| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Sho| Ikeda, Tomohiro| Nakanishi, Nobuto| Katsukawa, Hajime| Nawa, Ricardo Kenji| Perme, Christiane| Ozaki, Toshifumi| Hamada, Masanori| Sato, Ikumi| Hirohata, Satoshi| |
| Keywords | critical illness intensive care unit outcome assessment physical function rehabilitation |
| Published Date | 2025 |
| Publication Title | Progress in Rehabilitation Medicine |
| Volume | volume10 |
| Publisher | Japanese Association of Rehabilitation Medicine |
| Start Page | 20250037 |
| ISSN | 2432-1354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Japanese Association of Rehabilitation Medicine |
| File Version | publisher |
| PubMed ID | 41341922 |
| DOI | 10.2490/prm.20250037 |
| Web of Science KeyUT | 001641295700001 |
| Related Url | isVersionOf https://doi.org/10.2490/prm.20250037 |
| Title Alternative | The 19th Annual Meeting of Japanese Association of Medical Technology Education |
|---|---|
| Author | Hirohata, Satoshi| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 149 |
| End Page | 149 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.149 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.149 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Koumoto, Takuto| Kusachi, Shozo| Tomiya, Takumi| Akagi, Takuya| Kawamura, Hiroshi| Hirohata, Satoshi| Yamaji, Hirosuke| Murakami, Takashi| Kamikawa, Shigeshi| Murakami, Masaaki| |
| Keywords | Ischemic heart disease Reversible ischemia Coronary pressure Multi-slice CT Coronary hemodynamics |
| Published Date | 2025-07-23 |
| Publication Title | Scientific Reports |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 26737 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40702095 |
| DOI | 10.1038/s41598-025-11920-z |
| Web of Science KeyUT | 001535287200042 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-025-11920-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakanoue, Haruna| Yamaji, Hirosuke| Okamoto, Sayaka| Okano, Kumi| Fujita, Yuka| Higashiya, Shunichi| Murakami, Takashi| Hirohata, Satoshi| Kusachi, Shozo| |
| Keywords | anticoagulation heparin catheter supraventricular arrhythmia point-of-care testing |
| Published Date | 2025-03 |
| Publication Title | Clinical and Applied Thrombosis/Hemostasis |
| Volume | volume31 |
| Publisher | SAGE Publications |
| ISSN | 1076-0296 |
| NCID | AA11016631 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| PubMed ID | 40156227 |
| DOI | 10.1177/10760296251332938 |
| Web of Science KeyUT | 001456050100001 |
| Related Url | isVersionOf https://doi.org/10.1177/10760296251332938 |
| FullText URL | fulltext.pdf suppl.docx |
|---|---|
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Wake, Hidenori| Takahashi, Hideo| |
| Keywords | histidine-rich glycoprotein tumor necrosis factor-α integrin tube formation angiogenesis factor erythroid 2-related factor 2 |
| Published Date | 2025-03-21 |
| Publication Title | Frontiers in Pharmacology |
| Volume | volume16 |
| Publisher | Frontiers Media SA |
| Start Page | 1561628 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Hatipoglu, Nishinaka, Yaykasli, Mori, Watanabe, Toyomura, Nishibori, Hirohata, Wake and Takahashi. |
| File Version | publisher |
| PubMed ID | 40191430 |
| DOI | 10.3389/fphar.2025.1561628 |
| Web of Science KeyUT | 001458547300001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2025.1561628 |
| JaLCDOI | 10.18926/AMO/68723 |
|---|---|
| FullText URL | 79_3_157.pdf |
| Author | Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori| |
| Abstract | Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3. |
| Keywords | advanced glycation end product aging cartilage collagen aggrecan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 157 |
| End Page | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574254 |
| Web of Science KeyUT | 001524768800002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kakimoto, Mai| Fujii, Moe| Sato, Ikumi| Honma, Koki| Nakayama, Hinako| Kirihara, Sora| Fukuoka, Taketo| Ran, Shang| Hirohata, Satoshi| Kitamori, Kazuya| Yamamoto, Shusei| Watanabe, Shogo| |
| Keywords | Anti-inflammatory Atherosclerosis Febuxostat Non-alcoholic steatohepatitis (NASH) Oxidative stress Uric acid |
| Published Date | 2023-06-27 |
| Publication Title | Journal of Applied Biomedicine |
| Volume | volume21 |
