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JaLCDOI 10.18926/AMO/63205
FullText URL 76_1_25.pdf
Author Sugimoto, Kohei| Kuroda, Masahiro| Yoshimura, Yuuki| Hamada, Kentaro| Khasawneh, Abdullah| Barham, Majd| Tekiki, Nouha| Konishi, Kohei| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E. | Kamizaki, Ryo| Kanazawa, Susumu| Asaumi, Junichi|
Abstract The apparent diffusion coefficient subtraction method (ASM) was developed as a new restricted diffusionweighted imaging technique for magnetic resonance imaging (MRI). The usefulness of the ASM has been established by in vitro basic research using a bio-phantom, and clinical research on the application of the ASM for the human body is needed. Herein, we developed a short-time sequence for ASM imaging of the heads of healthy volunteers (n=2), and we investigated the similarity between the obtained ASM images and diffusion kurtosis (DK) images to determine the utility of the ASM for clinical uses. This study appears to be the first to report ASM images of the human head. We observed that the short-time sequence for the ASM imaging of the head can be scanned in approx. 3 min at 1.5T MRI. The noise reduction effect of median filter processing was confirmed on the ASM images scanned by this sequence. The obtained ASM images showed a weak correlation with the DK images, indicating that the ASM images are restricted diffusion-weighted images. The new shorttime imaging sequence could thus be used in clinical studies applying the ASM.
Keywords apparent diffusion coefficient apparent diffusion coefficient subtraction method diffusion kurtosis imaging restricted diffusion short-time imaging
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 25
End Page 32
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236995
Web of Science KeyUT 000762812700004
JaLCDOI 10.18926/AMO/63204
FullText URL 76_1_17.pdf
Author Fujishita, Keigo| Yasuhisa, Sando| Oka, Satoshi| Fujisawa, Yuka| Machida, Takuya| Imai, Toshi|
Abstract R-CHOP therapy is generally performed every 3 weeks. We investigated the effects of extending the interval of R-CHOP therapy for > 1 week on the prognoses of patients with non-indolent non-Hodgkin’s B-cell lymphoma. Among the 338 patients with non-indolent non-Hodgkin’s B-cell lymphoma who received initial chemotherapy at our institution, we focused on 178 patients who received R-CHOP therapy and analyzed the outcomes of the patients stratified by the treatment intervals. The estimated 3-year overall survival (OS) for the entire population was 82.1%. Patients treated at intervals of ≥ 4 weeks were significantly older, and they had significantly longer follow-up periods and lower relative dose intensity. But the estimated 3-year OS was comparable to those treated at <4 weeks (83.3% vs. 80.5% p=0.947). In a multivariate analysis, age and the dose of anti-cancer agents had significant impacts on OS, but there was no significant relationship regarding the treatment intervals. Propensity score matching confirmed the same result. R-CHOP therapy every around 4 weeks could achieve relatively good survival in some selected patients with non-indolent non-Hodgkin’s B-cell lymphoma.
Keywords R-CHOP therapy relative dose intensity non-Hodgkin’s lymphoma
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 17
End Page 24
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236994
Web of Science KeyUT 000762812700003
JaLCDOI 10.18926/AMO/63203
FullText URL 76_1_7.pdf
Author Takami, Masao| Yamamoto, Koichiro| Hanayama, Yoshihisa| Nakano, Yasuhiro| Hasegawa, Kou| Obika, Mikako| Hagiya, Hideharu| Furukawa, Masanori| Otsuka, Fumio|
Abstract Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH.
Keywords aging renal function cholesterol subclinical hypothyroidism thyroid function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236993
Web of Science KeyUT 000762812700002
JaLCDOI 10.18926/AMO/63202
FullText URL 76_1_1.pdf
Author Takao, Tomoka| Yamada, Daisuke| Takarada, Takeshi|
Abstract Optogenetics, a technology to manipulate biological phenomena thorough light, has attracted much attention in neuroscience. Recently, the Magnet System, a photo-inducible protein dimerization system which can control the intracellular behavior of various biomolecules with high accuracy using light was developed. Furthermore, photoactivation systems for controlling biological phenomena are being developed by combining this technique with genome-editing technology (CRISPR/Cas9 System) or DNA recombination technology (Cre-loxP system). Herein, we review the history of optogenetics and the latest Magnet System technology and introduce our recently developed photoactivatable Cre knock-in mice with temporal-, spatial-, and cell-specific accuracy.
