result 24410 件
| JaLCDOI | 10.18926/AMO/40009 |
|---|---|
| FullText URL | 64_3_171.pdf |
| Author | Kodama, Tomoe| Nakase, Katsumi| Tsuda, Toshihide| Yorifuji, Takashi| Doi, Hiroyuki| |
| Abstract | Physicians should educate patients with sexually transmitted infections (STIs) on measures to prevent reinfection and should also undertake human immunodeficiency virus (HIV) testing after diagnosis of STIs. These preventive measures are important, but it is not known to what extent these procedures are followed in Japan. We conducted a cross-sectional study to investigate the proportion of patients with STIs who received appropriate management from physicians, namely recommendation of HIV testing, encouragement of condom use and examination and/or treatment of sexual partners, to elucidate the factors affecting institution of each measure. From a mailshot of 566 physicians, 409 (72.3%) responded, with 176 diagnosing an STI in 967 patients. The proportions applying the 3 measures were low (recommendation of HIV testing:27.0;encouragement of condom use:64.8%;examination of sexual partners:17.5%), and were related to the sex of the patients and numbers of patients diagnosed by the physicians. Female patients received better care than male patients, particularly with respect to recommendation of HIV testing (odds ratio:2.82). Physicians who diagnosed more than 20 STI patients tended not to provide appropriate management. These findings suggest the necessity for better physician management of patients for effective prevention of STIs. |
| Keywords | sexually transmitted infections patient care management human immunodeficiency virus testing physician |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-06 |
| Volume | volume64 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 171 |
| End Page | 179 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20596128 |
| Web of Science KeyUT | 000279094300003 |
| JaLCDOI | 10.18926/AMO/40008 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hirai, Kazuyuki| Arimitsu, Hideyuki| Umeda, Koji| Yokota, Kenji| Shen, Lianhua| Ayada, Kiyoshi| Kodama, Yoshikatsu| Tsuji, Takao| Hirai, Yoshikazu| Oguma, Keiji| |
| Abstract | In an attempt to prepare egg yolk immunoglobulin (IgY) to treat and prevent cholera, hens were immunized by a mixture of heat- or formalin-killed Vibrio cholerae O1 and O139 organisms, or by the recombinant cholera toxin B subunit (CTB). The IgYs were partially purified from egg yolk and orally administered to suckling mice before or after challenge with live O1 or O139 cells. The anti-O1 and O139 IgYs and the mixture of either IgY with anti-CTB IgY significantly protected the occurrence of cholera caused by both O1 and O139 infection. Since large amounts of IgY can be prepared very easily and at low cost, this seems to be a useful procedure for preventing and treating cholera. |
| Keywords | Vibrio cholerae O1 O139 IgY |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-06 |
| Volume | volume64 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 163 |
| End Page | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20596127 |
| Web of Science KeyUT | 000279094300002 |
| JaLCDOI | 10.18926/AMO/40007 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Furumatsu, Takayuki| Ozaki, Toshifumi| |
| Abstract | Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis. |
| Keywords | epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-06 |
| Volume | volume64 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 155 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20596126 |
| Web of Science KeyUT | 000279094300001 |
