result 18200 件
FullText URL | K0005079 abstract_review.pdf K0005079_fulltext.pdf |
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Author | Matsumori, Kazuyuki| |
Published Date | 2015-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5079号 |
Granted Date | 2015-03-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005078 abstract_review.pdf K0005078_fulltext.pdf |
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Author | Tomoda, Takeshi| |
Published Date | 2015-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5078号 |
Granted Date | 2015-03-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
FullText URL | K0005077 abstract_review.pdf K0005077_fulltext.pdf |
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Author | Akita, Mitsuhiro| |
Published Date | 2015-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第5077号 |
Granted Date | 2015-03-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
JaLCDOI | 10.18926/AMO/53342 |
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FullText URL | 69_2_123.pdf |
Author | Waseda, Koichi| Hagiya, Hideharu| Hanayama, Yoshihisa| Terasaka, Tomohiro| Kimura, Kosuke| Tsuzuki, Takao| Hasegawa, Kou| Nada, Takahiro| Nakamura, Eri| Murakami, Kazutoshi| Kondo, Eisei| Otsuka, Fumio| |
Abstract | An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients. |
Keywords | bronchial alveolar lavage eosinophilic pneumonia eosinophilia interstitial lung diseases Sjögren syndrome |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 123 |
End Page | 127 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899635 |
Web of Science KeyUT | 000353181700008 |
JaLCDOI | 10.18926/AMO/53341 |
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FullText URL | 69_2_119.pdf |
Author | Terasaka, Tomohiro| Hagiya, Hideharu| Kimura, Kosuke| Nada, Takahiro| Nakamura, Eri| Hanayama, Yoshihisa| Sugiyama, Hitoshi| Kobayashi, Yasuyuki| Yanai, Hiroyuki| Otsuka, Fumio| |
Abstract | We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia. |
Keywords | catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 119 |
End Page | 122 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899634 |
Web of Science KeyUT | 000353181700007 |
JaLCDOI | 10.18926/AMO/53340 |
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FullText URL | 69_2_113.pdf |
Author | Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi| |
Abstract | A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control. |
Keywords | colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 113 |
End Page | 118 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899633 |
Web of Science KeyUT | 000353181700006 |
JaLCDOI | 10.18926/AMO/53339 |
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FullText URL | 69_2_105.pdf |
Author | Sawada, Daijo| Ogawa, Takaaki| Miyake, Minoru| Hasui, Yoshinori| Yamaguchi, Fuminori| Izumori, Ken| Tokuda, Masaaki| |
Abstract | We examined and compared the inhibitory effects of D-tagatose on the growth, acid production, and water-insoluble glucan synthesis of GS5, a bacterial strain of Streptococcus mutans, with those of xylitol, D-psicose, L-psicose and L-tagatose. GS5 was cultured for 12h in a medium containing 10オ (w/v) of xylitol, D-psicose, L-psicose, D-tagatose or L-tagatose, and the inhibitory effect of GS5 growth was assessed. Each sugar showed different inhibitory effects on GS5. Both D-tagatose and xylitol significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1オ (w/v) sucrose. However, the inhibitory effect of acid production by D-tagatose was significantly stronger than that of xylitol in presence of sucrose. |
Keywords | Streptococcus mutans D-tagatose xylitol acid production water-insoluble glucan |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 105 |
End Page | 111 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899632 |
Web of Science KeyUT | 000353181700005 |
JaLCDOI | 10.18926/AMO/53338 |
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FullText URL | 69_2_95.pdf |
