result 2435 件
| FullText URL | mjou_063_183_199.pdf |
|---|---|
| Author | Baba, Yoshitomo| |
| Abstract | In [8] M. Harada studied a left artinian ring R such that every non-small left R-module contains a non-zero injective submodule. And in [13] K. Oshiro called the ring a left Harada ring (abbreviated left H-ring). We can see many results on left Harada rings in [6] and many equivalent conditions in [4, Theorem B]. In this paper, to characterize two-sided Harada rings, we intruduce new concepts “co-H-sequence” and “H-epimorphism” and study them. |
| Keywords | Harada ring Artinian ring |
| Published Date | 2021-01 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volume63 |
| Issue | issue1 |
| Publisher | Department of Mathematics, Faculty of Science, Okayama University |
| Start Page | 183 |
| End Page | 199 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright©2021 by the Editorial Board of Mathematical Journal of Okayama University |
| FullText URL | mjou_063_001_014.pdf |
|---|---|
| Author | Graef, John R.| Beldjerd, Djamila| Remili, Moussadek| |
| Abstract | In this paper, sufficient conditions are established for the stability, boundedness and square integrability of solutions for some non-linear neutral delay differential equations of third order. Lyapunov’s direct method is used to obtain the results. |
| Keywords | boundedness stability square integrability |
| Published Date | 2021-01 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volume63 |
| Issue | issue1 |
| Publisher | Department of Mathematics, Faculty of Science, Okayama University |
| Start Page | 1 |
| End Page | 14 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright©2021 by the Editorial Board of Mathematical Journal of Okayama University |
| Author | Sakamoto, Syunya| |
|---|---|
| Published Date | 2013-05-03 |
| Publication Title | Multimedia and Ubiquitous Engineering |
| Content Type | Book |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takenoshita, Shintaro| Terada, S.| Kuwano, R.| Inoue, T.| Kurozumi, T.| Choju, A.| Suemitsu, S.| Yamada, Norihito| |
| Keywords | cognitive impairment dementia Down syndrome DSQIID intellectual disabilities screening tool |
| Note | This fulltext is available in Oct. 2021.| |
| Published Date | 2020-10-05 |
| Publication Title | Journal of Intellectual Disability Research |
| Volume | volume64 |
| Issue | issue12 |
| Publisher | Wiley |
| Start Page | 970 |
| End Page | 979 |
| ISSN | 0964-2633 |
| NCID | AA10826829 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33016572 |
| DOI | 10.1111/jir.12788 |
| Web of Science KeyUT | 000574940400001 |
| Related Url | isVersionOf https://doi.org/10.1111/jir.12788 |
| FullText URL | Bone_Joint_J_101B_8.pdf |
|---|---|
| Author | Fujiwara, T.| Medellin, M. R.| Sambri , A.| Tsuda, Y.| Balko, J.| Sumathi, V.| Gregory, J.| Jeys, L.| Abudu, A.| |
| Published Date | 2019-07-31 |
| Publication Title | Bone and Joint Journal |
| Volume | volume101-B |
| Issue | issue8 |
| Publisher | British Editorial Society of Bone and Joint Surgery |
| Start Page | 1024 |
| End Page | 1031 |
| ISSN | 2049-4394 |
| NCID | AA12602094 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31362545 |
| DOI | 10.1302/0301-620X.101B8.BJJ-2018-0963.R1 |
| Web of Science KeyUT | 000477976500019 |
| Related Url | isVersionOf https://doi.org/10.1302/0301-620X.101B8.BJJ-2018-0963.R1 |
| FullText URL | fulltext.pdf Figure.pptx Tables.pptx |
|---|---|
| Author | Kodama, Yuya| Furumatsu, Takayuki| Masuda, Shin| Okazaki, Yoshiki| Kamatsuki, Yusuke| Okazaki, Yuki| Hiranaka, Takaaki| Miyazawa, Shinichi| Yasumitsu, Masaharu| Ozaki, Toshifumi| |
| Keywords | Medial meniscus Posterior root tear Transtibial fixation Meniscus extrusion Open magnetic resonance imaging |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Knee Surgery, Sports Traumatology, Arthroscopy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00167-019-05810-x.| |
| Published Date | 2019-11-28 |
