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Author Shan, Qiusheng| Takabatake, Kiyofumi| Omori, Haruka| Kawai, Hotaka| Oo, May Wathone| Sukegawa, Shintaro| Fujii, Masae| Inada, Yasunori| Sano, Sho| Nakano, Keisuke| Nagatsuka, Hitoshi|
Keywords oral squamous cell carcinoma bone invasion gingival ligament tissue‑derived stromal cell periodontal ligament tissue‑derived stromal cell xenograft model microarray
Published Date 2022-09-13
Publication Title Oncology Letters
Volume volume24
Issue issue5
Publisher Spandidos Publications
Start Page 382
ISSN 1792-1074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Shan et al.
File Version publisher
PubMed ID 36238359
DOI 10.3892/ol.2022.13502
Web of Science KeyUT 000859364100001
Related Url isVersionOf https://doi.org/10.3892/ol.2022.13502
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Author Shan, Qiusheng| Takabatake, Kiyofumi| Kawai, Hotaka| Oo, May Wathone| Inada, Yasunori| Sukegawa, Shintaro| Fushimi, Shigeko| Nakano, Keisuke| Nagatsuka, Hitoshi|
Keywords oral squamous cell carcinoma bone invasion osteoclast receptor activator of NF‑κB ligand parathyroid hormone‑related peptide microarray cancer‑associated stromal cells
Published Date 2022-02-24
Publication Title Oncology Reports
Volume volume47
Issue issue4
Publisher Spandidos Publications
Start Page 81
ISSN 1021-335X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Shan et al.
File Version publisher
PubMed ID 35211756
DOI 10.3892/or.2022.8292
Web of Science KeyUT 000764236000001
Related Url isVersionOf https://doi.org/10.3892/or.2022.8292
FullText URL fulltext.pdf
Author Shan, Qiusheng| Takabatake, Kiyofumi| Kawai, Hotaka| Oo, May Wathone| Sukegawa, Shintaro| Fujii, Masae| Nakano, Keisuke| Nagatsuka, Hitoshi|
Keywords oral squamous cell carcinoma tumor-associated macrophages cancer stroma tumor microenvironment microvessel density microarray
Published Date 2022-05-06
Publication Title International Journal of Oncology
Volume volume60
Issue issue6
Publisher Spandidos Publications
Start Page 78
ISSN 1019-6439
NCID AA10992511
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Shan et al.
File Version publisher
PubMed ID 35514301
DOI 10.3892/ijo.2022.5368
Web of Science KeyUT 000795124900001
Related Url isVersionOf https://doi.org/10.3892/ijo.2022.5368
JaLCDOI 10.18926/AMO/65973
FullText URL 77_5_511.pdf
Author Sato, Kohei| Tsuji, Hironori| Yorimitsu, Masanori| Uehara, Takenori| Okazaki, Yuki| Takao, Shinichiro| Hata, Toshiaki| Fukuoka, Shiro| Noda, Tomoyuki| Kanda, Hideyuki| Ozaki, Toshifumi|
Abstract Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either “gait disturbance” or “independent gait”. Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required.
Keywords sarcopenia nutrition geriatric hip fracture psoas muscle index controlling nutritional status score
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 511
End Page 516
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899262
Web of Science KeyUT 001108661600008
JaLCDOI 10.18926/AMO/65967
FullText URL 77_5_451.pdf
Author Okita, Atsushi| Tsukuda, Kazunori| Ino, Hideo| Mitsui, Ema| Ikeya, Nanami| Yamamoto, Sumiharu| Yokoyama, Nobuji| Bulin, Aubra|
Abstract Using a Collaborative Action Research model, our research team established a one-month clinical resident training program for first- and second-year clinical residents. We created and implemented an assessment rubric to assess the residents’ progress toward independent practice in surgery, and thereby, to evaluate the program itself. The program included training in three areas: basic techniques and procedures in the operating room, surgical ward management, and academic activities. The rubric measured the residents’ performance according to three achievement levels: Level 1 (demonstration), Level 2 (active help) and Level 3 (passive help). The program and rubric implementation began in June 2019 and continued until March 2020, when the program outcomes and shortcomings were analyzed. Among nineteen clinical residents, a total of nine clinical residents participated in the study. Most participants reached achievement Level 3 for their performance of basic techniques in the operating room. Finally, we discussed ideas for improvement and drafted plans for an improved rubric to complete the action research cycle. Our research team found the rubric to be a useful tool in evaluating the status of the new clinical resident training program.