Author | Lee, Mi Geum| Lee, Dong Kyu| Huh, Billy K.| Choi, Sang Sik| Kim, Hee Zoo| Lim, Byung Gun| Kim, Hong Soon| Choi, Yun Suk| Hur, Won Seok| Lee, Mi Kyoung| |
Abstract | Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine-which has been shown to relieve intradermal capsaicin-induced hyperalgesia-on the initial hyperalgesic response and the thermal analgesic property of RTX. Thirty-six male rats were divided into 6 treatment groups (n=6 each):RTX 500ng, RTX 1μg, clonidine 20μg (Cl), Cl+RTX 500ng, Cl+RTX 1μg, or normal saline 20μL (control). We evaluated the short-term (180min) and long-term (20 days) analgesic effects of RTX after thermal stimulation and mechanical stimulation. RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500ng and RTX 1μg groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine. The Cl+RTX 1μg ratsʼ behavior scores indicated that they were more calm and comfortable compared to the RTX 1μg rats. Even though we cannot precisely confirm that pretreatment with clonidine potentiates or adds to the analgesic effect of RTX, clonidine pretreatment with epidural RTX eliminated the initial RTX-associated hyperalgesic response and systemic toxicity in this neuropathic pain rat model. |
Keywords | clonidine epidural administration resiniferatoxin spinal nerve ligation rat model thermal hyperalgesia |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 95 |
End Page | 103 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899631 |
Web of Science KeyUT | 000353181700004 |
JaLCDOI | 10.18926/AMO/53337 |
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FullText URL | 69_2_87.pdf |
Author | Murayama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Watanabe, Hirokazu| Shigemitsu, Yusuke| Iwasaki, Yuka| Tokorodani, Chiho| Miyazawa, Mari| Nishiuchi, Ritsuo| Kikkawa, Kiyoshi| |
Abstract | Ventriculoperitoneal shunts (VPSs) are used for the treatment of hydrocephalus. Here we analyzed the outcomes of VPS placements in 24 infants to determine the risk factors for shunt failure. The infants had undergone the initial VPS operation in our hospital between March 2005 and December 2013. They were observed until the end of January 2014. We obtained Kaplan-Meier curves and performed a multivariate Cox regression analysis of shunt failure. Of the 24 cases, the median (range) values for gestational age, birth weight, and birth head circumference (HC) were 37 (27-39) wks, 2,736 (686-3,788) g, and 35.3 (23.0-45.3) cm, respectively. The total number of shunt procedures was 45. Shunt failure rates were 0.51/shunt and 0.0053/shunt/year. Shunt infection rates were 0.13/shunt and 0.0014/shunt/year. The Kaplan-Meier analysis revealed an increased risk for shunt failure in infants <1 month old or in the HC >90オtile. The Cox regression analysis yielded hazard ratios (HRs) of 2.93 (95オ confidence interval (CI), 0.96-10.95, p=0.059) for age <1 month, and 4.46 (95オCI:1.20-28.91,p=0.023) for the HC >90オtile. The multivariate Cox regression analysis showed adjusted HRs of 17.56 (95オCI:2.69-202.8, p=0.001) for age <1 month, and 2.95 (95オCI:0.52-24.84, p=0.228) for the HC >90オtile. Our findings thus revealed that the risk factors for shunt failure in infants include age <1 month at the initial VPS placement. |
Keywords | head circumference shunt failure shunt infection ventriculoperitoneal shunt |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 87 |
End Page | 93 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899630 |
Web of Science KeyUT | 000353181700003 |
JaLCDOI | 10.18926/AMO/53335 |
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FullText URL | 69_2_71.pdf |
Author | Hiramoto, Hiroki| Dansako, Hiromichi| Takeda, Midori| Satoh, Shinya| Wakita, Takaji| Ikeda, Masanori| Kato, Nobuyuki| |
Abstract | Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies. |
Keywords | HCV annexin A1 Li23 cell line Li23-derived D7 cells HCV-JFH-1 |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-04 |
Volume | volume69 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 71 |
