result 5751 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawasaki, Kento| Noma, Kazuhiro| Kato, Takuya| Ohara, Toshiaki| Tanabe, Shunsuke| Takeda, Yasushige| Matsumoto, Hijiri| Nishimura, Seitaro| Kunitomo, Tomoyoshi| Akai, Masaaki| Kobayashi, Teruki| Nishiwaki, Noriyuki| Kashima, Hajime| Maeda, Naoaki| Kikuchi, Satoru| Tazawa, Hiroshi| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| |
| Keywords | Esophageal cancer Cancer-associated fibroblasts Programmed cell death 1 Program cell death ligand 1 Immune checkpoint inhibitors |
| Note | The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-023-03531-2| |
| Published Date | 2023-09-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume72 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 3787 |
| End Page | 3802 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37668710 |
| DOI | 10.1007/s00262-023-03531-2 |
| Web of Science KeyUT | 001062743200002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-023-03531-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Tanaka, Takehiro| Inokuchi, Toshihiro| Hiraoka, Sakiko| Otsuka, Motoyuki| |
| Keywords | Colonoscopy Esophagogastroduodenoscopy Graft-versus-host disease Hematopoietic stem cell transplantation Intestinal transplant-associated microangiopathy iTAM |
| Note | The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-024-03221-y| |
| Published Date | 2024-04-22 |
| Publication Title | BMC Gastroenterology |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 140 |
| ISSN | 1471-230X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38649868 |
| DOI | 10.1186/s12876-024-03221-y |
| Web of Science KeyUT | 001206319800003 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-024-03221-y |
| Title Alternative | The 2022 Incentive Award of the Okayama Medical Association in General Medical Science (2022 Yuuki Prize) |
|---|---|
| Author | Meguri, Yusuke| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-04-01 |
| Volume | volume136 |
| Issue | issue1 |
| Start Page | 4 |
| End Page | 6 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.4 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.4 |
| Title Alternative | The 2022 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2022 Sunada Prize) |
|---|---|
| Author | Itano, Junko| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-04-01 |
| Volume | volume136 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 3 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.1 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hochi, Hiroaki| Kubota, Satoshi| Takigawa, Masaharu| Nishida, Takashi| |
| Published Date | 2023-08-17 |
| Publication Title | Carcinogenesis |
| Volume | volume44 |
| Issue | issue8-9 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 695 |
| End Page | 707 |
| ISSN | 0143-3334 |
| NCID | AA00141799 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37590989 |
| DOI | 10.1093/carcin/bgad057 |
| Web of Science KeyUT | 001061431500001 |
| Related Url | isVersionOf https://doi.org/10.1093/carcin/bgad057 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Murata, Hitoshi| Phoo, May Tha Zin| Ochi, Toshiki| Tomonobu, Nahoko| Yamamoto, Ken-ichi| Kinoshita, Rie| Miyazaki, Ikuko| Nishibori, Masahiro| Asanuma, Masato| Sakaguchi, Masakiyo| |
| Keywords | JNK PARK2 Parkinson’sdisease Phosphorylation SARM1 |
| Published Date | 2023-09-19 |
| Publication Title | The Journal of Biochemistry |
| Volume | volume174 |
| Issue | issue6 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 533 |
| End Page | 548 |
| ISSN | 0021-924X |
| NCID | AA00694073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37725528 |
| DOI | 10.1093/jb/mvad068 |
| Web of Science KeyUT | 001079972500001 |
| Related Url | isVersionOf https://doi.org/10.1093/jb/mvad068 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ihara, Hiroki| Yoshio, Kotaro| Tanabe, Shunsuke| Sugiyama, Soichi| Hashimoto, Masashi| Maeda, Naoaki| Akagi, Shinsuke| Takao, Soshi| Noma, Kazuhiro| Hiraki, Takao| |
| Keywords | Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival |
| Note | The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4| |
| Published Date | 2023-04-07 |
| Publication Title | Esophagus |
| Volume | volume20 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 548 |
| End Page | 556 |
| ISSN | 1612-9059 |
| NCID | AA11885266 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37027045 |
| DOI | 10.1007/s10388-023-01000-4 |
