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Author Institute for Thermal Spring Research, Okayama University|
Published Date 1979-09-25
Publication Title 岡山大学温泉研究所報告
Volume volume49
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1980-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume50
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1980-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume50
Content Type Others
JaLCDOI 10.18926/21163
Title Alternative Determination of lithium in serum by emission spectrophotometry using "Spectraspan"
FullText URL pitsr_050_043_048.pdf
Author Mifune, Masaaki|
Abstract Lithium in serum was determined by a plasma emissionspectrophotometer "Spectraspan" (low power d.c. plasma are, operating on argon). The opitimum condition for ashing of serum by low temperature was studied. The influences of hydrochloric acid and several metallic ions (Na, K, Mg, Ca) on emission intensity were examined. There was a linear relationship between emission intensity and lithium content from 0 to 10μg/ml. Lithum in serum was easily determined by standard addition method. Precision, coefficient of variance and recovery of known amount of lithium added to the sample for 12 replicate analyses were 0.093μg/ml, 1.85%, 99-104%, respectively. Significantly positive correlationship was observed between emission spectrophotometry using spectraspan and atomic absoption spectrophotometry.
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 43
End Page 48
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002311034
JaLCDOI 10.18926/21162
Title Alternative No occcurrence of the oxygen isotope exchange with quartz glass of reaction tube through the conversion of oxygen into carbon dioxide in an externally heated carbon furnace
FullText URL pitsr_050_041_042.pdf
Author Matsubaya, Osamu|
Abstract Two oxygens of which δ(18)O is +28.83 and -79.57‰, respectively, were converted into carbon dioxide by means of both an external heating method and a Daylight's method where a graphite rod was heated by concentration of light from a slide projecter lamp on the graphite rod, and the δ(18)O of carbon dioxides obtained in the two methods were compared to each other. Except for data affected by memory of the previous sample, the averages in the external heating method were +28.85 and -79.56‰, respectively, and quite consistent with the averages in the Daylight's method, that were +28.81 and -79.67‰, respectively. This concludes that no oxygen isotope exchange occurs between the sample gas and the quartz glass of reaction tube in the external heating method. There is no significant difference in the results in four externally heated carbon furnaces, whereas the memory of previous samples was apparently observed within each furnaces. This memory was larger in the furnaces containing a used graphite rod (Nos. 3 and 4) than those containing new one (Nos. 1 and 2), and also more significant for smaller samples (Run 4 in No. 3). However, if the reaction tube was baked out at a higher temperature (750℃) than the reaction temperature (700℃) before reaction, the memory was mostly eliminated (Run 8 in No.3).
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 41
End Page 42
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310942
JaLCDOI 10.18926/21161
Title Alternative Radon contents in the air of radioactive spring areas
FullText URL pitsr_050_033_039.pdf
Author Furuno, Katsushi|
Abstract Radon(Rn) contents in the air of radioactive spring areas were determined using an ionization chamber equipped with vibrating reed electrometer. The results were as follows: (1) Rn contents in the outdoor air at spa areas of Misasa. Sekigane and Togoo were 0.7 ± 0.4 pCi/l. 0.6±0.3pCi/l and 0.5±0.2 pCi/l respectively. Rn contents in the air both at Misasa and at Sekigane were significantly higher than at none spa area of Kurayoshi city (0.3±0.2pCi/l). (2) Rn contents in the outdoor air at Misasa spa tend to increase from June to September in the year. (3) In usual rooms where spring water is not used. Rn contens in the air were below 1.0 pCi/l. Rn contents in the air of facilities using spring water were determined; peloid therapy room: 2.0±0.4 pCi/l, usual bath rooms: 6.3±1.3 pCi/l (before the bathing). 21.8±2.1 pCi/l (immediately after bathing), Hubbard bath room: 6.7±0.3 pCi/l (before the bubbling), 143.4±69.8 pCi/l (during the bubbling), exercise pool room : 4.3±0.3 pCi/l (before the exercise). 7.4 ± 0.8 pCi/l (during the exercise) and drinking hall: 30.0~47.0 pCi/l respectively.
