検索結果 - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

FullText URL	fulltext.pdf
Author	Tsuchida-Nishiwaki, Mariko\| Uchida, Haruhito A.\| Takeuchi, Hidemi\| Nishiwaki, Noriyuki\| Maeshima, Yohei\| Saito, Chie\| Sugiyama, Hitoshi\| Wada, Jun\| Narita, Ichiei\| Watanabe, Tsuyoshi\| Matsuo, Seiichi\| Makino, Hirofumi\| Hishida, Akira\| Yamagata, Kunihiro\|
Published Date	2021-07-22
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature Portfolio
Start Page	14990
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	34294784
DOI	10.1038/s41598-021-94467-z
Web of Science KeyUT	000682802200023
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-94467-z

A Case of Metastatic Fumarate Hydratase-Deficient–like Renal Cell Carcinoma Successfully Managed by Ipilimumab plus Nivolumab

JaLCDOI	10.18926/AMO/62237
FullText URL	75_3_397.pdf
Author	Sekito, Takanori\| Takamoto, Atsushi\| Kobayashi, Yasuyuki\| Mitsui, Masao\| Watari, Shogo\| Kubota, Risa\| Sadahira, Takuya\| Iwata, Takehiro\| Nishimura, Shingo\| Edamura, Kohei\| Sako, Tomoko\| Araki, Motoo\| Watanabe, Masami\| Watanabe, Toyohiko\| Shibata, Rei\| Ennishi, Daisuke\| Nasu, Yasutomo\|
Abstract	We report a 62-year-old male with metastatic fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) without fumarate hydratase (FH) mutation (FH-deficient–like RCC). The International Metastatic RCC Database Consortium risk score was intermediate, and immunotherapy with nivolumab and ipilimumab (Ipi/ Nivo) was initiated. Four cycles of Ipi/Nivo and 5 cycles of nivolumab resulted in a complete response of the metastases. Hypophysitis occurred as an immune-related adverse event after four cycles of Ipi/Nivo. The prognosis of patients with FH-deficient RCC is generally poor. Few reports of FH-deficient RCC successfully treated with Ipi/Nivo have been published. Ipi/Nivo can be effective for treating FH-deficient RCC.
Keywords	fumarate hydratase fumarate hydratase-deficient renal cell carcinoma renal cell carcinoma ipilimumab nivolumab
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2021-06
Volume	volume75
Issue	issue3
Publisher	Okayama University Medical School
Start Page	397
End Page	402
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34176946
Web of Science KeyUT	000667147700017
NAID	120007089822

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2)

FullText URL	fulltext.pdf
Author	Mise, Koki\| Imamura, Mariko\| Yamaguchi, Satoshi\| Watanabe, Mayu\| Higuchi, Chigusa\| Katayama, Akihiro\| Miyamoto, Satoshi\| Uchida, Haruhito A.\| Nakatsuka, Atsuko\| Eguchi, Jun\| Hida, Kazuyuki\| Nakato, Tatsuaki\| Tone, Atsuhito\| Teshigawara, Sanae\| Matsuoka, Takashi\| Kamei, Shinji\| Murakami, Kazutoshi\| Shimizu, Ikki\| Miyashita, Katsuhiro\| Ando, Shinichiro\| Nunoue, Tomokazu\| Yoshida, Michihiro\| Yamada, Masao\| Shikata, Kenichi\| Wada, Jun\|
Keywords	cardiovascular event diabetes lectins N-glycans urinary biomarkers
Published Date	2021-05-24
Publication Title	Frontiers In Cardiovascular Medicine
Volume	volume8
Publisher	Frontiers Media SA
Start Page	668059
ISSN	2297-055X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34109226
DOI	10.3389/fcvm.2021.668059
NAID	120007053373
Web of Science KeyUT	000658156400001
Related Url	isVersionOf https://doi.org/10.3389/fcvm.2021.668059

Current and future perspectives on functional molecular imaging in nephro-urology: theranostics on the horizon

