Kagawa, Shunsuke - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Long-term Survival with a Rare Advanced Primary Gastrointestinal Malignant Melanoma Treated with Laparoscopic Surgery/Immune Checkpoint Inhibitor

JaLCDOI	10.18926/AMO/61906
FullText URL	75_2_231.pdf
Author	Endo, Motochika\| Yano, Shuya\| Asano, Hiroaki\| Takeda, Sho\| Hamada, Yuki\| Kondo, Yoshitaka\| Kuroda, Shinji\| Shigeyasu, Kunitoshi\| Kikuchi, Satoru\| Tanaka, Takehiro\| Teraishi, Fuminori\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
Keywords	primary gastrointestinal melanoma laparoscopic surgery immune checkpoint antibody-blockade inhibitor
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2021-04
Volume	volume75
Issue	issue2
Publisher	Okayama University Medical School
Start Page	231
End Page	238
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33953431
NAID	120007029881

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

FullText URL	fulltext.pdf
Author	Ito, Atene\| Kagawa, Shunsuke\| Sakamoto, Shuichi\| Kuwada, Kazuya\| Kajioka, Hiroki\| Yoshimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date	2021-01-28
Publication Title	BMC Cancer
Volume	volume21
Issue	issue1
Publisher	BMC
Start Page	102
ISSN	1471-2407
NCID	AA12034763
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s). 2021
File Version	publisher
PubMed ID	33509150
DOI	10.1186/s12885-021-07816-6
Web of Science KeyUT	000615987400002
Related Url	isVersionOf https://doi.org/10.1186/s12885-021-07816-6

Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

FullText URL	fulltext.pdf
Author	Katsube, Ryoichi\| Noma, Kazuhiro\| Ohara, Toshiaki\| Nishiwaki, Noriyuki\| Kobayashi, Teruki\| Komoto, Satoshi\| Sato, Hiroaki\| Kashima, Hajime\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2021-01-18
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature Research
Start Page	1693
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	33462372
DOI	10.1038/s41598-021-81465-4
Web of Science KeyUT	000612156600008
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-81465-4

Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment

FullText URL	fulltext.pdf
Author	Yano, Shuya\| Tazawa, Hiroshi\| Kishimoto, Hiroyuki\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\| Hoffman, Robert M.\|
Keywords	cancer cell cycle fluorescent proteins FUCCI imaging adenovirus oncolytic virotherapy cancer stem cell mouse model orthotopic
Published Date	2021-01-17
Publication Title	International Journal of Molecular Sciences
Volume	volume22
Issue	issue2
Publisher	MDPI
Start Page	879
ISSN	1422-0067
NCID	AA12038549
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	33477279
DOI	10.3390/ijms22020879
Web of Science KeyUT	000611296000001
Related Url	isVersionOf https://doi.org/10.3390/ijms22020879

Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

FullText URL	fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf
Author	Kajioka, Hiroki\| Kagawa, Shunsuke\| Ito, Atene\| Yoshimoto, Masashi\| Sakamoto, Shuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model
Note	This fulltext is available in January, 2022.\|
Published Date	2021-01-28
Publication Title	Cancer Letters
Volume	volume497
Publisher	Elsevier
Start Page	1
End Page	3
ISSN	0304-3835
NCID	AA00598513
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	33065249
DOI	10.1016/j.canlet.2020.10.015
Web of Science KeyUT	000596072900001
Related Url	isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015

Short-term and long-term comparisons of laparoscopy-assisted proximal gastrectomy with esophagogastrostomy by the double-flap technique and laparoscopy-assisted total gastrectomy for proximal gastric cancer

FullText URL	fulltext.pdf
Author	Tsumura, Tomoko\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Takata, Nobuo\| Ito, Atene\| Watanabe, Megumi\| Kuwada, Kazuya\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2020-11-12
Publication Title	PLoS ONE
Volume	volume15
Issue	issue11
Publisher	Public Library of Science
Start Page	e0242223
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 Tsumura et al.
File Version	publisher
PubMed ID	33180871
DOI	10.1371/journal.pone.0242223
Web of Science KeyUT	000593948000022
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0242223

Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma

FullText URL	fulltext.pdf figures.pdf SuppleFigures.pdf
Author	Mochizuki, Yusuke\| Tazawa, Hiroshi\| Demiya, Koji\| Kure, Miho\| Kondo, Hiroya\| Komatsubara, Tadashi\| Sugiu, Kazuhisa\| Hasei, Joe\| Yoshida, Aki\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
Note	This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7.\|
Published Date	2020-11-05
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume70
Publisher	Springer
Start Page	1405
End Page	1417
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	33151368
DOI	10.1007/s00262-020-02774-7
Web of Science KeyUT	000586350500002
Related Url	isVersionOf https://doi.org/10.1007/s00262-020-02774-7

