result 47942 件
| FullText URL | fulltext20220428-2.pdf table20220428-2.pdf figure20220428-2.pdf |
|---|---|
| Author | Otani, Yoshihiro| Yoo, Ji Young| Shimizu, Toshihiko| Kurozumi, Kazuhiko| Date, Isao| Kaur, Balveen| |
| Keywords | Oncolytic virus Immune cells Glioma |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10014-022-00431-8| |
| Published Date | 2022-4-6 |
| Publication Title | Brain Tumor Pathology |
| Volume | volume39 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 57 |
| End Page | 64 |
| ISSN | 1433-7398 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to The Japan Society of Brain Tumor Pathology 2022 |
| File Version | author |
| PubMed ID | 35384530 |
| DOI | 10.1007/s10014-022-00431-8 |
| Web of Science KeyUT | 000781179200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10014-022-00431-8 |
| FullText URL | fulltext20220428-1.pdf |
|---|---|
| Author | Wang, Qiong| Li, Yuying| Kosami, Ken‐ichi| Liu, Chaochao| Li, Jing| Zhang, Dan| Miki, Daisuke| Kawano, Yoji| |
| Keywords | NLR protein plasma membrane localization self-association effector triggered immunity rice |
| Note | This is the peer reviewed version of the following article: [Wang, Q., Li, Y., Kosami, K.-i., Liu, C., Li, J., Zhang, D. et al. (2022) Three highly conserved hydrophobic residues in the predicted α2-helix of rice NLR protein Pit contribute to its localization and immune induction. Plant, Cell & Environment, 1– 15. https://doi.org/10.1111/pce.14315], which has been published in final form at https://doi.org/10.1111/pce.14315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-4-7 |
| Publication Title | Plant, Cell & |
| Volume | volume45 |
| Publisher | Wiley |
| Start Page | 1876 |
| End Page | 1890 |
| ISSN | 0140-7791 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 John Wiley & Sons Ltd. |
| File Version | author |
| PubMed ID | 35312080 |
| DOI | 10.1111/pce.14315 |
| Web of Science KeyUT | 000779738600001 |
| Related Url | isVersionOf https://doi.org/10.1111/pce.14315 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Tadashi| Taniguchi, Makoto| Matsunaga, Kazuyuki| Kawata, Yusuke| Kawamura, Mari| Okubo, Keisuke| Yamashiro, Keisuke| Omori, Kazuhiro| Takashiba, Shogo| |
| Keywords | disease progression dysbiosis environmental factors microbiome monozygotic twins periodontitis |
| Published Date | 2022-04-18 |
| Publication Title | Clinical Case Reports |
| Volume | volume10 |
| Issue | issue4 |
| Publisher | WILEY |
| Start Page | e05725 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35449775 |
| DOI | 10.1002/ccr3.5725 |
| Web of Science KeyUT | 000783225600001 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.5725 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Huang, Jie| Wang, Aijun| Tang, Xiaoyu| Zhang, Ming| |
| Published Date | 2022-04-05 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 5704 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35383294 |
| DOI | 10.1038/s41598-022-09837-y |
| Web of Science KeyUT | 000781522600033 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-09837-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyoshi, Toru| Nakamura, Kazufumi| Amioka, Naofumi| Hatipoglu, Omer F.| Yonezawa, Tomoko| Saito, Yukihiro| Yoshida, Masashi| Akagi, Satoshi| Ito, Hiroshi| |
| Published Date | 2022-03-23 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4930 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35322164 |
| DOI | 10.1038/s41598-022-09094-z |
| Web of Science KeyUT | 000772605500054 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-09094-z |
| JaLCDOI | 10.18926/AMO/63428 |
|---|---|
| FullText URL | 76_2_229.pdf |
| Author | Kono, Takashi| Monden, Nobuya| Chikuie, Nobuyuki| Taruya, Takayuki| Hamamoto, Takao| Ishino, Takashi| Ueda, Tsutomu| Takeno, Sachio| |
| Abstract | We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy. |
| Keywords | head and neck osteosarcomas tumor suppressor p16 |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 229 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503452 |
| Web of Science KeyUT | 000792291900006 |
| JaLCDOI | 10.18926/AMO/63427 |
|---|---|
| FullText URL | 76_2_225.pdf |
| Author | Mori, Yu| Sano, Yoshifumi| Sugimoto, Ryujiro| Sakao, Nobuhiko| Ryuko, Tsuyoshi| Takeda, Masashi| Kitazawa, Riko| Yukumi, Shungo| Izutani, Hironori| |
