes hypertension |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-10 |
| Volume | volume64 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 277 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2010 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20975760 |
| Web of Science KeyUT | 000283563300002 |
| JaLCDOI | 10.18926/40363 |
|---|---|
| Title Alternative | Studies on vitriol springs : 5. Polynuclear complex iron salts in vitriol waters |
| FullText URL | rbl_003_035_038.pdf |
| Author | Ashizawa, Takashi| |
| Publication Title | 放射能泉研究所報告 |
| Published Date | 1950-07-25 |
| Volume | volume3 |
| Start Page | 35 |
| End Page | 38 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002484887 |
| JaLCDOI | 10.18926/40344 |
|---|---|
| Title Alternative | STUDIES ON VITRIOL SPRINGS (4) ON THE COPPER, ZINC, NICKEL, AND COBALT CONTENTS OF BLOOD AFTER THE INTERNAL USE OF A VITRIOL WATER |
| FullText URL | 013_015_017.pdf |
| Author | Oshima, Yoshio| Ashizawa, Takashi| |
| Abstract | Sotozono proved that the administration of daily 20cc of Fujino Mineral Water (an acid vitriol water containing copper, zinc, nickel and cobalt) has a remarkably beneficial effect on several kinds of hypochromic anemia. It contains 9.56gms of iron, 0.007gm of zinc, 0.005gm of copper 0.001gm of nickel, and 0.006gm of cobalt in one liter. 20 - 40cc of Fujino water was diluted 5 - 10 fold with plain water and administered to the fasting patients perorally. Blood samples were taken from cubital vein before, 1, 2, 4, 6, 24, 48, and 72 hours after the intake of the vitriol water. Copper, zinc, nickel and cobalt contents of the blood samples were measured by Ashizawa' s dithizone- chromatographic method. It was shown that copper, nickel, and cobalt contents of blood rose unexpectedly high temporarily, in a manner that did not correspond to their amount in the given mineral water. So that the mobilization of copper, nickel, and cobalt in the body after the intake of the mineral IVrter was susrected. Zinc content of blood showed no constant tendency. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1953-12 |
| Volume | volume13 |
| Start Page | 15 |
| End Page | 17 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002484879 |
| JaLCDOI | 10.18926/40326 |
|---|---|
| Title Alternative | ASOZU (WEAK COMMON SALT SPRING), HAMAMURA (SULPHATED BITTER SPRING), KAlKE (CALCIUM CHLORIDE CONTAINING SALINE SPRING) AND FUJINO (ACID ALUM VITRIOL SPRING) SPRING WATERS AND THE ALIMENTARY HYPERGLYCEMIA |
| FullText URL | pitsr_014_022_029.pdf |
| Author | Morinaga, Hiroshi| |
| Abstract | There are many experimental reports and clinical observations about the internal use of thermal waters on carbohydrate metabolism, and alkaline springs, alkaline common salt springs and sulphur springs are used for the balneological therapy of diabetic patients. The author reported that the internal use of the radon springs of Japan, such as Misasa, Ikeda and Masutomi thermal waters promoted the action of insuline and inhibited the experimental hyperglycemia in rabbits, and he suggested that these radioactive waters also would be able to utilize for the diabetic treatment. On the other hand, trace elements such as Cu, Zn and Mn have protective effects against disturbed carbohydrate metabolism of diabetic body. Some thermal waters contain these trace elements in various degrees, and Oshima & Ashizawa observed that after the drinking of Fujino mineral water the iron, copper, nickel and cobalt content in blood rose temporarily. In this report, the author investigated the influence of the drinking of Asozu (weak common salt spring), Hamamura (sulphated bitter spring), Kaike (calcium chloride containing saline spring) and Fujino (acid alum vitriol spring) Spring waters upon the alimentary hyperglycemia in rabbits. Thirty ml. of 10% glucose solution in thermal water (Fujino Water was diluted twice with plain water) or in plain water per kg. of bodyweight was administered to the rabbit by stomach tube and blood sugar level was determined before, 1/2, 1, 2, 3 and 4 hours after the administration. The results were as follows: 1. The drinking of Asozu Spring water inhibited the alimentary hyperglycemia compared with the plain water as a control. 2. Hamamura Spring had a tendency to decrease the blood sugar level. 3. Kaike Spring water had no inhibitory a.ction upon the alimentary hyperglycemia. 4. In spite of the existence of trace elements, Fujino mineral water had no significant effect. The author supposed that this was due to its high acidity. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1954-03 |
| Volume | volume14 |
| Start Page | 22 |
