result 23258 件
Title Alternative | Pharmacokinetic analysis of drug absorption following nasal application to rats |
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FullText URL | poalas_033_003_007.pdf |
Author | 古林 呂之| |
Abstract | Since a drug applied to the nose in an in vivo physiologic condition is translocated to the gastrointestinal (GI) tract by mucociliary clearance (MC), the drug undergoes absorption both from the nasal cavity and from the GI tract. The detailed MC of the rat was examined, using inulin as a marker of the applied solution. Inulin disappeared monoexponentially from the nasal cavity, indicating that the MC can be assumed to follow first-order kinetics. In the proposed kinetic model, the fractional absorption of the drug following nasal application is predicted as the sum of fractional absorption from the nasal cavity and fractional absorption from the GI tract, both of which are estimated indirectly from the permeability to the Caco-2 monolayer. This kinetic model is the first estimation system for nasal drug absorption based on drug disposition after nasal application and is useful for the development of nasal dosage forms. |
Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
Published Date | 2017-04 |
Volume | volume33 |
Start Page | 3 |
End Page | 7 |
language | Japanese |
File Version | publisher |
Title Alternative | An Efficient Algorithm to Determine Equivalence of Pipelined Dependency Graphs for Their Simplification |
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FullText URL | j100-d_6_616.pdf |
Author | Kagotani, Hiroto| Sugiyama, Yuji| Okamoto, Takuji| |
Keywords | 非同期式制御回路 パイプライン 簡単化 因果関係 |
Note | 本研究は,JSPS 科研費 JP24500065,JP16H01723 の助成を受けたものである.| |
Published Date | 2017-06-01 |
Publication Title | The IEICE Transactions on Electronics |
Volume | volumeJ100-D |
Issue | issue6 |
Publisher | 電子情報通信学会 |
Start Page | 616 |
End Page | 626 |
ISSN | 18810225 |
NCID | AA12712944 |
Content Type | Journal Article |
language | Japanese |
OAI-PMH Set | 岡山大学 |
Copyright Holders | Copyright (c) by IEICE |
File Version | publisher |
DOI | 10.14923/transinfj.2016JDP7108 |
Official Url | https://search.ieice.org/| |
Author | Kondo, Mariko| Mori, Kazuo| Nomura, Hiroshi| Kadowaki, Hanako| Watanabe, Makiko| Doi, Akemi| Shima, Sayaka| |
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Published Date | 2016-12-29 |
Publication Title | Bioethics - Medical, Ethical and Legal Perspectives |
Content Type | Book |
Title Alternative | From Image to Icon : Making of the Idea of Representation |
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FullText URL | rpkj_024_021_031.pdf |
Author | Suzuki, Michitaka| |
Publication Title | 岡山大学文学部プロジェクト研究報告書 |
Published Date | 2017-03-31 |
Volume | volume24 |
Start Page | 21 |
End Page | 31 |
language | Japanese |
File Version | publisher |
FullText URL | O0004475_abstract_review.pdf O0004475_summary.pdf O0004475_fulltext.pdf |
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Author | Mandai, Kyoko| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 乙第4475号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Engineering |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005564_abstract_review.pdf K0005564_summary.pdf K0005564_fulltext.pdf |
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Author | Pineda Velasco, Ivan| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5564号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005562_abstract_review.pdf K0005562_fulltext.pdf |
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Author | Xu, Fang| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5562号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005560_abstract_review.pdf K0005560_fulltext.pdf |
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Author | Sanchez Calle, Anna| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5560号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Engineering |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005559_abstract_review.pdf K0005559_fulltext.pdf |
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Author | Kawaguchi, Yuka| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5559号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Engineering |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005558_abstract_review.pdf K0005558_fulltext .pdf |
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Author | Salmie Suhana Binti Che Abdullah| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5558号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005556_abstract_review.pdf K0005556_fulltext.pdf |
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Author | 郭 嘉躍| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5556号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Engineering |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005538_abstract_review.pdf K0005538_summary.pdf |
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Author | Uesugi, Eri| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5538号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005517_abstract_review.pdf K0005517_fulltext.pdf K0005517_summary.pdf |
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Author | Matsui, Miyuki| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5517号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Nursing Science |
Grantor | 岡山大学 |
language | Japanese |
FullText URL | K0005510 abstract_review.pdf K0005510_summary.pdf K0005510_fulltext.pdf |
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Author | Takeuchi, Mayu| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5510号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005509 abstract_review.pdf K0005509_summary.pdf K0005509_fulltext.pdf |
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Author | Kawabata, Yuya| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5509号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005508 abstract_review.pdf K0005508_summary.pdf K0005508_fulltext.pdf |
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Author | Kataoka, Kota| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5508号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005500 abstract_review.pdf K0005500_summary.pdf K0005500_fulltext.pdf |
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Author | Hashimoto, Yuki| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5500号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005499 abstract_review.pdf K0005499_summary.pdf K0005499_fulltext.pdf K0005499_other.pdf |
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Author | Kiyotaki, Yuya| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5499号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | Japanese |
FullText URL | K0005498 abstract_review.pdf K0005498_summary.pdf K0005498_fulltext.pdf K0005498_other.pdf |
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Author | Tamura, Shohei| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5498号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | Japanese |
FullText URL | K0005491 abstract_review.pdf K0005491_summary.pdf K0005491_fulltext.pdf |
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Author | Okada, Shunsuke| |
Published Date | 2017-03-24 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5491号 |
Granted Date | 2017-03-24 |
Thesis Type | Doctor of Philosophy in Dental Science |
Grantor | 岡山大学 |
language | Japanese |