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FullText URL K0005079 abstract_review.pdf K0005079_fulltext.pdf
Author Matsumori, Kazuyuki|
Published Date 2015-03-25
Content Type Thesis or Dissertation
Grant Number 甲第5079号
Granted Date 2015-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0005078 abstract_review.pdf K0005078_fulltext.pdf
Author Tomoda, Takeshi|
Published Date 2015-03-25
Content Type Thesis or Dissertation
Grant Number 甲第5078号
Granted Date 2015-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0005077 abstract_review.pdf K0005077_fulltext.pdf
Author Akita, Mitsuhiro|
Published Date 2015-03-25
Content Type Thesis or Dissertation
Grant Number 甲第5077号
Granted Date 2015-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
JaLCDOI 10.18926/AMO/53342
FullText URL 69_2_123.pdf
Author Waseda, Koichi| Hagiya, Hideharu| Hanayama, Yoshihisa| Terasaka, Tomohiro| Kimura, Kosuke| Tsuzuki, Takao| Hasegawa, Kou| Nada, Takahiro| Nakamura, Eri| Murakami, Kazutoshi| Kondo, Eisei| Otsuka, Fumio|
Abstract An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients.
Keywords bronchial alveolar lavage eosinophilic pneumonia eosinophilia interstitial lung diseases Sjögren syndrome
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 127
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899635
Web of Science KeyUT 000353181700008
JaLCDOI 10.18926/AMO/53341
FullText URL 69_2_119.pdf
Author Terasaka, Tomohiro| Hagiya, Hideharu| Kimura, Kosuke| Nada, Takahiro| Nakamura, Eri| Hanayama, Yoshihisa| Sugiyama, Hitoshi| Kobayashi, Yasuyuki| Yanai, Hiroyuki| Otsuka, Fumio|
Abstract We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.
Keywords catecholamine paraganglioma renal hypoplasia renovascular hypertension secondary hypertension
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 122
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899634
Web of Science KeyUT 000353181700007
JaLCDOI 10.18926/AMO/53340
FullText URL 69_2_113.pdf
Author Inada, Ryo| Nagasaka, Takeshi| Toshima, Toshiaki| Mori, Yoshiko| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Hiraki, Takao| Oshiro, Taihei| Kanemitsu, Yukihide| Fujiwara, Toshiyoshi|
Abstract A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control.
Keywords colorectal cancer recurrence total pelvic exenteration radiofrequency ablation systemic chemotherapy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 113
End Page 118
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899633
Web of Science KeyUT 000353181700006
JaLCDOI 10.18926/AMO/53339
FullText URL 69_2_105.pdf
Author Sawada, Daijo| Ogawa, Takaaki| Miyake, Minoru| Hasui, Yoshinori| Yamaguchi, Fuminori| Izumori, Ken| Tokuda, Masaaki|
Abstract We examined and compared the inhibitory effects of D-tagatose on the growth, acid production, and water-insoluble glucan synthesis of GS5, a bacterial strain of Streptococcus mutans, with those of xylitol, D-psicose, L-psicose and L-tagatose. GS5 was cultured for 12h in a medium containing 10オ (w/v) of xylitol, D-psicose, L-psicose, D-tagatose or L-tagatose, and the inhibitory effect of GS5 growth was assessed. Each sugar showed different inhibitory effects on GS5. Both D-tagatose and xylitol significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1オ (w/v) sucrose. However, the inhibitory effect of acid production by D-tagatose was significantly stronger than that of xylitol in presence of sucrose.
Keywords Streptococcus mutans D-tagatose xylitol acid production water-insoluble glucan
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 111
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899632
Web of Science KeyUT 000353181700005
JaLCDOI 10.18926/AMO/53338
FullText URL 69_2_95.pdf
Author Lee, Mi Geum| Lee, Dong Kyu| Huh, Billy K.| Choi, Sang Sik| Kim, Hee Zoo| Lim, Byung Gun| Kim, Hong Soon| Choi, Yun Suk| Hur, Won Seok| Lee, Mi Kyoung|
Abstract Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine-which has been shown to relieve intradermal capsaicin-induced hyperalgesia-on the initial hyperalgesic response and the thermal analgesic property of RTX. Thirty-six male rats were divided into 6 treatment groups (n=6 each):RTX 500ng, RTX 1μg, clonidine 20μg (Cl), Cl+RTX 500ng, Cl+RTX 1μg, or normal saline 20μL (control). We evaluated the short-term (180min) and long-term (20 days) analgesic effects of RTX after thermal stimulation and mechanical stimulation. RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500ng and RTX 1μg groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine. The Cl+RTX 1μg ratsʼ behavior scores indicated that they were more calm and comfortable compared to the RTX 1μg rats. Even though we cannot precisely confirm that pretreatment with clonidine potentiates or adds to the analgesic effect of RTX, clonidine pretreatment with epidural RTX eliminated the initial RTX-associated hyperalgesic response and systemic toxicity in this neuropathic pain rat model.
