| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshida, Kazuhiro| Umeda, Yuzo| Iwamuro, Masaya| Matsumoto, Kazuyuki| Kato, Hironari| Uka, Mayu| Matsui, Yusuke| Yoshida, Ryuichi| Kuise, Takashi| Yasui, Kazuya| Takagi, Kosei| Araki, Hiroyuki| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Hemobilia Bile duct resection Hepatectomy Endoscopic balloon tamponade Case report |
| Published Date | 2020-12-01 |
| Publication Title | BMC Surgery |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 307 |
| ISSN | 1471-2482 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020. |
| File Version | publisher |
| PubMed ID | 33261613 |
| DOI | 10.1186/s12893-020-00981-8 |
| Web of Science KeyUT | 000595042700001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12893-020-00981-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Omote, Sizuma| Matsueda, Katsunori| Tanaka, Takehiro| Ennishi, Daisuke| Otsuka, Fumio| Yoshino, Tadashi| Okada, Hiroyuki| |
| Keywords | Flow cytometry Light chain restriction Gastrointestinal lymphoma Lymphocyte isolation |
| Published Date | 2020 |
| Publication Title | MethodsX |
| Volume | volume7 |
| Publisher | Elsevier |
| Start Page | 101095 |
| ISSN | 2215-0161 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| PubMed ID | 33102158 |
| DOI | 10.1016/j.mex.2020.101095 |
| Web of Science KeyUT | 000607658800035 |
| Related Url | isVersionOf https://doi.org/10.1016/j.mex.2020.101095 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Tanaka, Takehiro| Toji, Tomohiro| Hiraoka, Sakiko| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-10-07 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 8893604 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 33083067 |
| DOI | 10.1155/2020/8893604 |
| Web of Science KeyUT | 000583201400001 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/8893604 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Murakami, Toshi| Tanaka, Takehiro| Oka, Shohei| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-06-04 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 6381670 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 32566328 |
| DOI | 10.1155/2020/6381670 |
| Web of Science KeyUT | 000542326600001 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/6381670 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Miyahara, Koji| Sakaguchi, Chihiro| Takenaka, Ryuta| Kobayashi, Sayo| Mouri, Hirokazu| Tanaka, Shigetomi| Toyokawa, Tatsuya| Tanaka, Shouichi| Nishimura, Mamoru| Yamauchi, Kenji| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | 18F-fluorodeoxyglucose-positron emission tomography mesenchymal tumor gastric neoplasms gastrointestinal stromal tumor schwannoma |
| Published Date | 2020-05-01 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 1301 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32370028 |
| DOI | 10.3390/jcm9051301 |
| Web of Science KeyUT | 000540223800058 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm9051301 |
| JaLCDOI | 10.18926/AMO/59957 |
|---|---|
| FullText URL | 74_3_237.pdf |
| Author | Oyama, Atsushi| Uchida, Daisuke| Shiraha, Hidenori| Sawahara, Hiroaki| Kato, Ryo| Iwamuro, Masaya| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Abstract | The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC. |
| Keywords | enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 237 |
| End Page | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577022 |
| Web of Science KeyUT | 000543363400007 |
| NAID | 120006862798 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Ota, Yoko| Tanaka, Takehiro| Asada, Noboru| Yano, Shuya| Uka, Mayu| Nakamura, Rei| Baba, Yuki| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Published Date | 2020-04-09 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Volume | volume2020 |
| Publisher | Hindawi |
| Start Page | 7947540 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 32328319 |
| DOI | 10.1155/2020/7947540 |
| Web of Science KeyUT | 000528921300002 |
| Related Url | isVersionOf https://doi.org/10.1155/2020/7947540 |
| Title Alternative | Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia |
|---|---|
| FullText URL | 131_139.pdf |
| Author | 三浦 公| Iwamuro, Masaya| Toyokawa, Tatsuya| Takenaka, Ryuta| Inoue, Masafumi| Ito, Mamoru| Okada, Hiroyuki| |
| Abstract | To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety. |
| Keywords | 機能性ディスペプシア (functional dyspepsia) ヘリコバクター・ピロリ (Helicobacter pylori) プロトンポンプ阻害剤 (proton pomp inhibitor) 消化管運動機能改善剤 (acotiamide) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2019-12-02 |
| Volume | volume131 |
| Issue | issue3 |
| Start Page | 139 |
| End Page | 143 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.131.139 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2019 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.131.139 |
| NAID | 130007782646 |
| FullText URL | CRGM_2019_5742672.pdf |
|---|---|
| Author | Iwamuro, Masaya| Urata, Haruo| Hirata, Shoichiro| Ueki, Toru| Hanabata, Tetsuro| Takeda, Sho| Teraoka, Akira| Okada, Hiroyuki| |
| Published Date | 2019-05-23 |