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 33
End Page 39
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310972
JaLCDOI 10.18926/21160
Title Alternative The determination of uric acid using modified Patel's method
FullText URL pitsr_050_025_031.pdf
Author Nishimura, Yoshiko| Aoki, Hiroko| Mifune, Masaaki|
Abstract N 13-b method for determination of uric acid by AutoAnalyzer- I was proposed from Technicon Corporation, but the sensitivity of this method was insufficient. According to the modification by Patel, good sensitivity was obtained for determining of uric acid, but insufficient separation between peaks was accompanied. To get good separation, Patel's method was reexamined by the authors, and the results were as follows. Sufficient separation was obtained by modifing the flow diagram of Patel's method. The mean recovery rates of uric acid added to serum and urine were 103.6% and 102.5%, and coefficients of variation were 1.27% and 1.05% respectively. The correlation between this modified Patel's method and the U.A. test Wako method was recognized (serum : n=95, r=0.97, urine : n=35, r =0.99). According to our modified method, uric acid concentration in serum of 68 subjects, were 5.8±0.9mg/100ml in 29 males and 4.4±0.8mg/100ml in 39 females.
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 25
End Page 31
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310944
JaLCDOI 10.18926/21159
Title Alternative An isotope study of hot springs in Nagano Prefecture
FullText URL pitsr_050_017_024.pdf
Author Matsubaya, Osamu| Sakai, Hitoshi| Kusakabe, Minoru| Sasaki, Akira|
Abstract Water samples from 28 hotsprings and mineral springs in Nagano Prefecture, central Japan, were examined for their stable isotope ratios of hydrogen, oxygen, carbon, and sulfur. Spring waters of Kashio are highly saline and enriched in heavy isotopes of oxygen and hydrogen (δ(18)O=-2.5~-4.6‰, δD=-54~-57‰). Linear relationships among δD, δ(18)O, and Cl(-) suggest that spring waters are the mixtures of a deep brine and local surface water. Extrapolation of the linear relationships indicates that the deep brine is both isotopically and chemically very similar to the deep brine previously suggested for the springs of Arima, Takarazuka, and Ishibotoke of which δD, δ(18)O, and Cl(-) are estimated as -33‰, +8.0‰, and 44g/l, respectively. A common origin may be warranted among these postulated brines, while their provenance is yet to be worked out. The hot springs in Matsushiro are a Na-Ca-Cl type of high carbonate content. Their hydrogen and oxygen isotope ratios (δD=-71~-46‰, δ(18)O=-9.1~-2.0‰) are higher than the local surface water. On the basis of the relationships among δD, δ(18)O, and Cl(-), they are considered to be the mixtures of fossil sea water and certain water of meteoric origin of which Cl(-) is about 4g/l and δ(18)O is higher by about 3‰ than the local surface water. The latter may be meteoric water circulating in the marine sedimentary formations (Green Tuff formations) with soluble sea salts. Isotopic exchange with carbonate minerals in the formations explains its (18)O enrichment. Spring waters from Yashio and Isobe (Gunma Pref.) as well as Yunosawa and Yatate (Akita Pref.) were previously interpreted to be mixtures of fossil sea water and local surface water of low Cl(-) content. Re-examination of their data revealed that the meteoric waters responsible for these springs contain about 3g/l Cl(-), similar to the value obtained for Matsushiro. However, unlike Matsushiro, the meteoric waters in these areas are found to be isotopically similar to the local surface waters. Waters from other hot springs studied here are of simply meteoric origin, thus belonging to the GreenTuff type water previously defined.
