Author Tazawa, Hiroshi| Yano, Syuya| Yoshida, Ryosuke| Yamasaki, Yasumoto| Sasaki, Tsuyoshi| Hashimoto, Yuuri| Kuroda, Shinji| Ouchi, Masaaki| Onishi, Teppei| Uno, Futoshi| Kagawa, Syunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/52006
FullText URL 67_6_333.pdf
Author Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords oncolytic adenovirus autophagy E2F1 microRNA
Amo Type Review
Published Date 2013-12
Publication Title Acta Medica Okayama
Volume volume67
Issue issue6
Publisher Okayama University Medical School
Start Page 333
End Page 342
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24356717
Web of Science KeyUT 000328915700001
FullText URL fulltext.pdf
Author Tazawa, Hiroshi| Hasei, Joe| Yano, Shuya| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords oncolytic adenovirus hTERT autophagy GFP p53
Published Date 2020-02-18
Publication Title Cancers
Volume volume12
Issue issue2
Publisher MDPI
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32085583
DOI 10.3390/cancers12020478
Web of Science KeyUT 000522477300224
Related Url isVersionOf https://doi.org/10.3390/cancers12020478
FullText URL fulltext.pdf
Author Tanimoto, Terutaka| Tazawa, Hiroshi| Ieda, Takeshi| Nouso, Hiroshi| Tani, Morimichi| Oyama, Takanori| Urata, Yasuo| Kagawa, Shunsuke| Noda, Takuo| Fujiwara, Toshiyoshi|
Keywords neuroblastoma MYCN hTERT adenovirus E2F1
Published Date 2020-09-25
Publication Title Molecular Therapy - Oncolytics
Volume volume18
Publisher Cell Press
Start Page 14
End Page 23
ISSN 2372-7705
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32637577
DOI 10.1016/j.omto.2020.05.015
Web of Science KeyUT 000575168700002
Related Url isVersionOf https://doi.org/10.1016/j.omto.2020.05.015
Author Kikuchi, Satoru| Kishimoto, Hiroyuki| Tazawa, Hiroshi| Hashimoto, Yuuri| Kuroda, Shinji| Nishizaki, Masahiko| Nagasaka, Takeshi| Shirakawa, Yasuhiro| Kagawa, Shunsuke| Urata, Yasuo| Robert M Hoffman| Fujiwara, Toshiyoshi|
Published Date 2014-12-19
Publication Title Molecular Therapy
Content Type Journal Article
Author Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Published Date 2014-05-28
Publication Title Gut
Content Type Journal Article
FullText URL OncoImmunol_8_12_1671760.pdf
Author Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date 2019-10-22
Publication Title OncoImmunology
Volume volume8
Issue issue12
Publisher TAYLOR & FRANCIS
Start Page e1671760
ISSN 2162402X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
DOI 10.1080/2162402X.2019.1671760
Web of Science KeyUT 000494085400001
Related Url isVersionOf https://doi.org/10.1080/2162402X.2019.1671760
FullText URL fulltext.pdf
Author Yano, Shuya| Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
Keywords cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date 2020-09-17
Publication Title Cancers
Volume volume12
Issue issue9
Publisher MDPI
Start Page 2655
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32957652
DOI 10.3390/cancers12092655
Web of Science KeyUT 000580315800001
Related Url isVersionOf https://doi.org/10.3390/cancers12092655
JaLCDOI 10.18926/AMO/53524
FullText URL 69_3_173.pdf
Author Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi|
Abstract A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position.
Keywords chyle leak thoracic duct thoracoscopy prone position
Amo Type Case Report
Published Date 2015-06
Publication Title Acta Medica Okayama
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 173
End Page 176
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101193
Web of Science KeyUT 000356903000006
JaLCDOI 10.18926/AMO/54421
FullText URL 70_3_213.pdf
Author Kikuchi, Satoru| Kagawa, Shunsuke| Ohara, Toshiaki| Kubota, Tetsushi| Kuwada, Kazuya| Kagawa, Tetsuya| Kuroda, Shinji| Shirakawa, Yasuhiro| Nishizaki, Masahiko| Fujiwara, Toshiyoshi|
Abstract A 69-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) at the lesser curvature in the angle of stomach. Histological examination revealed tub1, pM, ly0, v0, pLM(-), pVM(-), and the resection was considered curative. The scar after ESD was followed by esophagogastroduodenoscopy (EGD) and biopsy. Twenty months later, EGD showed an ulcerative lesion in the vicinity of the ESD scar, and histological examination of the biopsy specimen showed adenocarcinoma. A distal gastrectomy with lymph node dissection was then performed. Postoperative pathology showed tub1, pM, pN0, ly0, v0, and Stage 1A. Skip lesions were seen in the specimen resected by ESD, and the histological review confirmed so-called “dysplasia-like atypia” (DLA) between the lesions. It has been reported recently that in DLA, the dysplasia-like change involves only the bases of the pits, without upper pit or surface epithelium involvement, and it is said that the rate of DLA is higher in gastric cancer patients. We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence.
Keywords dysplasia-like atypia early gastric cancer endoscopic submucosal dissection local recurrence
Amo Type Case Report
Published Date 2016-06
Publication Title Acta Medica Okayama
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 213
End Page 216
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339211
Web of Science KeyUT 000379406100009
FullText URL K001672.pdf
Author 香川 俊輔|
Published Date 1997-09-30
Content Type Thesis or Dissertation
Grant Number 甲第1672号
Granted Date 1997-09-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language 日本語