result 20838 件
| FullText URL | K0007233_abstract_review.pdf |
|---|---|
| Author | NAOI, Yuto| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7233号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | ©2024 American Association for Cancer Research |
| FullText URL | K0007232_abstract_review.pdf K0007232_fulltext.pdf K0007232_summary.pdf |
|---|---|
| Author | FUTAGAWA, Mashu| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7232号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Author(s) 2024 |
| FullText URL | K0007225_abstract_review.pdf K0007225_fulltext.pdf K0007225_other.pdf K0007225_summary.pdf |
|---|---|
| Author | KEMMOTSU, Naoya| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7225号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 UICC. |
| FullText URL | K0007216_abstract_review.pdf K0007216_fulltext.pdf K0007216_summary.pdf |
|---|---|
| Author | IKEYA, Nanami| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7216号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| FullText URL | K0007208_abstract_review.pdf K0007208_fulltext.pdf K0007208_summary.pdf |
|---|---|
| Author | TAKAO, Shinichiro| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7208号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| FullText URL | K0007200_abstract_review.pdf K0007200_fulltext.pdf K0007200_summary.pdf |
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| Author | HORIO, Naohiro| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7200号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2024 The Author(s). |
| FullText URL | K0007199_abstract_review.pdf K0007199_fulltext.pdf K0007199_summary.pdf |
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| Author | SASAKURA, Minori| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7199号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2024 Japanese Society of Allergology. |
| FullText URL | K0007197_abstract_review.pdf K0007197_fulltext.pdf K0007197_summary.pdf |
|---|---|
| Author | MIURA, Taro| |
| Published Date | 2025-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7197号 |
| Granted Date | 2025-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oka, Naoki| Habumugisha, Janvier| Nakamura, Masahiro| Kataoka, Tomoki| Fujisawa, Atsuro| Kawanabe, Noriaki| Izawa, Takashi| Kamioka, Hiroshi| |
| Keywords | Kinetic MRI Posture Airway assessment |
| Published Date | 2025-05-21 |
| Publication Title | BMC Oral Health |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 745 |
| ISSN | 1472-6831 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 40399950 |
| DOI | 10.1186/s12903-025-06088-x |
| Web of Science KeyUT | 001493127600002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12903-025-06088-x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tomita, Yusuke| Otani, Yoshihiro| Omae, Ryo| Mizuta, Ryo| Ishida, Joji| Hirotsune, Nobuyuki| Tanaka, Shota| |
| Keywords | glioblastoma long-term survivor SEER short-term survivor United States |
| Published Date | 2025-02-09 |
| Publication Title | Neuro-Oncology Advances |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | Oxford University Press (OUP) |
| Start Page | vdaf036 |
| ISSN | 2632-2498 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 40376679 |
| DOI | 10.1093/noajnl/vdaf036 |
| Web of Science KeyUT | 001488411400001 |
| Related Url | isVersionOf https://doi.org/10.1093/noajnl/vdaf036 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Danchana, Kaewta| Namba, Haruka| Kaneta, Takashi| |
| Keywords | Phosphate Microfluidic paper-based analytical device Solid-phase extraction Anion exchanger Molybdenum blue method |
| Published Date | 2025-12-01 |
| Publication Title | Talanta |
| Volume | volume295 |
| Publisher | Elsevier BV |
| Start Page | 128303 |
| ISSN | 0039-9140 |
| NCID | AA00856594 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 40359681 |
| DOI | 10.1016/j.talanta.2025.128303 |
| Web of Science KeyUT | 001491577400001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.talanta.2025.128303 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Abe, Masaya| Fujii, Keiko| Mitsuhashi, Toshiharu| Kitamura, Wataru| Ikeuchi, Kazuhiro| Fukumi, Takuya| Washio, Kana| Otsuka, Fumio| Maeda, Yoshinobu| Fujii, Nobuharu| |
| Keywords | anticoagulant apheresis high sodium citrate concentration Spectra Optia |
| Published Date | 2025-05-19 |
| Publication Title | Transfusion |
| Publisher | Wiley |
| ISSN | 0041-1132 |
| NCID | AA00868753 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40387021 |
| DOI | 10.1111/trf.18280 |
| Web of Science KeyUT | 001490160900001 |
| Related Url | isVersionOf https://doi.org/10.1111/trf.18280 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takei, Kensuke| Inokuchi, Toshihiro| Hiraoka, Sakiko| Ishiguro, Mikako| Toyosawa, Junki| Aoyama, Yuki| Igawa, Shoko| Takeuchi, Keiko| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Kawano, Seiji| Mitsuhashi, Toshiharu| Otsuka, Motoyuki| |
| Keywords | CD, Crohn's disease LRG, Leucine-rich alpha-2 glycoprotein Fcal, Fecal calprotectin CRP, C-reactive protein ER, Endoscopic remission |
| Published Date | 2025-05-13 |
| Publication Title | BMC Gastroenterology |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 364 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 40355822 |
| DOI | 10.1186/s12876-025-03880-5 |
| Web of Science KeyUT | 001488265300002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-025-03880-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | La Rocca, Romain| Kato, Koji| Tsai, Pi-Cheng| Nakajima, Yoshiki| Akita, Fusamichi| Shen, Jian-Ren| |
| Published Date | 2025-05-05 |
| Publication Title | Nature Communications |
| Volume | volume16 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4175 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40325014 |
| DOI | 10.1038/s41467-025-59512-9 |
| Web of Science KeyUT | 001482932500018 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-025-59512-9 |
| JaLCDOI | 10.18926/AMO/68729 |
|---|---|
| FullText URL | 79_3_209.pdf |
| Author | Taguchi, Kenichi| Nishii, Kazuya| Hata, Sakura| Kuyama, Shoichi| Tanaka, Shoichi| |
| Abstract | A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered. |
| Keywords | methemoglobinemia aniline methylene blue cyanosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 209 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68726 |
|---|---|
| FullText URL | 79_3_185.pdf |
| Author | Yoshikawa, Ayumi| Taira, Naruto| Okanaga, Mayumi| Saito, Shinya| |
| Abstract | We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners. |
| Keywords | breast cancer patient young patient single partners relationships |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68724 |
|---|---|
| FullText URL | 79_3_167.pdf |
| Author | Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator| |
| Abstract | This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy. |
| Keywords | non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68723 |
|---|---|
| FullText URL | 79_3_157.pdf |
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
| Abstract | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
| Keywords | advanced glycation end product aging cartilage collagen aggrecan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 157 |
| End Page | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bufetov, Alexander I.| Kawamoto, Yosuke| |
| Keywords | Random matrices Intertwining relation Interacting Brownian motions |
| Note | The version of record of this article, first published in Journal of Statistical Physics, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10955-025-03441-w| |
| Published Date | 2025-04-16 |
| Publication Title | Journal of Statistical Physics |
| Volume | volume192 |
| Issue | issue5 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 58 |
| ISSN | 1572-9613 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| DOI | 10.1007/s10955-025-03441-w |
| Web of Science KeyUT | 001469294100001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10955-025-03441-w |