| Abstract | A 75-year-old man presented to our hospital 1 year after partial renal resection for clear cell carcinoma. A right lower lobe lung nodule noted at the time of surgery had increased to 3.0 cm in diameter and was confirmed as squamous cell lung carcinoma by bronchoscopic cytology. Computed tomography had also revealed paratracheal lymph node swelling. He underwent right lower lobectomy with lymph node dissection by video-assisted thoracic surgery. Pathological examination confirmed squamous cell carcinoma of the lung but diagnosed the right hilar and mediastinal lymph node metastases as clear cell carcinoma. |
| Keywords | renal cell carcinoma primary lung cancer double cancer mediastinal lymph node metastasis hilar lymph node metastasis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 225 |
| End Page | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503451 |
| Web of Science KeyUT | 000792291900005 |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| FullText URL | 76_2_217.pdf |
| Author | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| Abstract | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| Keywords | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 217 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| FullText URL | 76_2_203.pdf |
| Author | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| Keywords | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hongo, Takashi| Yamamoto, Ryohei| Liu, Keibun| Yaguchi, Takahiko| Dote, Hisashi| Saito, Ryusuke| Masuyama, Tomoyuki| Nakatsuka, Kosuke| Watanabe, Shinichi| Kanaya, Takahiro| Yamaguchi, Tomoya| Yumoto, Tetsuya| Naito, Hiromichi| Nakao, Atsunori| |
| Keywords | Post-extubation dysphagia Speech and language therapy Intensive care Dysphagia Aspiration pneumonia |
| Published Date | 2022-04-08 |
| Publication Title | Critical Care |
| Volume | volume26 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 98 |
| ISSN | 1364-8535 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35395802 |
| DOI | 10.1186/s13054-022-03974-6 |
| Web of Science KeyUT | 000779598400004 |
| Related Url | isVersionOf https://doi.org/10.1186/s13054-022-03974-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takatsu, Fumiaki| Yamamoto, Hiromasa| Tomioka, Yasuaki| Tanaka, Shin| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Toyooka, Shinichi| |
| Keywords | Retroperitoneal sarcoma Lung metastasis Metastasectomy |
| Published Date | 2022-04-08 |
| Publication Title | World Journal Of Surgical Oncology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 114 |
| ISSN | 1477-7819 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35395855 |
| DOI | 10.1186/s12957-022-02552-y |
| Web of Science KeyUT | 000780301100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12957-022-02552-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fukushima, Kazuhiko| Uchida, Haruhito A.| Fuchimoto, Yasuko| Mifune, Tomoyo| Watanabe, Mayu| Tsuji, Kenji| Tanabe, Katsuyuki| Kinomura, Masaru| Kitamura, Shinji| Miyamoto, Yosuke| Wada, Sae| Koyanagi, Taisaku| Sugiyama, Hitoshi| Kishimoto, Takumi| Wada, Jun| |
| Keywords | lupus nephritis lupus pneumonitis silicosis SLE |
| Published Date | 2022-02-18 |
| Publication Title | Medicine |
| Volume | volume101 |
| Issue | issue7 |
| Publisher | Lippincott Williams & Wilkins |
| Start Page | e28872 |
| ISSN | 0025-7974 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 the Author(s). |
| File Version | publisher |
| PubMed ID | 35363197 |
| DOI | 10.1097/MD.0000000000028872 |
| Web of Science KeyUT | 000776738500059 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000028872 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nagao, Ryo| Kato, Koji| Kumazawa, Minoru| Ifuku, Kentaro| Yokono, Makio| Suzuki, Takehiro| Dohmae, Naoshi| Akita, Fusamichi| Akimoto, Seiji| Miyazaki, Naoyuki| Shen, Jian-Ren| |
| Published Date | 2022-04-01 |
| Publication Title | Nature Communications |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 1764 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35365610 |
| DOI | 10.1038/s41467-022-29294-5 |
| Web of Science KeyUT | 000777408600010 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-022-29294-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Koichiro| Nakano, Yasuhiro| Tokumasu, Kazuki| Honda, Hiroyuki| Hasegawa, Kou| Sato, Asuka| Ogawa, Hiroko| Obika, Mikako| Hanayama, Yoshihisa| Otsuka, Fumio| |
