result 519 件
| Title Alternative | Gene therapy using REIC/Dkk-3-encoding adenoviral vector for the treatment of malignant pleural mesothelioma |
|---|---|
| FullText URL | 127_47.pdf |
| Author | Toyooka, Shinichi| |
| Keywords | 悪性胸膜中皮腫 REIC/DKK-3 遺伝子治療 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-04-01 |
| Volume | volume127 |
| Issue | issue1 |
| Start Page | 47 |
| End Page | 50 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.47 |
| NAID | 130005068349 |
| Title Alternative | A phase I trial of 100㎎/㎡ docetaxel in advanced or recurrent breast cancer patients |
|---|---|
| FullText URL | 127_41.pdf |
| Author | Hirata, Taizo| |
| Keywords | 進行・再発乳癌 ドセタキセル 100㎎/㎡ 医師主導治験 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2015-04-01 |
| Volume | volume127 |
| Issue | issue1 |
| Start Page | 41 |
| End Page | 45 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2015 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.127.41 |
| NAID | 130005068352 |
| Author | Mizoo, Taeko| Taira, Naruto| Nishiyama, Keiko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| Ishihara, Setsuko| Kawai, Hiroshi| Kawasaki, Kensuke| Ishibe, Youichi| Ogasawara, Yutaka| Komoike, Yoshifumi| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2013-12-01 |
| Publication Title | BMC Cancer |
| Volume | volume13 |
| Content Type | Journal Article |
| Author | Tomotsuka, Naoto| Kaku, Ryuji| Obata, Norihiko| Matsuoka, Yoshikazu| Kanzaki, Hirotaka| Taniguchi, Arata| Muto, Noriko| Omiya, Hiroki| Itano, Yoshitaro| Sato, Tadasu| Ichikawa, Hiroyuki| Mizobuchi, Satoshi| Morimatsu, Hiroshi| |
|---|---|
| Published Date | 2014-07-11 |
| Publication Title | Journal of Pain Research |
| Volume | volume7 |
| Content Type | Journal Article |
| FullText URL | K0005038_abstract_review.pdf K0005038_fulltext.pdf |
|---|---|
| Author | Mizoo, Taeko| |
| Published Date | 2014-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5038号 |
| Granted Date | 2014-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Title Alternative | Drug interaction (31. drug interaction in hormonal breast cancer therapy) |
|---|---|
| FullText URL | 126_245.pdf |
| Author | Masaoka, Yasuyuki| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-12-01 |
| Volume | volume126 |
| Issue | issue3 |
| Start Page | 245 |
| End Page | 248 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.245 |
| NAID | 130004903247 |
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize) |
|---|---|
| FullText URL | 126_187.pdf |
| Author | Yamamoto, Hiromasa| |
| Abstract | 受賞対象論文: Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S：Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst (2014) 106, djt338 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-12-01 |
| Volume | volume126 |
| Issue | issue3 |
| Start Page | 187 |
| End Page | 190 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.187 |
| NAID | 130004903235 |
| Author | Itoh, Mitsuya| Iwamoto, Takayuki| Matsuoka, Junji| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Niikura, Naoki| Hayashi, Naoki| Ohtani, Shoichiro| Higaki, Kenji| Fujiwara, Toshiyoshi| Doihara, Hiroyoshi| Symmans, W. Fraser| Pusztai, Lajos| |
|---|---|
| Published Date | 2014-01 |
| Publication Title | Breast Cancer Research and Treatment |
| Volume | volume143 |
| Issue | issue2 |
| Content Type | Journal Article |
| FullText URL | K0005011_abstract_review.pdf k0005011_fulltext.pdf |
|---|---|
| Author | Ito, Mitsuya| |
| Published Date | 2014-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5011号 |
| Granted Date | 2014-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Hayashida, Kaori| Nakatsuka, Mikiya| |
|---|---|
| Published Date | 2014-03 |
| Publication Title | Environmental Health and Preventive Medicine |
| Volume | volume19 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52785 |
|---|---|
| FullText URL | 68_4_191.pdf |
| Author | Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi| |
| Abstract | Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance. |
| Keywords | non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 191 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145405 |
| Web of Science KeyUT | 000340687500001 |
| Author | Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-05 |
| Publication Title | Journal of Cancer Research and Clinical Oncology |
| Volume | volume138 |
| Issue | issue5 |
| Content Type | Journal Article |
| Title Alternative | Induction therapy followed by surgery for non small-cell lung cancer |
|---|---|
| FullText URL | 126_103.pdf |
| Author | Toyooka, Shinichi| |
| Keywords | 非小細胞肺癌 導入療法 放射線化学療法 外科切除 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-08-01 |
| Volume | volume126 |
| Issue | issue2 |
| Start Page | 103 |
| End Page | 107 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.103 |
| NAID | 130004685260 |
