| ID | 57367 |
| JaLCDOI | |
| FullText URL | |
| Author |
Fu, Li
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nishibori, Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.
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| Keywords | HMGB1
epileptogenesis
inflammation
blood-brain barrier
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| Amo Type | Review
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2019-10
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| Volume | volume73
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| Issue | issue5
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| Publisher | Okayama University Medical School
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| Start Page | 383
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| End Page | 386
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
