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Title Alternative Pharmacokinetic analysis of drug absorption following nasal application to rats
FullText URL poalas_033_003_007.pdf
Author 古林 呂之|
Abstract Since a drug applied to the nose in an in vivo physiologic condition is translocated to the gastrointestinal (GI) tract by mucociliary clearance (MC), the drug undergoes absorption both from the nasal cavity and from the GI tract. The detailed MC of the rat was examined, using inulin as a marker of the applied solution. Inulin disappeared monoexponentially from the nasal cavity, indicating that the MC can be assumed to follow first-order kinetics. In the proposed kinetic model, the fractional absorption of the drug following nasal application is predicted as the sum of fractional absorption from the nasal cavity and fractional absorption from the GI tract, both of which are estimated indirectly from the permeability to the Caco-2 monolayer. This kinetic model is the first estimation system for nasal drug absorption based on drug disposition after nasal application and is useful for the development of nasal dosage forms.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2017-04
Volume volume33
Start Page 3
End Page 7
language Japanese
File Version publisher
Title Alternative An Efficient Algorithm to Determine Equivalence of Pipelined Dependency Graphs for Their Simplification
FullText URL j100-d_6_616.pdf
Author Kagotani, Hiroto| Sugiyama, Yuji| Okamoto, Takuji|
Keywords 非同期式制御回路 パイプライン 簡単化 因果関係
Note 本研究は,JSPS 科研費 JP24500065,JP16H01723 の助成を受けたものである.|
Published Date 2017-06-01
Publication Title The IEICE Transactions on Electronics
Volume volumeJ100-D
Issue issue6
Publisher 電子情報通信学会
Start Page 616
End Page 626
ISSN 18810225
NCID AA12712944
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
Copyright Holders Copyright (c) by IEICE
File Version publisher
DOI 10.14923/transinfj.2016JDP7108
Official Url https://search.ieice.org/|
Author Kondo, Mariko| Mori, Kazuo| Nomura, Hiroshi| Kadowaki, Hanako| Watanabe, Makiko| Doi, Akemi| Shima, Sayaka|
Published Date 2016-12-29
Publication Title Bioethics - Medical, Ethical and Legal Perspectives
Content Type Book
Title Alternative From Image to Icon : Making of the Idea of Representation
FullText URL rpkj_024_021_031.pdf
Author Suzuki, Michitaka|
Publication Title 岡山大学文学部プロジェクト研究報告書
Published Date 2017-03-31
Volume volume24
Start Page 21
End Page 31
language Japanese
File Version publisher
FullText URL O0004475_abstract_review.pdf O0004475_summary.pdf O0004475_fulltext.pdf
Author Mandai, Kyoko|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 乙第4475号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL K0005564_abstract_review.pdf K0005564_summary.pdf K0005564_fulltext.pdf
Author Pineda Velasco, Ivan|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5564号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language English
FullText URL K0005562_abstract_review.pdf K0005562_fulltext.pdf
Author Xu, Fang|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5562号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Science
Grantor 岡山大学
language English
FullText URL K0005560_abstract_review.pdf K0005560_fulltext.pdf
Author Sanchez Calle, Anna|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5560号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL K0005559_abstract_review.pdf K0005559_fulltext.pdf
Author Kawaguchi, Yuka|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5559号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL K0005558_abstract_review.pdf K0005558_fulltext .pdf
Author Salmie Suhana Binti Che Abdullah|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5558号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language English
FullText URL K0005556_abstract_review.pdf K0005556_fulltext.pdf
Author 郭 嘉躍|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5556号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL K0005538_abstract_review.pdf K0005538_summary.pdf
Author Uesugi, Eri|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5538号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Science
Grantor 岡山大学
language English
FullText URL K0005517_abstract_review.pdf K0005517_fulltext.pdf K0005517_summary.pdf
Author Matsui, Miyuki|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5517号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Nursing Science
Grantor 岡山大学
language Japanese
FullText URL K0005510 abstract_review.pdf K0005510_summary.pdf K0005510_fulltext.pdf
Author Takeuchi, Mayu|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5510号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
FullText URL K0005509 abstract_review.pdf K0005509_summary.pdf K0005509_fulltext.pdf
Author Kawabata, Yuya|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5509号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
FullText URL K0005508 abstract_review.pdf K0005508_summary.pdf K0005508_fulltext.pdf
Author Kataoka, Kota|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5508号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
FullText URL K0005500 abstract_review.pdf K0005500_summary.pdf K0005500_fulltext.pdf
Author Hashimoto, Yuki|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5500号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
FullText URL K0005499 abstract_review.pdf K0005499_summary.pdf K0005499_fulltext.pdf K0005499_other.pdf
Author Kiyotaki, Yuya|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5499号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language Japanese
FullText URL K0005498 abstract_review.pdf K0005498_summary.pdf K0005498_fulltext.pdf K0005498_other.pdf
Author Tamura, Shohei|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5498号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language Japanese
FullText URL K0005491 abstract_review.pdf K0005491_summary.pdf K0005491_fulltext.pdf
Author Okada, Shunsuke|
Published Date 2017-03-24
Content Type Thesis or Dissertation
Grant Number 甲第5491号
Granted Date 2017-03-24
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language Japanese