result 8785 件
| JaLCDOI | 10.18926/bgeou/66710 |
|---|---|
| Title Alternative | Study on the Development of Consumer Education Programs Aimed at Developing Independent Legal Decision-Making Skills: -Based on a Study of the Theory of Value Formation in Social Studies Education |
| FullText URL | bgeou_185_093_104.pdf |
| Author | KUWABARA, Toshinori| MIYAMOTO, Ayuha| |
| Abstract | 本研究は，学習者が法に基づいて主体的に判断し，自らが直面している消費者問題の解決に取り組むことができるようになることを目指した教育プログラムの開発・実践を目指したものである。その際に，社会科教育研究の価値観形成論の検討をふまえ，その原理を応用する。法教育として消費者教育を捉えた場合，それは，たんに個人の生活上の問題解決を目指すものにはとどまらない。権利と責任に対する認識に基づいて自立した市民として判断ができる力を育成するとともに，多様な考え方や生き方を尊重する社会を，法に基づいて作っていくことに参画できる市民を育てる教育として位置付けられることになる。開発したプログラムでは，人は誰でもそのような失敗をするものであるということを前提として，取り上げた事例において，なぜ失敗をしたのかを考えさせ，その人を取り巻く状況を把握させたうえで，その人の意図や動機を共感的に理解させることを目指した。 |
| Keywords | 法教育 消費者教育 法的判断力 社会科教育 価値観形成 |
| Publication Title | Bulletin of Graduate School of Education, Okayama University |
| Published Date | 2024-02-22 |
| Volume | volume185 |
| Start Page | 93 |
| End Page | 104 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhao, Songhao| Shen, Lili| Li, Xiaoyi| Tao, Qiushuang| Li, Zhenhua| Xu, Caizhe| Zhou, Cuicui| Yang, Yanyan| Sang, Min| Han, Guangye| Yu, Long-Jiang| Kuang, Tingyun| Shen, Jian-Ren| Wang, Wenda| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-44055-8| |
| Published Date | 2023-12-09 |
| Publication Title | Nature Communications |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 8164 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 38071196 |
| DOI | 10.1038/s41467-023-44055-8 |
| Web of Science KeyUT | 001118826100025 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-023-44055-8 |
| FullText URL | fulltext20240304-04.pdf |
|---|---|
| Author | Suzuki, Takehito| Murakami, Hironobu| Uchiyama, Jumpei| Sato, Reiichiro| Takemura-Uchiyama, Iyo| Ogata, Masaya| Sogawa, Kazuyuki| Ishida, Hiroho| Atipairin, Apichart| Matsushita, Osamu| Nagai, Makoto| |
| Keywords | Bovine leukemia virus Volatile fatty acids Rumen Gut, Microbiota Cows |
| Note | The version of record of this article, first published in Annals of Microbiology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13213-023-01737-4| |
| Published Date | 2023-09-16 |
| Publication Title | Annals of Microbiology |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 31 |
| ISSN | 1869-2044 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| DOI | 10.1186/s13213-023-01737-4 |
| Web of Science KeyUT | 001166589200001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13213-023-01737-4 |
| FullText URL | fulltext20240304-03.pdf |
|---|---|
| Author | Tomioka, Yasuaki| Sugimoto, Seiichiro| Shiotani, Toshio| Matsubara, Kei| Choshi, Haruki| Ishihara, Megumi| Tanaka, Shin| Miyoshi, Kentaroh| Otani, Shinji| Toyooka, Shinichi| |
| Keywords | Lung transplantation Dialysis Living-donor kidney transplantation End -stage renal disease Renal replacement therapy |
| Note | © 2024 The Japanese Respiratory Society. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-03 |
| Publication Title | Respiratory Investigation |
| Volume | volume62 |
| Issue | issue2 |
| Publisher | Elsevier BV |
| Start Page | 240 |
| End Page | 246 |
| ISSN | 2212-5345 |
| NCID | AA12579673 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Japanese Respiratory Society. |
| File Version | author |
| PubMed ID | 38241956 |
| DOI | 10.1016/j.resinv.2024.01.001 |
| Web of Science KeyUT | 001162771800001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.resinv.2024.01.001 |
| FullText URL | fulltext20240304-01.pdf |
|---|---|
| Author | Yamazawa, Yumi| Osaka, Akitane| Fujii, Yasushi| Nakayama, Takahiro| Nishioka, Kunio| Tanabe, Yoshinori| |
| Keywords | Radiotherapy Sagging correction Image matching Winston-Lutz test Deformable registration |
| Note | The version of record of this article, first published in Physical and Engineering Sciences in Medicine, is available online at Publisher’s website: http://dx.doi.org/10.1007/s13246-024-01388-y| |
| Published Date | 2024-02-19 |
| Publication Title | Physical and Engineering Sciences in Medicine |