Keywords optogenetics Cre recombinase
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-02
Volume volume76
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 5
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35236992
Web of Science KeyUT 000762812700001
FullText URL fulltext20220216-4.pdf
Author Nomura, Emi| Kawahara, Yuko| Omote, Yoshio| Takahashi, Yoshiaki| Matsumoto, Namiko| Ikegami, Ken| Takemoto, Mami| Hishikawa, Nozomi| Nakano, Yumiko| Yunoki, Taijun| Morihara, Ryuta| Uemura, Masahiro| Abe, Koji| Yamashita, Toru|
Keywords ATP-binding cassette subfamily C member 6 (ABCC6) neurovascular diseases pseudoxanthoma elasticum (PXE)
Note This is the peer reviewed version of the following article: [Nomura, E, Kawahara, Y, Omote, Y, et al. A case of a heterozygous ABCC6 mutation showing recurrent ischemic strokes and intracranial hemorrhages. Neurol Clin Neurosci. 2022; 00: 1– 4. doi:10.1111/ncn3.12575], which has been published in final form at https://doi.org/10.1111/ncn3.12575. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
Published Date 2022-2-4
Publication Title Neurology and Clinical Neuroscience
Volume volume10
Publisher Wiley
Start Page 98
End Page 101
ISSN 2049-4173
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1111/ncn3.12575
Web of Science KeyUT 000750987400001
Related Url isVerisonOf https://doi.org/10.1111/ncn3.12575
FullText URL fulltext.pdf
Author Nagasaki, Joji| Inozume, Takashi| Sax, Nicolas| Ariyasu, Ryo| Ishikawa, Masakazu| Yamashita, Kazuo| Kawazu, Masahito| Ueno, Toshihide| Irie, Takuma| Tanji, Etsuko| Morinaga, Takao| Honobe, Akiko| Ohnuma, Takehiro| Yoshino, Mitsuru| Iwata, Takekazu| Kawase, Katsushige| Sasaki, Keita| Hanazawa, Toyoyuki| Kochin, Vitaly| Kawamura, Tatsuyoshi| Matsue, Hiroyuki| Hino, Masayuki| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke|
Published Date 2022-02-01
Publication Title Cell Reports
Volume volume38
Issue issue5
Publisher Cell Press
Start Page 110331
ISSN 2211-1247
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35108529
DOI 10.1016/j.celrep.2022.110331
NAID 120007192058
Web of Science KeyUT 000750983700001
Related Url isVersionOf https://doi.org/10.1016/j.celrep.2022.110331
FullText URL fulltext.pdf
Author Higo, Hisao| Ohashi, Kadoaki| Tomida, Shuta| Okawa, Sachi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Senoo, Satoru| Makimoto, Go| Ninomiya, Kiichiro| Nakasuka, Takamasa| Nishii, Kazuya| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Miyahara, Nobuaki| Maeda, Yoshinobu| Toyooka, Shinichi| Kiura, Katsuyuki|
Keywords Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy
Published Date 2022-02-07
Publication Title Respiratory Research
Volume volume23
Issue issue1
Publisher BMC
Start Page 20
ISSN 1465-993X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35130915
DOI 10.1186/s12931-022-01940-y
Web of Science KeyUT 000752386100002
Related Url isVersionOf https://doi.org/10.1186/s12931-022-01940-y
FullText URL fulltext.pdf
Author Fujita, Claudia| Akhtar, M. Shahbaz| Hidaka, Ray| Nishigaki, Makoto|
Keywords Dissolved iron removal Chemical clogging Open-loop geothermal systems Retention potential Wooden charcoal
Published Date 2022-02-07
Publication Title Applied Water Science
Volume volume12
Issue issue3
Publisher SPRINGER HEIDELBERG
Start Page 30
ISSN 2190-5487
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
DOI 10.1007/s13201-022-01574-x
Web of Science KeyUT 000752014000004
Related Url isVersionOf https://doi.org/10.1007/s13201-022-01574-x
FullText URL fulltext.pdf
Author Oda, Shinsuke| Fujisawa, Masayoshi| Li, Chunning| Ito, Toshihiro| Yamaguchi, Takahiro| Yoshimura, Teizo| Matsukawa, Akihiro|
Published Date 2021-11-24
Publication Title Plos One
Volume volume16
Issue issue11
Publisher Public Library Science
Start Page e0254289
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Oda et al.
