Conditions

close

result 2505 件

JaLCDOI 10.18926/AMO/64038
FullText URL 76_5_565.pdf
Author Komagoe, Sho| Senoo, Takaya| Takao, Soshi| Shiraishi, Yoshinori| Matsumoto, Hiroshi| Kimata, Yoshihiro|
Abstract We herein introduce horizontal vector analysis, a simple method for assessing cranial morphology based on measurement of the head’s horizontal plane, and use this method to establish normal cranial morphology in Japanese children Computed tomography scans taken in 2010-2019 in healthy Japanese children aged ≤ 6 years. The two measurement planes were parallel to the orbitomeatal plane: namely, a plane passing through the dorsum sellae (DS) and the plane superior to that with the maximal area (Max plane). A protractor was used to circumferentially measure the lengths from the central point to the outer surface of the skull. A total of 487 images were extracted. The distances between the DS and Max planes were consistently almost 30 mm for each age group, so we fixed the Max plane as the plane 30 mm superior to the DS plane. Finally, we established datasets of normal values for each age group and sex. Using these norms, perioperative evaluation of various cranial deformities could be performed more easily and circumstantially.
Keywords craniofacial surgery craniosynostoses horizontal plane Japanese children reference values
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 565
End Page 575
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352804
Web of Science KeyUT 000884907100010
JaLCDOI 10.18926/AMO/64037
FullText URL 76_5_557.pdf
Author Pan, Yu| Song, Qingqing| Kanazawa, Tomoyuki| Morimatsu, Hiroshi|
Abstract Some pediatric cardiac patients might experience low regional cerebral oxygen saturation (rSO2) during surgery. We investigated whether a pediatric patient’s mean arterial pressure (MAP) can affect the rSO2 value during cardiopulmonary bypass (CPB). We retrospectively analyzed the cases of the pediatric patients who underwentcardiac surgery at our hospital (Jan. –Dec. 2019; n=141). At each MAP stage, we constructed line charts through the mean of the rSO2 values corresponding to each MAP and then calculated the correlation coefficients. We next divided the patients into age subgroups (neonates, infants, children) and into cyanotic congenital heart disease (CHD) and acyanotic CHD groups and analyzed these groups in the same way. The analyses of all 141 patients revealed that during CPB the rSO2 value increased with an increase in MAP (r=0.1626). There was a correlation between rSO2 and MAP in the children (r=0.2720) but not in the neonates (r=0.06626) or infants (r=0.05260). Cyanotic CHD or acyanotic CHD did not have a significant effect on the rSO2/MAP correlation. Our analysis demonstrated different patterns of a correlation between MAP and rSO2 in pediatric cardiac surgery patients, depending on age. MAP was positively correlated with rSO2 typically in children but not in neonate or infant patients.
Keywords mean arterial pressure cerebral oxygen saturation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 557
End Page 564
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352803
Web of Science KeyUT 000884907100009
JaLCDOI 10.18926/AMO/64036
FullText URL 76_5_547.pdf
Author Kagawa, Hidetoshi| Yamanaka, Ryutaro| Hiromasa, Tsutomu|
Abstract This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN.
Keywords combination therapy first-line therapy lupus nephritis mizoribine tacrolimus
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 547
End Page 555
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352802
Web of Science KeyUT 000884907100008
JaLCDOI 10.18926/AMO/64035
FullText URL 76_5_541.pdf
Author Akebi, Toru| Matsugaki, Ryutaro| Ono, Toshiro|
Abstract The purpose of this study was to conduct a self-reported questionnaire survey of work-related musculoskeletal disorders (WMSDs) among Japanese radiological technologists (RTs) and to report on the relationship between wearing a lead apron and WMSDs. Between February and April of 2021, RTs in Okayama Prefecture, Japan, were surveyed by mail and through a website. Information on individual characteristics, physical factors at work, and the presence of WMSDs were collected. All participants were also asked whether they frequently wore lead aprons. A multiple logistic regression analysis was used to assess the relationship between wearing a lead apron and WMSDs. The model was adjusted for age, sex, body mass index (BMI), and working hours. Of the 123 participants, 67 (54.5%) had WMSDs. Multiple logistic regression analysis revealed that WMSDs were significantly associated with wearing a lead apron. Compared to the “Never wear” group, the odds ratios for the “Always/Frequently wear” and “Sometimes/Rarely wear” groups were 7.87 (95% confidence interval [CI]=1.28-48.46; p=0.026) and 7.80 (95% CI=1.43-42.44; p=0.017), respectively. Our analysis suggests that wearing a lead apron is associated with WMSDs, and thus design modifications in lead aprons may improve the occupational health management of RTs.