| Title Alternative | Metastatic breast cancer presenting as severe anemia, platelet reduction and abnormal cells in peripheral blood |
|---|---|
| FullText URL | 126_31.pdf |
| Author | Ota, Seisuke| Kasahara, Akinori| Mizuno, Shoma| Fukatsu, Haruka| Kinoshita, Osamu| Noguchi, Toshio| Kishimoto, Nobuyasu| Matsumura, Tadashi| |
| Abstract | Worldwide, breast cancer accounts for 22.9% of all cancers excluding non-melanoma skin cancers in women. More than 80% of breast cancer cases are discovered when a woman discovers a lump that feels different from the rest of the breast tissue. We report the case of a 60-year-old woman who had been treated for one year at a psychiatric hospital for suspected schizophrenia, and was referred to our hospital on March 23, 2011 for consultation regarding complete blood count abnormalities: hemoglobin, 4.8g/㎗ ; Plt, 1.9×104/μl ; WBC, 12,700/μl with 18.5% abnormal cells. Computed tomography revealed an enhanced, irregular mass in her right breast as well as right axillary lymph node swelling, suggestive of breast cancer. BM biopsy confirmed the presence of abnormal, keratin-positive cells, suggesting metastasis to the bone. CA15-3 was 300U/㎖ (normal range ＜25). The patient died on April 11, 2011, post-admission day 20. We found a rare case of terminal breast cancer that presented with peripheral blood abnormality. Breast cancer in patients who do not notice breast abnormality can present with peripheral blood abnormality. |
| Keywords | 乳癌（breast cancer） 初発症状（initial symptom） 貧血（anemia） 骨髄転移（bone marrow metastasis） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 31 |
| End Page | 34 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.31 |
| Title Alternative | Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer |
|---|---|
| FullText URL | 126_25.pdf |
| Author | Mizoo, Taeko| Shien, Tadahiko| Ito, Maiko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| |
| Abstract | Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery. |
| Keywords | OSNA法（OSNA method） センチネルリンパ節（sentinel lymph node） micrometastases CK-19 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 25 |
| End Page | 30 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.25 |
| Title Alternative | A preoperative SUVmax greater than the ADCmin of the primary tumour : A predictor of disease recurrence and survival in patients with endometrial cancer |
|---|---|
| FullText URL | 126_11.pdf |
| Author | Nakamura, Keiichiro| Joja, Ikuo| Fukushima, Chikako| Haruma, Tomoko| Hayashi, Chiaki| Kusumoto, Tomoyuki| Seki, Noriko| Hongo, Atsushi| Hiramatsu, Yuji| |
| Keywords | endometrial cancer SUVmax PET/CT predictor of poor prognosis |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 11 |
| End Page | 15 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.11 |
| JaLCDOI | 10.18926/AMO/52010 |
|---|---|
| FullText URL | 67_6_369.pdf |
| Author | Yu, Shaonan| Wang, Xiaozhen| Liu, Guifeng| Zhu, Xuewei| Chen, Yan| |
| Abstract | Despite high sensitivity to chemotherapy, the prognosis for triple-negative breast cancer (TNBC) remains poor because of its high rate of metastasis and low sensitivity to endocrine therapy. CXCR4 expression has been reported in many subtypes of human breast cancers, but it remains unknown whether CXCR4 is expressed in TNBC and whether CXCR4 expression in TNBC could be a prognostic indicator. TNBCs tissues were formalin fixed, paraffin embedded and hematoxylin-eosin (H&E) stained. Immunohistochemical staining was utilized to determine the CXCR4 expression in those specimens. Statistical analyses were performed using SPSS16.0 software to reveal the correlation of CXCR4 expression in TNBC specimens and cancer recurrence and cancer-related death. Our results showed that there was a strong association between CXCR4 overexpression and both menopause and the histological cancer grade of TNBC patients (p values were separately 0.004 and 0.001). The 5-y disease-free survival (DFS) and the 5-y overall survival (OS) were 57.69% and 58.33% for the low-CXCR4 group versus 42.11% and 44.74% for the high-CXCR4 group, respectively (p＝0.031 and 0.048). CXCR4 overexpression plays an important role in triple-negative breast cancers, and may be a predictor of poor prognosis. |
| Keywords | CXCR4 immunohistochemical staining triple-negative breast cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 375 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356721 |
| Web of Science KeyUT | 000328915700005 |
| FullText URL | K0004854_abstract_review.pdf K0004854_fulltext.pdf |
|---|---|
| Author | Sreeja C Sekhar| |
| Published Date | 2013-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4854号 |
| Granted Date | 2013-09-30 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Doihara, Hiroyoshi| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ohuchi, Hideyo| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
