result 1266 件
| JaLCDOI | 10.18926/15315 |
|---|---|
| Title Alternative | Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations |
| FullText URL | 064_060_064.pdf |
| Author | Mimaki, Yuichi| Fujii, Yoshihiro| Furuno, Katsushi| Gomita, Yutaka| Araki, Yasunori| Tanizaki, Yoshiro| |
| Abstract | 薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる｡今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した｡溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した｡アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した｡また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した｡以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。 |
| Keywords | 溶出試験 (Dissolutionte test) 温泉水 (Spring water) 気管支喘息治療薬 (Bronchial asthma therapeutic drug) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 60 |
| End Page | 64. |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307434 |
| JaLCDOI | 10.18926/15205 |
|---|---|
| Title Alternative | Development of human limb volume meter for evaluation of edema |
| FullText URL | 014_1_031_035.pdf |
| Author | Nakamura, Takao| Goda, Noriko| Shirai, Kiyoko| Kusuhara, Toshimasa| Yamamoto, Yoshitake| |
| Abstract | 周産期医学にとって浮腫の定量評価は重要である｡これまでは,測定部位の2箇所の周囲長をメジャーで測り,その変化により浮腫を評価している｡また周囲長により容積を推定する方法も提案されている｡しかしながら,この方法ではメジャーの測定部位への巻き付け方による誤差や容積を推定する根拠となる測定部位のモデル形状と実際の測定部位の形状との誤差など様々な誤差の影響により,精度の点からは十分とはいえない｡そこで,本研究では浮腫評価のための高精度で日常的な使用に適した体肢容積計を開発した｡この測定原理はアルキメデスの原理を適用したもので,水を入れた水槽に測定部位を入れる前後の質量変化により,その容積を量るしくみである｡まず,この容積計の出力の線形性,分解能,安定性,再現性について検討を行った｡この結果,本装置の仕様は最大計測容積25,000cm(3),分解能1cm(3),非直線性0.007%以下となり,非常に高精度であるといえる｡また,被験者3名の足部,下腿部の容積の日内変化を測定した結果,各被験者の容積変化の特徴を明らかにすることができ,浮腫評価への応用ができることを確認した。 |
| Keywords | 体肢容積計 (volume meter) 浮腫 (edema) アルキメデスの原理 (Archimedes' Principle) |
| Publication Title | 岡山大学医学部保健学科紀要 |
| Published Date | 2003-12-25 |
| Volume | volume14 |
| Issue | issue1 |
| Start Page | 31 |
| End Page | 35 |
| ISSN | 1345-0948 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308024 |
| JaLCDOI | 10.18926/15186 |
|---|---|
| Title Alternative | Investigation of the tracheal suctioning-related microbialcolonization in home care patients with tracheotomy |
| FullText URL | 015_2_063_069.pdf |
| Author | Watanabe, Kumi| Kanzaki, Hitomi| Senda, Yoshiko| Okamoto, Motoi| |
| Abstract | 気管内吸引を必要とする在宅療養患者に対し,安全で経済的な感染管理方法を検討するため,在宅ケアにおける気管内吸引の実態と,吸引関連物品の細菌学的調査を実施した。対象は気管切開がされ,医療依存度の高い患者3名であり,気管内吸引は全て患者の妻が行っていた。吸引後のカテーテルは外側をアルコール綿で清拭し,内腔を洗浄水で洗浄していた。カテーテルは,0.05%グルコン酸クロルヘキシジンに浸漬あるいは,清潔な乾燥容器に保管されていた。カテーテルの交換時期は,1.5日から7日とばらつきがあった。カテーテル,洗浄水,浸潰液等の試料を,一般細菌,黄色ブドウ球菌,大腸菌群の寒天培地で培養したところ,各試料から一般細菌,黄色ブドウ球菌,大腸菌群が検出されたが,カテーテルの保管方法の違いによる細菌汚染に差は認められなかった｡また,気管切開部ガーゼからは,一般細菌,黄色ブドウ球菌,大腸菌群が検出された｡これらより,気管内吸引カテーテルおよび,洗浄水や浸溝用消毒液の清潔管理の必要性が示唆された｡ |
| Keywords | 感染管理 (Infection control) 気管内吸引 (tracheal suctioning) 在宅ケア (home care) 介護者 (caregiver) |
| Publication Title | 岡山大学医学部保健学科紀要 |
| Published Date | 2005-03-31 |
| Volume | volume15 |
| Issue | issue2 |
| Start Page | 63 |
| End Page | 69 |
| ISSN | 1345-0948 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307656 |
| JaLCDOI | 10.18926/15183 |
|---|---|
| Title Alternative | Influence of instructional posters on cleanness of the hands after hand washing |
| FullText URL | 016_1_049_055.pdf |
| Author | Matsushima, Taku| Akasaka, Maria| Ando, Hitomi| Inoue, Miwa| Mitsumata, Yuki| Senda, Yoshiko| |