Keywords resident program rubric assessment general surgery action research
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 451
End Page 460
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899256
Web of Science KeyUT 001108661600002
FullText URL fulltext.pdf
Author Umemori, Koki| Ono, Kisho| Kanemoto, Hideka| Obata, Kyoichi| Kawai, Hotaka| Nakamura, Tomoya| Nakano, Keisuke| Ibaragi, Soichiro| Nagatsuka, Hitoshi| Sasaki, Akira|
Keywords Pleomorphic adenoma (PA) upper lip lower lip minor salivary gland tumor case series
Published Date 2022-10-27
Publication Title Gland Surgery
Volume volume11
Issue issue10
Publisher AME Publishing Company
Start Page 1730
End Page 1740
ISSN 2227-684X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Gland Surgery.
File Version publisher
PubMed ID 36353586
DOI 10.21037/gs-22-308
Web of Science KeyUT 000860255900001
Related Url isVersionOf https://doi.org/10.21037/gs-22-308
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Author Sun, Hongming| Morihara, Ryuta| Feng, Tian| Bian, Zhihong| Yu, Haibo| Hu, Xiao| Hu, Xinran| Bian, Yuting| Sasaki, Ryo| Fukui, Yusuke| Takemoto, Mami| Yunoki, Taijun| Nakano, Yumiko| Abe, Koji| Yamashita, Toru|
Keywords ischemic stroke human cord blood-endothelial progenitor cells mechanical thrombectomy intimal hyperplasia
Published Date 2023-08-24
Publication Title Cell Transplantation
Volume volume32
Publisher SAGE Publications
ISSN 0963-6897
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37615293
DOI 10.1177/09636897231193069
Web of Science KeyUT 001059017900001
Related Url isVersionOf https://doi.org/10.1177/09636897231193069
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Author Soejima, Yoshiaki| Iwata, Nahoko| Nishioka, Ran| Honda, Mako| Nakano, Yasuhiro| Yamamoto, Koichiro| Suyama, Atsuhito| Otsuka, Fumio|
Keywords bone morphogenetic protein (BMP) orexin steroidogenesis and adrenal
Published Date 2023-08-08
Publication Title International Journal of Molecular Sciences
Volume volume24
Issue issue16
Publisher MDPI
Start Page 12559
ISSN 1661-6596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37628739
DOI 10.3390/ijms241612559
Web of Science KeyUT 001056982200001
Related Url isVersionOf https://doi.org/10.3390/ijms241612559
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Author Sukegawa, Shintaro| Ono, Sawako| Tanaka, Futa| Inoue, Yuta| Hara, Takeshi| Yoshii, Kazumasa| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Katsumitsu, Shimada| Nakai, Fumi| Nakai, Yasuhiro| Miyazaki, Ryo| Murakami, Satoshi| Nagatsuka, Hitoshi| Miyake, Minoru|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-38343-y|
Published Date 2023-07-19
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 11676
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37468501
DOI 10.1038/s41598-023-38343-y
Web of Science KeyUT 001033545700013
Related Url isVersionOf https://doi.org/10.1038/s41598-023-38343-y
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Author Yamamoto, Yukichika| Otsuka, Yuki| Tokumasu, Kazuki| Sunada, Naruhiko| Nakano, Yasuhiro| Honda, Hiroyuki| Sakurada, Yasue| Hasegawa, Toru| Hagiya, Hideharu| Otsuka, Fumio|
Keywords COVID-19 ferritin insulin-like growth factor-I (IGF-I) long COVID myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Published Date 2023-07-18
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue14
Publisher MDPI
Start Page 4737
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37510852
DOI 10.3390/jcm12144737
Web of Science KeyUT 001035871200001
Related Url isVersionOf https://doi.org/10.3390/jcm12144737
FullText URL fulltext.pdf
Author Hagiya, Hideharu| Nakano, Yasuhiro| Furukawa, Masanori| Sunada, Naruhiko| Hasegawa, Toru| Sakurada, Yasue| Hasegawa, Kou| Yamamoto, Koichiro| Ogawa, Hiroko| Obara, Takafumi| Ageta, Kouhei| Matsumoto, Naomi| Matsuo, Rumi| Kadowaki, Tomoka| Higashikage, Akihito| Hikita, Takao| Yorifuji, Takashi| Toyooka, Shinichi| Maeda, Yoshinobu| Yokokura, Yoshinori| Otsuka, Fumio| Nakayama, Masanori|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-022-24464-3|
Published Date 2022-11-30
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher nature portfolio
Start Page 20628
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36450786
DOI 10.1038/s41598-022-24464-3
Web of Science KeyUT 001002757900008
Related Url isVersionOf https://doi.org/10.1038/s41598-022-24464-3
JaLCDOI 10.18926/AMO/65502
FullText URL 77_3_323.pdf
Author Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao|
Abstract In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.