| Author | Nakamura, Hiroaki| |
|---|---|
| Published Date | 2006-08-24 |
| Publication Title | Developments in Mathematics |
| Volume | volume12 |
| Content Type | Journal Article |
| Author | Campabadal, F| Fleta, C| Key, M| Lozano, M| Martinez, C| Pellegrini, G| Rafi, J M| Ullan, M| Johansen, L G| Mohn, B| Oye, O| Solberg, A O| Stugu, B| Ciocio, A| Ely, R| Fadeyev, V| Gilchriese, M| Haber, C| Siegrist, J| Spieler, H| Vu, C| Bell, P J| Charlton, D G| Dowell, J D| Gallop, B J| Homer, R J| Jovanovic, P| Mahout, G| McMahon, T J| Wilson, J A| Barr, A J| Carter, J R| Goodrick, M J| Hill, J C| Lester, C G| Parker, M A| Robinson, D| Anghinolfi, F| Chesi, E| Jarron, P| Kaplon, J| Macpherson, A| Pernegger, H| Pritchard, T| Roe, S| Rudge, A| Weilhammer, P| Bialas, W| Dabrowski, W| Dwuznik, M| Toczek, B| Koperny, S| Bruckman, P| Gadomski, S| Gornicki, E| Malecki, P| Moszczynski, A| Stanecka, E| Szczygiel, R| Turala, M| Wolter, W| Andricek, L| Bethke, S| Hauff, D| Kudlaty, J| Lutz, G| Moser, H -G| Nisius, R| Richter, R| Schieck, J| Colijn, A-P| Cornelissen, T| Gorfine, G W| Hartjes, F G| Hessey, N P| Jong, P de| Kluit, R| Koffeman, E| Muijs, A J. M| Peeters, S J. M| Eijk, B van| Nakano, I| Tanaka, R| Dorholt, O| Danielsen, K M| Huse, T| Sandaker, H| Stapnes, S| Kundu, N| Nickerson, R B| Weidberg, A| Bohm, J| Mikestikova, M| Stastny, J| Broklova, Z| Broz, J| Dolezal, Z| Kodys, P| Kubik, P| Reznicek, P| Vorobel, V| Wilhelm, I| Cermak, P| Chren, D| Horazdovsky, T| Linhart, V| Pospisil, S| Sinor, M| Solar, M| Sopko, B| Stekl, I| Apsimon, R J| Batchelor, L E| Bizzell, J P| Falconer, N G| French, M J| Gibson, M D| Haywood, S J| Matson, R M| McMahon, S J| Morrissey, M| Murray, W J| Phillips, P W| Morrissey, M| Murray, W J| Phillips, P W| Tyndel, M| Villani, E G| Cosgrove, D P| Dorfan, D E| Grillo, A A| Kachiguine, S| Rosenbaum, F| Sadrozinski, H F. -W| Seiden, A| Spencer, E| Wilder, M| Akimoto, T| Hara, K| Tanizaki, K| Bingefors, N| Brenner, R| Ekelof, T| Eklund, L| Bernabeu, J| Civera, J V| Costa, M J| Fuster, J| Garcia, C| Garcia-Navarro, J E| Gonzalez-Sevilla, S| Lacasta, C| Llosa, G| Marti-Garcia, S| Modesto, P| Sanchez, F J| Sospedra, L| Vos, M| |
|---|---|
| Published Date | 2005-11 |
| Publication Title | Nuclear Instruments and Methods in Physics Research Section A: Accelerators |
| Volume | volume552 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Shigehara, Hiroshi| Kishi, Kanji| |
|---|---|
| Published Date | 2004-9 |
| Publication Title | European Journal of Radiology |
| Volume | volume51 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Okuda, Kiyoshi| Sakumoto, Ryosuke| |
|---|---|
| Published Date | 2003-11 |
| Publication Title | Reproductive Biology and Endocrinology |
| Content Type | Journal Article |
| Author | Kimura, Yoshinobu| Sakamura, Sho| Ushijima, Takayuki| Hama, Yoichiro| Kajiura, Hiroyuki| Fujiyama, Kazuhito| Okihara, Kiyoshi| Hashimoto, Ken| Sugimoto, Hiroyuki| Yamada, Hideo| |
|---|---|
| Published Date | 2007-04 |
| Publication Title | Bioscience, Biotechnology, and Biochemistry |
| Volume | volume71 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Fujitani, Yoshiyuki| Horiuchi, Terumi| Ito, Kazutoshi| Sugimoto, Manabu| |
|---|---|
| Published Date | 2007-6 |
| Publication Title | PHYTOCHEMISTRY |
| Volume | volume68 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Sawada, Keisuke| Echigo, Noriko| Juge, Narinobu| Miyaji, Takaaki| Otsuka, Masato| Omote, Hiroshi| Yamamoto, Akitsugu| Moriyama, Yoshinori| |
|---|---|
| Published Date | 2008-04-01 |
| Publication Title | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | volume105 |
| Issue | issue15 |
| Content Type | Journal Article |