End Page | 78 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25899628 |
Web of Science KeyUT | 000353181700001 |
JaLCDOI | 10.18926/OLR/53329 |
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Title Alternative | A note on the Continuing Legal Education Program for in-house lawyers (Part1) |
FullText URL | olr_014_013_023.pdf |
Author | Fujimoto, Kazunari| |
Publication Title | 臨床法務研究 |
Published Date | 2015-03 |
Volume | volume14 |
Start Page | 13 |
End Page | 23 |
ISSN | 1881-1485 |
language | Japanese |
File Version | publisher |
NAID | 120005595783 |
JaLCDOI | 10.18926/53320 |
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Title Alternative | A Bibliographic Study of the Transition of the Chinese Characters Representing 'Jomon' |
FullText URL | hss_039_213_232.pdf |
Author | Satomi, Ayako| |
Publication Title | 岡山大学大学院社会文化科学研究科紀要 |
Published Date | 2015-03-26 |
Volume | volume39 |
Start Page | 213 |
End Page | 232 |
ISSN | 1881-1671 |
language | Japanese |
Copyright Holders | Copyright © 2015 岡山大学大学院社会文化科学研究科 |
File Version | publisher |
NAID | 120005593537 |
Author | Kuranoshin, Kato| Rikako, Akagi| Haruko, Kato| Yuichi, Haga| |
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Published Date | 2015-02 |
Publication Title | 環境制御 |
Volume | volume36 |
Content Type | Departmental Bulletin Paper |
FullText URL | hara_CASPer15_final_rev2.pdf |
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Author | Hara, Sunao| Abe, Masanobu| Sonehara, Noboru| |
Note | © © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The article has been accepted for publication. Published in:Pervasive Computing and Communication Workshops (PerCom Workshops), 2015 IEEE International Conference on; Date of Conference:23-27 March 2015; Page(s):390 - 395; Conference Location : St. Louis, MO, USA; Publisher:IEEE; Publisher URL:http://dx.doi.org/10.1109/PERCOMW.2015.7134069 ; © Copyright 2015 IEEE - All rights reserved.| |
Published Date | 2015-03 |
Publication Title | Proceedings of 2015 IEEE International Conference on Pervasive Computing and Communication Workshops (PerCom Workshops) |
Publisher | IEEE |
Start Page | 390 |
End Page | 395 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
DOI | 10.1109/PERCOMW.2015.7134069 |
Title Alternative | PD-1,CTLA-4 |
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FullText URL | 127_63.pdf |
Author | Eikawa, Shingo| |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-04-01 |
Volume | volume127 |
Issue | issue1 |
Start Page | 63 |
End Page | 65 |
ISSN | 0030-1558 |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.63 |
NAID | 130005068337 |
Author | Makihara, Seiichiro| Okano, Mitsuhiro| |
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Published Date | 2015-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume127 |
Issue | issue1 |
Content Type | Journal Article |
Title Alternative | Gene therapy using REIC/Dkk-3-encoding adenoviral vector for the treatment of malignant pleural mesothelioma |
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FullText URL | 127_47.pdf |
Author | Toyooka, Shinichi| |
Keywords | 悪性胸膜中皮腫 REIC/DKK-3 遺伝子治療 |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-04-01 |
Volume | volume127 |
Issue | issue1 |
Start Page | 47 |
End Page | 50 |
ISSN | 0030-1558 |
Related Url | http://www.okayama-u.ac.jp/user/oma/ |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.47 |
NAID | 130005068349 |
Title Alternative | A phase I trial of 100㎎/㎡ docetaxel in advanced or recurrent breast cancer patients |
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FullText URL | 127_41.pdf |
Author | Hirata, Taizo| |
Keywords | 進行・再発乳癌 ドセタキセル 100㎎/㎡ 医師主導治験 |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-04-01 |
Volume | volume127 |
Issue | issue1 |
Start Page | 41 |
End Page | 45 |
ISSN | 0030-1558 |
Related Url | http://www.okayama-u.ac.jp/user/oma/ |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.41 |
NAID | 130005068352 |