| Keywords | cinacalcct evocalcet hypercalccmia primary hyperparathyroidism |
| Published Date | 2022-04-08 |
| Publication Title | Clinical Case Reports |
| Volume | volume10 |
| Issue | issue4 |
| Publisher | Wiley |
| Start Page | e05713 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35425612 |
| DOI | 10.1002/ccr3.5713 |
| Web of Science KeyUT | 000781095000001 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.5713 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Yukichika| Otsuka, Yuki| Sunada, Naruhiko| Tokumasu, Kazuki| Nakano, Yasuhiro| Honda, Hiroyuki| Sakurada, Yasue| Hagiya, Hideharu| Hanayama, Yoshihisa| Otsuka, Fumio| |
| Keywords | fatigue hypogonadism LOH syndrome long COVID testosterone |
| Published Date | 2022-03-31 |
| Publication Title | Journal Of Clinical Medicine |
| Volume | volume11 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 1955 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35407562 |
| DOI | 10.3390/jcm11071955 |
| Web of Science KeyUT | 000782056600001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm11071955 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oka, Kosuke| Takagi, Yume| Hagiya, Hideharu| Otsuka, Fumio| |
| Keywords | cat scratch disease lymphadenopathy and subcutaneous abscess |
| Published Date | 2022-04-14 |
| Publication Title | Clinical Case Reports |
| Volume | volume10 |
| Issue | issue4 |
| Publisher | Wiley |
| Start Page | e04816 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35441012 |
| DOI | 10.1002/ccr3.4816 |
| Web of Science KeyUT | 000782511000001 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.4816 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Obata, Nozomi| Tabuchi, Hiroaki| Kurihara, Miyu| Yamamoto, Eiji| Shirasawa, Kenta| Monden, Yuki| |
| Keywords | polyploidy nematode sweetpotato resistant cultivar breeding association study |
| Published Date | 2022-03-18 |
| Publication Title | Frontiers In Plant Science |
| Volume | volume13 |
| Publisher | Frontiers Media SA |
| Start Page | 858747 |
| ISSN | 1664-462X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Obata, Tabuchi, Kurihara, Yamamoto, Shirasawa and Monden. |
| File Version | publisher |
| PubMed ID | 35371138 |
| DOI | 10.3389/fpls.2022.858747 |
| Web of Science KeyUT | 000778596100001 |
| Related Url | isVersionOf https://doi.org/10.3389/fpls.2022.858747 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsui, Teppei| Taki, Masato| Pham, Trung Quang| Chikazoe, Junichi| Jimura, Koji| |
| Keywords | fMRI deep learning explainable AI decoding generative neural network counterfactual explanation |
| Published Date | 2022-03-16 |
| Publication Title | Frontiers In Neuroinformatics |
| Volume | volume15 |
| Publisher | Frontiers Media |
| Start Page | 802938 |
| ISSN | 1662-5196 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Matsui, Taki, Pham, Chikazoe and Jimura. |
| File Version | publisher |
| PubMed ID | 35369003 |
| DOI | 10.3389/fninf.2021.802938 |
| Web of Science KeyUT | 000778735900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fninf.2021.802938 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Higaki, Fumiyo| Inoue, Satoshi| Oda, Wakako| Matsusue, Eiji| Hiraki, Takao| |
| Keywords | pial blood supply peritumoral brain edema arachnoid plane peritumoral flow void magnetic resonance imaging |
| Published Date | 2022-04-08 |
| Publication Title | Acta Radiologica Open |
| Volume | volume11 |
| Issue | issue4 |
| Publisher | Sage Publications Ltd. |
| ISSN | 2058-4601 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35425642 |
| DOI | 10.1177/20584601221091208 |
| Web of Science KeyUT | 000780184200001 |
| Related Url | isVersionOf https://doi.org/10.1177/20584601221091208 |
| JaLCDOI | 10.18926/AMO/63414 |
|---|---|
| FullText URL | 76_2_195.pdf |
| Author | Inoue, Shinichiro| Maeda, Isseki| Ogawa, Asao| Yoshiuchi, Kazuhiro| Terada, Seishi| Yamada, Norihito| |
| Abstract | The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event. |
| Keywords | delirium cancer perospirone risperidone |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 195 |
| End Page | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503448 |
| Web of Science KeyUT | 000792291900002 |
