FullText URL fulltext.pdf
Author Fujihara, Miwa| Shien, Tadahiko| Shien, Kazuhiko| Suzawa, Ken| Takeda, Tatsuaki| Zhu, Yidan| Mamori, Tomoka| Otani, Yusuke| Yoshioka, Ryo| Uno, Maya| Suzuki, Yoko| Abe, Yuko| Hatono, Minami| Tsukioki, Takahiro| Takahashi, Yuko| Kochi, Mariko| Iwamoto, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Keywords breast cancer YES1 T-DM1 dasatinib drug resistance
Published Date 2021-11-26
Publication Title International Journal Of Molecular Sciences
Volume volume22
Issue issue23
Publisher MDPI
Start Page 12809
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34884609
DOI 10.3390/ijms222312809
Web of Science KeyUT 000735641400001
Related Url isVersionOf https://doi.org/10.3390/ijms222312809
FullText URL fulltext.pdf
Author Okazaki, Mikio| Suzawa, Ken| Shien, Kazuhiko| Miyoshi, Kentaroh| Otani, Shinji| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Yamane, Masaomi| Toyooka, Shinichi|
Published Date 2021-08-14
Publication Title Journal Of Surgical Case Reports
Volume volume2021
Issue issue8
Publisher Oxford Univ Press
Start Page rjab336
ISSN 2042-8812
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 34408837
DOI 10.1093/jscr/rjab336
Web of Science KeyUT 000732056400014
Related Url isVersionOf https://doi.org/10.1093/jscr/rjab336
FullText URL fulltext20210530_3.pdf
Author Nakahara, Kengo| Hamada, Kyohei| Tsuchida, Tomoki| Takasugi, Nobumasa| Abiko, Yumi| Shien, Kazuhiko| Toyooka, Shinichi| Kumagai, Yoshito| Uehara, Takashi|
Keywords epidermal growth factor receptor cell signaling chemical modification signal transduction apoptosis
Published Date 2021-12-31
Publication Title Journal of Biological Chemistry
Volume volume296
Publisher Elsevier
Start Page 100524
ISSN 00219258
NCID AA00251083
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
PubMed ID 33705793
DOI 10.1016/j.jbc.2021.100524
Related Url isVersionOf https://doi.org/10.1016/j.jbc.2021.100524
JaLCDOI 10.18926/AMO/60804
FullText URL 74_5_431.pdf
Author Miura, Akihiro| Shien, Kazuhiko| Toji, Tomohiro| Otani, Shinji| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Soh, Junichi| Yamane, Masaomi| Toyooka, Shinichi|
Abstract We encountered a rare case of thymic cyst accompanied by mediastinitis. A 39-year-old Japanese male presented with fever and chest pain. The chest CT revealed a mass composed of a lobular cystic lesion with inflammation, suggesting the onset of mediastinitis. A definitive histological diagnosis was not obtained, and we performed a thymectomy. Pathologically, the thymic cyst was accompanied by multiple cavities, mimicking thymic cysts, caused by the inflammatory abscess. The surrounding adipose tissue showed inflammatory cell infiltrations with chronic fibrosis. These findings indicate that clinicians should be aware that thymic cysts may cause severe mediastinitis.
Keywords thymic cyst multilocular thymic cyst mediastinitis
Amo Type Case Report
Published Date 2020-10
Publication Title Acta Medica Okayama
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 431
End Page 433
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106700
Web of Science KeyUT 000581970100009
NAID 120006892930
FullText URL fulltext.pdf figure1.tif figure2.tif figure3.tif spfigure1.tif spfigure2.tif SupTable1.xlsx
Author Ochi, Kosuke| Suzawa, Ken| Tomida, Shuta| Shien, Kazuhiko| Takano, Jui| Miyauchi, Shunsaku| Takeda, Tatsuaki| Miura, Akihiro| Araki, Kota| Nakata, Kentaro| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Yamane, Masaomi| Azuma, Kazuo| Okamoto, Yoshiharu| Toyooka, Shinichi|
Keywords Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance
Note This fulltext is available in Jul. 2021.|
Published Date 2020-08-27
Publication Title Biochemical and Biophysical Research Communications
Volume volume529
Issue issue3
Publisher Academic Press
Start Page 760
End Page 765
ISSN 0006-291X
NCID AA00564395
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version Author
PubMed ID 32736704
DOI 10.1016/j.bbrc.2020.06.077
Web of Science KeyUT 000555780500037
Related Url iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077
FullText URL fulltext.pdf Tables.pdf Fig1.tif Fig2.tif Supplementary Tables.pdf Supplementary Fig.pdf
Author Yamamoto, Hiromasa| Namba, Kei| Yamamoto, Haruchika| Toji, Tomohiro| Soh, Junichi| Shien, Kazuhiko| Suzawa, Ken| Kurosaki, Takeshi| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Kunisada, Toshiyuki| Oto, Takahiro| Toyooka, Shinichi|
Keywords Metastatic lung tumor Sarcoma Metastasectomy Survival rate Neutrophil-to-lymphocyte ratio (NLR)
Note This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5. |
Published Date 2020-08-03
Publication Title Surgery Today
Publisher Springer
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32747982
DOI 10.1007/s00595-020-02093-5
Web of Science KeyUT 000555382600001