| Publication Title | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | volume28 |
| Issue | issue11 |
| Publisher | Springer |
| Start Page | 3416 |
| End Page | 3425 |
| ISSN | 0942-2056 |
| NCID | AA10973641 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31781798 |
| DOI | 10.1007/s00167-019-05810-x |
| Web of Science KeyUT | 000575537100001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00167-019-05810-x |
| JaLCDOI | 10.18926/AMO/60808 |
|---|---|
| FullText URL | 74_5_455.pdf |
| Author | Yamanouchi, Kosho| Kuba, Sayaka| Matsumoto, Megumi| Yano, Hiroshi| Morita, Michi| Sakimura, Chika| Otsubo, Ryota| Kanetaka, Kengo| Nagayasu, Takeshi| Eguchi, Susumu| |
| Abstract | Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients’ records until 3 weeks after the fourth docetaxel administration. This study’s results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients. |
| Keywords | breast cancer docetaxel neuropathy compression |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 455 |
| End Page | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106704 |
| Web of Science KeyUT | 000581970100013 |
| NAID | 120006892934 |
| JaLCDOI | 10.18926/AMO/60807 |
|---|---|
| FullText URL | 74_5_449.pdf |
| Author | Tsuchiya, Junpei| Kondo, Naoki| Fujimoto, Atsushi| Kondo, Rie| Yamada, Masahiko| Kuraishi, Tatsuya| Yoda, Takuya| Abe, Riichiro| Endo, Naoto| |
| Abstract | We report a case of psoriatic arthritis where oligoarthritis preceded the skin lesions. A 57-year-old man complained of left third-finger pain. Laboratory examinations were negative for anti-cyclic citrullinated peptide antibodies and rheumatoid factor; he was treated for suspected rheumatoid arthritis. Six years later, X-ray revealed enthesitis of his fingers and wrist joint. At 9.5 years after the initial visit, skin lesions appeared in the left auricular region and buttock and dermatopathology findings indicated psoriasis vulgaris. The final diagnosis was psoriatic arthritis. In cases of seronegative oligoarthritis, psoriatic arthritis must be considered because some patients demonstrate osteoarticular lesions preceding skin lesions. |
| Keywords | enthesitis psoriatic arthritis seronegative oligoarthritis classification criteria for psoriatic arthritis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 453 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106703 |
| Web of Science KeyUT | 000581970100012 |
| NAID | 120006892933 |
| JaLCDOI | 10.18926/AMO/60806 |
|---|---|
| FullText URL | 74_5_443.pdf |
| Author | Sekito, Takanori| Araki, Motoo| Hiraki, Takao| Uka, Mayu| Komaki, Toshiyuki| Matsui, Yusuke| Iguchi, Toshihiro| Katayama, Satoshi| Yoshinaga, Kasumi| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Kubota, Risa| Sadahira, Takuya| Nishimura, Shingo| Wada, Koichiro| Takamoto, Atsushi| Edamura, Kohei| Sako, Tomoko| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Kanazawa, Susumu| Nasu, Yasutomo| |
| Abstract | We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ≥ 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. |
| Keywords | laparoscopic cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma von Hippel-Lindau disease |
| Amo Type | Case Report |
| Note | Fig. 1B is replaced on Dec. 23, 2020.| |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 443 |
| End Page | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106702 |
| Web of Science KeyUT | 000581970100011 |
| NAID | 120006892932 |
| JaLCDOI | 10.18926/AMO/60805 |
|---|---|
| FullText URL | 74_5_435.pdf |
| Author | Fujishita, Keigo| Oka, Satoshi| Kamei, Katsuhiko| Tani, Katsuma| Fujisawa, Yuka| Kitamura, Wataru| Machida, Takuya| Imai, Toshi| |
| Abstract | A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring normal hematopoiesis is important in the treatment of fusariosis, HSCT might be considered for patients with persistent pancytopenia. |
| Keywords | disseminated fusariosis Fusarium fujikuroi species complex allogeneic hematopoietic stem cell transplantation acute myeloid leukemia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 435 |
