result 49252 件
| FullText URL | olj_73_3_contents_eng.pdf |
|---|---|
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| FullText URL | olj_73_3_colophon.pdf |
|---|---|
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| FullText URL | olj_73_3_authors.pdf |
|---|---|
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| Start Page | 293 |
| End Page | 293 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| FullText URL | olj_73_3_155_200.pdf |
|---|---|
| Author | Omori, Hidetomi| |
| Abstract | Today, religious groups have increasingly represented themselves in various public scenes, making it difficult to address the issues under the existing legal framework; the separation of church and state and freedom of religion. Though political liberals, such as Rawls, have proposed a conception of political justice that attempts to be tolerant of religions, it is limited by their view of the public/private distinction as given and their representative viewpoint of public authority. To make political justice more open to religions, a paradigm shift to the religious viewpoint should be necessary. Political liberalism then is reconstructed so that it opens an interactive process between justice and religions. A theorist, adopting a distanced internal perspective of religions, can help with this task by providing a list of doctrinal reasons that religious believers can voluntarily endorse and appeal to when they are involved in consensus and deliberation. |
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| Start Page | 200 |
| End Page | 155 |
| ISSN | 0386-3050 |
| language | English |
| File Version | publisher |
| Title Alternative | Formation Process of the Operating System on Patent Law in Postwar Japan |
|---|---|
| FullText URL | olj_73_3_201_260.pdf |
| Author | Oizumi, Y.| |
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| Start Page | 260 |
| End Page | 201 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| Title Alternative | Telling of the Trouble in Mediation |
|---|---|
| FullText URL | olj_73_3_262_292.pdf |
| Author | Li, Y.| |
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| Start Page | 292 |
| End Page | 262 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| FullText URL | olj_73_3_contents.pdf |
|---|---|
| Publication Title | Okayama Law Journal |
| Published Date | 2024-02-26 |
| Volume | volume73 |
| Issue | issue3 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext20240226-04.pdf |
|---|---|
| Author | Kuribayashi, Tadahiro| Ohashi, Kadoaki| Nishii, Kazuya| Ninomiya, Kiichiro| Tsubata, Yukari| Ishikawa, Nobuhisa| Kodani, Masahiro| Kanaji, Nobuhiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kuyama, Shoichi| Takigawa, Nagio| Fujimoto, Nobukazu| Kubota, Tetsuya| Inoue, Masaaki| Fujiwara, Keiichi| Harita, Shingo| Takata, Ichiro| Takada, Kenji| Okawa, Sachi| Kiura, Katsuyuki| Hotta, Katsuyuki| |
| Keywords | EGFR EGFR-TKI Lung cancer Immune checkpoint inhibitors Performance status |
| Note | The version of record of this article, first published in Journal of Cancer Research and Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00432-024-05618-4| |
| Published Date | 2024-02-12 |
| Publication Title | Journal of Cancer Research and Clinical Oncology |
| Volume | volume150 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 89 |
| ISSN | 1432-1335 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38347279 |
| DOI | 10.1007/s00432-024-05618-4 |
| Web of Science KeyUT | 001160773600002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00432-024-05618-4 |
| FullText URL | fulltext20240226-03.pdf |
|---|---|
| Author | Zhou, Wenhao| Kawashima, Shusuke| Ishino, Takamasa| Kawase, Katsushige| Ueda, Youki| Yamashita, Kazuo| Watanabe, Tomofumi| Kawazu, Masahito| Dansako, Hiromichi| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Inozume, Takashi| Nagasaki, Joji| Togashi, Yosuke| |
| Keywords | cancer immunology follicular helper T cell cytotoxic CD4+ T cell CXCL13 T cell exhaustion stem-like progenitor exhaustion terminally differentiated exhaustion PD-1 LAG-3 TCF1 |