| End Page | 29 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462903 |
| JaLCDOI | 10.18926/40322 |
|---|---|
| Title Alternative | THE CLINICAL STUDIES OF RHEUMATOID ARTHRITIS (I) |
| FullText URL | 016_035_048.pdf |
| Author | Morinaga, Hiroshi| |
| Abstract | The value of spa treatment of rheumatic disease is an established feature of medical management based on experiences for many centuries. The author has been practising the balneotherapy of rheumatic diseases at Misasa Spa for several years, and has found this therapy efficacious in many cases in relieving the anemia that accompanies rheumatoid arthritis. For this reason, the author is investigating the metabolism of iron in rheumatic anemia, which is expected to occur in the course of the spa treatment. In this report, the results of clinical examinations of 24 patients with rheumatoid arthritis, of the type (2. 2. 2.) Polyarthritis systemica chronica (in Prof. Kodama's classification of arthritis), are described. I. Some observations of anemia in rheumatoid arthritis 1. The peripheral blood The number of erythrocytes is 266×10(4)～455×10(4)/c. mm. (average: (381±32)×10(4)/c. mm.), Hb-content : 55～90% (average : 76±5.8%), and the color index is about 1.0. The anemia of rheumatic disease treated is mostly normochromic. The white blood count is between 3240 and 13300/c. mm. (average: 6421±955/c. mm. ), and the number of the leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed in 15% of the cases. 2. Anemia-producing substance in the serum of rheumatoid arthritis When serum from rheumatoid arthritis patients was injected into rabbits, the number of erythrocytes and the hemoglobin -content of the rabbits was found to decrease markedly for 2～6hours after the injection. But no such effect was observed when the serum of healthy subjects was injected. From this, the author presumes the presence of an anemia-producing substance in the serum of rheumatoid arthritis. The nature of this substance in now under investigation. II. Clinical-biochemical studies 3. Gastric acidity of rheumatic patients Of 7 cases examined, anacidity of gastric juice was observed in 2 cases, subacidity in other 2 cases and normacidity in the remaining 3 cases. Thus, a decrease in the gastric acidity was found to occur in 57% of the cases. 4. Takata-serum-test and sedimentation rate It is said that the sedimentation rate and the Weltmann-reaction are very sensitive indicators of the extent of the activity of rheumatic disease. The Takata-serum-test was applied in 18 cases and was found to give positive results in 10 cases (55%). The sedimentation rate was found to increase in 17 of 20 cases (85%). 5. Blood uric acid As is well known, the concentration of uric acid is abnormally high in the blood of patients with gout; while, according to the literature, the blood uric acid levels of patients with rheumatoid arthritis range within the normal limits. The author, using the method of Benedict, obtained the following results for blood uric acid in 14 normal subjects in fasting state: Range - 2.30～3.47mg./dl. , 5% rejection limit -- 1.97～3.68mg./dl. In 5 of 7 cases of rheumatoid arthritis, the blood uric acid levels were shown to be above the upper limit of the normal range, but the concentrations of blood uric acid of non-rheumatic joint diseases and neuralgias were mostly within the normal range. 6. Blood sugar The fasting blood sugar levels of rheumatoid patients ranged from 82 to 1l0mg./dl. (average : 100mg./dl.), higher than the levels of healthy subjects (78～108mg./dl., average : 90mg./dl.). The intravenously injected glucose load test was applied to 8 rheumatoid patients. A solution of 40 ml. of 20% glucose was injected into a fasting subject for 2 minutes. Blood samples were taken before the injection, 3 minutes after the injection, and at each subsequent 10 minute-interval for 70 minutes. The glucose tolerance curves in 5 of these cases were found to be out of the normal range. It is to be noticed that the average blood sugar for rheumatoid arthritis is similar to the curve for liver disease. 7. Serum alkaline phosphatase activity and serum phosphorus The method of Taussky-Shorr was used for the determination of the level of alkaline phosphatase activity and inorganic phosphate in the serum. The alkaline phosphatase activity of 11 normal individuals ranged from 1.4 to 6.4 Shinowara-Jones-Rheinhart units/dl. (5% rejection limit), while in 4 of 8 cases of rheumatoid arthritis, it was of abnormally high levels. The concentration of inorganic phosphate in the serum of 12 normal subjects ranged from 2.9 to 5.0mg. /dl. (5% rejection limit), while in 3 cases of rheumatoid patients, it showed higher levels than normal. 