| End Page | 441 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106701 |
| Web of Science KeyUT | 000581970100010 |
| NAID | 120006892931 |
| JaLCDOI | 10.18926/AMO/60802 |
|---|---|
| FullText URL | 74_5_423.pdf |
| Author | Hirabae, Atsuko| Ichihara, Eiki| Sunami, Ryota| Ota, Moeko| Iwamoto, Yoshitaka| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Abstract | We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks. |
| Keywords | lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 423 |
| End Page | 425 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106698 |
| Web of Science KeyUT | 000581970100007 |
| NAID | 120006892928 |
| JaLCDOI | 10.18926/AMO/60801 |
|---|---|
| FullText URL | 74_5_415.pdf |
| Author | Narihiro, Naomasa| Oita, Masataka| Takeda, Yoshihiro| |
| Abstract | During radiation therapy, incident radiation oblique to the skin surface is high and may cause severe skin damage. Understanding the dose of radiation absorbed by the skin is important for predicting skin damage due to radiation. In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new equation in which the oblique surface dose can be calculated within the error range of −7.7-5.1%. |
| Keywords | optically stimulated luminescent dosimeter radiotherapy oblique surface dose high-energy X-ray therapy angular dependence |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 415 |
| End Page | 422 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106697 |
| Web of Science KeyUT | 000581970100006 |
| NAID | 120006892927 |
| JaLCDOI | 10.18926/AMO/60800 |
|---|---|
| FullText URL | 74_5_407.pdf |
| Author | Togo, Masaaki| Akazawa, Yuko| Akashi, Taro| Yamashita, Rika| Yoshitomi, Izumi| Ohba, Kazuo| Hashimoto, Satsuki| Iwashita, Hiroko| Kurogi, Tadafumi| Osada, Yukiko| Wada, Noriko| Imamura, Yoshifumi| Hashiguchi, Keiichi| Yamaguchi, Naoyuki| Kondo, Hisayoshi| Nakao, Kazuhiko| |
| Abstract | Endoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data were available for analysis, 5 (8.3%) experienced pneumonia confirmed either by chest radiography or computed tomography. Although no difference in the rate of pneumonia was found between the control and oral care groups, the post-oral care bacteria count was significantly higher in the saliva of patients who developed pneumonia compared to those without pneumonia. In addition, the presence of vascular brain diseases and the dose of meperidine were also significantly associated with the occurrence of pneumonia. These results suggest that the number of oral bacteria as well as pre-existing vascular brain diseases and high-dose narcotics can affect the incidence of post-ESD pneumonia. |
| Keywords | endoscopy oral bacteria respiratory disease pneumonia sedation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 413 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106696 |
| Web of Science KeyUT | 000581970100005 |
| NAID | 120006892926 |
| JaLCDOI | 10.18926/AMO/60799 |
|---|---|
| FullText URL | 74_5_401.pdf |
| Author | Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| |
| Abstract | Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC. |
| Keywords | differentiated thyroid carcinoma juvenile children |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 401 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106695 |
| Web of Science KeyUT | 000581970100004 |
| NAID | 120006892925 |
| JaLCDOI | 10.18926/AMO/60798 |
|---|---|
| FullText URL | 74_5_391.pdf |
| Author | Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakaif, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Shimada, Hayato| Dohmae, Yoichiro| Endo, Naoto| |