| Note | Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induces CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part of the TFH cells in the TME exhibits cytotoxicity and directly attacks major histocompatibility complex-II-expressing tumors. TFH-like cytotoxic CD4+ T cells have high LAG-3/BLIMP1 and low TCF1 expression without self-renewal ability, whereas non-cytotoxic TFH cells express low LAG-3/BLIMP1 and high TCF1 with self-renewal ability, closely resembling the relationship between terminally differentiated and stem-like progenitor exhaustion in CD8+ T cells, respectively. Our findings provide deep insights into TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti-tumor immunity orchestrally with CD8+ T cells.| |
| Published Date | 2024-02-27 |
| Publication Title | Cell Reports |
| Volume | volume43 |
| Issue | issue2 |
| Publisher | Elsevier BV |
| Start Page | 113797 |
| ISSN | 2211-1247 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 38363680 |
| DOI | 10.1016/j.celrep.2024.113797 |
| Web of Science KeyUT | 001185865700001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.celrep.2024.113797 |
| FullText URL | fulltext20240226-01.pdf |
|---|---|
| Author | Kawazu, Toshiyuki| Takeshita, Yohei| Fujikura, Mamiko| Okada, Shunsuke| Hisatomi, Miki| Asaumi, Junichi| |
| Keywords | Deep neural networks Caries detection Domain-Specific transfer learning Panoramic tomography |
| Note | The version of record of this article, first published in Journal of Medical and Biological Engineering, is available online at Publisher’s website: http://dx.doi.org/10.1007/s40846-024-00848-w| |
| Published Date | 2024-02-13 |
| Publication Title | Journal of Medical and Biological Engineering |
| Volume | volume44 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 43 |
| End Page | 48 |
| ISSN | 1609-0985 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| DOI | 10.1007/s40846-024-00848-w |
| Web of Science KeyUT | 001160649900001 |
| Related Url | isVersionOf https://doi.org/10.1007/s40846-024-00848-w |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuya| Matsumoto, Yoshinori| Nawachi, Shoichi| Asano, Yosuke| Katayama, Yu| Miyawaki, Yoshia| Katsuyama, Takayuki| Katsuyama, Eri| Nasu, Yoshihisa| Sada, Ken-Ei| Wada, Jun| |
| Keywords | Nail-patella syndrome Rheumatoid arthritis Joint dislocation Iliac horn Case report |
| Note | The version of record of this article, first published in BMC Musculoskeletal Disorders, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12891-024-07242-2| |
| Published Date | 2024-02-14 |
| Publication Title | BMC Musculoskeletal Disorders |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 139 |
| ISSN | 1471-2474 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38355529 |
| DOI | 10.1186/s12891-024-07242-2 |
| Web of Science KeyUT | 001162669400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12891-024-07242-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sato, Haruna| Kato, Kosuke| Koreishi, Mayuko| Nakamura, Yoshimasa| Tsujino, Yoshio| Satoh, Ayano| |
| Published Date | 2024-01-05 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | Public Library of Science |
| Start Page | e0296408 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Sato et al. |
| File Version | publisher |
| PubMed ID | 38181031 |
| DOI | 10.1371/journal.pone.0296408 |
| Web of Science KeyUT | 001153716700065 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0296408 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin |
| Published Date | 2024-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1443 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38338721 |
| DOI | 10.3390/ijms25031443 |
| Web of Science KeyUT | 001161430700001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25031443 |
| FullText URL | fulltext20240222-01.pdf |
|---|---|
| Author | Kubo, Kazuki| Yagi, Kairi| Kanda, Takefumi| Yasuda, Koa| Yamaguchi, Daisuke| Wakimoto, Shuichi| |
| Keywords | cryogenic ultrasonic piezoelectric transducer |
| Note | This is the Accepted Manuscript version of an article accepted for publication in Japanese Journal of Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.35848/1347-4065/ad1e9b.| This fulltext file will be available in Feb. 2025.| |
| Published Date | 2024-02-07 |
| Publication Title | Japanese Journal of Applied Physics |
| Volume | volume63 |
| Issue | issue3 |
| Publisher | IOP Publishing |
| Start Page | 03SP03 |
| ISSN | 0021-4922 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Japan Society of Applied Physics |
| File Version | author |
| DOI | 10.35848/1347-4065/ad1e9b |
| Web of Science KeyUT | 001157397300001 |
| Related Url | isVersionOf https://doi.org/10.35848/1347-4065/ad1e9b |
| JaLCDOI | 10.18926/AMO/66676 |