Keywords clonidine epidural administration resiniferatoxin spinal nerve ligation rat model thermal hyperalgesia
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 95
End Page 103
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899631
Web of Science KeyUT 000353181700004
JaLCDOI 10.18926/AMO/53337
FullText URL 69_2_87.pdf
Author Murayama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Watanabe, Hirokazu| Shigemitsu, Yusuke| Iwasaki, Yuka| Tokorodani, Chiho| Miyazawa, Mari| Nishiuchi, Ritsuo| Kikkawa, Kiyoshi|
Abstract Ventriculoperitoneal shunts (VPSs) are used for the treatment of hydrocephalus. Here we analyzed the outcomes of VPS placements in 24 infants to determine the risk factors for shunt failure. The infants had undergone the initial VPS operation in our hospital between March 2005 and December 2013. They were observed until the end of January 2014. We obtained Kaplan-Meier curves and performed a multivariate Cox regression analysis of shunt failure. Of the 24 cases, the median (range) values for gestational age, birth weight, and birth head circumference (HC) were 37 (27-39) wks, 2,736 (686-3,788) g, and 35.3 (23.0-45.3) cm, respectively. The total number of shunt procedures was 45. Shunt failure rates were 0.51/shunt and 0.0053/shunt/year. Shunt infection rates were 0.13/shunt and 0.0014/shunt/year. The Kaplan-Meier analysis revealed an increased risk for shunt failure in infants <1 month old or in the HC >90オtile. The Cox regression analysis yielded hazard ratios (HRs) of 2.93 (95オ confidence interval (CI), 0.96-10.95, p=0.059) for age <1 month, and 4.46 (95オCI:1.20-28.91,p=0.023) for the HC >90オtile. The multivariate Cox regression analysis showed adjusted HRs of 17.56 (95オCI:2.69-202.8, p=0.001) for age <1 month, and 2.95 (95オCI:0.52-24.84, p=0.228) for the HC >90オtile. Our findings thus revealed that the risk factors for shunt failure in infants include age <1 month at the initial VPS placement.
Keywords head circumference shunt failure shunt infection ventriculoperitoneal shunt
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 87
End Page 93
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899630
Web of Science KeyUT 000353181700003
JaLCDOI 10.18926/AMO/53335
FullText URL 69_2_71.pdf
Author Hiramoto, Hiroki| Dansako, Hiromichi| Takeda, Midori| Satoh, Shinya| Wakita, Takaji| Ikeda, Masanori| Kato, Nobuyuki|
Abstract Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies. In the present study, we found that the expression level of annexin A1 (ANXA1) in human hepatoma cell line Li23-derived D7 cells was remarkably lower than that in parental Li23 cells, whereas the susceptibility of D7 cells to HCV infection was much higher than that of Li23 cells. Therefore, we hypothesized that ANXA1 negatively regulates persistent HCV infection through the inhibition of viral RNA replication. The results revealed that HCV production was significantly inhibited without a concomitant reduction in the amount of lipid droplets in the D7 cells stably expressing exogenous ANXA1. Further, we demonstrated that ANXA1 negatively regulated the step of viral RNA replication rather than that of viral entry in human hepatocytes. These results suggest that ANXA1 would be a novel target for the development of anti-HCV strategies.
Keywords HCV annexin A1 Li23 cell line Li23-derived D7 cells HCV-JFH-1
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-04
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 71
End Page 78
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899628
Web of Science KeyUT 000353181700001
JaLCDOI 10.18926/OLR/53329
Title Alternative A note on the Continuing Legal Education Program for in-house lawyers (Part1)
FullText URL olr_014_013_023.pdf
Author Fujimoto, Kazunari|
Publication Title 臨床法務研究
Published Date 2015-03
Volume volume14
Start Page 13
End Page 23
ISSN 1881-1485
language Japanese
File Version publisher
NAID 120005595783
JaLCDOI 10.18926/53320
Title Alternative A Bibliographic Study of the Transition of the Chinese Characters Representing 'Jomon'
FullText URL hss_039_213_232.pdf
Author Satomi, Ayako|
Publication Title 岡山大学大学院社会文化科学研究科紀要
Published Date 2015-03-26
Volume volume39
Start Page 213
End Page 232
ISSN 1881-1671
language Japanese
Copyright Holders Copyright © 2015 岡山大学大学院社会文化科学研究科
File Version publisher
NAID 120005593537
Author Kuranoshin, Kato| Rikako, Akagi| Haruko, Kato| Yuichi, Haga|
Published Date 2015-02
Publication Title 環境制御
Volume volume36
Content Type Departmental Bulletin Paper
FullText URL hara_CASPer15_final_rev2.pdf
Author Hara, Sunao| Abe, Masanobu| Sonehara, Noboru|
Note © © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The article has been accepted for publication.