| Abstract | Indexes for objectively evaluating abnormal gait in hip osteoarthritis (OA) patients and determining effective interventions are unclear. We analyzed the abnormal gait of hip OA patients by focusing on movements of the trunk and pelvis to establish an effective evaluation index for each direction of motion. We studied 28 patients with secondary hip OA due to developmental dysplasia of the hip and 16 controls. The trunk and pelvic movements during gait were measured in the medial-lateral (x), vertical (y), and back-and-forth (z) directions by a triaxial angular accelerometer. Gait speed, steps, step length, muscle strength, range of motion, and timed up-and-go (TUG) test performance were measured. We determined the correlations between physical function and the index of abnormal gait in the hip OA patients. Movements other than trunk and pelvic motions in the y-direction indicated abnormal gait in the patients. Significant correlations were found between abnormal gait and range of motions (extension, internal rotation), TUG score, stride length, and steps. The TUG test, stride length and steps were important for evaluating abnormal gait in hip OA patients. Individual interventions for each movement direction are required. |
| Keywords | hip osteoarthritis three-dimensional gait analysis abnormal gait timed up and go test range of motion |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 399 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106694 |
| Web of Science KeyUT | 000581970100003 |
| NAID | 120006892924 |
| JaLCDOI | 10.18926/AMO/60797 |
|---|---|
| FullText URL | 74_5_381.pdf |
| Author | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
| Abstract | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
| Keywords | hormones hyperprolactinemia inflammation pituitary prolactin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 381 |
| End Page | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106693 |
| Web of Science KeyUT | 000581970100002 |
| NAID | 120006892923 |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| FullText URL | 74_5_371.pdf |
| Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 371 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Abdelsalam, Sobhy S. H.| Kouzai, Yusuke| Watanabe, Megumi| Inoue, Komaki| Matsui, Hidenori| Yamamoto, Mikihiro| Ichinose, Yuki| Toyoda, Kazuhiro| Tsuge, Seiji| Mochida, Keiichi| Noutoshi, Yoshiteru| |
| Keywords | Fungi Microbiology Pathogens Plant immunity Plant sciences Transcription |
| Published Date | 2020-09-10 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 14889 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32913311 |
| DOI | 10.1038/s41598-020-71968-x |
| Web of Science KeyUT | 000571915100010 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-71968-x |
| FullText URL | EJSO_2020.06.020.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Stevenson, Jonathan| Parry, Michael| Tsuda, Yusuke| Kaneuchi, Yoichi| Jeys, Lee| |
| Keywords | Soft-tissue sarcoma Non-infiltrative subtype Margin Local recurrence Prognosis |
| Note | This is an Accepted Manuscript of an article published by European Society of Surgical Oncology.| |
| Published Date | 2020-06-18 |
| Publication Title | EJSO - European Journal of Surgical Oncology |
| Volume | volume47 |
| Issue | issue2 |
| Publisher | European Society of Surgical Oncology |
| Start Page | 429 |
| End Page | 435 |
| ISSN | 0748-7983 |
| NCID | AA10516435 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1016/j.ejso.2020.06.020 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejso.2020.06.020 |
| FullText URL | Surgical_oncology_35_303.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Kaneuchi, Yoichi| Tsuda, Yusuke| Stevenson, Jonathan| Parry, Michael| Jeys, Lee| |
| Keywords | Soft-tissue sarcoma Low-grade Surgery Margin Local control |
| Note | This is an Accepted Manuscript of an article published by Elsevier.| |
| Published Date | 2020-08-26 |
| Publication Title | Surgical Oncology |
| Volume | volume35 |
| Publisher | Elsevier |
| Start Page | 303 |
| End Page | 308 |
| ISSN | 0960-7404 |
| NCID | AA10850448 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32961431 |
| DOI | 10.1016/j.suronc.2020.08.022 |
| Related Url | isVersionOf https://doi.org/10.1016/j.suronc.2020.08.022 |