| Abstract | 本研究の目的は,手洗いポスターの違いによる手洗い消毒後の手洗いミスを比較することである｡調査対象は看護学生82名であった｡対象を41名ずつ2グループに分け,1グループには手洗い順序を示したポスターを,もう1グループには,手洗いミスを起こしやすい部位を図示したポスターを教材として与えた｡学生は,手指と手首に蛍光塗料を塗布後,抗菌石けんと流水による手洗い消毒を実施した｡次に蛍光塗料の残存状況を写真撮影後,画像処理し手洗いミスとして点数化した｡その結果,手洗いミスを起こしやすいポスターを使用したグループの方が,手洗い順序ポスターを用いたグループより手洗いミスが少ない傾向にあった｡なかでも手背側は,手洗いミスのポスターを使ったグループの方が手洗いミスは有意に少なかった(p<0.05)｡日常,手洗い場に掲示されているポスターは,手洗い順序を示したものが多い｡しかし,手洗いミスを起こしやすい部位を図示したポスターでも,手指衛生効果があることが示唆された｡ |
| Keywords | 手指衛生 (hand hygiene) 手洗い消毒 (antiseptic handwash) ポスター (poster) |
| Publication Title | 岡山大学医学部保健学科紀要 |
| Published Date | 2005-12-25 |
| Volume | volume16 |
| Issue | issue1 |
| Start Page | 49 |
| End Page | 55 |
| ISSN | 1345-0948 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307297 |
| JaLCDOI | 10.18926/15180 |
|---|---|
| Title Alternative | Perimenstrual symptoms and it's management - Assessment with Menstrual Distress Questionnaire - |
| FullText URL | 016_1_021_030.pdf |
| Author | Goto, Yuka| Okuda, Hiroyuki| |
| Abstract | 月経周期の変化に伴う多様で複雑な月経周辺期の症状を,出来るだけ単純で基本的に共通した変化として捉え,症状に適した対応を検討することを目的として本研究を行った｡月経を有する22～45歳の女性34名に対し,Menstrual Distress Questionnaireの即時的回答法を用いて月経周辺期を[痛み],[集中力],[行動変化],[自律神経反応],[水分貯留],[負の感情]から構成された35症状6領域で縦断的に追究し,以下の結果を得た｡ 1.月経周辺期の症状を縦断的に比較検討した結果,Moosのデータと近似した日本人のデータを示した｡ 2.月経周辺期における領域の推移では,身体的症状で構成される[痛み領域],[水分貯留領域]の2領域が精神的症状で構成される他の領域に比べ,常に上位を占めていた｡以上の事より,月経周辺期の生理的変化に伴う精神的愁訴は,身体的変化によって誘発されている可能性が示唆された｡ |
| Keywords | Menstrual Distress Questionnaire 月経周辺期 (perimenstrual) 月経前症候群 (premenstrual) 月経随伴症状 (menstrual symptom) |
| Publication Title | 岡山大学医学部保健学科紀要 |
| Published Date | 2005-12-25 |
| Volume | volume16 |
| Issue | issue1 |
| Start Page | 21 |
| End Page | 30 |
| ISSN | 1345-0948 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307941 |
| JaLCDOI | 10.18926/15088 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 |
| FullText URL | 067_063_070.pdf |
| Author | Hosaki, Yasuhiro| Nawa, Yuichiro| Takeuchi, Kazuaki| Tsugeno, Hirofumi| Ashida, Kozo| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure. |
| Keywords | Thermography (サーモグラフィー) Diabetes Mellitus (糖尿病) Peripheral Circulation (末梢循環) Cold Loading (冷水負荷) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307566 |
| JaLCDOI | 10.18926/fest/15045 |
|---|---|
| FullText URL | 014_023_028.pdf |
| Author | Chegbeleh Larry Pax| Nishigaki, Makoto| Akudago John Apambilla| Alim Md. Abdul| Komatsu, Mitsuru| |
| Abstract | During underground space development, groundwater seepage mostly occurs which may seriously affect the stability of deep excavations as well as retard progress of construction. For smooth progress of work, effective construction and operation of a disposal facility for high level radioactive waste (HLW), it is important to control seepage into excavations by sealing off fractures or fissures and excavation disturbed zones (EDZ) to control groundwater inflow during the construction phase of such a facility. In this study, a series of experiments were conducted on ethanol/bentonite slurries in the laboratory with the aim of determining the effect of a hydrophilic solvent such as ethanol on the hydraulic and injection characteristic of bentonite slurry for the sealing of fissures to control ground water seepage during the construction phase of a repository. Preliminary results revealed ethanol/bentonite slurry as an effective grouting material capable of penetrating micro fractures (100μm or less) and with the permeability of the grouted medium being as low as 10E-7cm/s. The results also show that the effectiveness and efficiency of grouting is dependent on the type of injection and fissure size. Dynamic injection was observed to be efficient as it was able to inject high dense slurry. |
