| ID | 56439 |
| Sort Key | 3
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| Title Alternative | Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus Species
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| FullText URL | |
| Author |
Kiyota, Hiromasa
Graduate School of Environmental and Life Science, Okayama University
ORCID
Kaken ID
publons
researchmap
Saito, Akihito
Graduate School of Agricultural Science, Tohoku University
Takai, Momoko
Graduate School of Agricultural Science, Tohoku University
Kuwahara, Shigefumi
Graduate School of Agricultural Science, Tohoku University
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| Abstract | Synthetic studies of ancistrocladinium A and B, antileishmanial compounds isolated from a Congolese Ancistrocladus sp., are described. Buchwald‒Hartwig coupling reaction between the dihydroisoquinoline and the naphthyl triflate failed. The main framework of ancistrocladinium A was constructed by 1,2‒addition of the amine to the naphthoquinone in the presence of celium trichloride as a catalyst. On the other hand, 1,4‒addition of the amine to the naphthoquinone proceeded without catalyst to form the framework of B. These products will be valuable leads for antileishmanial agents.
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| Keywords | ancistrocladinium A and B
synthetic studies
leishmania, Ancistrocladus
isoquinoline
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| Note | 原著論文 (Original paper)
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| Publication Title |
Scientific Reports of the Faculty of Agriculture, Okayama University
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| Published Date | 2019-02-01
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| Volume | volume108
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| Publisher | 岡山大学農学部
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| Publisher Alternative | The Faculty of Agriculture, Okayama University
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| Start Page | 1
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| End Page | 4
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| ISSN | 2186-7755
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| Content Type |
Departmental Bulletin Paper
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| OAI-PMH Set |
岡山大学
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| language |
Japanese
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| File Version | publisher
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| Eprints Journal Name | srfa
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