Keywords work-related musculoskeletal disorders radiological technologists lead apron questionnaire survey multiple logistic regression analysis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 541
End Page 545
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352801
Web of Science KeyUT 000884907100007
JaLCDOI 10.18926/AMO/64034
FullText URL 76_5_535.pdf
Author Matsuda, Tadashi| Akezaki, Yoshiteru| Tsuji, Yoko| Hamada, Kazunori| Ookura, Mitsuhiro|
Abstract The purpose of this study was to investigate the psychological impact of various positionings in subjects with cerebral palsy (CP). The participants were 17 individuals with severe motor and intellectual disability due to CP. They began in a sitting position in their wheelchair, and were placed consecutively in prone or supine positions, with no intervals between placements. Physiological observations were made in each position, and included salivary α-amylase activity, pulse, percutaneous oxygen saturation, respiratory rate, learance or not of airway secretions, and occurrence or not of adverse events. Salivary α-amylase activity values were higher in the prone position than in the baseline and supine positions (p<0.05). Clearance of airway secretions was significantly more prevalent in the prone position than in the baseline and supine positions (p <0.05). The participants’ pulse was significantly lower in the supine and prone positions than in the baseline position (p<0.05). Greater prevalence of airway secretion clearance and significantly higher stress levels as indicated by saliva amylase were observed in the prone position than in the other two positions. Therefore, when such patients are placed in a prone position, close attention to airway management and the potential for psychological stress may be necessary.
Keywords alpha-amylase stress positioning cerebral palsy severe motor and intellectual disability
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 535
End Page 540
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352800
Web of Science KeyUT 000884907100006
JaLCDOI 10.18926/AMO/64033
FullText URL 76_5_527.pdf
Author Makihara, Seiichiro| Kariya, Shin| Miyamoto, Shotaro| Uraguchi, Kensuke| Oka, Aiko| Tsumura, Munechika| Noda, Yohei| Ando, Mizuo| Okano, Mitsuhiro|
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 527
End Page 533
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352799
Web of Science KeyUT 000884907100005
JaLCDOI 10.18926/AMO/64032
FullText URL 76_5_519.pdf
Author Ishioka, Yoko| Yamashita, Hiroyuki| Hamaguchi, Kinya| Kuwahara, Yoshitaka| Nakamura, Kaoru| Nakatsuka, Mikiya|
Abstract To examine the outcome of gestational blood pressure and birth weight in women with normal pre-pregnancy BMI (18.5-25 kg/m2) who are at the lower and upper limits of this range, i.e., slightly underweight or slightly overweight. Overall, 2,038 Japanese women with low -risk who had delivered during January 2014–December 2016 were classified according to their pre-pregnancy BMI: underweight (< 18.5 kg/m2), slightly underweight (18.5≤BMI<21 kg/m2), normal (21≤BMI<23 kg/m2), slightly overweight (23≤BMI<25 kg/m2) and overweight (≤ 25 kg/m2). Their blood pressure during each trimester and birth weight was evaluated. The slightly overweight group showed a significantly higher blood pressure than the underweight and slightly underweight groups. Birth weight was lower in the slightly underweight than in the slightly overweight group (p<0.01). The incidence rate of “heavy for dates” (HFD) infants was significantly higher in the slightly overweight and overweight groups than in the other groups (p<0.05 and p<0.01, respectively). Weight gain of < 7 kg significantly increased the rate of “light for dates” (LFD) infants, while a weight gain of ≥13 kg significantly increased the rate of HFD infants (p<0.05 and p<0.01, respectively). Blood pressure during pregnancy was ssociated with pre-pregnancy BMI. The birth weight of infants of low-risk pregnant women is affected by both pre-pregnancy BMI and gestational weight gain.
