result 627 件
Author | Nakarai, Asuka| Kato, Jun| Hiraoka, Sakiko| Kuriyama, Motoaki| Inokuchi, Toshihiro| Takei, Daisuke| Moritou, Yuki| Akita, Mitsuhiro| Takahashi, Sakuma| Harada, Keita| Okada, Hiroyuki| Yamamoto, Kazuhide| |
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Published Date | 2013-12-02 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue3 |
Content Type | Journal Article |
Author | Tazawa, Hiroshi| Yano, Syuya| Yoshida, Ryosuke| Yamasaki, Yasumoto| Sasaki, Tsuyoshi| Hashimoto, Yuuri| Kuroda, Shinji| Ouchi, Masaaki| Onishi, Teppei| Uno, Futoshi| Kagawa, Syunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
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Published Date | 2013-12-02 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue3 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/51864 |
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FullText URL | 67_5_285.pdf |
Author | Akita, Mitsuhiro| Hiraoka, Sakiko| Kaji, Eisuke| Takemoto, Koji| Nagahara, Yasuhiro| Yamamoto, Hiroshi| Yamamoto, Kazuhide| Kato, Jun| |
Abstract | Whether presence or history of extracolonic primary malignancy is a risk for colorectal neoplasia is not fully known. In this study, 26,452 first-time colonoscopy cases were examined using a colonoscopy database. Among the analyzed subjects, 3,026 (11%) subjects had history or concomitance of extracolonic primary malignancy, while the remaining 23,426 subjects did not. Colorectal neoplasia was observed in 39% of all the subjects. A crude comparison showed that the prevalence of any type of colorectal neoplasia was higher in subjects with extracolonic malignancy than in those without (42% vs. 39%, p=0.0012). However, after adjusting for confounding factors, the odds ratios (ORs) of subjects with extracolonic malignancy for having colorectal neoplasia, advanced neoplasia, and cancer were all less than 1.0, and all significantly different from those of subjects without extracolonic malignancy. Analysis according to the type of extracolonic malignancy revealed that gastric cancer cases had a significantly lower risk for colorectal advanced neoplasia (OR:0.81;95% CI:0.67-0.99). Among major malignancies, only esophageal squamous cell cancer cases had increased risk for colorectal neoplasia (OR:1.66;95% CI:1.20-2.29). Patients with presence or history of extracolonic malignancy did not carry a higher risk of occurrence of colorectal neoplasia. |
Keywords | colorectal cancer colonoscopy risk factor database |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2013-10 |
Volume | volume67 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 285 |
End Page | 292 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 24145728 |
Web of Science KeyUT | 000325836100002 |
Author | Nishimura, Mamoru| Takaki, Akinobu| Tamaki, Naofumi| Maruyama, Takayuki| Onishi, Hideki| Kobayashi, Sayo| Nouso, Kazuhiro| Yasunaka, Tetsuya| Koike, Kazuko| Hagihara, Hiroaki| Kuwaki, Kenji| Nakamura, Shinichiro| Ikeda, Fusao| Iwasaki, Yoshiaki| Tomofuji, Takaaki| Morita, Manabu| Yamamoto, Kazuhide| |
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Published Date | 2013-01-30 |
Publication Title | Hepatology Research |
Volume | volume43 |
Issue | issue10 |
Content Type | Journal Article |
FullText URL | WorldJHepatology_5_4_189-195.pdf |
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Author | Satoh, Daisuke| Yagi, Takahito| Nagasaka, Takeshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Utsumi, Masashi| Tanaka, Takehiro| Sadamori, Hiroshi| Fujiwara, Toshiyoshi| |
Keywords | Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells |
Published Date | 2013-04-27 |
Publication Title | World Journal of Hepatology |
Volume | volume5 |
Issue | issue4 |
Start Page | 189 |
End Page | 195 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | ©2013 Baishideng Publishing Group Co., Limited. All rights reserved. |
File Version | publisher |
DOI | 10.4254/wjh.v5.i4.189 |
Official Url | http://www.wjgnet.com/1948-5182/full/v5/i4/189.htm| |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/51448 |
Author | Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
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Published Date | 2013-03 |
Publication Title | Molecular Cancer Therapeutics |
