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JaLCDOI 10.18926/AMO/60364
FullText URL 74_4_275.pdf
Author Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki|
Abstract Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
Keywords oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 275
End Page 283
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843758
Web of Science KeyUT 000562508700002
NAID 120006880203
JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
FullText URL fulltext.pdf
Author Sugimoto, Seiichiro| Soh, Junichi| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Yamane, Masaomi| Oto, Takahiro| Kanazawa, Susumu| Kiura, Katsuyuki| Toyooka, Shinichi|
Keywords Lung cancer Aspergillosis Surgery Radiation Chemotherapy
Note This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-01960-5.|
Published Date 2020-01-21
Publication Title Surgery Today
Volume volume50
Issue issue8
Publisher Springer
Start Page 863
End Page 871
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31965262
DOI 10.1007/s00595-020-01960-5
Web of Science KeyUT 000550244700010
Related Url isVersionOf https://doi.org/10.1007/s00595-020-01960-5
FullText URL JEM_fulltext.pdf
Author Okayasu, Mitsuhiro| Ogawa, Tsukasa|
Keywords Piezoelectric ceramic lead zirconate titanate ceramic electrical power generation domain switching cyclic loading
Note This is a post-peer-review, pre-copyedit version of an article published in Journal of Electronic Materials. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11664-020-08303-7.
This fulltext is available in Jul. 2021.|
Published Date 2020-07-08
Publication Title Journal of Electronic Materials
Publisher Springer
ISSN 0361-5235
NCID AA00697093
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1007/s11664-020-08303-7
Web of Science KeyUT 000546531900001
Related Url isVersionOf https://doi.org/10.1007/s11664-020-08303-7
FullText URL fulltext.pdf
Author Yamamoto, Haruchika| Sugimoto, Seiichiro| Kurosaki, Takeshi| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Yamane, Masaomi| Oto, Takahiro| Toyooka, Shinichi|
Published Date 2020-06-29
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature
Start Page 10595
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32601414
DOI 10.1038/s41598-020-67433-4
Web of Science KeyUT 000548360700030
Related Url isVersionOf https://doi.org/10.1038/s41598-020-67433-4
FullText URL fulltext.pdf
Author Lee, Yoon-Seok| Makino, Yuya| Nitta, Jun| Lee, Eunkyung|
Keywords aluminum alloy casting speed solidification Ohno continuous casting gravity casting dendritic spacing
Published Date 2020-05-11
Publication Title Metals
Volume volume10
Issue issue5
Publisher MDPI
Start Page 625
ISSN 2075-4701
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
DOI 10.3390/met10050625
Web of Science KeyUT 000540220000073
Related Url isVersionOf https://doi.org/10.3390/met10050625
FullText URL cis_5_2842.pdf
Author Matsuo, Toshihiko|
Keywords Congenital blepharoptosis Anisometropia Levater muscle placation
Published Date 2020-06-13
Publication Title Clinics in Surgery
Volume volume5
Publisher Remedy
Start Page 2842
ISSN 2474-1647
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2020 Toshihiko Matsuo
File Version publisher
Official Url http://clinicsinsurgery.com/|
FullText URL cis_5_2847.pdf
Author Matsuo, Toshihiko|
Keywords Trabeculectomy Filtering surgery In-the-bag intraocular lens dislocation Intraocular lens-suturing Conjunctiva-sparing
Published Date 2020-06-15
Publication Title Clinics in Surgery
Volume volume5
Publisher Remedy
Start Page 2847
ISSN 2474-1647
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2020 Toshihiko Matsuo
File Version publisher
Official Url http://www.clinicsinsurgery.com/|
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Miyahara, Koji| Sakaguchi, Chihiro| Takenaka, Ryuta| Kobayashi, Sayo| Mouri, Hirokazu| Tanaka, Shigetomi| Toyokawa, Tatsuya| Tanaka, Shouichi| Nishimura, Mamoru| Yamauchi, Kenji| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords 18F-fluorodeoxyglucose-positron emission tomography mesenchymal tumor gastric neoplasms gastrointestinal stromal tumor schwannoma
Published Date 2020-05-01
Publication Title Journal of Clinical Medicine
Volume volume9
Issue issue5
Publisher MDPI
Start Page 1301
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32370028
DOI 10.3390/jcm9051301
Web of Science KeyUT 000540223800058
Related Url isVersionOf https://doi.org/10.3390/jcm9051301
FullText URL fulltext.pdf
