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Author Kataoka, Takahiro| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Tanaka, Ayumi| Yamaoka, Kiyonori|
Keywords autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation
Published Date 2022-08-26
Publication Title International Journal Of Environmental Research And Public Health
Volume volume19
Issue issue17
Publisher MDPI
Start Page 10632
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36078348
DOI 10.3390/ijerph191710632
Web of Science KeyUT 000851073300001
Related Url isVersionOf https://doi.org/10.3390/ijerph191710632
JaLCDOI 10.18926/AMO/63906
FullText URL 76_4_465.pdf
Author Bekku, Kensuke| Tsugawa, Takuji| Tsuboi, Kazuma| Noda, Gaku| Inoue, Yousuke| Murao, Wataru| Ebara, Shin|
Abstract We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk.
Keywords metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 465
End Page 472
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123162
JaLCDOI 10.18926/AMO/63905
FullText URL 76_4_457.pdf
Author Sun, Weiying| Hasebe, Satoshi|
Abstract To clarify the preventive effects of 0.01% atropine eye drops against myopia progression and axial elongation in children, a meta-analysis was carried out based on data obtained from PubMed and Web of Science as of August 1, 2021. Randomized controlled trials (RCTs) that enrolled myopic children who had received atropine for at least one year were included in this study, Key search terms included myopia, children, and 0.01% or low-dose atropine. Heterogeneity was quantified by I2 statistics, and meta-analyses were performed using the fixed-effect model. Five RCTs involving 809 unique children were analyzed. One trial was excluded because of a poor Jadad score and markedly rapid myopia progression in controls. The mean effect sizes for 12 months in myopia progression and axial elongation synthesized from the remaining 4 RCTs were 0.20 (95% CI: 0.13 to 0.27) D and −0.08 (−0.11 to −0.04) mm, respectively (p<0.0001). The corresponding inhibition ratios were 28% and 19%. I2 statistics were 6% or less. Sensitivity analysis and funnel plots demonstrated the robustness of the estimation. The 0.01% atropine-induced inhibition ratio for myopia progression in Asian children was roughly half of that originally reported and did not reach the minimum requirement for clinical treatment.
Keywords myopia 0.01% atropine low-dose atropine axial length myopia progression
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 457
End Page 463
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123161
Web of Science KeyUT 000882167300011
JaLCDOI 10.18926/AMO/63903
FullText URL 76_4_439.pdf
Author Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi|
Abstract This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex.
Keywords social capital post-traumatic stress disorder disaster flooding
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 439
End Page 446
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123159
Web of Science KeyUT 000882167300010
JaLCDOI 10.18926/AMO/63902
FullText URL 76_4_429.pdf
Author Yamadori, Yusuke| Hirao, Tomohiro| Nlandu R. Ngatu| Kanda, Kanae| Syed Mahfuz Al Hasan| Murakami, Akitsu| Mashima, Yukinori| Shirakami, Gotaro|
Abstract Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice.
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 429
End Page 437
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123158
Web of Science KeyUT 000882167300009
FullText URL fulltext.pdf
Author Sumi, Tomonari| Harada, Kouji|
Published Date 2022-08-19
Publication Title ISCIENCE
Volume volume25
Issue issue8
Publisher CELL PRESS
Start Page 104723
ISSN 2589-0042
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35813874
DOI 10.1016/j.isci.2022.104723
Web of Science KeyUT 000843628600010
Related Url isVersionOf https://doi.org/10.1016/j.isci.2022.104723
FullText URL fulltext.pdf
Author Kajiwara, Tsuyoshi| Sasaki, Toru| Otani, Yoji|
Keywords global stability two routes of infection two compartments type reproduction number lyapunov functional
Published Date 2022-08-02
Publication Title Mathematical Biosciences And Engineering
Volume volume19
Issue issue11
Publisher American Institute of Mathematical Sciences
Start Page 11047
End Page 11070
ISSN 1547-1063
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s), licensee AIMS Press.