8. Total cholesterol in serum The total cholesterol in the serum of fasting normal individuals was measured by Bloor's method, and the concentration was found to range from 124 to 188mg./dl. (rejection limit of 5% level of significance), and the total cholesterol in the serum of rheumatoid arthritis to be abnormally high in concentration in 6 of 7 cases. The liver function was evaluated by the Takata-serum-test, the test of fasting blood sugar levels, the glucose load test, and the test of serum alkaline phosphatase activity; and from this the hepatic dysfunction was found to occur in rheumatoid arthritis patients in about 50% of the cases examined. Disturbances in the protein, fat, and carbohydrate metabolism were also found to occur. The above-mentioned findings indicate that rheumatoid arthritis is not only a disease of the joints, but also a general and systemic illness. Attention must accordingly be given to the general condition of the patient in the treatment of rheumatic disease. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1956-01 |
| Volume | volume16 |
| Start Page | 35 |
| End Page | 48 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40318 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532470 |
| JaLCDOI | 10.18926/40312 |
|---|---|
| Title Alternative | o-PHENANTHROLINE METHOD APPLIED TO THE DETERMINATION OF IRON IN NATURAL WATERS |
| FullText URL | pitsr_017_001_007.pdf |
| Author | Tanaka, Shigeo| |
| Abstract | The o-phenanthroline method was tested as to its applicability to the separate determination of iron in natural water: ionic ferrous iron, reducible iron, snd colloidally dispersed iron. In connection with this, the results of the following experiments are given in this paper. 1. Determination of the absorption curve of o-phenanthroline ferrous complex. (Figure 1.) 2. Construction of the calibration curve for a Purfrich's photometer with filter S 50, 15 cm cuvettes. (Figure 2.) 3. Examination of the effects of coexisting anions on the determination of iron by the method of three way layout. (Table 1., Table 2.) 4. Trial determinations of iron in three different states in solution. (Table 3., Table 4. ) 5. Test of the applicability of this method to the determination of ionic ferrous iron and reducible iron in thermal water. (Table 5., Table 6.) From the above, it was revealed that ionic ferrous iron and reducible iron in natural water are separately determinable with sufficient accuracy by the o-phenanthroline method, and that ionic iron and colloidally dispersed iron are also separately determinable, when the dispersed iron is present in amount more than 1.3% of the total iron. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1956-03 |
| Volume | volume17 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40311 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462897 |
| Author | Yamaguchi, Kenji| |
|---|---|
| Published Date | 1957-09 |
| Publication Title | 岡山大学温泉研究所報告 |
| Volume | volume19 |
| Content Type | Conference Paper |
| JaLCDOI | 10.18926/40272 |
|---|---|
| Title Alternative | THE CHANGE IN CONCENTRATION OF FERROUS IRON AND REDUCIBLE IRON, DISSOLVED IN SPRING WATER AT MISASA HOT SPRINGS, JAPAN, DURING PRESERVATION OF THE WATER SAMPLE IN A SEALED BOTTLE |
| FullText URL | pitsr_020_048_054.pdf |
| Author | Tanaka, Shigeo| |
| Abstract | The two sprigns called "Tanaka-no-Yu" and "Hisui-no-Yu" at Misasa Hot Springs, japan (Fig. 1), suitable for sampling the unpolluted water, the locations of which, are shown in Fig. 2, were chosen for this study. The o-phenanthroline method, details of which were discussed in the previous report by the author (Repts. Balneol. Lab. Okyama Univ., 17, 1, (1956)) was used for the determination of ferrous iron, ferrous iron + reducible iron, and ferrous iron + reducible iron + colloidally dispersed iron (to be referred to as "total irons" in this report). For comparison, the change in concentratin of iron dissolved in distilled water during preservation in a sealed bottle was observed, and the results obtained for the solutions with the pH values of 5.4 and 5.8 are illustrated in Fig.3 and Fig.5, rspectively. Both ferrous and reducible iron disappear within 5 minutes, when the pH of the solution is 6.4. The hydrogen ion concentration was thus seen to give a sensitive effects on the speed of diminution of ferrous and reducible iron dissolved in the distilled water. It should be noticed that no appreciable diminution was observed during the period from 60 min. to 120 min,. It is probable that the diminution of total iron is caused by the adsorption of colloidal iron hydroxides on the wall of glass bottle. The effects of charged anion (SO(4)(--)) on the