Keywords birth weight blood pressure normal body weight pregnancy pre-pregnancy BMI
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 519
End Page 526
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352798
Web of Science KeyUT 000884907100004
JaLCDOI 10.18926/AMO/64031
FullText URL 76_5_511.pdf
Author Tomita, Hayato| Kuramochi, Kenji| Fujikawa, Atsuko| Ikeda, Hirotaka| Komita, Midori| Kurihara, Yoshiko| Kobayashi, Yasuyuki| Mimura, Hidefumi|
Abstract Iterative reconstruction (IR) improves image quality compared with filtered back projection (FBP). This study investigated the usefulness of model-based IR (forward-projected model-based iterative reconstruction solution [FIRST]) in comparison with FBP and hybrid IR (adaptive iterative dose reduction three-dimensional processing [AIDR 3D]) in low-dose paranasal CT. Twenty-four patients with paranasal sinusitis who underwent standard-dose CT (120 kV) and low-dose CT (100 kV) scanning before and after medical treatment were enrolled. Standard-dose CT scans were reconstructed with FBP (FBP120), and low-dose CT scans with FBP (FBP100), AIDR 3D, and FIRST. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in three anatomical structures and effective doses were compared using Mann–Whitney U test. Two radiologists independently evaluated the visibility of 16 anatomical structures, overall image quality, and artifacts. Effective doses in lowdose CT were significantly reduced compared with those in standard-dose CT (0.24 vs 0.43 mSv, p<0.001). FIRST achieved significantly higher SNR (p<0.01, respectively) and CNR (p<0.001, respectively) of evaluated structures and significant improvement in overall image quality (p<0.001), artifacts (p<0.001), and visibility related to muscles (p<0.05) compared to FBP120, FBP100, and AIDR 3D. FIRST allowed radiation-dose reduction, while maintaining objective and subjective image quality in low-dose paranasal CT.
Keywords paranasal sinuses iterative reconstruction dose reduction low dose
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 511
End Page 517
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352797
Web of Science KeyUT 000884907100003
JaLCDOI 10.18926/AMO/64025
FullText URL 76_5_503.pdf
Author Ogawa, Hirohito| Honda, Tomoyuki|
Abstract Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches.
Keywords EVE nrEVE bornavirus filovirus antiviral
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 503
End Page 510
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352796
Web of Science KeyUT 000884907100002
JaLCDOI 10.18926/AMO/64024
FullText URL 76_5_489.pdf
Author Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
Abstract Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
Keywords glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-10
Volume volume76
Issue issue5
Publisher Okayama University Medical School
Start Page 489
End Page 502
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36352795
Web of Science KeyUT 000884907100001
FullText URL mjou_065_035_081.pdf
Author Morita, Jun| Pianzola, Arturo| Shibata, Taiki|
Abstract We provide explicit generators and relations for the affine Kac-Moody groups, as well as a realization of them as (twisted) loop groups by means of Galois descent considerations. As a consequence, we show that the affine Kac-Moody group of type X(r) N is isomorphic to the fixed-point subgroup of the affine Kac-Moody group of type X(1) N under an action of the Galois group.
Keywords Affine Kac-Moody groups Loop groups Twisted Chevalley groups
Published Date 2023-01
Publication Title Mathematical Journal of Okayama University
Volume volume65
Issue issue1
Publisher Department of Mathematics, Faculty of Science, Okayama University
Start Page 35
End Page 81
ISSN 0030-1566
NCID AA00723502
Content Type Journal Article
language English
Copyright Holders Copyright ©2023 by the Editorial Board of Mathematical Journal of Okayama University
FullText URL fulltext20221017-5.pdf
Author Iwanaga, Yasuhiro| Sakemoto, Ryuta|
Keywords commodity futures decomposition momentum
Note This is the peer reviewed version of the following article: [Iwanaga, Y., & Sakemoto, R. (2023). Commodity momentum decomposition. Journal of Futures Markets, 43, 198–216. https://doi.org/10.1002/fut.22382], which has been published in final form at [ https://doi.org/10.1002/fut.22382]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext is available in Oct. 2024.|
Published Date 2022-10
Publication Title Journal of Futures Markets
Volume volume43
Issue issue2
Publisher Wiley
Start Page 198
End Page 216
ISSN 0270-7314
NCID AA10621291
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Wiley Periodicals LLC.