| Volume | volume47 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 589 |
| End Page | 596 |
| ISSN | 2662-4729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38372942 |
| DOI | 10.1007/s13246-024-01388-y |
| Web of Science KeyUT | 001164468200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s13246-024-01388-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Ogawa, Chikako| Masuyama, Hisashi| Tabuchi, Takahiro| |
| Keywords | cervical cancer screening social inequality screening hesitation internet survey |
| Published Date | 2024-02-13 |
| Publication Title | International Journal of General Medicine |
| Volume | volume17 |
| Publisher | Dove Press |
| Start Page | 541 |
| End Page | 551 |
| ISSN | 1178-7074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Mitoma et al. |
| File Version | publisher |
| PubMed ID | 38371520 |
| DOI | 10.2147/IJGM.S453675 |
| Web of Science KeyUT | 001162765400001 |
| Related Url | isVersionOf https://doi.org/10.2147/IJGM.S453675 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kamada, Shinji| Nakajima, Yoshiki| Shen, Jian-Ren| |
| Keywords | Photosystem II photosynthesis electron transfer structural biology crystal structure electron acceptor |
| Published Date | 2023-07 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume299 |
| Issue | issue7 |
| Publisher | Elsevier |
| Start Page | 104839 |
| ISSN | 1083-351X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37209822 |
| DOI | 10.1016/j.jbc.2023.104839 |
| Web of Science KeyUT | 001166336800001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jbc.2023.104839 |
| FullText URL | fulltext20240226-04.pdf |
|---|---|
| Author | Kuribayashi, Tadahiro| Ohashi, Kadoaki| Nishii, Kazuya| Ninomiya, Kiichiro| Tsubata, Yukari| Ishikawa, Nobuhisa| Kodani, Masahiro| Kanaji, Nobuhiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kuyama, Shoichi| Takigawa, Nagio| Fujimoto, Nobukazu| Kubota, Tetsuya| Inoue, Masaaki| Fujiwara, Keiichi| Harita, Shingo| Takata, Ichiro| Takada, Kenji| Okawa, Sachi| Kiura, Katsuyuki| Hotta, Katsuyuki| |
| Keywords | EGFR EGFR-TKI Lung cancer Immune checkpoint inhibitors Performance status |
| Note | The version of record of this article, first published in Journal of Cancer Research and Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00432-024-05618-4| |
| Published Date | 2024-02-12 |
| Publication Title | Journal of Cancer Research and Clinical Oncology |
| Volume | volume150 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 89 |
| ISSN | 1432-1335 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38347279 |
| DOI | 10.1007/s00432-024-05618-4 |
| Web of Science KeyUT | 001160773600002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00432-024-05618-4 |
| FullText URL | fulltext20240226-01.pdf |
|---|---|
| Author | Kawazu, Toshiyuki| Takeshita, Yohei| Fujikura, Mamiko| Okada, Shunsuke| Hisatomi, Miki| Asaumi, Junichi| |
| Keywords | Deep neural networks Caries detection Domain-Specific transfer learning Panoramic tomography |
| Note | The version of record of this article, first published in Journal of Medical and Biological Engineering, is available online at Publisher’s website: http://dx.doi.org/10.1007/s40846-024-00848-w| |
| Published Date | 2024-02-13 |
| Publication Title | Journal of Medical and Biological Engineering |
| Volume | volume44 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 43 |
| End Page | 48 |
| ISSN | 1609-0985 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| DOI | 10.1007/s40846-024-00848-w |
| Web of Science KeyUT | 001160649900001 |
| Related Url | isVersionOf https://doi.org/10.1007/s40846-024-00848-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuya| Matsumoto, Yoshinori| Nawachi, Shoichi| Asano, Yosuke| Katayama, Yu| Miyawaki, Yoshia| Katsuyama, Takayuki| Katsuyama, Eri| Nasu, Yoshihisa| Sada, Ken-Ei| Wada, Jun| |
| Keywords | Nail-patella syndrome Rheumatoid arthritis Joint dislocation Iliac horn Case report |
| Note | The version of record of this article, first published in BMC Musculoskeletal Disorders, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12891-024-07242-2| |