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 17
End Page 24
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310953
JaLCDOI 10.18926/21158
Title Alternative Experimental study of sulfur isotope exchange between S0(4)(2-) and H(2)S (aqueous) at 400℃ and 1000 bars water pressure
FullText URL pitsr_050_001_015.pdf
Author Kamada, Emi| Sakai, Hitoshi| Kishima, Noriaki|
Abstract Experimental procedures used in this study are the same as those developed by Sakai and Dickson (1978). 0.005 M Na(2)S(2)O(3) solutions were heated to 400℃ under 1000 bar water pressure in a gold bag of Dickson gold-bag equipment (Fig. 1). At an elevated temperature Na(2)S(2)O(3) quickly and completely decomposed into 1:1 mixture of SO(4)(2-) and H(2)S (eq. (1)) and subsequent isotope exchange (eq. (2)) was monitored by consecutively withdrawing aliquots of solution for chemical and isotopic analyses at desired time intervals. For the preparation of SO(2) for isotope analyses, 2 to 5 mg BaSO(4) was thoroughly mixed with silica glass powder of 10 times the BaSO(4) in weight and heated to 1400℃ or so in sealed, evacuated silica glass tubings (see Fig. 2 and equation (4)). The technique is a modification of Holt and Engelkemeir (1971). The (18)O/(16)O ratios of SO(2) thus formed stayed constant by exchange with silica glass powder (Fig. 3). Numerical data of the three runs performed in this study are summarized in Tables 1 to 3. In runs 2 and 3, a small aliquot of (34)S- enriched H(2)SO(4) was added into the starting solution and thus equilibrium was approached from above the quilibrium value (see Fig. 4). When isotope exchange occurs between two molecules, X and Y, the reaction rate, r, is related to the extent of exchange, F, at given time, t, by equation (17), where X and Y indicate concentrations of given species, α(e), α(o) and α denote the fractionation factor at equilibrium, at time t=0 and at an arbitrary time t, and F = (α - α(o))/(α(e) - α(0)) or the extent of isotope exchange. Assuming the exchange rate is of the first order with respect to both X and Y and to the β'th power of hydrogen ion activity, a(H)(+), eq. (17) reduces to eq. (19), where k(1) denotes the rate constant. If X, Y and pH of solution stayed constant during the run, the half-time, t(1/2), of the exchange reaction can be obtained graphically as shown in Fig. 5. The t(1/2) for runs 1, 2, and 3 are determined to be 5.8, 5.5 and 6.1 hrs, respectively. Introducing F=0.5 and t=t(1/2) into eq. (19), we obtain eq. (20) which is graphically shown in Fig. 6 using the data by the present work and those by Sakai and Dickson(1978). The numerical values of log k(1) + 0.16 may be obtained by extrapolating the lines to pH=0 and, from these values, the rate constant, k(1) , may be calculated for temperatures of 300° and 400℃. From these two values of k(1) and from the Arrhenius plot, the activation energy of the exchange reaction was calculated to be 22 kcal/mole, a much smaller value than 55 kcal/mole obtained by Igumnov (1977). The value of β is found to be 0.29 at 300℃ and 0.075 at 400℃, although the physico-chemical nature of β is not clear to the present authors. Using these values, eq. (24), where C is a constant, is derived which would enable us to calculate the t(1/2) of any system of known ΣS and pH. However, as we do not know yet how β varies with different systems, eq. (24) is applicable only to limited systems in which temperature, total sulfur contents and pH are similar to those of the present study. Fig. 7 illustrates how t(1/2) varies with pH and total sulfur content at 300° and 400℃ and predicts t(1/2) for some solutions obtainable by hydrothermal reactions of seawater with various igneous rocks. The average equilibrium fractionation factor at 400℃ obtained by this study is 1.0153, in good accord with 1.0151 given by Igumnov et al. (1977). Theoretical fractionation factors between SO(4)(2-) and H(2)S have been calculated by Sakai (1968) , who gives too high values compared to the experimental data obtained by this and other researchers (Fig. 9). In the present study, the reduced partition function ratio (R.P.F.R.) of SO(4)(2-) was recalculated using two sets of the vibrational frequencies of SO(4)(2-) (shown in Table 5) and the valence force fields of Heath and Linnett (1947), which reproduces the observed frequencies of SO(4)(2-) better than Urey-Bradley force field used by Sakai (1968). The results of new calculation are shown in Table 6. This table also includes the R.P.F.R. of H(2)S which was calculated by Thode et al. (1971). Using these new R.P.F.R. of SO(4)(2-) and H(2)S, the fractionation factors between SO(4)(2-) and H(2)S were calculated and are listed in the last column of Table 6 and plotted in Fig. 9. Fig. 9 indicates that the new calculation gives values more shifted from the experimental values than before. The major sulfate ions in our solution at 300° and 400℃ exist as NaSO(4)(-) (Sakai and Dickson, 1978; see also Table 4 of this paper) and, therefore, the measured fractionation factors are those between NaSO(4)(-) and H(2)S. The discrepancy between the theory and experiments may, at least, be partially explained by this fact, although other more important reasons, which are not known to us at the moment, may also exist.