Volume | volume12 |
Issue | issue3 |
Content Type | Journal Article |
Author | Nishikawa, Toshio| Takaoka, Munenori| Ohara, Toshiaki| Tomono, Yasuko| Hao, Huifang| Bao, Xiaohong| Fukazawa, Takuya| Wang, Zhigang| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Motoki, Takayuki| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Tanaka, Noriaki| Fujiwara, Toshiyoshi| Naomoto, Yoshio| |
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Published Date | 2013-03 |
Publication Title | Cancer Biology & Therapy |
Volume | volume14 |
Issue | issue3 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/51068 |
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FullText URL | 67_4_239.pdf |
Author | Nakamura, Shinichiro| Nouso, Kazuhiro| Kobayashi, Yoshiyuki| Shiraha, Hidenori| Ohnishi, Hideki| Toshimori, Junichi| Kuwaki, Kenji| Hagihara, Hiroaki| Takayama, Hiroki| Yamamoto, Kazuhide| |
Abstract | The aim of this study was to evaluate the histologic diagnosis of hypovascular hepatic lesions showing hypointensity on hepatobiliary phase images of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI (EOB-MRI). In 38 patients with hepatocellular carcinoma (HCC) after curative treatments and 18 patients with liver cirrhosis, 105 hypovascular nodules that were hypointense at the hepatobiliary phase of EOB-MRI were biopsied and the clinical usefulness of these EOB-MRI findings for the diagnosis of HCC was examined. Of the 105 nodules (median diameter=12mm), 78 (74.3%), 11 (10.5%), and 16 (15.2%) were diagnosed as HCC, dysplastic, and non-neoplastic, respectively. The positive predictive value (PPV) of hypointensity at the hepatobiliary phase of EOB-MRI for the diagnosis of HCC increased to 77-90% when combined with the following factors: washout appearance on the delayed phase of triple-phase CT, hyperintensity in diffusion-weighted image of MRI, or the appearance of a hypoechoic part in ultrasonography. PPV increased to 100% when all 3 factors were positive. A relatively large proportion of hypovascular lesions that showed hypo-intensity in the hepatobiliary phase were confirmed to be HCC, and the accuracy of HCC increased when combined with other imaging findings. |
Keywords | hepatocellular carcinoma hypovascular diagnosis gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2013-08 |
Volume | volume67 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 239 |
End Page | 244 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23970322 |
Web of Science KeyUT | 000323470100005 |
JaLCDOI | 10.18926/AMO/51065 |
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FullText URL | 67_4_213.pdf |
Author | Kawahara, Michiko| Sato, Shuhei| Ida, Yukiko| Watanabe, Masao| Fujishima, Mamoru| Ishii, Hiroaki| Hori, Keisuke| Kanazawa, Susumu| |
Abstract | A relatively large number of women in their 40s with high-density breasts, in which it can be difficult to detect lesions, are encountered in mammography cancer screenings in Japan. Here, we retrospectively investigated factors related to breast density. Two hundred women (40-49 years old) were examined at the screening center in our hospital. Multivariate analysis showed that factors such as small abdominal circumference, high HDL cholesterol, and no history of childbirth were related to high breast density in women in their 40s undergoing mammography. Other non-mammographic screening methods should be considered in women with abdominal circumferences <76cm, HDL-C >53mg/dl, and no history of childbirth, as there is a strong possibility of these women having high-density breasts that can make lesion detection difficult. |
Keywords | high-density breasts abdominal circumference high-density lipoprotein cholesterol childbirth mammography |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2013-08 |
Volume | volume67 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 213 |
End Page | 217 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23970319 |
Web of Science KeyUT | 000323470100002 |
Author | Suzuki, Hideyuki| Kato, Jun| Kuriyama, Motoaki| Hiraoka, Sakiko| Kuwaki, Kenji| Yamamoto, Kazuhide| |
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Published Date | 2010-03-14 |
Publication Title | World Journal of Gastroenterology |
Volume | volume16 |