| Web of Science KeyUT | 000964113700001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10388-023-01000-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iguchi, Toshihiro| Matsui, Yusuke| Toji, Tomohiro| Sakurai, Jun| Tomita, Koji| Uka, Mayu| Umakoshi, Noriyuki| Kawabata, Takahiro| Munetomo, Kazuaki| Mitsuhashi, Toshiharu| Hiraki, Takao| |
| Keywords | Biopsy Kidney Tumor Computed tomography Ultrasound |
| Note | The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-023-01496-x| |
| Published Date | 2023-10-14 |
| Publication Title | Japanese Journal of Radiology |
| Volume | volume42 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 319 |
| End Page | 325 |
| ISSN | 1867-1071 |
| NCID | AA12375935 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37833443 |
| DOI | 10.1007/s11604-023-01496-x |
| Web of Science KeyUT | 001086535200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11604-023-01496-x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hara, Naofumi| Ichihara, Eiki| Kano, Hirohisa| Ando, Chihiro| Morita, Ayako| Nishi, Tatsuya| Okawa, Sachi| Nakasuka, Takamasa| Hirabae, Atsuko| Abe, Masaya| Asada, Noboru| Ninomiya, Kiichiro| Makimoto, Go| Fujii, Masanori| Kubo, Toshio| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | Epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) cell cycle CDK4/6 inhibitor |
| Published Date | 2023-10-31 |
| Publication Title | Translational Lung Cancer Research |
| Volume | volume12 |
| Issue | issue10 |
| Publisher | AME Publishing Company |
| ISSN | 2218-6751 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Translational Lung Cancer Research. |
| File Version | publisher |
| PubMed ID | 38025818 |
| DOI | 10.21037/tlcr-23-99 |
| Web of Science KeyUT | 001091030600001 |
| Related Url | isVersionOf https://doi.org/10.21037/tlcr-23-99 |
| JaLCDOI | 10.18926/AMO/66930 |
|---|---|
| FullText URL | 78_2_197.pdf |
| Author | Teraishi, Fuminori| Matsumi, Yuki| Tachibana, Kota| Watanabe, Toshiyuki| Fujiwara, Toshiyoshi| |
| Abstract | A 90-year-old Japanese woman who had been aware of a subcutaneous mass on the right perineal region for 5 years was referred to our hospital for further examination and treatment because of the rapid growth of the mass and bleeding that began 3 months earlier. A biopsy of the mass revealed a diagnosis of well-differentiated squamous cell carcinoma. On preoperative examination, the tumor was 90×40 mm in size and was suspected to have partially invaded the levator ani muscle and external sphincter. Since a preoperative cardiac evaluation indicated severe aortic stenosis, we performed transcatheter aortic valve implantation. A radical resection was then performed with general anesthesia. The skin and subcutaneous tissue defects were reconstructed with a posterior gluteal-thigh propeller flap, and a sigmoid colostomy was created. The patient had a good postoperative course and was transferred to a rehabilitation facility 28 days after the surgery. Epidermal cysts are a common benign tumor, and clinicians should keep in mind that these cysts can become malignant. |
| Keywords | squamous cell carcinoma epidermoid cyst gluteal thigh flap |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688838 |
| Web of Science KeyUT | 001227932200004 |
| JaLCDOI | 10.18926/AMO/66927 |
|---|---|
| FullText URL | 78_2_185.pdf |
| Author | Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun| |
| Abstract | The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients. |
| Keywords | obesity type 2 diabetes COVID-19 vaccination |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 191 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688836 |
| Web of Science KeyUT | 001227932200002 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| JaLCDOI | 10.18926/AMO/66923 |
|---|---|
| FullText URL | 78_2_143.pdf |
| Author | Shigematsu, Hisayuki| Yamashita, Natsumi| Suehisa, Hiroshi| Ueno, Tsuyoshi| Ryuko, Tsuyoshi| Sugihara, Takahito| Nakashima, Shohei| Sano, Yoshifumi| Yamashita, Motohiro| |