File Version publisher
DOI 10.3934/mbe.2022515
Web of Science KeyUT 000850188600006
Related Url isVersionOf https://doi.org/10.3934/mbe.2022515
JaLCDOI 10.18926/AMO/63896
FullText URL 76_4_415.pdf
Author Kang, Haijun| Huang, Dongmei| Kang, Gangjin| Yang, Xu| Li, Heng| Liu, Siyuan| Gou, Wenjun| Liu, Linglin| Qiu, Yuyan|
Abstract Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction.
Keywords 5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 415
End Page 421
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123156
Web of Science KeyUT 000882167300007
JaLCDOI 10.18926/AMO/63894
FullText URL 76_4_399.pdf
Author Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Abstract According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67.
Keywords breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 399
End Page 408
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123154
Web of Science KeyUT 000882167300005
FullText URL fulltext.pdf
Author Nara, Shigetoshi| Fujii, Hiroshi| Tsukada, Hiromichi| Tsuda, Ichiro|
Published Date 2022-08-19
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 14172
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35986200
DOI 10.1038/s41598-022-18313-6
Web of Science KeyUT 000842561700031
Related Url isVersionOf https://doi.org/10.1038/s41598-022-18313-6
JaLCDOI 10.18926/AMO/63887
FullText URL 76_4_359.pdf
Author Hiramatsu-Asano, Sumie| Wada, Jun|
Abstract Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
Keywords systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 359
End Page 371
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123150
Web of Science KeyUT 000882167300002
FullText URL fulltext.pdf
Author Tsuge, Mitsuru| Ikeda, Masanori| Tsukahara, Hirokazu|
Keywords bronchial asthma chronic obstructive pulmonary disease lung function trajectory type 2 inflammation airway remodeling omalizumab mepolizumab benralizumab dupilumab
Published Date 2022-08-19
Publication Title Children - Basel
Volume volume9
Issue issue8
Publisher MDPI
Start Page 1253
ISSN 2227-9067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36010143
DOI 10.3390/children9081253
Web of Science KeyUT 000846009500001
Related Url isVersionOf https://doi.org/10.3390/children9081253
FullText URL fulltext20220906-1.pdf
Author Kakehi, Ayaka| Hagiya, Hideharu| Iio, Koji| Nakano, Yasuhiro| Ihoriya, Hiromi| Taira, Yuki| Nakamoto, Kenta| Hasegawa, Kou| Higashikage, Akihito| Otsuka, Fumio|
Keywords Candida dubliniensis Candidemia COVID-19 Sequencing analysis
Note © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.07.007] . |
Published Date 2022-10
Publication Title Journal of Infection and Chemotherapy
Volume volume28
Issue issue10
Publisher Elsevier BV
Start Page 1433
End Page 1435
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 35863730
DOI 10.1016/j.jiac.2022.07.007
Web of Science KeyUT 000843880400016
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2022.07.007
FullText URL fulltext20220830-3.pdf
Author Amioka, Naofumi| Takaishi, Atsushi| Nakamura, Kazufumi| Endo, Toyohiro| Iida, Toshihiro| Yamaji, Tatsuya| Mori, Hisatoshi| Kishinoue, Takao| Yasuhara, Kentaro| Matsuo, Naoaki| Tanimoto, Masafumi| Nakano, Yukari| Onishi, Nobuhiko| Ueeda, Masayuki| Ito, Hiroshi|
Keywords Clinical pathway Acute decompensated heart failure Tolvaptan Cardiac rehabilitation Prognosis
Note © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jjcc.2022.03.014] . |
Published Date 2022-09
Publication Title Journal of Cardiology
Volume volume80
Issue issue3
Publisher Elsevier BV
Start Page 232
End Page 239
ISSN 0914-5087
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
PubMed ID 35428556
DOI 10.1016/j.jjcc.2022.03.014
Web of Science KeyUT 000838175500008
Related Url isVersionOf https://doi.org/10.1016/j.jjcc.2022.03.014
FullText URL fulltext.pdf
Author Yamamoto, Norio| Tsujimoto, Yasushi| Yokoo, Suguru| Demiya, Koji| Inoue, Madoka| Noda, Tomoyuki| Ozaki, Toshifumi| Yorifuji, Takashi|
Keywords trochanteric fracture intertrochanteric fracture pertrochanteric fracture reduction tip-apex distance mechanical failure fixation failure cut-out systematic review meta-analysis
Published Date 2022-08-19
Publication Title Journal Of Clinical Medicine
Volume volume11
Issue issue16
Publisher MDPI
Start Page 4879
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36013114
DOI 10.3390/jcm11164879
Web of Science KeyUT 000845562100001
Related Url isVersionOf https://doi.org/10.3390/jcm11164879
FullText URL fulltext.pdf
Author Mitsudo, Koichi| Inoue, Haruka| Niki, Yuta| Sato, Eisuke| Suga, Seiji|
Keywords enone hydrogenation iridium palladium PEM reactor
Published Date 2022-08-19
Publication Title Beilstein Journal Of Organic Chemistry
Volume volume18
Publisher Beilstein-Institut
Start Page 1055
End Page 1061
ISSN 1860-5397
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Mitsudo et al.