| FullText URL | Fulltext.pdf fig.pdf table.pdf |
|---|---|
| Author | Matsumoto, Yohsuke| Motoki, Takahiro| Kubota, Satoshi| Takigawa, Masaharu| Tsubouchi, Hirohito| Gohda, Eiichi| |
| Keywords | hepatocyte growth factor valproic acid histone deacetylase inhibitor butyric acid trichostatin A induction tumor invasion dermal fibroblast |
| Note | Published with permission from the copyright holder. This is a author's copy,as published in Biochemical and Biophysical Research Communications, 2008 Vol.366 Issue.1 pp.110-116 | |
| Published Date | 2008-02-01 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume366 |
| Issue | issue1 |
| Publisher | Academic Press |
| Start Page | 110 |
| End Page | 116 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 18053801 |
| DOI | 10.1016/j.bbrc.2007.11.089 |
| Web of Science KeyUT | 000252392400018 |
| Author | Higashi, Kuniaki| Ishiga, Yasuhiro| Inagaki, Yoshishige| Toyoda, Kazuhiro| Shiraishi, Tomonori| Ichinose, Yuki| |
|---|---|
| Published Date | 2008-03-01 |
| Publication Title | Molecular Genetics and Genomics |
| Volume | volume279 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Shi, Jian-Xiao| Li, Zhi-Xuan| Nitoda, Teruhiko| Izumi, Minoru| Kanzaki, Hiroshi| Baba, Naomichi| Kawazu, Kazuyoshi| Nakajima, Shuhei| |
|---|---|
| Published Date | 2007-04 |
| Publication Title | Bioscience, Biotechnology, and Biochemistry |
| Volume | volume71 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Tahara, Makoto| Aoki, Takahiro| Suzuka, Shinya| Yamashita, Hiroki| Tanaka, Masaru| Matsunaga, Sachi| Kokumai, Shuhei| |
|---|---|
| Published Date | 2004-8 |
| Publication Title | Molecular Genetics and Genomics |
| Volume | volume272 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Toyoshima, Megumi| Hosoda, Kanako| Hanamura, Miho| Okamoto, Keinosuke| Kobayashi, Hiroshi| Negishi, Tomoe| |
|---|---|
| Published Date | 2003-11 |
| Publication Title | Journal of Photochemistry and Photobiology B: Biology |
| Volume | volume73 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Takahata, Muneaki| Tamura, Takashi| Abe, Katsumasa| Mihara, Hisaaki| Kurokawa, Suguru| Yamamoto, Yoshihiro| Nakano, Ryuhei| Esaki, Nobuyoshi| Inagaki, Kenji| |
|---|---|
| Published Date | 2008-06-26 |
| Publication Title | Journal of Biochemistry |
| Volume | volume143 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Teraishi, Fuminori| Kagawa, Shunsuke| Watanabe, Takanori| Tango, Yasuhisa| Kawashima, Takeshi| Umeoka, Tatsuo| Nisizaki, Masahiko| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2005-08-01 |
| Publication Title | FEBS Letters |
| Volume | volume579 |
| Issue | issue19 |
| Content Type | Journal Article |
| Author | Okada, Katsuhide| Zhao, Haisuo| Izumi, Minoru| Nakajima, Shuhei| Baba, Naomichi| |
|---|---|
| Published Date | 2007-03 |
| Publication Title | Bioscience, Biotechnology, and Biochemistry |
| Volume | volume71 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Marutani, Mizuri| Taguchi, Fumiko| Ogawa, Yujiro| Hossain, Mijan Md.| Yoshishige, Inagaki| Toyoda, Kazuhiro| Shiraishi, Tomonori| Ichinose, Yuki| |
|---|---|
| Published Date | 2008-04 |
| Publication Title | Molecular Genetics and Genomics |
| Volume | volume279 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Agawa, Yasuo| Sarhan, Moustafa| Kageyama, Yuji| Akagi, Kazutaka| Takai, Masayoshi| Hashiyama, Kazuya| Wada, Tadashi| Handa, Hiroshi| Iwamatsu, Akihiro| Hirose, Susumu| Ueda, Hitoshi| |
|---|---|
| Published Date | 2008-07-06 |
| Publication Title | Molecular and Cellular Biology |
| Volume | volume27 |
| Issue | issue24 |
| Content Type | Journal Article |