| Keywords | Dynamic injection permeability swelling bentonite clay |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Published Date | 2009-03-16 |
| Volume | volume14 |
| Issue | issue1 |
| Start Page | 23 |
| End Page | 28 |
| ISSN | 1341-9099 |
| language | English |
| File Version | publisher |
| NAID | 120002307422 |
| JaLCDOI | 10.18926/fest/15044 |
|---|---|
| FullText URL | 014_017_022.pdf |
| Author | Akudago John Apambilla| Nishigaki, Makoto| Chegbeleh Larry Pax| Komatsu, Mitsuru| Alim Md. Abdul| |
| Abstract | Soil-groundwater salinity issues have assumed a worldwide dimension. It is believed that when groundwater level is less than 2 m there is the possibility of salinity transfer between the soil and groundwater due to factors such as capillary forces. One-dimensional column tests were conducted in the laboratory to find a suitable capillary cut design. The capillary cut material comprised a 20 cm thick 2–4.7 mm and a combination of 2–4.7 mm and 9.5–19 mm gravel material. In all, four different designs were tested by compacting Oji sand in the various columns. Groundwater level of 0.75 m from the top was maintained while salt solution of 10% concentration was allowed to flow under capillary forces through the columns. The water content in the columns were monitored using frequency domain reflectrometry-vector analyzer (FDR-V) after which soil samples from 10 m interval in each column was taken for electrical conductivity measurements. The results showed that 5 cm thick, 2–4.7 mm gravel sandwiching coarser material (e.g. 5 cm thick 9.5–19 mm or 10 cm thick 9.5–19 mm gravel material) proved to be very useful design to cut capillarity. |
| Keywords | soil-groundwater salinity capillary cut filter media design |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Published Date | 2009-03-16 |
| Volume | volume14 |
| Issue | issue1 |
| Start Page | 17 |
| End Page | 22 |
| ISSN | 1341-9099 |
| language | English |
| File Version | publisher |
| NAID | 120002308001 |
| JaLCDOI | 10.18926/fest/15043 |
|---|---|
| FullText URL | 014_013_016.pdf |
| Author | Alim Md. Abdul| Nishigaki, Makoto| Chegbeleh Larry Pax| Akudago John Apambilla| Komatsu, Mitsuru| |
| Abstract | Soil-water characteristic curve (SWCC) is an important soil function in an unsaturated soil mechanics field for design and analyses of any unsaturated earth structures. Determination of SWCC is not easy and more so time consuming. Generally, ceramic disc with high air-entry value has been used in the pressure plate apparatus for this purpose by many people. Now-a-days membrane filter is being used as a suitable alternative to ceramic disc. However, experience shows, it has disadvantage of breakage after one time use especially with coarse grain soils (sandy soils). In this study, membrane filter with stainless wire mesh was used to solve this problem and the SWWC was compared with the results obtained without wire mesh. Results showed that membrane filter with stainless wire mesh can be used to determine the SWCC for coarse grain soils. |
| Keywords | SWCC Unsaturated sandy soils Membrane filter Stainless wire mesh |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Published Date | 2009-03-16 |
| Volume | volume14 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 16 |
| ISSN | 1341-9099 |
| language | English |
| File Version | publisher |
| NAID | 120002307956 |
| JaLCDOI | 10.18926/14963 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 2.温水負荷の効果 |