Intracorporeal semi‐hand‐sewn Billroth I reconstruction in total laparoscopic distal gastrectomy

FullText URL	Fulltext.pdf Tables.pdf Figure 1.tiff
Author	Kikuchi, Satoru\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kuwada, Kazuya\| Takata, Nobuo\| Kakiuchi, Yoshihiko\| Yano, Shuya\| Noma , Kazuhiro\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Keywords	Billroth I reconstruction gastric cancer laparoscopic distal gastrectomy
Note	This is the peer reviewed version of the following article: Satoru Kikuchi et. al. Intracorporeal semi‐hand‐sewn Billroth I reconstruction in total laparoscopic distal gastrectomy. Asian Journal of Endoscopic Surgery (2020), which has been published in final form at https://doi.org/10.1111/ases.12887. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This fulltext is available on Oct. 2021.\|
Published Date	2020-10-27
Publication Title	Asian Journal of Endoscopic Surgery
Volume	volume2021
Issue	issue14
Publisher	Wiley
Start Page	640
End Page	643
ISSN	1758-5902
NCID	AA12488501
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	33111451
DOI	10.1111/ases.12887
Web of Science KeyUT	000583948100001
Related Url	isVersionOf https://doi.org/10.1111/ases.12887

FUCCI Real-Time Cell-Cycle Imaging as a Guide for Designing Improved Cancer Therapy: A Review of Innovative Strategies to Target Quiescent Chemo-Resistant Cancer Cells

FullText URL	fulltext.pdf
Author	Yano, Shuya\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\| Hoffman, Robert M.\|
Keywords	cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date	2020-09-17
Publication Title	Cancers
Volume	volume12
Issue	issue9
Publisher	MDPI
Start Page	2655
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32957652
DOI	10.3390/cancers12092655
Web of Science KeyUT	000580315800001
Related Url	isVersionOf https://doi.org/10.3390/cancers12092655

Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

FullText URL	fulltext.pdf
Author	Tanimoto, Terutaka\| Tazawa, Hiroshi\| Ieda, Takeshi\| Nouso, Hiroshi\| Tani, Morimichi\| Oyama, Takanori\| Urata, Yasuo\| Kagawa, Shunsuke\| Noda, Takuo\| Fujiwara, Toshiyoshi\|
Keywords	neuroblastoma MYCN hTERT adenovirus E2F1
Published Date	2020-09-25
Publication Title	Molecular Therapy - Oncolytics
Volume	volume18
Publisher	Cell Press
Start Page	14
End Page	23
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32637577
DOI	10.1016/j.omto.2020.05.015
Web of Science KeyUT	000575168700002
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.05.015

Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

FullText URL	fulltext.pdf
Author	Ishikawa, Wataru\| Kikuchi, Satoru\| Ogawa, Toshihiro\| Tabuchi, Motoyasu\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
Published Date	2020-09-25
Publication Title	Molecular Therapy - Oncolytics
Volume	volume18
Publisher	Cell Press
Start Page	262
End Page	271
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32728614
DOI	10.1016/j.omto.2020.06.021
Web of Science KeyUT	000575168700023
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.06.021

Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy

FullText URL	fulltext.pdf
Author	Tazawa, Hiroshi\| Hasei, Joe\| Yano, Shuya\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	oncolytic adenovirus hTERT autophagy GFP p53
Published Date	2020-02-18
Publication Title	Cancers
Volume	volume12
Issue	issue2
Publisher	MDPI
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32085583
DOI	10.3390/cancers12020478
Web of Science KeyUT	000522477300224
Related Url	isVersionOf https://doi.org/10.3390/cancers12020478

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

FullText URL	fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Morihiro, Toshiaki\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date	2020-01-10
Publication Title	Molecular Therapy
Volume	volume28
Issue	issue3
Publisher	Cell Press
Start Page	794
End Page	804
ISSN	15250016
NCID	AA11475060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31991110
DOI	10.1016/j.ymthe.2020.01.003
Web of Science KeyUT	000518887200012
Related Url	isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

Author	Ieda, Takeshi\| Tazawa, Hiroshi\| Okabayashi, Hiroki\| Yano, Shuya\| Shigeyasu, Kunitoshi\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Kishimoto, Hiroyuki\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Saitou, Takashi\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
Published Date	2019-11-8
Publication Title	Scientific Reports
Volume	volume9
Publisher	Nature Publishing Group
Start Page	16378
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2019
File Version	publisher
PubMed ID	31705021
DOI	10.1038/s41598-019-52816-z
Web of Science KeyUT	000495372900001
Related Url	isVersionOf https://doi.org/10.1038/s41598-019-52816-z