change in concentration of iron during preservation was also investigated, but no appreciable effect was found. (Fig. 5 and Fig. 6). Fig.7, Fig.8, and Fig.9 show the change in concentration of iron during preservation of the spring water at "Tanaka-no-Yu". The content of iron in the spring water is about 0.3 mg/l, and its pH value is about 7.1. For the first 30 minutes, ferrous iron diminishes rapidly, the slope of the diminution curve being sharp and almost straight. Thereafter the slope becomes gentler, and, after an hour, the slope approaches nearly zero. On the other hand, ferrous iron dissolved in distilled water disappears in a moment at the same pH 7.1. Fig.10, Fig.11, and Fig.12 show the change in concentration of iron during preservation of the spring water at "Hisui-no-Yu". The content of iron in the spring water is about 1.0 mg/l, and its pH value is about 6.4. In this case, the diminution of ferrous iron is not remarkable, and only 20% of the initial quantity diminishes within 2 days. Whereas, in the case of distilled water, the diminution is very rapid at the same pH 6,4, and the ferrous iron disappears completely within 5 minutes. In Fig.13 the speed of diminution of iron in distilled water and that in spring water are compared. The difference here seen may probably be due either to that the ferrous iron in spring water is in a certain complex form not easily oxidizable, or to that the spring water contains some reducing substances. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-01 |
| Volume | volume20 |
| Start Page | 48 |
| End Page | 54 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462895 |
| JaLCDOI | 10.18926/40267 |
|---|---|
| Title Alternative | Studies on Balneotherapy of Gynecological Chronic Inflammations |
| FullText URL | pitsr_021_001_046.pdf |
| Author | Ishii, Chikara| |
| Abstract | The effects of balneotherapy on gynecological chronic inflammations were examined both clinically and experimentally. Clinical study. Statistical observations were made on the patients with gynecological diseases who visited the spa of Misasa. It was ascertained that, among them, the patients with gynecological chronic inflammati on whose chief complains were hypogastric and Lumbar pains were most common and that, by balneotherapy, their conditions were frequently improved both subjectively and objectively. Experimental study. An experimental foreign body inflammation was evoked by inserting a Sponge into the abdominal cavity of an adult female rat and the effects of hot-spring bath were examined. Acceleration of the absorption of the inflammation, enhancement of phagocytosis of the subcutaneous histiocytes, activation of the fibrohistiocytic system of the subcutaneous connective tissue, and acceleration of return of the free cells in the abdominal cavity were proved. Furthermore, comparative studies were made on the effects of various artificial mineral waters and ultra short waves. It was found that, though they were less effective than natural mineral water, artificial strong saline water, artificial sulfur water, artificial sulfate water, artificial iron water and ultra short waves were effective and that artificial weak saline water, artificial bicarbonate water, artificial humimic acid water, artificial alkaline water, and artificial acidic water were as effective as fresh water. Compared with hot bath, insensible bath was more effective. No significant difference of therapeutic effect was found by bathing once a day or three times a day. In short, balneotherapy had a facilitatory action on the absorption of the inflammatory changes in the abdominal cavity. This should be ascribed not only to the increase in the deep blood flow by warming but also to the general defence mechanism enhanced by cutaneous stimulation. Some differences were also assumed depending on the ions contained in the mineral waters. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-04 |
| Volume | volume21 |
| Start Page | 1 |
| End Page | 46 |
| ISSN | 0369-7142 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462893 |
| JaLCDOI | 10.18926/40265 |
|---|---|
| Title Alternative | Studies on Paper-Analysis in the Field of Balneology (I) Studies on Iron in Serum by Means of Parper-Electrophoresis and Paper-Chromatography |
| FullText URL | 022_037_054.pdf |
| Author | Ishibashi, Maruo| |