| Abstract | Travel burden is a poor prognostic factor for many cancers worldwide because it hinders optimal diagnosis and treatment planning. Currently, the impact of travel burden on survival after surgery for non-small cell lung cancer (NSCLC) in Japan is largely unexplored. We examined the impact of travel distance on the postoperative outcomes of patients with NSCLC in Ehime Prefecture, Japan. The data of 1212 patients who underwent surgical resection for NSCLC were retrospectively reviewed. Patients were divided into quartiles based on the travel distance from their home to the hospital (≤ 13 km, 13-40 km, 40-57 km, and > 57 km) in Ehime Prefecture. We found no significant differences among the quartiles in baseline clinicopathological characteristics, including sex, smoking status, histology, surgical procedure, clinical stage, and pathological stage. Overall survival (OS) and relapse-free survival (RFS) also were not significantly different among the travel distance quartiles. We conclude that travel distance did not impact OS or RFS among patients with NSCLC who underwent surgical resection at our institution. |
| Keywords | non-small cell lung cancer travel distance travel burden lung surgery surgical outcome |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 143 |
| End Page | 149 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688832 |
| Web of Science KeyUT | 001229151800006 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohsawa, Kumiko| Momose, Shuji| Nishikori, Asami| Nishimura, Midori Filiz| Gion, Yuka| Sawada, Keisuke| Higashi, Morihiro| Tokuhira, Michihide| Tamaru, Jun-Ichi| Sato, Yasuharu| |
| Keywords | classic Hodgkin lymphoma methotrexate immunodeficiency programmed cell death-ligand 1 rheumatoid arthritis |
| Published Date | 2024-03-27 |
| Publication Title | Cancers |
| Volume | volume16 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 1298 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38610976 |
| DOI | 10.3390/cancers16071298 |
| Web of Science KeyUT | 001201068000001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers16071298 |
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| FullText URL | 78_2_123.pdf |
| Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |
| JaLCDOI | 10.18926/AMO/66914 |
|---|---|
| FullText URL | 78_2_115.pdf |
| Author | Nakamura-Maruyama, Emi| Irie, Keiichiro| Narita, Kazuhiko| Himi, Naoyuki| Miyamoto, Osamu| Nakamura, Takehiro| |
| Abstract | Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model’s usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4−) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4− was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments. |
| Keywords | brain edema water intoxication model age gender AQP4 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 115 |
| End Page | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688829 |
| Web of Science KeyUT | 001229151800003 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| FullText URL | 78_2_095.pdf |
| Author | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Abstract | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| Keywords | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hassan, Ghmkin| Afify, Said M.| Zahra, Maram H.| Nawara, Hend M.| Kumon, Kazuki| Iwasaki, Yoshiaki| Salomon, David S.| Seno, Akimasa| Seno, Masaharu| |
| Keywords | Cancer stem cells Human iPSCs Signal pathway inhibitors Tumor initiation |
| Note | The version of record of this article, first published in Cytotechnology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10616-023-00575-1| |
| Published Date | 2023-04-01 |
| Publication Title | Cytotechnology |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 243 |
| End Page | 253 |
| ISSN | 0920-9069 |
| NCID | AA10678299 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37181678 |
| DOI | 10.1007/s10616-023-00575-1 |
| Web of Science KeyUT | 000961388400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10616-023-00575-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Asada, Noboru| Ando, Jun| Takada, Satoru| Yoshida, Chikashi| Usuki, Kensuke| Shinagawa, Atsushi| Ishizawa, Kenichi| Miyamoto, Toshihiro| Iida, Hiroatsu| Dobashi, Nobuaki| Okubo, Sumiko| Honda, Hideyuki| Soshin, Tomomi| Nishimura, Yasuko| Tsutsui, Atsuko| Mukai, Harumi| Yamamoto, Kazuhito| |
| Keywords | acute myeloid leukemia venetoclax low-dose cytarabine expanded access study tumor lysis syndrome |
| Published Date | 2023-04-04 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume53 |
| Issue | issue7 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 595 |
| End Page | 603 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37017320 |
| DOI | 10.1093/jjco/hyad027 |
| Web of Science KeyUT | 000963113000001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad027 |
