result 627 件
Author | Hirakawa, Tomoko| Kato, Jun| Okumura, Yoshihiro| Hori, Keisuke| Takahashi, Sakuma| Suzuki, Hideyuki| Akita, Mitsuhiro| Higashi, Reiji| Saito, Shunsuke| Kaji, Eisuke| Uraoka, Toshio| Hiraoka, Sakiko| Yamamoto, Kazuhide| |
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Published Date | 2012-02 |
Publication Title | Journal of Gastroenterology |
Volume | volume47 |
Issue | issue2 |
Content Type | Journal Article |
Author | Shinoura, Susumu| Fujiwara, Toshiyoshi| |
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Published Date | 2013-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue1 |
Content Type | Journal Article |
Author | Inada, Ryo| Nagasaka, Takeshi| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
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Published Date | 2013-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue1 |
Content Type | Journal Article |
Author | Inada, Ryo| Nagasaka, Takeshi| Takehara, Kiyoto| Sugihara, Masahiro| Mori, Yoshiko| Umeda, Yuzo| Kubota, Nobuhito| Morikawa, Tatsuya| Kondo, Yoshitaka| Uno, Futoshi| Sadamori, Yu| Yagi, Takahito| Fujiwara, Toshiyoshi| |
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Published Date | 2013-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue1 |
Content Type | Journal Article |
Author | Uno, Futoshi| Fujiwara, Yasuhiro| Fujiwara, Toshiyoshi| |
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Published Date | 2013-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue1 |
Content Type | Journal Article |
Author | Kojima, Toru| Watanabe, Yuichi| Hashimoto, Yuuri| Kuroda, Shinji| Yamasaki, Yasumoto| Yano, Shuya| Tazawa, Hiroshi| Uno, Futoshi| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
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Published Date | 2013-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue1 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/49040 |
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FullText URL | 66_6_443.pdf |
Author | Ugawa, Toyomu| Sakurama, Kazufumi| Yorifuji, Takashi| Takaoka, Munenori| Fujiwara, Yasuhiro| Kabashima, Narutoshi| Azuma, Daisuke| Hirayama, Takahiro| Tsukahara, Kohei| Morisada, Sunao| Iida, Atsuyoshi| Tada, Keitaro| Shiba, Naoki| Sato, Nobuo| Ichiba, Shingo| Kino, Koichi| Fukushima, Masaki| Ujike, Yoshihito| |
Abstract | The functioning of an arteriovenous fistula (AVF) used for vascular access during hemodialysis has been assessed mainly by dilution methods. Although these techniques indicate the immediate recirculation rate, the results obtained may not correlate with Kt/V. In contrast, the clearance gap (CL-Gap) method provides the total recirculation rate per dialysis session and correlates well with Kt/V. We assessed the correlation between Kt/V and CL-Gap as well as the change in radial artery (RA) blood flow speed in the fistula before percutaneous transluminal angioplasty (PTA) in 45 patients undergoing continuous hemodialysis. The dialysis dose during the determination of CL-Gap was 1.2 to 1.4 Kt/V. Patients with a 10% elevation or more than a 10% relative increase in CL-Gap underwent PTA (n=45), and the values obtained for Kt/V and CL-Gap before PTA were compared with those obtained immediately afterward. The mean RA blood flow speed improved significantly (from 52.9 to 97.5cm/sec) after PTA, as did Kt/V (1.07 to 1.30) and CL-Gap (14.1% to -0.2%). A significant correlation between these differences was apparent (r=-0.436 and p=0.003). These findings suggest that calculating CL-Gap may be useful for determining when PTA is required and for assessing the effectiveness of PTA, toward obtaining better dialysis. |
Keywords | hemodialysis recirculation clearance gap vascular access percutaneous transluminal angioplasty |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2012-12 |
Volume | volume66 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 443 |
End Page | 447 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23254578 |
Web of Science KeyUT | 000312966100003 |
Author | Takuma, Yoshitaka| Nouso, Kazuhiro| |
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Published Date | 2010-03-28 |
Publication Title | World Journal of Gastroenterology |
Volume | volume16 |
Issue | issue12 |
Content Type | Journal Article |
Author | Noguchi, Hirofumi| Fujiwara, Toshiyoshi| |
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Published Date | 2012-12-03 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue3 |
Content Type | Journal Article |
Author | Huang, P| Kaku, H| Chen, J| Kashiwakura, Y| Saika, T| Nasu, Y| Urata, Y| Fujiwara, T| Watanabe, M| Kumon, H| |
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Published Date | 2010-07 |
Publication Title | Cancer Gene Therapy |
Volume | volume17 |
Issue | issue7 |
Content Type | Journal Article |
Author | Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
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Published Date | 2009-10-01 |
Publication Title | The Journal of Clinical Investigation |
Volume | volume119 |
Issue | issue10 |
Content Type | Journal Article |
Author | Tanabe, Shunsuke| Shirakawa, Yasuhiro| Maeda, Naoaki| Ohara, Toshiaki| Noma, Kazuhiro| Sakurama, Kazufumi| Yanai, Hiroyuki| Yamatsuji, Tomoki| Naomoto, Yoshio| Fujiwara, Toshiyoshi| |
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Published Date | 2012-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue2 |
Content Type | Journal Article |
Author | Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
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Published Date | 2012-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue2 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/48268 |
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FullText URL | 66_2_177.pdf.pdf |
Author | Utsumi, Masashi| Matsuda, Hiroaki| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Satoh, Daisuke| Hashimoto, Masaaki| Yagi, Takahito| Fujiwara, Toshiyoshi| |
