実験的アレルギー性肝炎の研究 第1編 AKRマウス肝抽出液によるC57Blマウス長期感作後の組織学的変化

ヒトのウイルス性肝炎の発症および慢性化のアレルギー性機序を解明するための一手段として, AKR肝抽出液を抗原としてC57Blに長期感作を施行し,肝グリソン氏鞘内に著明な円形細胞浸潤,piecemeal necrosis,肝細胞壊死,星細胞の反応を作成しえたが,リンパ沪胞の形成,肝グリソン氏鞘の結合織の増生は認められなかった.以上の組織変化は肝炎B抗原,すなわち,　hetero抗原とその抗体とのアレルギー機序によって生じると考えられるヒトのウイルス性肝炎の組織表現にかなり類似している.しかし,長期感作を中止し放置すると,組織変化は消褪した.

In an attempt to evaluate histologically an allergic phenomenon involved in the development of chronic hepatitis in man, the inbred strain C57BL mice were sensitized for prolonged durations from 5 to 19 weeks with a homologous liver extract from AKR mice as well as with complete Freund's adjuvant. Histological changes in the liver of the sensitized mice immediately after the treatment comprised a marked round cell infiltration in the portal areas, piece-meal necrosis, various types of liver cell necrosis and degeneration, and an activation of the Kupffer cells as compared with control groups. These histological changes somewhat resembled the findings of chronic hepatitis in human liver disease, but they have greatly subsided in 5 weeks post to the last sensitization. It may be assumed on the basis of the present experiment that a persistent sensitization for a longer duration is necessitated for the establishment of a chronic murine hepatitis similar to a human chronic hepatitis.