Related Url isVersionOf https://doi.org/10.1007/s00595-020-02093-5
FullText URL fulltext.pdf
Author Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi|
Keywords breast cancer drug resistance lung cancer neratinib YES1
Published Date 2019-12-19
Publication Title Cancer Science
Volume volume111
Issue issue3
Publisher Wiley
Start Page 849
End Page 856
ISSN 1347-9032
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31856375
DOI 10.1111/cas.14289
Web of Science KeyUT 000507433400001
Related Url isVersionOf https://doi.org/10.1111/cas.14289
FullText URL fulltext.pdf
Author Yoshioka, Takahiro| Shien, Kazuhiko| Takeda, Tatsuaki| Takahashi, Yuta| Kurihara, Eisuke| Ogoshi, Yusuke| Namba, Kei| Torigoe, Hidejiro| Sato, Hiroki| Tomida, Shuta| Yamamoto, Hiromasa| Soh, Junichi| Fujiwara, Toshiyoshi| Toyooka, Shinichi|
Keywords afatinib gastric cancer HER2 MET YES1
Published Date 2019-06-04
Publication Title Cancer Science
Volume volume110
Issue issue8
Publisher Wiley Open Access
Start Page 2549
End Page 2557
ISSN 1347-9032
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31162771
DOI 10.1111/cas.14089
Web of Science KeyUT 000478616800022
Related Url isVersionOf https://doi.org/10.1111/cas.14089
FullText URL fulltext.pdf
Author Chen, Youyi| Sumardika, I Wayan| Tomonobu, Nahoko| Kinoshita, Rie| Inoue, Yusuke| Iioka, Hidekazu| Mitsui, Yosuke| Saito, Ken| Ruma, I Made Winarsa| Sato, Hiroki| Yamauchi, Akira| Murata, Hitoshi| Yamamoto, Ken-ichi| Tomida, Shuta| Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Futami, Junichiro| Kubo, Miyoko| Putranto, Endy Widya| Murakami, Takashi| Liu, Ming| Hibino, Toshihiko| Nishibori, Masahiro| Kondo, Eisaku| Toyooka, Shinichi| Sakaguchi, Masakiyo|
Published Date 2019-07
Publication Title Neoplasia
Volume volume21
Issue issue7
Start Page 627
End Page 640
ISSN 1522-8002
NCID AA11470191
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31100639
DOI 10.1016/j.neo.2019.04.006
Web of Science KeyUT 000472189700001
Related Url isVersionOf https://doi.org/10.1016/j.neo.2019.04.006
JaLCDOI 10.18926/AMO/54514
FullText URL 70_4_327.pdf
Author Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi|
Abstract A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines.
Keywords metformin CD8+ T cells cancer immunology
Amo Type Clinical Study Protocols
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549683
Web of Science KeyUT 000384748600018
JaLCDOI 10.18926/AMO/52140
FullText URL 68_1_23.pdf
Author Ueno, Tsuyoshi| Toyooka, Shinichi| Fukazawa, Takuya| Kubo, Takafumi| Soh, Junichi| Asano, Hiroaki| Muraoka, Takayuki| Tanaka, Norimitsu| Maki, Yuho| Shien, Kazuhiko| Furukawa, Masashi| Sakaguchi, Masakiyo| Yamamoto, Hiromasa| Tsukuda, Kazunori| Miyoshi, Shinichiro|
Abstract The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM.
Keywords mesothelioma microRNA microRNA-34b/c p53
Amo Type Original Article
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 23
End Page 26
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553485
Web of Science KeyUT 000331592800004
Author Muraoka, Takayuki| Soh, Junichi| Toyooka, Shinichi| Aoe, Keisuke| Fujimoto, Nobukazu| Hashida, Shinsuke| Maki, Yuho| Tanaka, Norimitsu| Shien, Kazuhiko| Furukawa, Masashi| Yamamoto, Hiromasa| Asano, Hiroaki| Tsukuda, Kazunori| Kishimoto, Takumi| Otsuki, Takemi| Miyoshi, Shinichiro|
Published Date 2013-12
Publication Title Lung Cancer
Volume volume82
Issue issue3
Content Type Journal Article
Author Maki, Yuho| Soh, Junichi| Ichimura, Kouichi| Shien, Kazuhiko| Furukawa, Masashi| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Yamamoto, Hiromasa| Asano, Hiroaki| Tsukuda, Kazunori| Toyooka, Shinichi| Miyoshi, Shinichiro|
Published Date 2013-01
Publication Title Oncology Reports
Volume volume29
Issue issue1
Content Type Journal Article
Author Ueno, Tsuyoshi| Tsukuda, Kazunori| Toyooka, Shinichi| Ando, Midori| Takaoka, Munenori| Soh, Junichi| Asano, Hiroaki| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Shien, Kazuhiko| Furukawa, Masashi| Yamatsuji, Tomoki| Kiura, Katsuyuki| Naomoto, Yoshio| Miyoshi, Shinichiro|
Published Date 2012-04
Publication Title Lung Cancer
Volume volume76
Issue issue1
Content Type Journal Article
Author Tanaka, Norimitsu| Toyooka, Shinichi| Soh, Junichi| Kubo, Takafumi| Yamamoto, Hiromasa| Maki, Yuho| Muraoka, Takayuki| Shien, Kazuhiko| Furukawa, Masashi| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Aoe, Keisuke| Miyoshi, Shinichiro|
Published Date 2012-04
Publication Title Lung Cancer
Volume volume76
Issue issue1
Content Type Journal Article
Author Shien, Kazuhiko| Toyooka, Shinichi| Ichimura, Kouichi| Soh, Junichi| Furukawa, Masashi| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Yamane, Masaomi| Oto, Takahiro| Kiura, Katsuyuki| Miyoshi, Shinichiro|
Published Date 2012-07
Publication Title Lung Cancer
Volume volume77
Issue issue1
Content Type Journal Article