Abstract | We report 4 cases of surgical resection of metachronous lymph node (LN) metastases from hepatocellular carcinoma (HCC) following hepatectomy. Clinicopathological features and results of LN dissection were investigated in the 4 patients. One patient was found to have a single metastasis in the mediastinal LNs, another had multiple metastases in the mediastinal and abdominal LNs, and the other 2 had single metastases in the abdominal LN. The locations of the abdominal LN metastases were behind the pancreas head in 2 patients and around the abdominal aorta in 1 patient. They all underwent surgical resection of metastatic LNs and had no postoperative complications. The 3 patients whose LN metastases were solitary have been alive for more than 2 years after LN resection, and one of them is free from recurrence. The patient with multiple LN metastases died 13 months after LN resection due to carcinomatosis. With the expectation of long-term survival, a single metachronous LN metastasis from HCC after hepatectomy should be resected in patients without uncontrollable intrahepatic or extrahepatic tumors. |
Keywords | hepatocellular carcinoma lymph node metastasis hepatectomy |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2012-04 |
Volume | volume66 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 177 |
End Page | 182 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22525476 |
Web of Science KeyUT | 000303175300011 |
JaLCDOI | 10.18926/AMO/48258 |
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FullText URL | 66_2_83.pdf.pdf |
Author | Kuroda, Shinji| Urata, Yasuo| Fujiwara, Toshiyoshi| |
Abstract | Radiotherapy plays a central part in cancer treatment, and use of radiosensitizing agents can greatly enhance this modality. Although studies have shown that several chemotherapeutic agents have the potential to increase the radiosensitivity of tumor cells, investigators have also studied a number of molecularly targeted agents as radiosensitizers in clinical trials based on reasonably promising preclinical data. Recent intense research into the DNA damage-signaling pathway revealed that ataxia-telangiectasia mutated (ATM) and the Mre11-Rad50-NBS1 (MRN) complex play central roles in DNA repair and cell cycle checkpoints and that these molecules are promising targets for radiosensitization. Researchers recently developed three ATM inhibitors (KU-55933, CGK733, and CP466722) and an MRN complex inhibitor (mirin) and showed that they have great potential as radiosensitizers of tumors in preclinical studies. Additionally, we showed that a telomerase-dependent oncolytic adenovirus that we developed (OBP-301 [telomelysin]) produces profound radiosensitizing effects by inhibiting the MRN complex via the adenoviral E1B55kDa protein. A recent Phase I trial in the United States determined that telomelysin was safe and well tolerated in humans, and this agent is about to be tested in combination with radiotherapy in a clinical trial based on intriguing preclinical data demonstrating that telomelysin and ionizing radiation can potentiate each other. In this review, we highlight the great potential of ATM and MRN complex inhibitors, including telomelysin, as radiosensitizing agents. |
Keywords | ATM (ataxia-telangiectasia mutated) MRN (Mre11-Rad50-NBS1) complex radiosensitization adenovirus E1B55kDa |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2012-04 |
Volume | volume66 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 83 |
End Page | 92 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22525466 |
Web of Science KeyUT | 000303175300001 |
Author | Nishizaki, Masahiko| Fujiwara, Yasuhiro| Chouda, Yasuhiro| Kanazawa, Takashi| Ninomiya, Motoki| Fujiwara, Toshiyoshi| |
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Published Date | 2012-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue1 |
Content Type | Journal Article |
Author | Shinoura, Susumu| Yagi, Takahito| Sadamori, Hiroshi| Matsuda, Hiroaki| Umeda, Yuzo| Yoshida, Ryuichi| Satoh, Daisuke| Utsumi, Masashi| Yokomichi, Naosuke| Kuise, Takashi| Fujiwara, Toshiyoshi| |
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Published Date | 2012-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue1 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/47265 |
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FullText URL | 65_6_395.pdf |
Author | Harada, Sosuke| Sato, Shuhei| Suzuki, Etsuji| Okumura, Yoshihiro| Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Kanazawa, Susumu| Kaji, Mitsumasa| Fujiwara, Toshiyoshi| |
Abstract | The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUVmax). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUVmax. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUVmax and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUVmax showed higher recurrence odds ratios (medium group;1.84, high group;4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67);we thought this was mainly due to selection bias because we excluded tumors less than 10mm in diameter. This study demonstrated the pre-RFA SUVmax in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors. |
Keywords | fluorodeoxyglucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) lung |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2011-12 |
Volume | volume65 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 395 |
End Page | 402 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22189480 |
Web of Science KeyUT | 000298516900006 |
Author | Satoh, Daisuke| Yagi, Takahito| Sadamori, Hiroshi| Umeda, Yuzo| Fujiwara, Toshiyoshi| |
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Published Date | 2011-12-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume123 |
Issue | issue3 |
Content Type | Journal Article |
Author | Satoh, Daisuke| Yagi, Takahito| Sadamori, Hiroshi| Matsuda, Hiroaki| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Utsumi, Takashi| Fujiwara, Toshiyoshi| |
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Published Date | 2011-12-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume123 |
Issue | issue3 |
Content Type | Journal Article |