FullText URL fulltext.pdf suppl1.pdf suppl2.pdf suppl3.docx suppl4.docx suppl5.docx suppl6.docx suppl7.docx
Author Yanagida, Shota| Kawagishi, Hiroyuki| Saito, Mitsuo| Hamano, Hirofumi| Zamami, Yoshito| Kanda, Yasunari|
Keywords cardiomyocytes cardiotoxicity contractility EGFR-tyrosine kinase inhibitor FAERS human iPS cell
Published Date 2025-08
Publication Title Clinical and Translational Science
Volume volume18
Issue issue8
Publisher Wiley
Start Page e70325
ISSN 1752-8054
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40820655
DOI 10.1111/cts.70325
Web of Science KeyUT 001551510200001
Related Url isVersionOf https://doi.org/10.1111/cts.70325
FullText URL fulltext.pdf suppl.pptx
Author Sakamoto, Yoshika| Niimura, Takahiro| Goda, Mitsuhiro| Tomochika, Nanami| Murakawa, Wakana| Aizawa, Fuka| Yagi, Kenta| Hamano, Hirofumi| Izawa-Ishizawa, Yuki| Zamami, Yoshito| Ishizawa, Keisuke|
Keywords Sunitinib Advanced renal cell carcinoma Cardiotoxicity Calcitriol Autophagy MTOR
Published Date 2025-07
Publication Title Biomedicine & Pharmacotherapy
Volume volume188
Publisher Elsevier BV
Start Page 118137
ISSN 0753-3322
NCID AA10506249
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
PubMed ID 40373630
DOI 10.1016/j.biopha.2025.118137
Related Url isVersionOf https://doi.org/10.1016/j.biopha.2025.118137
FullText URL fulltext.pdf suppl.docx
Author Sayer, Michael| Hamano, Hirofumi| Nagasaka, Misako| Lee, Benjamin J.| Doh, Jean| Patel, Pranav M.| Zamami, Yoshito| Ozaki, Aya F.|
Keywords Immune checkpoint inhibitors Immune-Related adverse events Myocarditis Pericarditis Predictive modeling TriNetx
Published Date 2025-04-28
Publication Title Cardio-Oncology
Volume volume11
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 40
ISSN 2057-3804
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 40296103
DOI 10.1186/s40959-025-00331-8
Web of Science KeyUT 001478001700001
Related Url isVersionOf https://doi.org/10.1186/s40959-025-00331-8
Title Alternative Drug interaction (63. Precautions for the use of antifungal agents from the perspective of drug–drug interactions)
Author Kikuoka, Ryo| Higashionna, Tsukasa| Hamano, Hirofumi| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2025-08-01
Volume volume137
Issue issue2
Start Page 72
End Page 75
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.137.72
language Japanese
Copyright Holders Copyright (c) 2025 岡山医学会
File Version publisher
DOI 10.4044/joma.137.72
FullText URL fulltext.pdf suppl1.docx suppl2.pdf
Author Hagiya, Hideharu| Harada, Ko| Nishimura, Yoshito| Yamamoto, Maki| Nishimura, Sayoko| Yamamoto, Michio| Niimura, Takahiro| Osaki, Yuka| Vu, Quynh Thi| Fujii, Mariko| Sako, Nanami| Takeda, Tatsuaki| Hamano, Hirofumi| Zamami, Yoshito| Koyama, Toshihiro|
Keywords Pulmonary embolism Mortality WHO Global trends
Published Date 2025-08
Publication Title eClinicalMedicine
Volume volume86
Publisher Elsevier BV
Start Page 103389
ISSN 2589-5370
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
DOI 10.1016/j.eclinm.2025.103389
Related Url isVersionOf https://doi.org/10.1016/j.eclinm.2025.103389
FullText URL fulltext.pdf suppl1.docx suppl2.docx
Author Harada, Ko| Vu, Quynh Thi| Nishimura, Yoshito| Takeda, Tatsuaki| Hamano, Hirofumi| Minato, Yusuke| Zamami, Yoshito| Koyama, Toshihiro| Hagiya, Hideharu|
Keywords Population surveillance Mortality Nontuberculous mycobacterial infections
Published Date 2025-09
Publication Title International Journal of Infectious Diseases
Volume volume158
Publisher Elsevier BV
Start Page 107932
ISSN 1201-9712
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
PubMed ID 40354928
DOI 10.1016/j.ijid.2025.107932
Web of Science KeyUT 001513103900001
Related Url isVersionOf https://doi.org/10.1016/j.ijid.2025.107932
Author Takeda, Tatsuaki| Matsumoto, Jun| Sakai, Tomonori| Iwata, Naohiro| Hamano, Hirofumi| Koyama, Toshihiro| Ariyoshi, Noritaka| Zamami, Yoshito|
Keywords adverse event breast cancer pertuzumab trastuzumab VigiBase
Note This is the peer reviewed version of the following article: [Takeda T, Matsumoto J, Sakai T, et al. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Br J Clin Pharmacol. 2025; 1-13. doi:10.1002/bcp.70094], which has been published in final form at [https://doi.org/10.1002/bcp.70094]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.|
Published Date 2025-05-08
Publication Title British Journal of Clinical Pharmacology
Publisher Wiley
ISSN 0306-5251
NCID AA00574388
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 British Pharmacological Society.