FullText URL	fulltext.pdf
Author	Toyama, Yoshitaka\| Werner, Rudolf A.\| Ruiz-Bedoya, Camilo A.\| Ordonez, Alvaro A.\| Takase, Kei\| Lapa, Constantin\| Jain, Sanjay K.\| Pomper, Martin G.\| Rowe, Steven P.\| Higuchi, Takahiro\|
Keywords	Glomerular filtration rate renal kidney renal function positron emission tomography nephrology urology molecular imaging theranostics
Note	This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.\|
Published Date	2021-04-07
Publication Title	Theranostics
Volume	volume11
Issue	issue12
Publisher	Ivyspring Int Publ
Start Page	6105
End Page	6119
ISSN	1838-7640
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The author(s).
File Version	publisher
PubMed ID	33897902
DOI	10.7150/thno.58682
NAID	120007037373
Web of Science KeyUT	000642591000007
Related Url	isVersionOf https://doi.org/10.7150/thno.58682

Artificial intelligence supported anemia control system (AISACS) to prevent anemia in maintenance hemodialysis patients

FullText URL	fulltext.pdf
Author	Ohara, Toshiaki\| Ikeda, Hiroshi\| Sugitani, Yoshiki\| Suito, Hiroshi\| Huynh, Viet Quang Huy\| Kinomura, Masaru\| Haraguchi, Soichiro\| Sakurama, Kazufumi\|
Keywords	anemia artificial intelligence chronic kidney disease erythropoiesis-stimulating agents hemodialysis iron
Published Date	2021-02-22
Publication Title	International Journal of Medical Sciences
Volume	volume18
Issue	issue8
Publisher	Ivyspring International Publisher
Start Page	1831
End Page	1839
ISSN	1449-1907
NCID	AA1197928X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The author(s).
File Version	publisher
DOI	10.7150/ijms.53298
Related Url	isVersionOf https://www.medsci.org/v18p1831.htm

The next era of renal radionuclide imaging: novel PET radiotracers

FullText URL	fulltext.pdf
Author	Werner, Rudolf A.\| Chen, Xinyu\| Lapa, Constantin\| Koshino, Kazuhiro\| Rowe, Steven P.\| Pomper, Martin G.\| Javadi, Mehrbod S.\| Higuchi, Takahiro\|
Keywords	Kidney Positron emission tomography PET [18F]Fluorodeoxysorbitol GFR ERPF
Published Date	2019-05-30
Publication Title	European Journal of Nuclear Medicine and Molecular Imaging
Volume	volume46
Issue	issue9
Publisher	Springer
Start Page	1773
End Page	1786
ISSN	1619-7070
NCID	AA1161516X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	publisher
PubMed ID	31144061
DOI	10.1007/s00259-019-04359-8
Web of Science KeyUT	000475673300003
Related Url	isVersionOf https://doi.org/10.1007/s00259-019-04359-8

Possible Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Elective Percutaneous Coronary Intervention: Secondary Analysis of a Multicenter, Randomized Study

JaLCDOI	10.18926/AMO/61433
FullText URL	75_1_45.pdf
Author	Otsuka, Hiroaki\| Miyoshi, Toru\| Ejiri, Kentaro\| Kohno, Kunihisa\| Nakahama, Makoto\| Doi, Masayuki\| Munemasa, Mitsuru\| Murakami, Masaaki\| Nakamura, Kazufumi\| Ito, Hiroshi\|
Abstract	Remote ischemic preconditioning (RIPC) is a promising strategy for protecting against ischemic reperfusion injury. This study is a secondary analysis of a randomized study that aimed to evaluate the effect of RIPC on the early increase in serum creatinine (SCr) following percutaneous coronary intervention (PCI), which is associ-ated with contrast-induced acute kidney injury. Patients with stable angina undergoing elective PCI were assigned to control, RIPC, and continuous infusion of nicorandil (nicorandil) groups. The endpoint of this study was the incidence of the early increase in SCr, a predictor of contrast-induced acute kidney injury, which was defined as either a > 20% or absolute increase by 0.3 mg/dl of SCr levels after 24 h of PCI. This study included 220 patients for whom a dataset of SCr values was available. The incidence of the early increase in SCr was significantly lower in the RIPC than in the control (1.3% vs 10.8%, p = 0.03) group, but was not significantly different between the nicorandil and control groups. In multivariate analysis, RIPC remained a significant fac-tor associated with a reduction in the incidence of early increase in SCr. RIPC reduces the incidence of early increase in SCr in patients with stable angina following elective PCI.
Keywords	remote ischemic preconditioning stable angina serum creatinine acute kidney injury
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-02
Volume	volume75
Issue	issue1
Publisher	Okayama University Medical School
Start Page	45
End Page	53
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33649613

Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 5

FullText URL	fulltext.pdf
Author	Shikata, Kenichi\| Kodera, Ryo\| Utsunomiya, Kazunori\| Koya, Daisuke\| Nishimura, Rimei\| Miyamoto, Satoshi\| Tajima, Naoko\| the JDCP study group\|
Keywords	Diabetic nephropathy Diabetic kidney disease Japan Diabetes Complication and its Prevention study
Published Date	2020-05-17
Publication Title	Journal of Diabetes Investigation
Volume	volume11
Issue	issue2
Publisher	Wiley
Start Page	325
End Page	332
ISSN	2040-1116
NCID	AA12488319
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors.
File Version	publisher
PubMed ID	31317670
DOI	10.1111/jdi.13116
Web of Science KeyUT	000519857400011
Related Url	isVersionOf https://doi.org/10.1111/jdi.13116

Clinical Characteristics and Risk Factors for Rebleeding in Patients with Obscure Gastrointestinal Bleeding

FullText URL	fulltext.pdf
Author	Baba, Yuki\| Kawano, Seiji\| Kono, Yoshiyasu\| Inokuchi, Toshihiro\| Kanzaki, Hiromitsu\| Iwamuro, Masaya\| Harada, Keita\| Kawahara, Yoshiro\| Okada, Hiroyuki\|
Keywords	obscure gastrointestinal bleeding overt previous bleeding vascular lesions chronic kidney disease
Published Date	2020-06-01
Publication Title	Internal Medicine
Volume	volume59
Issue	issue11
Publisher	The Japanese Society of Internal Medicine
Start Page	1345
End Page	1350
ISSN	1349-7235
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	32023585
DOI	10.2169/internalmedicine.3628-19
Web of Science KeyUT	000537806600001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.3628-19

Robotic CT-guided out-of-plane needle insertion: comparison of angle accuracy with manual insertion in phantom and measurement of distance accuracy in animals

FullText URL	fulltext.pdf
Author	Komaki, Toshiyuki\| Hiraki, Takao\| Kamegawa, Tetsushi\| Matsuno, Takayuki\| Sakurai, Jun\| Matsuura, Ryutaro\| Yamaguchi, Takuya\| Sasaki, Takanori\| Mitsuhashi, Toshiharu\| Okamoto, Soichiro\| Uka, Mayu\| Matsui, Yusuke\| Iguchi, Toshihiro\| Gobara, Hideo\| Kanazawa, Susumu\|
Keywords	Robotics Interventional radiology Animal experiments
Published Date	2019-11-26
Publication Title	European Radiology
Volume	volume30
Issue	issue3
Publisher	Springer
Start Page	1342
End Page	1349
ISSN	0938-7994
NCID	AA10824302
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Authors
File Version	publisher
PubMed ID	31773299
DOI	10.1007/s00330-019-06477-1
Web of Science KeyUT	000517458800006
Related Url	isVersionOf https://doi.org/10.1007/s00330-019-06477-1

Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

FullText URL	fulltext.pdf
Author	Chen, Xinyu\| Kudo, Takashi\| Lapa, Constantin\| Buck, Andreas\| Higuchi, Takahiro\|
Keywords	Norepinephrine transporter Benzylguanidine Phenethylguanidine Antidepressant Organic cation transporter
Published Date	2020-04-09
Publication Title	Journal of Neural Transmission
Volume	volume127
Issue	issue6
Publisher	Springer
Start Page	851
End Page	873
ISSN	0300-9564
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	Author(s)
File Version	author
PubMed ID	32274584
DOI	10.1007/s00702-020-02180-4
Web of Science KeyUT	000535371000001
Related Url	isVersionOf https://doi.org/10.1007/s00702-020-02180-4

Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice

FullText URL	fulltext.pdf
Author	Hada, Yoshiko\| Uchida, Haruhito A.\| Mukai, Tomoyuki\| Kojima, Fumiaki\| Yoshida, Masashi\| Takeuchi, Hidemi\| Kakio, Yuki\| Otaka, Nozomu\| Morita, Yoshitaka\| Wada, Jun\|
Keywords	MR16-1 interleukin-1 receptor antagonist aortitis arthritis LV hypertrophy
Note	This is an accepted version of Yoshiko Hada et. al. Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice published in Clinical Science 134(20). For final published version, see https://doi.org/10.1042/CS20201036.\|
Published Date	2020-10-30
Publication Title	Clinical Science
Volume	volume134
Issue	issue20
Publisher	Portland Press
Start Page	2771
End Page	2787
ISSN	0143-5221
NCID	AA00143386
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Authors
File Version	author
PubMed ID	33064141
DOI	10.1042/CS20201036
Web of Science KeyUT	000587350600004
Related Url	isVersionOf https://doi.org/10.1042/CS20201036

Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance

JaLCDOI	10.18926/AMO/61215
FullText URL	74_6_545.pdf
Author	Tatebe, Yasuhisa\| Kanamitsu, Kiichiro\| Kanzaki, Hirotaka\| Ishida, Hisashi\| Fujiwara, Kaori\| Washio, Kana\| Kitamura, Yoshihisa\| Sendo, Toshiaki\| Shimada, Akira\| Tsukahara, Hirokazu\|
Abstract	Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
Keywords	methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2020-12
Volume	volume74
Issue	issue6
Publisher	Okayama University Medical School
Start Page	545
End Page	550
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33361876
Web of Science KeyUT	000601203600012
NAID	120006948942

Concomitant vancomycin and piperacillin/tazobactam treatment is associated with an increased risk of acute kidney injury in Japanese patients

FullText URL	JIC_26.pdf
Author	Haruki, Yuto\| Hagiya, Hideharu\| Haruki, Mai\| Inoue, Yuta\| Sugiyama, Tetsuhiro\|
Keywords	Acute kidney injury β-lactams Piperacillin/tazobactam Vancomycin
Note	This fulltext is available in Oct. 2021.\|
Published Date	2020-10
Publication Title	Journal of Infection and Chemotherapy
Volume	volume26
Issue	issue10
Publisher	Elsevier
Start Page	1026
End Page	1032
ISSN	1341-321X
NCID	AA11057978
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	32561128
DOI	10.1016/j.jiac.2020.05.012
Web of Science KeyUT	000561076200003
Related Url	isVersionOf https://doi.org/10.1016/j.jiac.2020.05.012

Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes

FullText URL	fulltext.pdf
Author	La, The Mon\| Tachibana, Hiromi\| Li, Shun-Ai\| Abe, Tadashi\| Seiriki, Sayaka\| Nagaoka, Hikaru\| Takashima, Eizo\| Takeda, Tetsuya\| Ogawa, Daisuke\| Makino, Shin-Ichi\| Asanuma, Katsuhiko\| Watanabe, Masami\| Tian, Xuefei\| Ishibe, Shuta\| Sakane, Ayuko\| Sasaki, Takuya\| Wada, Jun\| Takei, Kohji\| Yamada, Hiroshi\|
Keywords	dynamin microtubules podocyte primary process
Published Date	2020-10-17
Publication Title	FASEB Journal
Volume	volume34
Issue	issue12
Publisher	Wiley
Start Page	16449
End Page	16463
ISSN	0892-6638
NCID	AA1066874X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Authors.
File Version	publisher
PubMed ID	33070431
DOI	10.1096/fj.202001240RR
NAID	120006900792
Web of Science KeyUT	000581167100001
Related Url	isVersionOf https://doi.org/10.1096/fj.202001240RR

Dysfunction of CD8+PD-1+T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

FullText URL	fulltext.pdf
Author	Nojima, Ichiro\| Eikawa, Shingo\| Tomonobu, Nahoko\| Hada, Yoshiko\| Kajitani, Nobuo\| Teshigawara, Sanae\| Miyamoto, Satoshi\| Tone, Atsuhito\| Uchida, Haruhito A.\| Nakatsuka, Atsuko\| Eguchi, Jun\| Shikata, Kenichi\| Udono, Heiichiro\| Wada, Jun\|
Keywords	Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology
Published Date	2020-09-10
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature Research
Start Page	14928
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	32913271
DOI	10.1038/s41598-020-71946-3
Web of Science KeyUT	000571915100049
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-71946-3

Randomized trial of an intensified, multifactorial intervention in patients with advanced‐stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan)

