result 19474 件
| JaLCDOI | 10.18926/AMO/46630 |
|---|---|
| FullText URL | 65_3_185.pdf |
| Author | Watanabe, Kumi| Okada, Ayumi| Okabe, Nobuyuki| Onishi, Masaru| Morishima, Tsuneo| |
| Abstract | The purpose of this study was to investigate the psychological needs of children and adolescents with eating disorders (ED) directed toward their mothers. Patients with ED have low self-assertion and various abnormal eating behaviors. Therefore, mothers face difficulty in understanding their children's psychological needs, and the mother-child relationship is sometimes strained. We developed a One-Message Question (OMQ)-structured interview. The OMQ was easy to answer, and it helped the patients with ED. We examined the relationship between psychological needs and illness phase of the children and adolescents, and we discuss the viability of implementing the OMQ in clinical settings. The subjects were 23 patients and their parents. Their parents were just asked about the patients' background. The mean age of the patients was 15.8 years, and the average age of ED onset was 13.5 years. The EDs were anorexia nervosa (n＝20) and bulimia nervosa (n＝3). The phases of patients' illness were identified as anorexic (n＝5), bulimic (n＝7), chronic (n＝3), and stable (n＝8). All subjects provided specific responses to the OMQ-structured interview. Data analyses revealed the following seven categories of patients' psychological needs directed toward their mothers:attachment, cooperation in meeting their goals, longing for love, changing attitude toward family members, respect for self-reliance, expression of apology, and expression of appreciation. These findings suggested that the OMQ-structured interview may prove useful for mothers to understand their children's psychological needs and may encourage positive interactions as a foundation for future recovery. |
| Keywords | family support mother-child relationships eating disorders in children and adolescents interview methods team approach |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-06 |
| Volume | volume65 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 192 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21709716 |
| Web of Science KeyUT | 000292017500005 |
| JaLCDOI | 10.18926/AMO/46628 |
|---|---|
| FullText URL | 65_3_169.pdf |
| Author | Takeda, Masanori| Nagasaka, Takeshi| Dong-Sheng, Sun| Nishie, Hiroyuki| Oka, Tetsuhiro| Yamada, Eiji| Mori, Yoshiko| Shigeyasu, Kunitoshi| Morikawa, Tatsuya| Mizobuchi, Satoshi| Fujiwara, Toshiyoshi| |
| Abstract | Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout the promoter during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) of the SFRP2 promoter were investigated in 569 specimens of colorectal tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC patients (N-Cs), and 36 normal colonic mucosa from subjects with no evidence of colorectal neoplasia at colonoscopy (N-Ns). Extensive (including both Regions A and B) and partial (either Region A or B) SFRP2 methylation levels were found in 61.7% and 24.8% of CRCs, 8.7% and 37.9% of APs, 3.9% and 39.9% of N-Cs, and 0% and 30.6% of N-Ns, respectively. Extensive methylation of the SFRP2 promoter was present primarily in CRCs, while partial methylation was common in APs. Whereas APs with the KRAS mutant showed no correlation to any pattern of SFRP2 methylation, extensive methylation of the SFRP2 promoter was significantly associated with KRAS mutant CRCs (p＜.0001), suggesting that genetic alteration in the RAS-RAF pathway might precede the spread of CpG methylation through the SFRP2 promoter, which is observed in over 60% of advanced colorectal tumors. |
| Keywords | BRAF/KRAS mutations promoter methylation colorectal cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-06 |
| Volume | volume65 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 169 |
| End Page | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21709714 |
| Web of Science KeyUT | 000292017500003 |
| JaLCDOI | 10.18926/AMO/46626 |
|---|---|
| FullText URL | 65_3_151.pdf |
| Author | Fujiwara, Toshiyoshi| |
| Abstract | Replication-selective tumor-specific viruses constitute a novel approach for treatment of neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells after selective viral propagation within the tumor. Human telomerase is highly active in more than 85ｵ of primary cancers, regardless of their tissue origins, and its activity correlates closely with human telomerase reverse transcriptase (hTERT) expression. We constructed an attenuated adenovirus 5 vector (Telomelysin, OBP-301), in which the hTERT promoter element drives expression of E1 genes. Since only tumor cells that express telomerase activity would activate this promoter, the hTERT proximal promoter would allow for preferential expression of viral genes in tumor cells, leading to selective viral replication and oncolytic cell death. Lymphatic invasion is a major route for cancer cell dissemination, and adequate treatment of locoregional lymph nodes is required for curative treatment in patients with gastrointestinal tumors. We demonstrated that intratumoral injection of Telomelysin mediates effective in vivo purging of metastatic tumor cells from regional lymph nodes. Moreover, using noninvasive whole-body imaging, we found that intratumoral injection of Telomelysin followed by regional irradiation induces a substantial antitumor effect, resulting from tumor cell-specific radiosensitization, in an orthotopic human esophageal cancer xenograft model. These results illustrate the potential of oncolytic virotherapy as a promising strategy in the management of human gastrointestinal cancer. |
| Keywords | telomerase adenovirus metastasis lymph node colorectal cancer |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-06 |
| Volume | volume65 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 162 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21709712 |
| Web of Science KeyUT | 000292017500001 |
| Author | Sigenoi, Siko| |
|---|---|
| Published Date | 1929-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume41 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Takahashi, Shozo| |
|---|---|
| Published Date | 1929-07-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume41 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Ennishi, Daisuke| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Nakamura, Eri| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kikuchi, Yoichiro| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Shiozawa, Nobuyoshi| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Iwase, Toshihide| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Morikawa, Toshio| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Iishi, Tatsuhiko| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Huang, Xingang| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kajitani, Nobuo| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Wakimoto, Mari| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kumada, Ai| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Watanabe, Kumi| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Sasaki, Motofumi| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Tsuzuki, Takao| |
|---|---|
| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Adachi, Hideyuki| |
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| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