| Abstract | 1. The author showed by means of paper-electrophoresis using o-nitrosoresorcinmonomethylether (hereafter N. R. M. E.), a colourdeveloping reagent, that iron in serum combines with β-fraction of serum protein. 2. The author proposed a new method for the determination of serum iron by means of paper-chromatography. Procedure is as follows. In a centriguged tube, 0.5 ml. of clear serum is taken, acidified with 0.15 ml. of 20% HNO(3), and allowed to stand for 20 minutes. After addition of 0.2 ml. of saturated solution of CH(3)COONa and 1 ml. of acetic acid-sodium acetate buffer solution (pH: 3.8), the mixture is kept for at least 10 min. and filtered through Toyo-filter-paper No.5 A. The clear filtrate is taken in a stoppered test tube (the inside diameter: 1.2 cm.; height: 15 cm.). To this filtrate are added 0.2 ml. of 20% Hydroxylamine hydrochloride and 0.25 ml. of saturated aqueous solution of N. R. M. E. After being allowed to stand for at least 20 min., the mixture is shaken with 5 ml. of carbon tebrachloride. Then the excess of N. R. M. E. is removed. The supernatant aqueous solution (0.2 ml.) is used for a determination sample. The sample is placed on the paper (Toyo,filter-paper No.51 or 50) in a thin line at a distance of 10 cm. from the edge, and the spots are developed with 90 % ethylalcohol. After development for 4-6 hours, a green-coloured linear spot appsars at a distance of 12-16 cm. from the origin-point. Spot intensity at 670 mμ is measured with Natsume's densitometer, and from this, concentration of Fe can be estimat.ed on the standard graph (Fig. 5). 3, Effects of radioactive thermal spring bathing and internal use of vitriol water upon serum iron levels were studied with the result.s as follows. The above-mentioned author's method of determining the iron level in a small amount of serum is very convenient in investigating iron metabolism in the field of balneotherapy. The author examined changes of iron levels in serum after radioactive thermal bathing as well as after internal use of acid vitriol water. a) The iron levels in serum were maasurecl by the author's method before and 5, 30 and 60 minutes after the radioactive thermal bath (Rn-content: 10-30 Mache, 42-3°C., for 10 min,). The iron levels in the serum of healthy subjects showed no significant change after the thermal bathing. b) Yanahara Mineral Water (an acid vitriol water, pH; 2.2) contains 0.045 gm. of Cl(-), 12.35 gm. of SO(4)(--), 2.5 gm. of Fe(++)+Fe(+++), 0.0938 gm. of Al(+++) and 0.0001 gm. of Cobalt in one liter. i) Thirty ml. of Yanahara, water diluted with plain water to 200 ml. (Fe(++) content: ca. 75 mg.) and administered to health fasting subjects orally. As a control matter, 0.65 gm. of Glukon-F powder (Fe(++) content.: ca. 75 mg.) was then given. Blood samples were taken from the cubital vein before and 1, 3 and 6 hours after the intake of the dtriol water. Iron contents of the serum samples were measured by the author's paper chromatographic method. The results were shown in the table and the figure. The iron contents of the serum after the intake of the mineral water were higher than in the case of the control. ii) Two ml. of Yanahara vitriol water was administered to rabbits with the aid of a stomach tube, and serum iron levels wera determined before and 1, 3, 4 and 6 hours after the administration. An amount of 0.05 gm. of Glukon-F powder was dissolved in 5 ml. of plain water, and this solution was given to rabbits as a control. After the internal use of vitriol water, iron levels in serum rose and remained unexpactedly high for about 1-4 hours, in a manner that did not. correspond to the amount of iron in the given mineral water. So that it was suspected that the iron originally contained in the living subjects had been mobilized by the intake of vitriol water. Iron levels in serum after administration of a solution of Glukon-F powder were lower than in the case of the mineral water. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1958-07 |
| Volume | volume22 |
| Start Page | 37 |
| End Page | 54 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40263 |
| language | Japanese |
| File Version | publisher |
| NAID | 40017532359 |
| JaLCDOI | 10.18926/40248 |
|---|---|
| Title Alternative | Clinical Studies on Anemia in Rheumatoid Arthritis |
| FullText URL | pitsr_025_053_069.pdf |
| Author | Yamamoto, Yasuhisa| |