Publication Title 岡山大学温泉研究所報告
Published Date 1980-03-25
Volume volume50
Start Page 1
End Page 15
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310990
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1980-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume50
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1980-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume50
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1981-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume51
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1981-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume51
Content Type Others
JaLCDOI 10.18926/21153
Title Alternative Evaluation of the coulter counter Model Sr
FullText URL pitsr_051_057_063.pdf
Author Nishimura, Yoshiko| Yamane, Sachiko| Mano, Fumie| Mifune, Masaaki|
Abstract An automatic blood analyser, Coulter Counter Model Sr(CC-SR) was recently introduced in our hospital. This blood analyser is able to provide simultaneous measurements of seven blood parameters, i.e. WBC, REC, Hgb, Hct, MCV, MCH, MCHC, and also produces the results within 40 seconds from aspiration of the sample into the instrument. The performance and precision of this blood analyser have been clitically evaluated by comparing the results obtained from the previous blood cell counter, the Coulter Counter Model Dn (CC-DN), a haemoglobinometer, and a high speed centfugal separator. The results are as follows: 1) The precision and liniarity for readings and dilutions on WBC, RBC, Hgb and Hct by the use of the CC-SR is satisfactory. 2) Good correlation between the measurements by whole blood analysis procedure and micro sample analysis procedure is recognized. 3) The amount of carryover from one sample to the next is negligible for practical purpose. 4) High correlation factors are obtained between the measurements by the CC-SR method and former methods: i. e. 0.99 for WBC, 0.93 for RBC, 0.99 for Hgb and 0.99 for Hct. 5) For these reason, it can be said that CC-SR is more useful successive instrument to measure WBC, RBC, Hgb, Hct than the CC-DN and other above mentioned instruments.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 57
End Page 63
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002311033
JaLCDOI 10.18926/21152
Title Alternative Changes in plasma metabolites after the injection of noradrenalin -effect of hot spring serial bathing-
FullText URL pitsr_051_053_056.pdf
Author Seno, Toshinobu|
Abstract In attempt to clarify the effect of serial bathing on metabolic actions of noradrenaline (NA) by using rats which took a bath (for 10 minutes, 40℃ in temperature) in the hot spring in Misasa or a city water once daily for one and four weeks, changes in plasma metabolites after the injection of NA (20μg/100g, subcutaneously) were studied. No significant difference in the rising degree of plasma free fatty acid (FFA) or glucose levels by NA injection was observed in rats which took serial bathing for one week, while triglyceride levels of rats, which took a city water bath, rised significantly by NA in jection. After serial bathing for four weeks, however, remarkable difference in the rising degree of FFA levels by NA injection was observed between rats taking a city water bath and ones taking hot spring bath and between rats taking a bath and non-treated ones. The rising degree of glucose levels by NA injection was slightly supressed only in rats taking a city water bath compared with nontreated rats. Little difference in the rising degree of β-hydroxybutyrate levels by NA injection was observed in rats taking serial bathing for one or four weeks compared with non-treated rats.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 53
End Page 56
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310994
JaLCDOI 10.18926/21151
Title Alternative Effect of hot spring serial bathing on plasma metabolites
FullText URL pitsr_051_049_052.pdf