File Version publisher
PubMed ID 34818323
DOI 10.1371/journal.pone.0254289
Web of Science KeyUT 000747234800004
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0254289
FullText URL fulltext20220216-3.pdf Figure20220216-3.pdf Supplementary Figure20220216-3.pdf
Author Nishimura, Yoshito| Hagiya, Hideharu| Keitoku, Koichi| Koyama, Toshihiro| Otsuka, Fumio|
Note © 2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ajic.2021.08.033] .|
Published Date 2022-01-28
Publication Title American Journal of Infection Control
Volume volume50
Issue issue2
Publisher Elsevier BV
Start Page 141
End Page 147
ISSN 0196-6553
NCID AA10617749
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Association for Professionals in Infection Control and Epidemiology, Inc.
File Version author
PubMed ID 34718066
DOI 10.1016/j.ajic.2021.08.033
Web of Science KeyUT 000749317500004
Related Url isVersionOf https://doi.org/10.1016/j.ajic.2021.08.033
FullText URL fulltext20220216-2.pdf
Author Thi Cam, Nguyen| Sunagawa, Naomichi| Sesumi, Miho| Kitamura, Yoshikuni| Tanaka, Yoshiyuki| Goto, Tanjuro| Yasuba, Ken-ichiro| Yoshida, Yuichi|
Published Date 2022-01-22
Publication Title The Horticulture Journal
Volume volume91
Issue issue1
Publisher Japanese Society for Horticultural Science
Start Page 58
End Page 67
ISSN 2189-0102
NCID AA12708073
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society for Horticultural Science (JSHS)
File Version publisher
DOI 10.2503/hortj.utd-315
NAID 120007193740
Web of Science KeyUT 000749466800001
Related Url isVersionOf https://doi.org/10.2503/hortj.utd-315
FullText URL fulltext20220216-1.pdf
Author Khan, Haris Ahmed| Sato, Yukiyo| Kondo, Hideki| Jamal, Atif| Bhatti, Muhammad Faraz| Suzuki, Nobuhiro|
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00705-021-05304-7|
Published Date 2022-02-03
Publication Title Archives of Virology
Volume volume167
Publisher Springer Science and Business Media LLC
Start Page 923
End Page 929
ISSN 0304-8608
NCID AA00548901
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022
File Version author
PubMed ID 35112205
DOI 10.1007/s00705-021-05304-7
Web of Science KeyUT 000749980300010
Related Url isVersionOf 1https://doi.org/0.1007/s00705-021-05304-7
FullText URL fulltext20220208-1.pdf
Author Onishi, Yasuhiro| Mise, Koki| Kawakita, Chieko| Uchida, Haruhito A.| Sugiyama, Hitoshi| Sugawara, Ryosuke| Yamaguchi, Satoshi| Yoshida, Michihiro| Mitsuhashi, Toshiharu| Yamada, Masao| Hirabayashi, Jun| Wada, Jun|
Keywords Glomerulonephritis IgA nephropathy Diagnostic biomarkers Lectins Glycomics
Note This is an Accepted Manuscript published by S. Karger AG.|
Published Date 2021-12-29
Publication Title American Journal of Nephrology
Volume volume53
Issue issue1
Publisher S. Karger AG
Start Page 10
End Page 20
ISSN 0250-8095
NCID AA10424676
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 S. Karger AG, Basel
File Version author
PubMed ID 34965524
DOI 10.1159/000520998
Web of Science KeyUT 000747743400001
Related Url isVersionOf https://doi.org/10.1159/000520998
Title Alternative Four types of duodenal white lesions (follicular lymphoma, lymphoid hyperplasia, lymphangiectasia, and lymphangioma) : A case report
FullText URL 133_175.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Okada, Hiroyuki|
Abstract  A 70-year-old Japanese man underwent esophagogastroduodenoscopy that revealed multiple whitish duodenal granules. The histopathological analysis of the biopsied specimen led to the diagnosis of duodenal-type follicular lymphoma. The lesion showed spontaneous improvement ; however, 14 months later a few small whitish granules were observed by esophagogastroduodenoscopy. Observation under magnification revealed slightly elevated opaque white spots and whitish granular protrusions of roughly the same size that were uniformly distributed in the duodenal bulb. The duodenal bulb lesions were histopathologically diagnosed as lymphoid hyperplasia. The patient also exhibited lymphangiectasia (which presented as scattered white spots) and lymphangioma (which presented as a soft submucosal tumor with white spots on the surface) in the second portion of the duodenum. This patient presented with four white lesions in the duodenum : duodenal-type follicular lymphoma, lymphoid hyperplasia, lymphangiectasia, and lymphangioma. Careful endoscopic evaluation enabled a prompt diagnosis in this case.