Published in:Pervasive Computing and Communication Workshops (PerCom Workshops), 2015 IEEE International Conference on;
Date of Conference:23-27 March 2015;
Page(s):390 - 395;
Conference Location : St. Louis, MO, USA;
Publisher:IEEE;
Publisher URL:http://dx.doi.org/10.1109/PERCOMW.2015.7134069 ;
© Copyright 2015 IEEE - All rights reserved.|
Published Date 2015-03
Publication Title Proceedings of 2015 IEEE International Conference on Pervasive Computing and Communication Workshops (PerCom Workshops)
Publisher IEEE
Start Page 390
End Page 395
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1109/PERCOMW.2015.7134069
Title Alternative PD-1,CTLA-4
FullText URL 127_63.pdf
Author Eikawa, Shingo|
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 63
End Page 65
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.63
NAID 130005068337
Author Makihara, Seiichiro| Okano, Mitsuhiro|
Published Date 2015-04-01
Publication Title 岡山医学会雑誌
Volume volume127
Issue issue1
Content Type Journal Article
Title Alternative Gene therapy using REIC/Dkk-3-encoding adenoviral vector for the treatment of malignant pleural mesothelioma
FullText URL 127_47.pdf
Author Toyooka, Shinichi|
Keywords 悪性胸膜中皮腫 REIC/DKK-3 遺伝子治療
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 47
End Page 50
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.47
NAID 130005068349
Title Alternative A phase I trial of 100㎎/㎡ docetaxel in advanced or recurrent breast cancer patients
FullText URL 127_41.pdf
Author Hirata, Taizo|
Keywords 進行・再発乳癌 ドセタキセル 100㎎/㎡ 医師主導治験
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 41
End Page 45
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.41
NAID 130005068352
Title Alternative Cholelithiasis with a cholecystoduodenal fistula complicated with paroxysmal nocturnal hemoglobinuria
FullText URL 127_35.pdf
Author Kato, Takuya| Matsukawa, Hiroyoshi| Shiozaki, Shigehiro| Fuji, Tomokazu| Fujiwara, Yasuhiro| Ninomiya, Motoki|
Abstract  In cases of paroxysmal nocturnal hemoglobinuria (PNH), attention must be paid to potential complications such as thrombosis and hemolysis due to perioperative stress and infection from complement activation. Here we present the case of a 61-year-old Japanese woman with PNH. We made the diagnosis of PNH when she was 28 years old, and we administered repeated steroid medication and erythrocyte transfusion. The patient's cholecystocholedocholithiasis with a cholecystoduodenal fistula was diagnosed based on a survey of the right hypochondriac pain. We performed endoscopic nasobiliary drainage (ENBD) for the prophylaxis of perioperative infection, plus a cholecystectomy and fistulectomy. There were no complications, including hemolysis attack, infection, thrombosis with irrigation erythrocyte transfusion, steroid cover, or the need for heparin administration during the perioperative period. The reduction of the complement activation is necessary in the perioperative management of PNH patients. The prevention of the development of acidosis and hypoxemia, the selection of washed red blood cells, steroid use, appropriate infection measures and thrombosis prophylaxis are all important for the prevention of complications.
Keywords 発作性夜間血色素尿症(PNH)(paroxysmal nocturnal hemoglobinuria (PNH)) 胆嚢十二指腸瘻(cholecystoduodenal fistula) 溶血発作(hemolysis)
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 35
End Page 39
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.35
NAID 130005068351
Title Alternative Laparoscopic repair of an abdominal incisional hernia above the pubis
FullText URL 127_31.pdf
Author Nakano, Kanyu| Idani, Hitoshi| Asami, Shinya| Ookawa, Hiro| Yoshimoto, Masashi| Ito, Atene| Monden, Kazuteru| Kurose, Yohei| Hioki, Masayoshi| Ishii, Tatsuhiro| Sadamori, Hiroshi| Oono, Satoshi| Kin, Hitoshi| Takakura, Norihisa|
Abstract   Laparoscopic repair of a suprapubic hernia typically carries a high risk of recurrence, because fixation of the mesh in the peripubic area is difficult. We herein report a patient undergoing laparoscopic repair of a suprapubic hernia, along with a description of the surgical techniques employed.  A 78-year-old woman visited our hospital with a chief complaint of swelling at the median hypogastric incision site after surgery for an ovarian cyst performed at age 25 years. Laparoscopic examination revealed the hernia orifice to be 3.5×3.0 cm in size and that the distance between the caudal margin of the hernia orifice and the pubis was 2.5 cm. Parietex composite mesh was used for fixation through all layers of the abdominal wall with non-absorbable sutures and tack fixation. On the pubic side, after the pubis had been exposed by separating it from the bladder, we performed mesh fixation through all layers of the abdominal wall immediately above the pubis with the sutures placed inside the mesh, combined with tack mesh fixation directly to the pubis. This procedure enabled definite fixation of the mesh. Six days after surgery, she was discharged without complications. To date, two years and five months after surgery, no recurrence has been observed.
Keywords 腹壁瘢痕ヘルニア(incisional hernia) 恥骨上ヘルニア(suprapubic hernia) 腹腔鏡下修復術(laparoscopic repair)
Publication Title 岡山医学会雑誌
Published Date 2015-04-01
Volume volume127
Issue issue1
Start Page 31
End Page 34
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.31
NAID 130005068354