| Publication Title | Case Reports in Gastrointestinal Medicine |
| Publisher | HINDAWI |
| Start Page | 5742672 |
| ISSN | 20906528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2019 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 31240139 |
| DOI | 10.1155/2019/5742672 |
| Web of Science KeyUT | 000470161500001 |
| Related Url | isVersionOf https://doi.org/10.1155/2019/5742672 |
| FullText URL | ecancermedicalscience2019_933.pdf |
|---|---|
| Author | Iwamuro, Masaya| Tanaka, Takehiro| Nishida, Kenji| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki| |
| Keywords | follicular gastritis gastric neoplasms gastrointestinal endoscope mucosa-associated lymphoid tissue lymphoma nodular gastritis |
| Published Date | 2019-06-03 |
| Publication Title | ecancermedicalscience |
| Volume | volume13 |
| Publisher | CANCER INTELLIGENCE |
| Start Page | 933 |
| ISSN | 1754-6605 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © the authors |
| File Version | publisher |
| PubMed ID | 31281430 |
| DOI | 10.3332/ecancer.2019.933 |
| Web of Science KeyUT | 000472729000001 |
| Related Url | isVersionOf https://doi.org/10.3332/ecancer.2019.933 |
| FullText URL | GRP_8159072.pdf |
|---|---|
| Author | Iwamuro, Masaya| Aoyama, Yuki| Suzuki, Seiyuu| Kobayashi, Sayo| Toyokawa, Tatsuya| Moritou, Yuki| Hori, Shinichiro| Matsueda, Kazuhiro| Yoshioka, Masao| Tanaka, Takehiro| Okada, Hiroyuki| |
| Published Date | 2019-09-08 |
| Publication Title | Gastroenterology Research and Practice |
| Publisher | Hindawi |
| Start Page | 8159072 |
| ISSN | 1687-6121 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2019 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 31582972 |
| DOI | 10.1155/2019/8159072 |
| Web of Science KeyUT | 000487588000001 |
| Related Url | isVersionOf https://doi.org/10.1016/bs.aiip.2019.01.001 |
| JaLCDOI | 10.18926/AMO/57377 |
|---|---|
| FullText URL | 73_5_457.pdf |
| Author | Iwamuro, Masaya| Takahara, Masahiro| Yamazaki, Tatsuhiro| Tanaka, Takehiro| Kondo, Yoshitaka| Hiraoka, Sakiko| Okada, Hiroyuki| |
| Abstract | A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis. |
| Keywords | colonoscopy colonic neoplasms granulation polyp |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 457 |
| End Page | 461 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649373 |
| Web of Science KeyUT | 000491886600012 |
| FullText URL | DLD51_1_168.pdf |
|---|---|
| Author | Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Okada, Hiroyuki| |
| Published Date | 2019-01-31 |
| Publication Title | Digestive and Liver Disease |
| Volume | volume51 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 168 |
| ISSN | 15908658 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
| File Version | author |
| PubMed ID | 30145054 |
| DOI | 10.1016/j.dld.2018.07.031 |
| Web of Science KeyUT | 000454119300026 |
| Related Url | isVersionOf https://doi.org/10.1016/j.dld.2018.07.031 |
| JaLCDOI | 10.18926/AMO/55436 |
|---|---|
| FullText URL | 71_5_391.pdf |
| Author | Iwamuro, Masaya| Takata, Katsuyoshi| Hayashi, Eiko| Kawano, Seiji| Hiraoka, Sakiko| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki| |
| Abstract | To evaluate the usefulness of colonoscopy for the detection of ileal involvement in patients with intestinal follicular lymphoma, seventeen patients with intestinal follicular lymphoma who underwent colonoscopy and biopsy sampling from the terminal ileum were enrolled. The patients were divided into 2 groups: cases with ileal involvement (n=6) and cases without ileal involvement (n=11). Patients’ clinical backgrounds were compared between the two groups. Subsequently, 10 board-certified endoscopists independently evaluated the endoscopic pictures and determined whether the ileum was involved with follicular lymphoma. Infiltration of follicular lymphoma cells were identified in 6 patients (35.3%). Cases with positive ileal involvement were diagnosed with follicular lymphoma at a younger age than were cases without ileal involvement (55.4±7.4 vs. 68.1±10.3 years, p=0.011). Macroscopically, in patients with ileal involvement, there were multiple polypoid elevations smaller than 5 mm in 4 cases, single polypoid elevation smaller than 5 mm in 1 case, and single polypoid elevation larger than 5 mm in 1 case. In patients without ileal involvement, there were no lesions in the terminal ileum in 7 cases, and multiple polypoid elevations smaller than 5 mm were seen in 4 cases. The accuracy of the macroscopic evaluation by 10 board-certified endoscopists was 68.8%. Colonoscopy is particularly recommended during the initial workup of patients with follicular lymphoma diagnosed at age ≤ 60 years. The diagnosis of ileal involvement based on morphology alone is difficult; thus, biopsy and pathologic diagnosis are required for accurate diagnosis. |
| Keywords | follicular lymphoma colonoscopy ileal neoplasms terminal ileum small intestine |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-10 |
| Volume | volume71 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 398 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29042696 |
| JaLCDOI | 10.18926/AMO/55207 |