|---|---|
| FullText URL | 78_1_089.pdf |
| Author | Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki| |
| Abstract | We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis. |
| Keywords | breast cancer ectopic breast cancer axillary lymph node |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 93 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419320 |
| Web of Science KeyUT | 001204421300001 |
| JaLCDOI | 10.18926/AMO/66675 |
|---|---|
| FullText URL | 78_1_085.pdf |
| Author | Miyake, Keisuke| Tanikawa, Tomohiro| Haruma, Ken| Kawada, Mayuko| Ishii, Katsunori| Urata, Noriyo| Nishino, Ken| Suehiro, Mitsuhiko| Kawanaka, Miwa| Manabe, Noriaki| Kawamoto, Hirofumi| |
| Abstract | A 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential efficacy of TM in treating IPUD and the importance of considering hypercontractility as the underlying cause in cases of IPUD. |
| Keywords | gastric ulcer idiopathic peptic ulcerative disease trimebutine maleate |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 88 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419319 |
| Web of Science KeyUT | 001204421300002 |
| JaLCDOI | 10.18926/AMO/66674 |
|---|---|
| FullText URL | 78_1_079.pdf |
| Author | Takahara, Masahiro| Hiraoka, Sakiko| Ohmori, Masayasu| Takeuchi, Keiko| Takei, Kensuke| Aoyama, Yuki| Yasutomi, Eriko| Igawa, Shoko| Inokuchi, Toshihiro| Toyosawa, Junki| Yamasaki, Yasushi| Kinugasa, Hideaki| Harada, Keita| Onishi, Hideki| Okada, Hiroyuki| |
| Abstract | This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful in noninvasive treatment strategies. |
| Keywords | transabdominal ultrasonography fecal immunochemical test ulcerative colitis Mayo endoscopic subscore |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419318 |
| Web of Science KeyUT | 001203658200004 |
| JaLCDOI | 10.18926/AMO/66673 |
|---|---|
| FullText URL | 78_1_071.pdf |
| Author | Kaneda, Daisuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Hotta, Yoshifumi| Naniwa, Shuichi| Ozaki, Toshifumi| |
| Abstract | We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute. |
| Keywords | AVANTA silicone implant boutonniere deformity implant fracture thumb metacarpophalangeal joint arthroplasty rheumatoid arthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419317 |
| Web of Science KeyUT | 001203658200011 |
| JaLCDOI | 10.18926/AMO/66672 |
|---|---|
| FullText URL | 78_1_063.pdf |
| Author | Murakami, Daizo| Nishimoto, Kohei| Takao, Soshi| Miyamaru, Satoru| Kadowaki, Tomoka| Saito, Haruki| Takeda, Hiroki| Ise, Momoko| Suyama, Koichi| Orita, Yorihisa| |
| Abstract | The tyrosine kinase inhibitor lenvatinib has been confirmed as an effective treatment option for patients with unresectable thyroid carcinoma. We conducted a retrospective analysis of the significance of the effect of continued lenvatinib treatment for the longest duration possible at a reasonable daily dose and with a minimum discontinuation period in 42 patients with unresectable thyroid carcinoma treated with lenvatinib between 2015 and 2020. A Cox proportional hazard model-based analysis revealed that the overall survival of the patients treated with a <8 mg/day mean dose of lenvatinib was significantly better than that of the patients treated with 8-24 mg/day (hazard ratio [HR] 0.38 for 1.14-4.54 mg/day, and HR 0.01 for 4.56-7.97 mg/day) adjusted for various factors (e.g., sex, age, drug interruption period). The cumulative dose of lenvatinib administered tended to be higher in the patients treated with low doses (< 8 mg/day) than in the patients treated with relatively high doses (8-24 mg/day). Considering its adverse events, the continuation of lenvatinib treatment with an adequate daily dose and drug interruption may help prolong the survival of patients with unresectable thyroid carcinoma. |
| Keywords | thyroid carcinoma lenvatinib adverse effect survival |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419316 |
| Web of Science KeyUT | 001203658200007 |
| JaLCDOI | 10.18926/AMO/66671 |
|---|---|
| FullText URL | 78_1_053.pdf |
| Author | Ichikawa, Yukiko| Ogino, Tetsuya| |
| Abstract | Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy. |
| Keywords | cold compress fever hyperthermia thermal conductivity thermoregulation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 61 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419315 |
| Web of Science KeyUT | 001203658200009 |