| Published Date | 2024-02-14 |
| Publication Title | BMC Musculoskeletal Disorders |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 139 |
| ISSN | 1471-2474 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38355529 |
| DOI | 10.1186/s12891-024-07242-2 |
| Web of Science KeyUT | 001162669400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12891-024-07242-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin |
| Published Date | 2024-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1443 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38338721 |
| DOI | 10.3390/ijms25031443 |
| Web of Science KeyUT | 001161430700001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25031443 |
| FullText URL | fulltext20240222-01.pdf |
|---|---|
| Author | Kubo, Kazuki| Yagi, Kairi| Kanda, Takefumi| Yasuda, Koa| Yamaguchi, Daisuke| Wakimoto, Shuichi| |
| Keywords | cryogenic ultrasonic piezoelectric transducer |
| Note | This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/ad1e9b.| This fulltext file will be available in Feb. 2025.| |
| Published Date | 2024-02-07 |
| Publication Title | Japanese Journal of Applied Physics |
| Volume | volume63 |
| Issue | issue3 |
| Publisher | IOP Publishing |
| Start Page | 03SP03 |
| ISSN | 0021-4922 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Japan Society of Applied Physics |
| File Version | author |
| DOI | 10.35848/1347-4065/ad1e9b |
| Web of Science KeyUT | 001157397300001 |
| Related Url | isVersionOf https://doi.org/10.35848/1347-4065/ad1e9b |
| JaLCDOI | 10.18926/AMO/66673 |
|---|---|
| FullText URL | 78_1_071.pdf |
| Author | Kaneda, Daisuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Hotta, Yoshifumi| Naniwa, Shuichi| Ozaki, Toshifumi| |
| Abstract | We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute. |
| Keywords | AVANTA silicone implant boutonniere deformity implant fracture thumb metacarpophalangeal joint arthroplasty rheumatoid arthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419317 |
| Web of Science KeyUT | 001203658200011 |
| JaLCDOI | 10.18926/AMO/66672 |
|---|---|
| FullText URL | 78_1_063.pdf |
| Author | Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa| |
| Abstract | The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma. |
| Keywords | thyroid carcinoma lenvatinib adverse effect survival |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419316 |
| Web of Science KeyUT | 001203658200007 |
| JaLCDOI | 10.18926/AMO/66670 |
|---|---|
| FullText URL | 78_1_047.pdf |
| Author | Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)| |
| Abstract | Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen. |
| Keywords | metastatic colorectal cancer chemotherapy S-1 prospective phase II study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 47 |
| End Page | 52 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419314 |
| Web of Science KeyUT | 001203658200005 |
| JaLCDOI | 10.18926/AMO/66669 |
|---|---|
| FullText URL | 78_1_037.pdf |
| Author | Tanaka, Masato| Meena, Umesh| Taoka, Takuya| Fujiwara, Yoshihiro| Yokomizo, Daiichiro| Bashyal, Santosh Kumar| Sake, Naveen| Arataki, Shinya| |
| Abstract | In adult spinal deformity (ASD) surgery, one of the key factors working to prevent proximal junctional kyphosis is the proximal anchor. The aim of this study was to compare clinical and radiographic outcomes of triangular fixation with conventional fixation as proximal anchoring techniques in ASD surgery. We retrospectively evaluated 54 patients who underwent corrective spinal fusion for ASD. Fourteen patients underwent proximal triangular fixation (Group T; average 74.6 years), and 40 patients underwent the conventional method (Group C; average 70.5 years). Clinical and radiographic outcomes were assessed using visual analogue scale (VAS) values for back pain and the Oswestry disability index (ODI). Radiographic evaluation was also collected preoperatively and postoperatively. Surgical times and intraoperative blood loss of the two groups were not significantly different (493 vs 490 min, 1,260 vs 1,173 mL). Clinical outcomes such as VAS and ODI were comparable in the two groups. Proximal junctional kyphosis in group T was slightly lower than that of group C (28.5% vs 47.5%, p=0.491). However, based on radiology, proximal screw pullout occurred significantly less frequently in the triangular fixation group than the conventional group (0.0% vs 22.5%, p=0.049). Clinical outcomes in the two groups were not significantly different. |