Keywords 十二指腸濾胞性リンパ腫(duodenal-type follicular lymphoma) リンパ濾胞過形成(lymphoid hyperplasia) リンパ管腫(lymphangioma) リンパ管拡張(lymphangiectasia)
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 175
End Page 180
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.175
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.175
Title Alternative Establishment of a new disease entity : Duodenal-type follicular lymphoma
FullText URL 133_166.pdf
Author Yoshino, Tadashi|
Keywords リンパ腫 濾胞性リンパ腫 疾患単位
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 166
End Page 168
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.166
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.166
Title Alternative The 2020 Incentive Award of the Okayama Medical Association in Cancer Research (2020 Hayashibara Prize and Yamada Prize)
FullText URL 133_144.pdf
Author Morita, Takuya|
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 144
End Page 146
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.144
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.144
Title Alternative The 2020 Incentive Award of the Okayama Medical Association in General Medical Science (2020 Yuuki Prize)
FullText URL 133_141.pdf
Author Ogawa, Taiji|
Publication Title Journal of Okayama Medical Association
Published Date 2021-12-01
Volume volume133
Issue issue3
Start Page 141
End Page 143
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.133.141
language Japanese
Copyright Holders Copyright (c) 2021 岡山医学会
File Version publisher
DOI 10.4044/joma.133.141
FullText URL fulltext.pdf
Author Shinaoka, Akira| Kamiyama, Kazuyo| Yamada, Kiyoshi| Kimata, Yoshihiro|
Published Date 2022-01-10
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 309
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35013357
DOI 10.1038/s41598-021-03637-6
Web of Science KeyUT 000741645800052
Related Url isVersionOf https://doi.org/10.1038/s41598-021-03637-6
FullText URL fulltext.pdf
Author Takemoto, Genta| Matsushita, Masaki| Okamoto, Takaaki| Ito, Toshinari| Matsuura, Yuki| Takashima, Chieko| Chen-Yoshikawa, Toyofumi Fengshi| Ebi, Hiromichi| Imagama, Shiro| Kitoh, Hiroshi| Ohno, Kinji| Hosono, Yasuyuki|
Keywords FGFR3 achondroplasia meclozine zebrafish bone
Published Date 2022-01-18
Publication Title Frontiers In Cell And Developmental Biology
Volume volume9
Publisher Frontiers Media SA
Start Page 694018
ISSN 2296-634X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Takemoto, Matsushita, Okamoto, Ito, Matsuura, Takashima, Chen-Yoshikawa, Ebi, Imagama, Kitoh, Ohno and Hosono.
File Version publisher
PubMed ID 35118060
DOI 10.3389/fcell.2021.694018
Web of Science KeyUT 000749267500001
Related Url isVersionOf https://doi.org/10.3389/fcell.2021.694018
FullText URL fulltext.pdf
Author Xu, Yanning| Afify, Said M.| Du, Juan| Liu, Bingbing| Hassan, Ghmkin| Wang, Qing| Li, Hanbo| Liu, Yixin| Fu, Xiaoying| Zhu, Zhengmao| Chen, Ling| Seno, Masaharu|
Published Date 2022-01-10
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 347
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35013447
DOI 10.1038/s41598-021-04265-w
Web of Science KeyUT 000741645800111
Related Url isVersionOf https://doi.org/10.1038/s41598-021-04265-w