| FullText URL | 069_068_075.pdf |
| Author | Hosaki, Yasuhiro| Takata, Shingo| Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Tsuji, Takao| |
| Abstract | The body surface temperature of 41 patients suffering coldness, numbness or pain in their feet was examined using thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as: Recovery ratio =[Total counts of thermography (Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). Three different baseline temperatures, 26℃. 27℃ and 28℃, were used in processing the thermographic results into pictures. The recovery ratio was susceptible to temperature, and we recommend a baseline temperature limitation of 27℃ for clinical study. A bi-modal distribution of recovery ratio was observed in 18 patients with diabetes mellitus. One group (6 subjects) had high recovery ratio between 80%-100%, and another group (10 subjects) had a low recovery ratio between 0%-19%. The results of thermography were also influenced by weather. To reduce the effect of outside temperature, we used pre-loading with hot water at 36℃ for 5 min (hot loading). A large difference in recovery ratio between presence and absence of hot loading was observed in 6 of the 30 subjects. The difference was over-estimated in more than 20% of recovery ratio without hot loading as compared with hot loading in these 6 subjects. The effect of drugs on peripheral circulation, such as beraprost sodium and sarpogrelate hydrochloride, was clear and quantified using thermography under these conditions of hot loading. |
| Keywords | サーモグラフィー (thermography) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) 温水負荷 (hot loading) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 68 |
| End Page | 75 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308316 |
| JaLCDOI | 10.18926/14927 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 |
| FullText URL | 070_036_042.pdf |
| Author | Hosaki, Yasuhiro| Takata, Shingo| Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Tanizaki, Yoshiro| Ochi, Koji| Tsuji, Takao| |
| Abstract | The body surface peripheral circulation in 12 cases, including 9 patients with diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3
healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p |
| Keywords | サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 36 |
| End Page | 42 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308240 |
| JaLCDOI | 10.18926/14908 |
|---|---|
| Title Alternative | 寒冷負荷の末梢循環に及ぼす影響 |
| FullText URL | 071_042_049.pdf |
| Author | Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| Ochi, Koji| Tsuji, Takao| |
| Abstract | The purpose of this study is the effect of partial cold-loading on whole body peripheral circulation. The body surface peripheral circulation in 24 cases (25 years old to 86 years old, the average was 64.3 years) who were suffering coldness, numbness or pain in their feet was examined using Laser-Doppler blood flowmetry. The peripheral circulation at the base of the 2nd toe of the right foot was estimated after the foot was submerged and cooled for 5 min in a water bath at 20°C (i. e. cold-loading). At the same time, the distant body surface peripheral circulation was estimated at the base of the 2nd finger of the right hand. Simultaneous observations were made of blood flow, blood mass and blood velocity. The peripheral blood flow of the upper limbs at a room temperature of 20°C (pre-loading) was 5.00 ml/min 100 9 tissue on average. The