FullText URL	fulltext.pdf
Author	Shikata, Kenichi\| Haneda, Masakazu\| Ninomiya, Toshiharu\| Koya, Daisuke\| Suzuki, Yoshiki\| Suzuki, Daisuke\| Ishida, Hitoshi\| Akai, Hiroaki\| Tomino, Yasuhiko\| Uzu, Takashi\| Nishimura, Motonobu\| Maeda, Shiro\| Ogawa, Daisuke\| Miyamoto, Satoshi\| Makino, Hirofumi\| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group\|
Keywords	Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan
Published Date	2020-08-08
Publication Title	Journal of Diabetes Investigation
Volume	volume12
Issue	issue2
Publisher	Wiley
Start Page	207
End Page	216
ISSN	2040-1116
NCID	AA12488319
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Authors
File Version	publisher
PubMed ID	32597548
DOI	10.1111/jdi.13339
NAID	120006880216
Web of Science KeyUT	000557091100001
Related Url	isVersionOf https://doi.org/10.1111/jdi.13339

Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C

JaLCDOI	10.18926/AMO/60376
FullText URL	74_4_365.pdf
Author	Chuma, Masayuki\| Kondo, Masateru\| Zamami, Yoshito\| Takechi, Kenshi\| Goda, Mitsuhiro\| Okada, Naoto\| Shibata, Akitomo\| Asada, Mizuho\| Oto, Jun\| Yanagawa, Hiroaki\| Ishizawa, Keisuke\|
Abstract	Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function.
Keywords	vancomycin, therapeutic drug monitoring cystatin C bacterial meningitis sepsis
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2020-08
Volume	volume74
Issue	issue4
Publisher	Okayama University Medical School
Start Page	365
End Page	370
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32843769
Web of Science KeyUT	000562508700013
NAID	120006880215

Recurrence of Solitary Fibrous Tumor/Hemangiopericytoma Could Be Predicted by Ki-67 Regardless of Its Origin

JaLCDOI	10.18926/AMO/60372
FullText URL	74_4_335.pdf
Author	Yamamoto, Yumiko\| Hayashi, Yoshihiro\| Murakami, Ichiro\|
Abstract	Since the discovery of the NAB2-STAT6 gene fusion in 2013, solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have been considered the same disease. STAT6 nuclear stain is approved as a highly sensitive and specific marker to diagnose SFT/HPC from other tumors with similar histology. As the next step, detection of fusion variants that may predict clinical malignancy of SFT/HPC has been attempted. However, no fusion variants with a clear relation to malignancy have been identified. In this study, the clinical and histological backgrounds of 23 Japanese patients diagnosed with SFT/HPC from 2000 to 2019 at Kochi University Hospital were examined to identify factors potentially related to recurrence. A significant relationship to recurrence was detected for mitosis ≥ 1/10 HPF (400×), necrosis, and Ki-67>5%. These findings indicate that a deliberate investigation of histological features such as mitosis and necrosis is crucial for the clinical observation of SFT/ HPC patients. In addition, Ki-67 was revealed to be a useful parameter to predict recurrence in SFT/HPC patients.
Keywords	solitary fibrous tumor hemangiopericytoma Ki-67 NAB2-STAT6 WHO classification WHO grading criteria Marseille Grading System
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2020-08
Volume	volume74
Issue	issue4
Publisher	Okayama University Medical School
Start Page	335
End Page	343
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32843765
Web of Science KeyUT	000562508700009
NAID	120006880211

Preoperative Use of Alpha-1 Receptor Blockers in Male Patients Undergoing Extracorporeal Shock Wave Lithotripsy for a Ureteral Calculus

JaLCDOI	10.18926/AMO/60367
FullText URL	74_4_293.pdf
Author	Yoshioka, Takashi\| Omae, Kenji\| Kawada, Tatsushi\| Inoue, Yosuke\| Sugimoto, Morito\| Oeda, Tadashi\| Uehara, Shinya\| Araki, Motoo\| Fukuhara, Shunichi\|
Abstract	In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality.
Keywords	urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2020-08
Volume	volume74
Issue	issue4
Publisher	Okayama University Medical School
Start Page	293
End Page	299
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	32843760
Web of Science KeyUT	000562508700004
NAID	120006880206

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