Author Seno, Toshinobu|
Abstract In order to study the effect of bathing for 10 minutes, 34℃ and 40℃ in temperature, in the hot spring in Misasa on plasma metabolites of rats which took a bath once daily for one, two and four weeks, the body weight and the catecholamine, free fatty acid(FFA) and glucose contents in plasma were measured after serial bathing. The body weight tended to decrease by serial bathing compared with non-treated rats. Plasma noradrenaline (NA) content decreased slightly after one and four weeks-serial bathing, but no change was observed after two weeks-serial bathing. Adrenaline content showed the same tendency to decrease as NA content after one and four weeks-serial bathing, but it increased slightly after two weeks-serial bathing. Plasma FFA contents increased by serial bathing compared with those in controls. As to plasma glucose content, a slight decreasing tendency was observed after four weeks-serial bathing although no change was observed after one and two weeksserial bathing.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 49
End Page 52
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310962
JaLCDOI 10.18926/21150
Title Alternative Effect of serial bathing on plasma metabolites
FullText URL pitsr_051_043_047.pdf
Author Seno, Toshinobu|
Abstract The present experiments were undertaken to elucidate the effect of serial bathing on plasma metabolites of rats. The rat took a bath for 10 minutes, 34℃ and 40℃ in temperature, in a city water once daily for two or four weeks. After serial bathing, the body weight and the catecholamines, free fatty acid (FFA) and glucose contents in plasma were measured. The results are as follows: 1) The body weight showed a marked decrease after four weeks-serial bathing compared with that of the non-treated rats. 2) After two weeks-serial bathing, the noradrenaline (NA) content decreased slightly, but the adrenaline (A) content increased slightly compared with those in controls. After four weeks-serial bathing, no changes were observed in NA and A contents. 3) Plasma FFA content tended to increase by serial bathing compared with that in controls. 4) Although plasma glucose content tended to increase after two weeks-serial bathing, no change was observed after four weeks-serial bathing compared with that in corresponding controls.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 43
End Page 47
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310979
JaLCDOI 10.18926/21149
Title Alternative Studies on sinter deposits in Misasa radioactive hot springs (2nd report)
FullText URL pitsr_051_035_042.pdf
Author Furuno, Katsushi| Mifune, Masaaki| Morinaga, Hiroshi| Fukushima, Satoru| Wada, Hiroaki|
Abstract Qualitative and quantitative analysis of sinter deposits in a distributing pipe used for seventeen years (Sample No.1) and adhere to bathtub wall for eleven years (Sample No.2 and Sample No.3) in Misasa radioactive hot springs were investigated. The results were as follows ; (1) The color of deposits of Sample No.1 and Sample No.2 was black and the color of deposits of Sample No.3 was white. The metal elements in these deposits were qualitative analysed by spectraspan plasma emission spectrophotometry (SPES) and by fluorescent X-ray spectrometry. Following elements were detected, in Sample No.1 : Na, Mg, Al, K, Ca, Mn, Fe, Cu, As, Sr, Ba, Mo, and Pb, in Sample No.2 : Na, Mg, Al, Si, K, Ca, Ti, Mn, Fe, Cu, Zn, As, Sr, Ba, Pb and Cl and in Sample No.3 : Na, Mg, Al, Si, K, Ca, Mn, Fe, Cu, Zn, As, Rb, Sr, Mo, Ba, S, and Cl, (2) The metal elements in these deposits were quantitative analysed by SPES, atomic absorption spectrophotometry and emission spectrophometry. Following elements were determined, in Sample No.1 ; Mn : 411.6, Fe : 65.7, Ba : 20.0, Ca : 11.9, Na : 5.7, Cu : 4.5, K : 4.2, Sr : 2.9, Zn : 2.6, Mg : 1.4, in Sample No.2 ; Mn : 248.2, Fe : 28.5, Ba : 15.6, Ca : 25.0, Mg : 10.5, Na : 9.3, Cu : 5.4, K : 4.9, Sr: 7.4, Zn : 3.3, and in Sample No.3 ; Ca : 275.2, Sr : 32.4, Mg: 12.4, Na: 18.7, K: 5.0, Mn: 1.7 and Fe: 0.6mg per gram. The main components of these deposits were manganese compounds (Sample No.1 and Sample No.2) and calcium compounds (Sample No.3). Qualitative and quantitative analysis of barium in sinter deposits of Misasa spa was done by authers for the first time. (3) Radioactivity in these deposits were observed by autoradiography. Among the radioactive elements, concentration of radium were 3.41×10(-8) Ci/g (Sample No.1), 4.70×10(-9) Ci/g (Sample No.2) anp 2.36×10(-11) Ci/g (Sample No.3), respectively.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 35
End Page 42
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002311013
JaLCDOI 10.18926/21148
Title Alternative Determination of environmental radiation at radioactive spa areas in the Sanin districts
FullText URL pitsr_051_025_033.pdf
Author Furuno, Katsushi|
Abstract Dose rates of environmental radiation were determined with NaI (Tl) cristal scintillation survey meter at Misasa, Sekigane and Ikeda spa areas which were known as radioactive spring in the Sanin districts. The results were as follows ; (1) Dose rates of radiation in the air of outdoor at spa areas of Misasa, Sekigane and Ikeda were 11.8±2.3μR/h, 11.3±2.1μR/h and 18.4±5.8μR/h, respectively. Dose rates of radiation in the air of these spa areas were significantly higher (P<0.01) than at none spa area of Kurayoshi city (8.6±1.2μR/h). Dose rates of radiation in the outdoor air at Misasa and Sekigane tends to increase near the spring sources. (2) In the room where spring water is not used, dose rates of radiation in the air were 9.5~10.5μR/h. Dose rates of radiation in the air of the room with facilities using spring water were determined; peloid therapy room: 13.3±0.5μR/h, Hubbard bath room : 12.5±0.4μR/h, drinking hall : 11.8±0.7μR/h, hot air bathing room : 18.2±1.7μR/h, usual bath room (Onkensen) : 13.0±1.0μR/h and bath room for patients : 17.9±1.2μR/h (males), 17.0±1.2μR/h (females), respectively. Dose rates of radiation in the air of the bath room of Gunze-hotel and Ohashi-hotel-Gankutsunoyu were 30.1±9.0μR/h and22.3±3.0μR/h, respectively. At Ikeda spa, dose rates of radiation in the air of the guest room and the bath room were range of 13.0~19.0μR/h and 14.0~23.0μR/h.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 25
End Page 33
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002310936
JaLCDOI 10.18926/21147
Title Alternative Ketamine-amitriptyline therapy for the intractable cancer pain with restlessness
FullText URL 051_021_023.pdf
Author Noishiki, Yasuharu|
Abstract A combination therapy of ketamine-amtriptyline for the intractable pain with restlessness of cancer patients in the end stage was presented. Seven patients with peritonitis carcinomatosis due to recurrence of stomach cancer were administrated the therapy. They ranged in age from 29 to 79 years. The results were eminently desirable. Intractable pain with restlessness were diminished by the therapy though languid feeling was yet remained. Anodyne (pentazocine), which was nessesary many times in one day before the therapy, was not used in the duration of the therapy. The experimental and clinical studies of analgesic property of ketamine by HATANO revealed that it is more twice as potent an analgesic in low dosage compared with pethidine, despite its rather short duration of action. There was no respiratory depression. No hypotension nor bradycardia were observed during the therapy. The only use of ketamine however, could not release the pain and anguish of cancer patients. The author applied amitriptyline to these cases. The combination use of ketamine and amitriptyline could release them. These drugs demonstrated their full effect by the combination use.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 21
End Page 23
ISSN 0369-7142
language Japanese
File Version publisher
NAID 40000321153