File Version author
PubMed ID 40344285
DOI 10.1002/bcp.70094
Web of Science KeyUT 001483932800001
Related Url isVersionOf https://doi.org/10.1002/bcp.70094
Title Alternative Drug interaction (62. Drug interactions of potassium absorption agents)
Author Ariki, Saori| Hamano, Hirofumi| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2025-04-01
Volume volume137
Issue issue1
Start Page 30
End Page 32
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.137.30
language Japanese
Copyright Holders Copyright (c) 2025 岡山医学会
File Version publisher
DOI 10.4044/joma.137.30
JaLCDOI 10.18926/AMO/68362
FullText URL 79_1_051.pdf
Author Miura, Taro| Kawasaki, Yoichi| Hamano, Hirofumi| Zamami, Yoshito| Sendo, Toshiaki|
Abstract Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected in human serum. Here, we investigated the histamine-producing effects in HMC-1 cells and the inflammatory cytokine release effects in RAW264 cells for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; and 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All four promoted histamine production in HMC-1 cells; however, they did not significantly affect the release of inflammatory cytokines in RAW264 cells. These findings suggest that these four photoinitiators induce inflammatory cytokine-independent histamine production, potentially contributing to histamine-mediated chronic inflammation in vitro.
Keywords photoinitiator ink injection histamine inflammation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 51
End Page 58
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012160
Web of Science KeyUT 001440463800007
Title Alternative Drug interaction (61. Drug interactions of cancer cachexia therapeutics)
Author Kawakami, Eiji| Okuda, Hiroto| Hamano, Hirofumi| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2024-12-02
Volume volume136
Issue issue3
Start Page 135
End Page 138
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.136.135
language Japanese
Copyright Holders Copyright (c) 2024 岡山医学会
File Version publisher
DOI 10.4044/joma.136.135
FullText URL fulltext.pdf
Author Okawa, Yasumasa| Ushio, Soichiro| Izushi, Yasuhisa| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki|
Keywords anxiolytic chotosan inflammation serotonin receptor Uncaria hook
Published Date 2024-09-04
Publication Title Frontiers in Pharmacology
Volume volume15
Publisher Frontiers Media
Start Page 1471602
ISSN 1663-9812
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Okawa, Ushio, Izushi, Kitamura, Zamami and Sendo.
File Version publisher
PubMed ID 39295939
DOI 10.3389/fphar.2024.1471602
Web of Science KeyUT 001315388700001
Related Url isVersionOf https://doi.org/10.3389/fphar.2024.1471602
Title Alternative mRNA-vaccine
Author Tanaka, Yuta| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2024-08-01
Volume volume136
Issue issue2
Start Page 83
End Page 84
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.136.83
language Japanese
Copyright Holders Copyright (c) 2024 岡山医学会
File Version publisher
DOI 10.4044/joma.136.83
JaLCDOI 10.18926/AMO/67197
FullText URL 78_3_227.pdf
Author Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki|
Abstract Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression.
Keywords lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-06
Volume volume78
Issue issue3
Publisher Okayama University Medical School
Start Page 227
End Page 235
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38902210
Web of Science KeyUT 001267351000003
Title Alternative Drug interaction (59. Drug interaction of molecular targeted therapies for rare lung cancer)
Author Okuda, Hiroto| Kuroda, Satoshi| Hamano, Hirofumi| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2024-04-01
Volume volume136
Issue issue1
Start Page 29
End Page 32
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.136.29
language Japanese
Copyright Holders Copyright (c) 2024 岡山医学会
File Version publisher
DOI 10.4044/joma.136.29
FullText URL fulltext.pdf
Author Takahashi, Tetta| Tomonobu, Nahoko| Kinoshita, Rie| Yamamoto, Ken-Ichi| Murata, Hitoshi| Komalasari, Ni Luh Gede Yoni| Chen, Youyi| Jiang, Fan| Gohara, Yuma| Ochi, Toshiki| Ruma, I. Made Winarsa| Sumardika, I. Wayan| Zhou, Jin| Honjo, Tomoko| Sakaguchi, Yoshihiko| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Inoue, Yusuke| Futami, Junichiro| Toyooka, Shinichi| Zamami, Yoshito| Sakaguchi, Masakiyo|
Keywords breast cancer lysyl oxidase annexin A2 S100A11 plasmin cancer microenvironment
Published Date 2024-03-26
Publication Title Frontiers in Oncology
Volume volume14
Publisher Frontiers Media
Start Page 1371342
ISSN 2234-943X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Takahashi, Tomonobu, Kinoshita, Yamamoto, Murata, Komalasari, Chen, Jiang, Gohara, Ochi, Ruma, Sumardika, Zhou, Honjo, Sakaguchi, Yamauchi, Kuribayashi, Kondo, Inoue, Futami, Toyooka, Zamami and Sakaguchi.