Keywords comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 323
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357634
Web of Science KeyUT 001025850000001
FullText URL fulltext.pdf
Author Fujita, Kana| Otsuka, Yuki| Sunada, Naruhiko| Honda, Hiroyuki| Tokumasu, Kazuki| Nakano, Yasuhiro| Sakurada, Yasue| Obika, Mikako| Hagiya, Hideharu| Otsuka, Fumio|
Keywords COVID-19 aftercare clinic (CAC) headache quality of life (QOL) long COVID post COVID-19 condition (PCC)
Published Date 2023-05-18
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue10
Publisher MDPI
Start Page 3533
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37240639
DOI 10.3390/jcm12103533
Web of Science KeyUT 000997859300001
Related Url isVersionOf https://doi.org/10.3390/jcm12103533
FullText URL K0006804_abstract_review.pdf K0006804_fulltext.pdf K0006804_summary.pdf
Author BIAN, ZHIHONG|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6804号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0006777_abstract_review.pdf K0006777_fulltext.pdf K0006777_summary.pdf
Author TAKAMI, Masao|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6777号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
FullText URL K0006776_abstract_review.pdf K0006776_fulltext.pdf K0006776_summary.pdf
Author ISHIDA, Tomoharu|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6776号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2021 Ishida et al.
FullText URL fulltext20230418-05.pdf figure20230418-05.pdf
Author Hu, Xinran| Fukui, Yusuke| Feng, Tian| Bian, Zhihong| Yu, Haibo| Morihara, Ryuta| Hu, Xiao| Bian, Yuting| Sun, Hongming| Takemoto, Mami| Nakano, Yumiko| Yunoki, Taijun| Abe, Koji| Yamashita, Toru|
Keywords Ischemic stroke Carnosine Middle cerebral artery occlusion Oxidative stress Inflammation Pyroptosis
Note ©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jns.2023.120608. | This fulltext file will be available in Apr. 2024.|
Published Date 2023-04-15
Publication Title Journal of the Neurological Sciences
Volume volume447
Publisher Elsevier BV
Start Page 120608
ISSN 0022-510X
NCID AA00703265
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Elsevier B.V.
File Version author
PubMed ID 36906993
DOI 10.1016/j.jns.2023.120608
Web of Science KeyUT 000956027800001
Related Url isVersionOf https://doi.org/10.1016/j.jns.2023.120608
JaLCDOI 10.18926/AMO/65155
FullText URL 77_2_227.pdf
Author Obayashi, Atsuto| Aoki, Kazuma| Wada, Tadayoshi| Furuie, Hiromi | Kuraoka, Kazuya| Hamamoto, Takao| Tatsukawa, Takaharu|
Abstract We describe the use of the tyrosine kinase inhibitor lenvatinib in a patient with brain tumor metastases from anaplastic thyroid carcinoma (ATC). A 52-year-old Japanese male presented with consciousness loss. Imaging revealed a thyroid tumor and multiple brain lesions. After the brain tumor’s resection, pathology results provided the diagnosis of ATC. Total thyroidectomy was performed, followed by whole-brain irradiation. Additional brain lesions later developed, and lenvatinib therapy was initiated with no remarkable complications. However, the treatment effects were limited, and the patient died 2 months after starting lenvatinib, 202 days after the initial brain surgery. Relevant literature is discussed.
Keywords anaplastic thyroid carcinoma brain metastasis lenvatinib
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 227
End Page 232
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094963
Web of Science KeyUT 000982563800006
FullText URL fulltext.pdf
Author Inada, Yasunori| Takabatake, Kiyofumi| Tsujigiwa, Hidetsugu| Nakano, Keisuke| Shan, Qiusheng| Piao, Tianyan| Chang, Anqi| Kawai, Hotaka| Nagatsuka, Hitoshi|
Keywords honeycomb TCP bone marrow formation scaffold hematopoietic stem cell (HSC) N-cadherin-positive spindle-shaped osteoblasts (SNO cells)
Published Date 2023-02-07
Publication Title Materials
Volume volume16
Issue issue4
Publisher MDPI
Start Page 1393
ISSN 1996-1944
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36837023
DOI 10.3390/ma16041393
Web of Science KeyUT 000953562700001
Related Url isVersionOf https://doi.org/10.3390/ma16041393
FullText URL fulltext.pdf
Author Matsuda, Yui| Tokumasu, Kazuki| Otsuka, Yuki| Sunada, Naruhiko| Honda, Hiroyuki| Sakurada, Yasue| Nakano, Yasuhiro| Hasegawa, Toru| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio|
Keywords dysgeusia dysosmia fatigue hypozincemia long COVID
Published Date 2023-03-06
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue5
Publisher MDPI
Start Page 2062
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 36902849
DOI 10.3390/jcm12052062
Web of Science KeyUT 000947564300001
Related Url isVersionOf https://doi.org/10.3390/jcm12052062