Title Alternative | Cholelithiasis with a cholecystoduodenal fistula complicated with paroxysmal nocturnal hemoglobinuria |
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FullText URL | 127_35.pdf |
Author | Kato, Takuya| Matsukawa, Hiroyoshi| Shiozaki, Shigehiro| Fuji, Tomokazu| Fujiwara, Yasuhiro| Ninomiya, Motoki| |
Abstract | In cases of paroxysmal nocturnal hemoglobinuria (PNH), attention must be paid to potential complications such as thrombosis and hemolysis due to perioperative stress and infection from complement activation. Here we present the case of a 61-year-old Japanese woman with PNH. We made the diagnosis of PNH when she was 28 years old, and we administered repeated steroid medication and erythrocyte transfusion. The patient's cholecystocholedocholithiasis with a cholecystoduodenal fistula was diagnosed based on a survey of the right hypochondriac pain. We performed endoscopic nasobiliary drainage (ENBD) for the prophylaxis of perioperative infection, plus a cholecystectomy and fistulectomy. There were no complications, including hemolysis attack, infection, thrombosis with irrigation erythrocyte transfusion, steroid cover, or the need for heparin administration during the perioperative period. The reduction of the complement activation is necessary in the perioperative management of PNH patients. The prevention of the development of acidosis and hypoxemia, the selection of washed red blood cells, steroid use, appropriate infection measures and thrombosis prophylaxis are all important for the prevention of complications. |
Keywords | 発作性夜間血色素尿症(PNH)(paroxysmal nocturnal hemoglobinuria (PNH)) 胆嚢十二指腸瘻(cholecystoduodenal fistula) 溶血発作(hemolysis) |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-04-01 |
Volume | volume127 |
Issue | issue1 |
Start Page | 35 |
End Page | 39 |
ISSN | 0030-1558 |
Related Url | http://www.okayama-u.ac.jp/user/oma/ |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.35 |
NAID | 130005068351 |
Title Alternative | Laparoscopic repair of an abdominal incisional hernia above the pubis |
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FullText URL | 127_31.pdf |
Author | Nakano, Kanyu| Idani, Hitoshi| Asami, Shinya| Ookawa, Hiro| Yoshimoto, Masashi| Ito, Atene| Monden, Kazuteru| Kurose, Yohei| Hioki, Masayoshi| Ishii, Tatsuhiro| Sadamori, Hiroshi| Oono, Satoshi| Kin, Hitoshi| Takakura, Norihisa| |
Abstract | Laparoscopic repair of a suprapubic hernia typically carries a high risk of recurrence, because fixation of the mesh in the peripubic area is difficult. We herein report a patient undergoing laparoscopic repair of a suprapubic hernia, along with a description of the surgical techniques employed. A 78-year-old woman visited our hospital with a chief complaint of swelling at the median hypogastric incision site after surgery for an ovarian cyst performed at age 25 years. Laparoscopic examination revealed the hernia orifice to be 3.5×3.0 cm in size and that the distance between the caudal margin of the hernia orifice and the pubis was 2.5 cm. Parietex composite mesh was used for fixation through all layers of the abdominal wall with non-absorbable sutures and tack fixation. On the pubic side, after the pubis had been exposed by separating it from the bladder, we performed mesh fixation through all layers of the abdominal wall immediately above the pubis with the sutures placed inside the mesh, combined with tack mesh fixation directly to the pubis. This procedure enabled definite fixation of the mesh. Six days after surgery, she was discharged without complications. To date, two years and five months after surgery, no recurrence has been observed. |
Keywords | 腹壁瘢痕ヘルニア(incisional hernia) 恥骨上ヘルニア(suprapubic hernia) 腹腔鏡下修復術(laparoscopic repair) |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-04-01 |
Volume | volume127 |
Issue | issue1 |
Start Page | 31 |
End Page | 34 |
ISSN | 0030-1558 |
Related Url | http://www.okayama-u.ac.jp/user/oma/ |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.31 |
NAID | 130005068354 |