|---|---|
| FullText URL | 71_3_241.pdf |
| Author | Iwamuro, Masaya| Tanaka, Shouichi| Moritou, Yuki| Inaba, Tomoki| Higashi, Reiji| Kusumoto, Chiaki| Yunoki, Naoko| Ishikawa, Shin| Okamoto, Yuko| Kawai, Yoshinari| Kitada, Ken-ichi| Takenaka, Ryuta| Toyokawa, Tatsuya| Okada, Hiroyuki| |
| Abstract | Most gastric bezoars can be treated with endoscopic fragmentation combined with or without cola dissolution, whereas laparotomy or laparoscopic surgery is generally inevitable for small intestinal bezoars because they cause small bowel obstruction. Therefore, early diagnosis and management of gastric bezoars are necessary to prevent bezoar-induced ileus. To investigate the incidence of overlooked gastric bezoars during the initial esophagogastroduodenoscopy, we retrospectively reviewed the cases of 27 patients diagnosed with gastrointestinal bezoars. The bezoars were diagnosed using esophagogastroduodenoscopy (n=25), abdominal ultrasonography (n=1), and barium follow-through examination (n=1). Bezoars were overlooked in 9/25 patients (36.0%) during the initial endoscopy examination because the bezoars were covered with debris in the stomach. Of the 9 patients, 8 had concomitant gastric ulcers, and the other patient had gastric lymphoma. Although a computed tomography (CT) scan was performed before the second-look endoscopy in 8 of the 9 patients, the bezoars were mistaken as food debris on CT findings and were overlooked in these patients. In conclusion, gastric bezoars may not be discovered during the initial esophagogastroduodenoscopy and CT scan. In cases with debris in the stomach, second-look endoscopy is essential to detect bezoars. |
| Keywords | bezoar gastric ulcer foreign bodies phytobezoar |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-06 |
| Volume | volume71 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 241 |
| End Page | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28655944 |
| JaLCDOI | 10.18926/AMO/54977 |
|---|---|
| FullText URL | 71_2_97.pdf |
| Author | Iwamuro, Masaya| Kondo, Eisei| Tanaka, Takehiro| Hagiya, Hideharu| Kawano, Seiji| Kawahara, Yoshiro| Otsuka, Fumio| Okada, Hiroyuki| |
| Abstract | We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD). All 14 patients had been taking one or more immunosuppressive agents including cyclosporine (n=10), corticosteroids (n=9), mycophenolic acid (n=6), tacrolimus (n=3), and methotrexate (n=1). Tests for CMV antigenemia were positive in 11 patients (78.6%). EGD examinations revealed esophageal (n=3), gastric (n=9), and duodenal involvement (n=6). Macroscopically, esophageal lesions by CMV infection presented as redness (n=1), erosions (n=1), and ulcers (n=1). Gastric lesions manifested as redness (n=7), erosions (n=3), exfoliated mucosa (n=2), and verrucous erosions (n=1). Mucosal appearances in the duodenum varied: redness (n=2), ulcers (n=2), multiple erosions (n=2), single erosion (n=1), edema (n=1). CMV was detected even in the intact duodenal mucosa (n=1). In conclusion, physicians must recall the relevance of CMV infection when any mucosal alterations exist in the upper gastrointestinal tract of immunosuppressed patients. |
| Keywords | cytomegalovirus duodenum esophagogastroduodenoscopy esophagus stomach |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420890 |
| Title Alternative | Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone |
|---|---|
| FullText URL | 129_23.pdf |
| Author | Iwano, Eiji| Iwamuro, Masaya| 岡田 裕之| |
| Abstract | Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were ＜ 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ≥ 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n＝118) , followed by hyperplastic polyp ( n＝52) and inflammatory changes with edema ( n＝22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term. |
| Keywords | アントラセン誘導体（anthracene derivatives) アントラキノン（anthraquinone） 大腸黒皮症（melanosis coli） 大腸メラノーシス（pseudomelanosis coli） リンパ濾胞過形成（lymphoid follicle hyperplasia） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 23 |
| End Page | 30 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.23 |
| NAID | 130005632078 |
| Author | Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Ando, Akemi| Nada, Takahiro| Kimura, Kosuke| Yamauchi, Kenji| Kusumoto, Chiaki| Otsuka, Fumio| Okada, Hiroyuki| |
|---|---|
| Published Date | 2017-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54828 |
| Author | Gotoda, Tatsuhiro| Kawano, Seiji| Kono, Yoshiyasu| Miura, Kou| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Shirakawad, Yasuhiro| Tabata, Masahiro| Tanimoto, Mitsune| Okada, Hiroyuki| |
|---|---|
| Published Date | 2016-12-01 |
| Publication Title | Journal of Okayama Medical Association |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Iwamuro, Masaya| Okada, Hiroyuki| Harada, Keita| Kanzaki, Hiromitsu| Hori, Keisuke| Kita, Masahide| Kawano, Seiji| Kawahara, Yoshiro| Tanaka, Takehiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2016-12-01 |
| Publication Title | Journal of Okayama Medical Association |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Journal Article |