Issue | issue10 |
Content Type | Journal Article |
Author | Nagasaka, Takeshi| Fujiwara, Toshiyoshi| |
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Published Date | 2013-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume125 |
Issue | issue2 |
Content Type | Journal Article |
Author | Nobuoka, Daisuke| Yoshikawa, Toshiaki| Takahashi, Mari| Iwama, Tatsuaki| Horie, Kazutaka| Shimomura, Manami| Suzuki, Shiro| Sakemura, Noriko| Nakatsugawa, Munehide| Sadamori, Hiroshi| Yagi, Takahito| Fujiwara, Toshiyoshi| Nakatsura, Tetsuya| |
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Published Date | 2013-04 |
Publication Title | Cancer Immunology, Immunotherapy |
Volume | volume62 |
Issue | issue4 |
Content Type | Journal Article |
Author | Tsutsumi, Koichiro| Kawamoto, Hirofumi| Hirao, Ken| Sakakihara, Ichiro| Yamamoto, Naoki| Noma, Yasuhiro| Fujii, Masakuni| Kato, Hironari| Ogawa, Tsuneyoshi| Ishida, Etsuji| Kuwaki, Kenji| Nouso, Kazuhiro| Okada, Hiroyuki| Yamamoto, Kazuhide| |
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Published Date | 2012-09 |
Publication Title | Pancreatology |
Volume | volume12 |
Issue | issue5 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/49672 |
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FullText URL | 67_2_123.pdf |
Author | Tanabe, Shunsuke| Shirakawa, Yasuhiro| Takehara, Yuko| Maeda, Naoaki| Katsube, Ryoichi| Ohara, Toshiaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi| |
Abstract | An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patientʼs condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital. |
Keywords | pneumatosis cystoides intestinalis pneumoperitoneum α-glucosidase inhibitor |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2013-04 |
Volume | volume67 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 123 |
End Page | 128 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23603930 |
Web of Science KeyUT | 000317801700008 |
JaLCDOI | 10.18926/AMO/49671 |
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FullText URL | 67_2_117.pdf |
Author | Sadamori, Hiroshi| Yagi, Takahito| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Sato, Daisuke| Nobuoka, Daisuke| Utsumi, Masashi| Fujiwara, Toshiyoshi| |
Abstract | We present a case of living donor liver transplantation to a 3-year disease-free survivor of liver resection for hepatocellular carcinoma (HCC) with major portal vein invasion. A 48-year-old man had HCC in the right lobe with a portal venous tumor thrombus extending into the left portal vein. An extended right lobectomy with thrombectomy was performed to remove the thrombus. Three years after liver resection, the patient experienced liver failure, with massive ascites and jaundice due to the formation of a thrombus in the main and left portal veins. During the 3 years after liver resection, no metastasis or recurrence of HCC had been detected, and tumor markers had been within normal ranges. The portal venous thrombus did not show any arterial enhancement under contrast-enhanced computed tomography, suggesting that the co-existence of any HCC component in the portal venous thrombus may have been negative. Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patientʼs son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence. |
Keywords | living donor liver transplantation hepatocellular carcinoma portal vein invasion liver resection |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2013-04 |
Volume | volume67 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 117 |
End Page | 121 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23603929 |
Web of Science KeyUT | 000317801700007 |
JaLCDOI | 10.18926/AMO/49669 |
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FullText URL | 67_2_105.pdf |
Author | Alafate, Aierken| Shinya, Takayoshi| Okumura, Yoshihiro| Sato, Shuhei| Hiraki, Takao| Ishii, Hiroaki| Gobara, Hideo| Kato, Katsuya| Fujiwara, Toshiyoshi| Miyoshi, Shinichiro| Kaji, Mitsumasa| Kanazawa, Susumu| |