| Keywords | adult spinal deformity proximal junctional kyphosis triangular fixation minimally invasive surgery C arm free |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419313 |
| Web of Science KeyUT | 001203658200003 |
| JaLCDOI | 10.18926/AMO/66668 |
|---|---|
| FullText URL | 78_1_029.pdf |
| Author | Kitayama, Takahiro| Tanaka, Takashi| Kanie, Yuichiro| Marukawa, Yohei| Kojima, Katsuhide| Tanaka, Takehiro| Takao, Soshi| Hiraki, Takao| |
| Abstract | This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD. |
| Keywords | methotrexate lymphoproliferative disorder computed tomography necrosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 36 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419312 |
| Web of Science KeyUT | 001203658200001 |
| JaLCDOI | 10.18926/AMO/66665 |
|---|---|
| FullText URL | 78_1_009.pdf |
| Author | Akagi, Naoki| Kanematsu, Akihiro| Shigesaka, Koji| Shimatani, Kimihiro| Yamamoto, Shingo| |
| Abstract | Bacillus Calmette-Guérin (BCG) treatment for non-muscle-invasive bladder cancer frequently causes an intraprostatic BCG granuloma. We investigated the optimal timing for a prostate biopsy after BCG treatment by retrospectively analyzing the cases of 22 patients with non-muscle-invasive bladder cancer who underwent a prostate biopsy after BCG treatment at our institute (2013-2017). Biopsies were indicated for a rising prostate-specific antigen (PSA) level, positive digital rectal examination findings, or the appearance of de novo low apparent diffusion coefficient lesions on MRI. The control group was comprised of 28 age- and PSA-matched patients. The relationships among the cancer detection rate and the patients’ PSA levels and MRI findings were analyzed. Prostate cancer was detected by biopsy in only 13.9% (3/22) of the patients in the BCG group but in 78.5% (22/28) of the control patients (p=0.0001). The three patients in the BCG group in whom prostate cancer was detected had all undergone the biopsy > 1 year after their BCG treatment. The remaining biopsies were performed within 1 year after BCG treatment and resulted in no diagnoses of prostate cancer. We suggest that performing a prostate biopsy early after BCG treatment is not informative or useful. |
| Keywords | bacillus Calmette-Guérin prostate granuloma prostate cancer bladder cancer prostate biopsy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 13 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419309 |
| Web of Science KeyUT | 001203658200010 |
| JaLCDOI | 10.18926/AMO/66664 |
|---|---|
| FullText URL | 78_1_001.pdf |
| Author | Sun, Cuiming| Matsukawa, Akihiro| |
| Abstract | Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis. |
| Keywords | ERK-MAPK SPRED2 fibrosis macrophages |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419308 |
| Web of Science KeyUT | 001203658200006 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tamura, Masanori| Furumatsu, Takayuki| Yokoyama, Yusuke| Higashihara, Naohiro| Kawada, Koki| Ozaki, Toshifumi| |
| Keywords | Knee injuries Arthroscopy Meniscus Root tear |
| Note | The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-023-00206-1| |
| Published Date | 2024-02-08 |
| Publication Title | Knee Surgery & Related Research |
| Volume | volume36 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 8 |
| ISSN | 2234-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38331953 |
| DOI | 10.1186/s43019-023-00206-1 |
| Web of Science KeyUT | 001160637100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s43019-023-00206-1 |