| Abstract | Anemia of moderate severity is commonly present in patients suffering from rheumatoid arthritis, but one to which little attention has been paid and despite its frequency the exact mechanism of its production is uncertain. Anemia in rheumatoid arthritis is refractory to anti-anemic therapy. The presence of anemia may hinder adequate physical or orthopedic treatment and may produce a degree of lassitude that considerably aggravates the joint disability. This anemia, therefore, seemed worthy of study and investigations of three aspects are reported here: 1. Changes in peripheral blood, bone marrow, liver function and gastric acidity. 2. Alternations in iron metabolism. 3. Balneotherapy and anemia in rheumatoid arthritis. I. Peripheral Blood Picture, Liver Function, Serum Protein Fraction and Gastric Acidity. 1. The peripheral blood and bone marrow. The number of erythrocytes is 558～216×10(4)/c. mm. (average:402×10(4)/c. mm.), hemoglobin-content:110～40% (average: 78.6%), and the color index is about 1.0. The anemia of rheumatoid arthritis treated is mostly normochromic. The white blood cell count is between 11200 and 3720/c. mm. (average: 7504/c. mm.), and the number of leucocytes in 80% of the cases ranges within the normal limits. Eosinophilia is observed 27% of the cases. Films of the sternal marrow showed no major abnormality in the eight cases examined. Several minor points, however, deserve mention. The nucleated cell count was diminished in seven cases examined, and the decrease of normoblasts in bone marrow would explain the reduced red cell count in peripheral blood. The myeloid series showed a relative increase. 2. Liver function tests and gastric acidity. To illustrate the possible appearance of liver function disturbances in connection with rheumatoid arthritis, the author has made different liver function tests on patients suffering from this disease. From the results it appears that in protein metabolism tests more than 83% of the cases gave abnormal albumin/globulin ratios and Takata's and erthrocyte sedimentation reactions. The detoxication capacity determined by hippuric acid synthesis tests had decreased in 25% of the cases examined. The dye excreting capacity, determined by the bromsulfalein tolerance test, was found to be reduced in 64% of the cases examined. The urin-urobilinogen test showed positive in 28% of the cases. In all cases the insulin sensitivity test gave pathological readings. Of 40 cases examined, anacidity of gastric juice was observed in 17 cases, subacidity in other 10 cases and normacidity, hyperacidity in remammg 13 cases. Thus, a decrease in the gastric acidity was found to occur in 67.5% of the cases. 3. Serum protein fraction. The total serum protein of 31 cases with rheumatoid arthritis appeared to be on the same level as in normal material. Serum protein fraction was determined in 19 cases by paperelectrophoresis. In rheumatoid patients, albumin fraction of serum protein decreased and γ-globulin fraction increased in all cases examined, compared with the data of normal subject as a control. Alubumin/globulin ratio of rheumatoid arthritis was below the 5% rejection limit of normal value. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-05 |
| Volume | volume25 |
| Start Page | 53 |
| End Page | 69 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40244 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002462889 |
| JaLCDOI | 10.18926/40246 |
|---|---|
| Title Alternative | Studies on the Chemical Composition and Levels of Ground Water at Misasa Hot Springs |
| FullText URL | 025_013_024.pdf |
| Author | Sakanoue, Masanobu| |
| Abstract | The water levels of the thermal springs and the ground water levels were measured and the contour of the water table was obtained. The contour was disturbed at two regions in which many springs issue. The thermal and ground waters were sampled all over the springs district, and the water temperatures were measured when they were sampled. The chloride, bicarbonate, sulfate, calcium and magnesium content was also determined. In addition, the analytical methods for the determination of arsenic, phosphorus and acid-soluble iron were improved. Also the concentration of these elements was determined. Based on the results of the observations and chemical analysis, the relations between the water temperatures and content of chemical constituent and the chloride content were checked respectively. Positive correlations were found in the relations between water temperature～Cl(-), HCO(3)(-)～Cl(-), SO(4)(2-)～Cl(-), Ca(2+)～Cl(-), and As～Cl(-). Furthermore, the regional differences were detectable in the ratios of water temperature to chloride content and of bicarbonate to chloride content, nevertheless the correlation as a whole were valid. The diversity and regional differences of the chemical composition of the waters were explained as due to the differences in the mixing proportion of the magmatic thermal water and the varying kinds of ground water at the deep site in the ground and at the site near the ground surfaces. |
| Publication Title | 岡山大学温泉研究所報告 |
| Published Date | 1959-05 |
| Volume | volume25 |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0369-7142 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/40244 |
| language | Japanese |
| File Version | publisher |