File Version publisher
DOI 10.3762/bjoc.18.107
Web of Science KeyUT 000843361500001
Related Url isVersionOf https://doi.org/10.3762/bjoc.18.107
FullText URL fulltext.pdf
Author Maruyama, Takayuki| Ekuni, Daisuke| Higuchi, Masakazu| Takayama, Eiji| Tokuno, Shinichi| Morita, Manabu|
Keywords periodontitis psychological stress voice analysis prospective cohort study
Published Date 2022-08-02
Publication Title International Journal Of Environmental Research
Volume volume19
Issue issue15
Publisher MDPI
Start Page 9489
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35954845
DOI 10.3390/ijerph19159489
Web of Science KeyUT 000838914100001
Related Url isVersionOf https://doi.org/10.3390/ijerph19159489
FullText URL fulltext.pdf
Author Tokumasu, Kazuki| Honda, Hiroyuki| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Yamamoto, Koichiro| Nakano, Yasuhiro| Hasegawa, Toru| Yamamoto, Yukichika| Otsuka, Yuki| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio|
Keywords general fatigue post-exertional malaise long COVID myalgic encephalomyelitis chronic fatigue syndrome post COVID-19 condition
Published Date 2022-06-25
Publication Title Medicina
Volume volume58
Issue issue7
Publisher MDPI
Start Page 850
ISSN 1010-660X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35888568
DOI 10.3390/medicina58070850
Web of Science KeyUT 000834490500001
Related Url isVersionOf https://doi.org/10.3390/medicina58070850
FullText URL fulltext.pdf
Author Ono, Kisho| Sato, Kohei| Nakamura, Tomoya| Yoshida, Yume| Murata, Shogo| Yoshida, Kunihiro| Kanemoto, Hideka| Umemori, Koki| Kawai, Hotaka| Obata, Kyoichi| Ryumon, Shoji| Hasegawa, Kazuaki| Kunisada, Yuki| Okui, Tatsuo| Ibaragi, Soichiro| Nagatsuka, Hitoshi| Sasaki, Akira|
Keywords oral cancer spheroid three-dimensional culture anticancer drug
Published Date 2022-07-18
Publication Title International Journal Of Medical Sciences
Volume volume19
Issue issue8
Publisher Ivyspring International Publisher
Start Page 1320
End Page 1333
ISSN 1449-1907
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The author(s).
File Version publisher
PubMed ID 35928727
DOI 10.7150/ijms.74109
Web of Science KeyUT 000830781500011
Related Url isVersionOf https://doi.org/10.7150/ijms.74109
FullText URL s41598-022-16279-z.pdf
Author Takeuchi-Hatanaka, Kazu| Koyama, Yoshinobu| Okamoto, Kentaro| Sakaida, Kyosuke| Yamamoto, Tadashi| Takashiba, Shogo|
Published Date 2022-07-19
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 12353
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35854051
DOI 10.1038/s41598-022-16279-z
Web of Science KeyUT 000827810800083
Related Url isVersionOf https://doi.org/10.1038/s41598-022-16279-z