Author Wang, Wu| Yang, Jiajia| Wu, Qiong| Yu, Jiabin| Takahashi, Satoshi| Ejima, Yoshimichi| Wu, Jinglong|
Keywords between-session learning generalization tactile angle discriminability training time interval
Published Date 2019-10-25
Publication Title Journal of Neurophysiology
Volume volume122
Issue issue5
Publisher American Physiological Society
Start Page 1918
End Page 1927
ISSN 0022-3077
NCID AA00703334
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © the American Physiological Society
File Version publisher
PubMed ID 31461363
DOI 10.1152/jn.00161.2019
Web of Science KeyUT 000498170200008
Related Url isVersionOf https://doi.org/10.1152/jn.00161.2019
Title Alternative Pressure dependence of Si diffusion in gamma-Fe
FullText URL fulltext.pdf
Author Tsujino, Noriyoshi| Mârza, Andreea| Yamazaki, Daisuke|
Keywords γ-Fe silicon diffusion high pressure planetary core
Note This is an Accepted Manuscript of an article published by Mineralogical Society of America.|
Published Date 2020-05-01
Publication Title American Mineralogist
Volume volume105
Issue issue3
Publisher Mineralogical Society of America
Start Page 319
End Page 324
ISSN 0003-004X
NCID AA00521712
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.2138/am-2020-7197
Web of Science KeyUT 000518370300003
Related Url isVersionOf https://doi.org/10.2138/am-2020-7197
JaLCDOI 10.18926/AMO/59959
FullText URL 74_3_251.pdf
Author Murakami, Takashi| Tokuda, Takanori| Nishimura, Shinsuke| Fujii, Hiromichi| Takahashi, Yosuke| Yamane, Kokoro| Inoue, Kazushige| Yamada, Koichi| Kakeya, Hiroshi| Shibata, Toshihiko|
Abstract A 62-year-old Japanese male presented with graft infection by Staphylococcus schleiferi 50 days after debranching of the left subclavian artery and frozen elephant trunk repair for the entry closure of a Stanford type B aortic dissection. The graft was removed, and the patient was successfully treated using in situ reconstruction of the arch with omental flap coverage, removal of the debranching graft, autologous iliac artery grafting, and longterm antibiotics. Domino reconstruction of the infected debranching graft using autologous external iliac artery and a Dacron graft can thus be a good option in similar cases.
Keywords autologous iliac artery graft Staphylococcus schleiferi graft infection domino reconstruction Dacron graft
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 251
End Page 255
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577024
Web of Science KeyUT 000543363400009
NAID 120006862800
JaLCDOI 10.18926/AMO/59952
FullText URL 74_3_215.pdf
Author Chou, Hsi-Hsien|
Abstract Due to cultural traditions, most Taiwanese do not have an advance directive or healthcare proxy. We explored how patients with mild dementia in Taiwan may still make self-determined decisions concerning advance directives for their healthcare and end-of-life care choices as the disease progresses. We examined 260 respondents with mild dementia at a Taiwan medical center: 199 patients who agreed (and 61 patients who disagreed) with the concept of advance directives completed a structured questionnaire. Multiple logistic regression models to determine the between-group differences revealed that the following were positively associated with approval of end-of-life directives: maintaining one’s quality of life (adjusted odds ratio [AOR], 2.44; 95% CI: 1.07-5.53), discussion with family members (AOR, 3.50; 95% CI: 1.49-8.26), and friend support networks (AOR, 3.36; 95% CI: 1.34-8.43). Cardiopulmonary resuscitation (AOR, 0.27; 95% CI: 0.09-0.79) was negatively associated with approval. There was also a positive association between the support of the legal validity of end-of-life directives (OR, 1.93; 95% CI: 1.07-3.48), without other confounding factors. In Taiwanese society, we remain mindful of cultural influences that may impact patients, including maintaining one’s quality of life, discussion with family members, and friend/support networks. These influences may help dementia patients complete their advance directives.
Keywords advance directive dementia patient autonomy quality of life culture
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 215
End Page 220
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577019
Web of Science KeyUT 000543363400005
NAID 120006862794
JaLCDOI 10.18926/AMO/59950
FullText URL 74_3_199.pdf
Author Fujita, Hirofumi| Bando, Tetsuya| Oyadomari, Seiichi| Ochiai, Kazuhiko| Watanabe, Masami| Kumon, Hiromi| Ohuchi, Hideyo|
Abstract Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland.