average blood rnass was 287 and the average blood velocity was 0.516. On the other hand, the average peripheral blood flow of the lower limbs was 2.23, the average blood mass was 149 and the average blood velocity was 0.574. This result shows that the blood flow and blood mass of the upper limbs were more than in the lower limbs. The average blood flow at the upper limbs decreased to 3.69 from 5.00 (or at 26.2% ) when the lower limbs were submerged and cooled for 5 min in a water bath at 20°C (i. e. cold-loading). On the other hand, blood flow of the lower limb was 1.51 m l under a condition of cold-loading, and decreased 32.3% from 2.23. Blood mass of the upper limb was 241 on average and decreased 16.0% from 287. Blood mass of the lower limb was 113 on average and decreased 24.2% from 149. There was no difference between blood velocity of the upper limb under the conditions of room temperature at 20°C (0.516) and cold-loading (0.501). However, blood velocity of the lower limb increased to 0.642 from 0.574. After the end of cold loading, there was some tendency for blood flow, blood rnass and blood velocity to return to the amount at pre-loading. Twenty minutes after the end of cold-loading, blood flow increased to 5.74 (14.8% ) compared with pre-loading (5.00). However, blood flow of the lower limb remained at only 83.9% (1.87) of the amount at pre-loading (2.23). These results show that partial cold-loading of the lower limb had a quantitative effect on the distant peripheral circulation. The speculated mechanism of this phenomenon is that it to protects against loosing body heat from the body surface under the conditions of local cold-loading. Our body has defense mechanisms to decrease whole body peripheral circulation to protect against loosing body heat. |
| Keywords | Laser-Doppler blood flowmetry (レーザードプラー血流計) cold loading (冷水負荷) peripheral circulation (末梢循環) blood flow (血流量) blood velocity (血流速度) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 42 |
| End Page | 49 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308072 |
| Author | Higuchi, Keiro| Inoue, Akiko| Tamanouchi, Hiromitsu| Hattori, Takayasu| Motomizu, Shoji| |
|---|---|
| Published Date | 1999 |
| Publication Title | 分析化学 |
| Volume | volume48 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Mitsunobu, Fumihiro| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Ninomiya, Takahiko| Lee, Kyue-Hyung| Oshima, Mitsuko| Motomizu, Shoji| |
|---|---|
| Published Date | 2000 |
| Publication Title | 分析化学 |
| Volume | volume49 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Ninomiya, Takahiko| Oshita, Koji| Oshima, Mitsuko| Motomizu, Shoji| |
|---|---|
| Published Date | 2004 |
| Publication Title | 分析化学 |
| Volume | volume52 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Li, Zhen Hai| Oshima, Mitsuko| Motomizu, Shoji| |
|---|---|
| Published Date | 2004 |
| Publication Title | 分析化学 |
| Volume | volume53 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Nakatsuka, Ayako| |
|---|---|
| Published Date | 1966-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue7-9 |
| Content Type | Journal Article |
| Author | Moroizumi, Toshitsugu| Sasaki, Yumi| Miura, Takeshi| |
|---|---|
| Published Date | 2008-12 |
| Publication Title | 環境制御 |
| Volume | volume30 |
| Content Type | Journal Article |
| Author | Narusue, Mitsuo| |
|---|---|
| Published Date | 1966-03-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue2-3 |
| Content Type | Journal Article |