Abstract | We retrospectively evaluated the accumulation of fluorodeoxy glucose (FDG) in pulmonary malignancies without local recurrence during 2-year follow-up on positron emission tomography (PET)/computed tomography (CT) after radiofrequency ablation (RFA). Thirty tumors in 25 patients were studied (10 non-small cell lung cancers;20 pulmonary metastatic tumors). PET/CT was performed before RFA, 3 months after RFA, and 6 months after RFA. We assessed the FDG accumulation with the maximum standardized uptake value (SUVmax) compared with the diameters of the lesions. The SUVmax had a decreasing tendency in the first 6 months and, at 6 months post-ablation, FDG accumulation was less affected by inflammatory changes than at 3 months post-RFA. The diameter of the ablated lesion exceeded that of the initial tumor at 3 months post-RFA and shrank to pre-ablation dimensions by 6 months post-RFA. SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA. |
Keywords | fluorodeoxy glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) non-small cell lung cancer (NSCLC) |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2013-04 |
Volume | volume67 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 105 |
End Page | 112 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23603927 |
Web of Science KeyUT | 000317801700005 |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/50688 |
JaLCDOI | 10.18926/AMO/49667 |
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FullText URL | 67_2_93.pdf |
Author | Kita, Masahide| Yokota, Kenji| Okada, Hiroyuki| Take, Susumu| Takenaka, Ryuta| Kawahara, Yoshiro| Oguma, Keiji| Matsushita, Osamu| Yamamoto, Kazuhide| |
Abstract | Atrophy of the gastric mucosa is a precursor of intestinal-type gastric cancer, and Helicobacter pylori infection causes atrophic gastritis. The aim of this study was to determine whether the genetic diversity of H. pylori virulence genes is associated with the development and progression of gastric atrophy in humans. We isolated and cultured H. pylori strains from patients with gastric ulcer and duodenal ulcer accompanied by atrophic gastritis in background mucosa. H. pylori strains were stored at -80℃ prior to the experiments being carried out. We analyzed iceA, babA, vacA, cagA, and cagE genes by PCR. The cagA gene was analyzed through sequencing of the C-terminal region containing the EPIYA motif, which is related to tyrosine phosphorylation. Severe atrophy was observed in patients with gastric ulcer. The major phenotype of the vacA gene was s1c/m1 (93オ). The cagA gene was detected in all strains. The cagE gene was not detected in 2 and 5 strains from the mild cases and severe cases, respectively. The major cagA EPIYA motif, which is amino acids repeat in the C terminus, was the A-B-D type (44 of 58 strains). The virulence genes were not statistically associated with the severity of atrophy in the background gastric mucosa in humans. Not only identification of bacterial virulence factors but also studies of the host response will be necessary to investigate the progression of gastric atrophy and subsequent cancer development in humans. |
Keywords | Helicobacter pylori virulence genes chronic atrophic gastritis |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2013-04 |
Volume | volume67 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 93 |
End Page | 98 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 23603925 |
Web of Science KeyUT | 000317801700003 |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52508 |
Author | Hao, Hui-fang| Takaoka, Munenori| Bao, Xiao-hong| Wang, Zhi-gang| Tomono, Yasuko| Sakurama, Kazufumi| Ohara, Toshiaki| Fukazawa, Takuya| Yamatsuji, Tomoki| Fujiwara, Toshiyoshi| Naomoto, Yoshio| |
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Published Date | 2012-07-13 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume423 |
Issue | issue4 |
Content Type | Journal Article |
Author | Hashimoto, Yuuri| Tazawa, Hiroshi| Teraishi, Fuminori| Kojima, Toru| Watanabe, Yuichi| Uno, Futoshi| Yano, Shuya| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
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Published Date | 2012-06-15 |
Publication Title | PLoS ONE |
Volume | volume7 |
Issue | issue6 |
Content Type | Journal Article |
Author | Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
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Published Date | 2012-11 |
Publication Title | Cancer Immunology, Immunotherapy |
Volume | volume61 |
Issue | issue11 |
Content Type | Journal Article |