File Version publisher
PubMed ID 38595825
DOI 10.3389/fonc.2024.1371342
Web of Science KeyUT 001198366100001
Related Url isVersionOf https://doi.org/10.3389/fonc.2024.1371342
FullText URL fulltext20240206-02.pdf
Author Takeda, Tatsuaki| Sugimoto, Shiho| Matsumoto, Jun| Iwata, Naohiro| Nakamoto, Akihiko| Ozaki, Aya Fukuma| Hamano, Hirofumi| Ariyoshi, Noritaka| Zamami, Yoshito|
Keywords Abemaciclib Adverse event Breast cancer Cyclin-dependent kinase 4/6 inhibitor Palbociclib
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11096-023-01687-6| This fulltext file will be available in Jan. 2025.|
Published Date 2024-01-19
Publication Title International Journal of Clinical Pharmacy
Volume volume46
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 536
End Page 541
ISSN 2210-7703
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024
File Version author
PubMed ID 38240964
DOI 10.1007/s11096-023-01687-6
Web of Science KeyUT 001145361500002
Related Url isVersionOf https://doi.org/10.1007/s11096-023-01687-6
FullText URL fulltext20240117-01.pdf fig1_20240117-01.pdf fig2_20240117-01.pdf fig3_20240117-01.pdf
Author Koyama, Toshihiro| Iinuma, Shunya| Yamamoto, Michio| Niimura, Takahiro| Osaki, Yuka| Nishimura, Sayoko| Harada, Ko| Zamami, Yoshito| Hagiya, Hideharu|
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s40264-023-01387-0| This fulltext file will be available in Dec. 2024.|
Published Date 2023-12-22
Publication Title Drug Safety
Volume volume47
Issue issue3
Publisher Springer Science and Business Media LLC
Start Page 237
End Page 249
ISSN 0114-5916
NCID AA10748827
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG
File Version author
PubMed ID 38133735
DOI 10.1007/s40264-023-01387-0
Web of Science KeyUT 001132965700001
Related Url isVersionOf https://doi.org/10.1007/s40264-023-01387-0
Title Alternative Drug interaction (58. Drug interactions in tacrolimus)
Author Kimura, Ikuya| Hamano, Hirofumi| Kajizono, Makoto| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2023-12-01
Volume volume135
Issue issue3
Start Page 167
End Page 171
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.135.167
language Japanese
Copyright Holders Copyright (c) 2023 岡山医学会
File Version publisher
DOI 10.4044/joma.135.167
JaLCDOI 10.18926/AMO/66151
FullText URL 77_6_595.pdf
Author Bando, Takashi| Chuma, Masayuki| Hamano, Hirofumi| Niimura, Takahiro| Okada, Naoto| Kondo, Masateru| Izumi, Yuki| Ishida, Shunsuke| Yoshioka, Toshihiko| Asada, Mizuho| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Miyata, Koji| Yagi, Kenta| Izawa-Ishizawa, Yuki| Azuma, Momoyo| Yanagawa, Hiroaki| Tasaki, Yoshikazu| Ishizawa, Keisuke|
Abstract There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
Keywords vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 595
End Page 605
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145933
Web of Science KeyUT 001164631200004
Title Alternative Drug interaction (57. Drug interactions in renal failure)
Author Hamano, Hirofumi| Kajizono, Makoto| Nishihara, Shigeki| Murakawa, Kiminaka| Zamami, Yoshito|
Publication Title Journal of Okayama Medical Association
Published Date 2023-08-01
Volume volume135
Issue issue2
Start Page 89
End Page 91
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.135.89
language Japanese
Copyright Holders Copyright (c) 2023 岡山医学会
File Version publisher
DOI 10.4044/joma.135.89