Keywords Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 199
End Page 208
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577017
Web of Science KeyUT 000543363400003
NAID 120006862792
JaLCDOI 10.18926/AMO/59949
FullText URL 74_3_191.pdf
Author Ohashi, Keiji| Sada, Ken-Ei| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Asano, Sumie Hiramatsu| Miyawaki, Yoshia| Morishita, Michiko| Katsuyama, Eri| Watanabe, Haruki| Tatebe, Noriko| Narazaki, Mariko| Matsumoto, Yoshinori| Sunahori-Watanabe, Katsue| Kawabata, Tomoko| Yajima, Nobuyuki| Wada, Jun|
Abstract Chronic damage accumulation affects not only mortality but also quality of life in patients with systemic lupus erythematosus (SLE). Risk factors for chronic damage were explored in SLE through different onset eras. Two hundred forty-five patients at Okayama University Hospital and Showa University Hospital were divided into three groups based on the onset era: a past-onset group (onset before 1995; n=83), middle-onset group (1996-2009; n=88), and recent-onset group (after 2010; n=74). The mean Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) score as an index of chronic damage was 1.93, 1.24, and 0.53 in the past-, middle-, and recent-onset groups, respectively. In the pastonset group, the total SDI score was significantly associated with glucocorticoid monotherapy by linear regression analysis (β-coefficient [β]=0.63; 95% confidence interval [CI], 0.21-1.05) and C-reactive protein levels (β=0.67; 95% CI, 0.27-1.07). In the middle-onset group, the total SDI score was significantly associated with the SLE Disease Activity Index at registration (β=0.09; 95% CI, 0.03-0.12). Reducing the accumulation of chronic damage in SLE patients might be possible with the concomitant use of immunosuppressants and tight control of disease activity.
Keywords systemic lupus erythematosus chronic damage glucocorticoids, disease activity disease duration
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-06
Volume volume74
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 198
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32577016
Web of Science KeyUT 000543363400002
NAID 120006862791
FullText URL fulltext.pdf
Author Kondo, Hideki| Fujita, Miki| Hisano, Hiroshi| Hyodo, Kiwamu| Andika, Ida Bagus| Suzuki, Nobuhiro|
Keywords negevirus kitavirus aphid virome RNA seq barley diversity horizontal transmission
Published Date 2020-04-07
Publication Title Frontiers in Microbiology
Volume volume11
Publisher Frontiers Media
Start Page 509
ISSN 1664-302X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Kondo, Fujita, Hisano, Hyodo, Andika and Suzuki.
File Version publisher
PubMed ID 32318034
DOI 10.3389/fmicb.2020.00509
Web of Science KeyUT 000529047600001
Related Url isVersionOf https://doi.org/10.3389/fmicb.2020.00509
FullText URL fulltext.pdf
Author Katsui, Kuniaki| Ogata, Takeshi| Watanabe, Kenta| Katayama, Norihisa| Kuroda, Masahiro| Kiura, Katsuyuki| Hiraki, Takao| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu|
Keywords cisplatin docetaxel dose-volume histogram non-small cell lung cancer PACIFIC trial radiation pneumonitis
Published Date 2020-05-04
Publication Title Cancer Medicine
Publisher Wiley
ISSN 2045-7634
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32364685
DOI 10.1002/cam4.3093
Web of Science KeyUT 000530411600001
Related Url isVersionOf https://doi.org/10.1002/cam4.3093
FullText URL fulltext.pdf
Author Paneer Selvam, Karthik| Nakagawa, Tomohiro| Marui, Tatsuki| Inoue, Hirotaka| Nishikawa, Takeshi| Hayashi, Yasuhiko|
Keywords carbon nanohorns cellulose conductive sheets vapor sensor
Published Date 2020-05-04
Publication Title Materials Research Express
Volume volume7
Issue issue5
Publisher IOP Publishing
Start Page 056402
ISSN 2053-1591
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
DOI 10.1088/2053-1591/ab89dc
Web of Science KeyUT 000531254300001
Related Url isVersionOf https://doi.org/10.1088/2053-1591/ab89dc
File URL 07200kingayaturi.jpg
APG3family カヤツリグサ科 (Cyperaceae)
YList ylist.info/ylist_detail_display.php?pass=2073
Database Naturalized plants in Japan : Seed-Image database
Database(alternative) Naturalized plants in Japan : Seed-Image database
Publisher 岡山大学 資源植物科学研究所 野生植物グループ
Resource Type Data or Dataset
Official URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|
File URL 15226hosomikingayaturi.jpg k-hosomikingayaturi.jpg
APG3family カヤツリグサ科 (Cyperaceae)
YList ylist.info/ylist_detail_display.php?pass=27969
Database Naturalized plants in Japan : Seed-Image database
Database(alternative) Naturalized plants in Japan : Seed-Image database
Publisher 岡山大学 資源植物科学研究所 野生植物グループ
Resource Type Data or Dataset
Official URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|