File Version author
DOI 10.1002/fut.22382
Web of Science KeyUT 000862234100001
Related Url isVersionOf https://doi.org/10.1002/fut.22382
FullText URL fulltext.pdf
Author Makimoto, Go| Shimonishi, Atsushi| Ohashi, Kadoaki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords MET Tepotinib Non-small-cell lung cancer
Published Date 2022
Publication Title Case Reports In Oncology
Volume volume15
Issue issue2
Publisher Karger
Start Page 494
End Page 498
ISSN 1662-6575
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35702678
DOI 10.1159/000524326
Web of Science KeyUT 000864085100005
Related Url isVersionOf https://doi.org/10.1159/000524326
FullText URL fulltext.pdf
Author Minematsu, Hideki| Afify, Said M.| Sugihara, Yuki| Hassan, Ghmkin| Zahra, Maram H.| Seno, Akimasa| Adachi, Masaki| Seno, Masaharu|
Published Date 2022-09-17
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 15628
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36115905
DOI 10.1038/s41598-022-19265-7
Web of Science KeyUT 000854870500011
Related Url isVersionOf https://doi.org/10.1038/s41598-022-19265-7
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Abe, Makoto| Sakae, Hiroyuki| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Tanaka, Takehiro| Kawano, Seiji| Otsuka, Fumio| Kawahara, Yoshiro| Yanai, Hiroyuki| Okada, Hiroyuki|
Keywords eradication flow cytometry Helicobacter pylori T lymphocytes
Published Date 2022-08-26
Publication Title Medicine
Volume volume101
Issue issue34
Publisher Lippincott Williams & Wilkins
Start Page e30241
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s).
File Version publisher
PubMed ID 36042652
DOI 10.1097/MD.0000000000030241
Web of Science KeyUT 000847532100050
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000030241
FullText URL fulltext20220922-2.pdf Table1_20220922-2.pdf Table2_20220922-2.pdf figure20220922-2.pdf
Author Sato, Ryosuke| Matsumoto, Kazuyuki| Matsumi, Akihiro| Morimoto, Kosaku| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Horiguchi, Shigeru| Kato, Hironari|
Keywords EUS-guided pancreatic duct drainage Pancreatic duct perforation ERCP-related perforation
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12328-022-01699-1
This fulltext is available in Sep. 2023.|
Published Date 2022-09-12
Publication Title Clinical Journal of Gastroenterology
Volume volume15
Issue issue6
Publisher Springer Science and Business Media LLC
Start Page 1179
End Page 1184
ISSN 1865-7257
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Japanese Society of Gastroenterology 2022
File Version author
PubMed ID 36094734
DOI 10.1007/s12328-022-01699-1
Web of Science KeyUT 000852906700001
Related Url isVersionOf https://doi.org/10.1007/s12328-022-01699-1
FullText URL fulltext.pdf
Author Matsuoka-Uchiyama, Natsumi| Tsuji, Kenji| Sang, Yizhen| Takahashi, Kensaku| Fukushima, Kazuhiko| Takeuchi, Hidemi| Inagaki, Kenichi| Uchida, Haruhito A.| Kitamura, Shinji| Sugiyama, Hitoshi| Wada, Jun|
Published Date 2022-09-02
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 14999
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36056164
DOI 10.1038/s41598-022-19226-0
Web of Science KeyUT 000849436000046
Related Url isVersionOf https://doi.org/10.1038/s41598-022-19226-0
JaLCDOI 10.18926/AMO/63909
FullText URL 76_4_485.pdf
Author Takahashi, Yuya| Watanabe, Mototsugu| Furukawa, Shinichi| Shiotani, Toshio| Kataoka, Kazuhiko|
Abstract Aspergillosis is an infection caused by Aspergillus species, and it manifests in various clinical presentations. We describe the case of a 73-year-old man with a small area of thickening on the thoracic wall detected by computed tomography. Surgical resection confirmed the diagnosis of an Aspergillus abscess. We report this case in view of the rarity of Aspergillus abscess localized to a parietal pleura without any signs of lung parenchymal involvement. After a thorough literature review, we consider this could be the first report of this manifestation. Accumulation of similar cases will be necessary to help spread recognition of this condition.
Keywords Aspergillus abscess empyema fungal infection pulmonary aspergillosis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 485
End Page 488
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123165
JaLCDOI 10.18926/AMO/63908
FullText URL 76_4_479.pdf
Author Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance.
Keywords hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 479
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123164
Web of Science KeyUT 000882167300012
JaLCDOI 10.18926/AMO/63907
FullText URL 76_4_473.pdf
Author Tsuboi, Nobushige| Ishida, Joji| Shimazu, Yosuke| Edaki, Hisanori| Uneda, Atsuhito| Otani, Yoshihiro| Fujii, Kentaro| Kurozumi, Kazuhiko| Ennishi, Daisuke| Yanai, Hiroyuki| Date, Isao|
Abstract Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.
Keywords glioneuronal tumor with neuropil-like islands genomic profiling
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 473
End Page 477
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123163