PD-L1 expression combined with microsatellite instability/CD8+tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

FullText URL	SR9_1_4633.pdf
Author	Morihiro, Toshiaki\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kakiuchi, Yoshihiko\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Tanaka, Takehiro\| Kikuch, Satoru\| Nagasaka, Takeshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Published Date	2019-3-15
Publication Title	Scientific Reports
Volume	volume9
Publisher	Nature Publishing Group
Start Page	4633
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2019
File Version	publisher
PubMed ID	30874607
DOI	10.1038/s41598-019-41177-2
Web of Science KeyUT	000461303000015
Related Url	isVersionOf https://doi.org/10.1038/s41598-019-41177-2

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study)

FullText URL	AGS3_1_96.pdf SI.pdf
Author	Kuroda, Shinji\| Choda, Yasuhiro\| Otsuka, Shinya\| Ueyama, Satoshi\| Tanaka, Norimitsu\| Muraoka, Atsushi\| Hato, Shinji\| Kimura, Toshikazu\| Tanakaya, Kohji\| Kikuchi, Satoru\| Tanabe, Shunsuke\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kamikawa, Yasuaki\| Fujiwara, Toshiyoshi\|
Keywords	Kamikawa procedure antireflux surgery double‐flap technique esophagogastrostomy proximal gastrectomy
Published Date	2018-10-11
Publication Title	Annals of Gastroenterological Surgery
Volume	volume3
Issue	issue1
Publisher	Woley
Start Page	96
End Page	103
ISSN	2475-0328
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2018 The Authors
File Version	publisher
PubMed ID	30697614
DOI	10.1002/ags3.12216
Web of Science KeyUT	000456643500012
Related Url	isVersionOf https://doi.org/10.1002/ags3.12216

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness

FullText URL	cancers_11_2_177.pdf
Author	Katsura, Yuki\| Ohara, Toshiaki\| Noma, Kazuhiro\| Ninomiya, Takayuki\| Kashima, Hajime\| Kato, Takuya\| Sato, Hiroaki\| Komoto, Satoshi\| Narusaka, Toru\| Tomono, Yasuko\| Xing, Boyi\| Chen, Yuehua\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kasai , Tomonari\| Seno, Masaharu\| Matsukawa, Akihiro\| Fujiwara, Toshiyoshi\|
Keywords	cancer stem cells combination therapy iron stemness
Published Date	2019-02-03
Publication Title	Cancers
Volume	volume11
Issue	issue2
Publisher	MDPI
Start Page	177
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors
File Version	publisher
PubMed ID	30717462
DOI	10.3390/cancers11020177
Web of Science KeyUT	000460747200051
Related Url	isVersionOf https://doi.org/10.3390/cancers11020177

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

FullText URL	OncoImmunol_8_12_1671760.pdf
Author	Sakamoto, Shuichi\| Kagawa, Shunsuke\| Kuwada, Kazuya\| Ito, Atene\| Kajioka, Hiroki\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kagawa, Tetsuya\| Yoshida, Ryuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date	2019-10-22
Publication Title	OncoImmunology
Volume	volume8
Issue	issue12
Publisher	TAYLOR & FRANCIS
Start Page	e1671760
ISSN	2162402X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Author(s).
File Version	publisher
DOI	10.1080/2162402X.2019.1671760
Web of Science KeyUT	000494085400001
Related Url	isVersionOf https://doi.org/10.1080/2162402X.2019.1671760

Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer

JaLCDOI	10.18926/AMO/54981
FullText URL	71_2_127.pdf
Author	Shirakawa, Yasuhiro\| Noma, Kazuhiro\| Maeda, Naoaki\| Tanabe, Shunsuke\| Kuroda, Shinji\| Kagawa, Shunsuke\| Katsui, Kuniaki\| Katayama, Norihisa\| Kanazawa, Susumu\| Fujiwara, Toshiyoshi\|
Abstract	Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.
Keywords	esophageal cancer radiation therapy high-risk patient
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2017-04
Volume	volume71
Issue	issue2
Publisher	Okayama University Medical School
Start Page	127
End Page	133
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2017 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	28420894

A Phase II Clinical Trial of the Efficacy and Safety of Short-term (3 days) Enoxaparin for the Prevention of Venous Thromboembolism after Gastric Cancer Surgery

JaLCDOI	10.18926/AMO/54601
FullText URL	70_5_401.pdf
Author	Kuroda, Shinji\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\|
Abstract	Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.
Keywords	venous thromboembolism enoxaparin short-term use gastric cancer surgery
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-10
Volume	volume70
Issue	issue5
Publisher	Okayama University Medical School
Start Page	401
End Page	404
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27777435
Web of Science KeyUT	000388098700012