| Issue | issue2 |
| Publisher | University of South Bohemia in Ceske Budejovice |
| Start Page | 80 |
| End Page | 90 |
| ISSN | 1214-021X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37376883 |
| DOI | 10.32725/jab.2023.009 |
| Web of Science KeyUT | 000995964300001 |
| Related Url | isVersionOf https://doi.org/10.32725/jab.2023.009 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Sato, Ikumi| Takashita, Ren| Kodama, Shintaro| Ikemura, Kentaro| Opoku, Gabriel| Watanabe, Shogo| Furumatsu, Takayuki| Yamada, Hiroshi| Ando, Mitsuru| Akiyoshi, Kazunari| Nishida, Keiichiro| Hirohata, Satoshi| |
| Keywords | extracellular vesicles (EVs) chondrocytes synoviocytes osteoarthritis (OA) |
| Published Date | 2024-11-06 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue22 |
| Publisher | MDPI |
| Start Page | 11942 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| DOI | 10.3390/ijms252211942 |
| Web of Science KeyUT | 001365437300001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms252211942 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Akagi, Satoshi| Nakamura, Kazufumi| Kondo, Megumi| Hirohata, Satoshi| Udono, Heiichiro| Nishida, Mikako| Saito, Yukihiro| Yoshida, Masashi| Miyoshi, Toru| Ito, Hiroshi| |
| Keywords | glycolysis mitochondrial respiration pulmonary arterial hypertension pulmonary artery smooth muscle cells Seahorse technology hypoxia ATP production |
| Published Date | 2023-07-31 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume12 |
| Issue | issue15 |
| Publisher | MDPI |
| Start Page | 5028 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37568430 |
| DOI | 10.3390/jcm12155028 |
| Web of Science KeyUT | 001045690800001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm12155028 |
| JaLCDOI | 10.18926/AMO/64358 |
|---|---|
| FullText URL | 77_1_29.pdf |
| Author | Yamamoto, Shusei| Sato, Ikumi| Fujii, Moe| Kakimoto, Mai| Honma, Koki| Akiyama, Natsumi| Sakai, Miku| Fukuhama, Natsuki| Kumazaki, Shota| Hirohata, Satoshi| Kitamori, Kazuya| Yamori, Yukio| Watanabe, Shogo| |
| Abstract | The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased. |
| Keywords | SHRSP5/Dmc nonalcoholic steatohepatitis cardiovascular disease glycine-conjugated bile acids unconjugated bile acids |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 36 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849143 |
| Web of Science KeyUT | 000953019200001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Inagaki, Junko| Nakano, Airi| Hatipoglu, Omer Faruk| Ooka, Yuka| Tani, Yurina| Miki, Akane| Ikemura, Kentaro| Opoku, Gabriel| Ando, Ryosuke| Kodama, Shintaro| Ohtsuki, Takashi| Yamaji, Hirosuke| Yamamoto, Shusei| Katsuyama, Eri| Watanabe, Shogo| Hirohata, Satoshi| |
| Keywords | osteoarthritis matrix metalloproteinase MMP13 ADAMTS9 expression screening chondrocytes |
| Published Date | 2022-02-28 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 2681 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35269821 |
| DOI | 10.3390/ijms23052681 |
| Web of Science KeyUT | 000773522200001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms23052681 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hatipoglu, Omer Faruk| Uctepe, Eyyup| Opoku, Gabriel| Wake, Hidenori| Ikemura, Kentaro| Ohtsuki, Takashi| Inagaki, Junko| Gunduz, Mehmet| Gunduz, Esra| Watanabe, Shogo| Nishinaka, Takashi| Takahashi, Hideo| Hirohata, Satoshi| |
| Keywords | Pulmonary fibrosis Osteopontin Epithelial-mesenchymal transition |
| Published Date | 2021-07 |
| Publication Title | Biomedicine & Pharmacotherapy |
| Volume | volume139 |
| Publisher | Elsevier France-Editions Scientifiques Medicales e |
| Start Page | 111633 |
| ISSN | 0753-3322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.biopha.2021.111633 |
| Web of Science KeyUT | 000663683300007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biopha.2021.111633 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hatipoglu, Omer F.| Miyoshi, Toru| Yonezawa, Tomoko| Kondo, Megumi| Amioka, Naofumi| Yoshida, Masashi| Akagi, Satoshi| Nakamura, Kazufumi| Hirohata, Satoshi| Ito, Hiroshi| |
| Keywords | Aneurysm Aortic diseases |
| Published Date | 2020-04-22 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 6869 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32321956 |
| DOI | 10.1038/s41598-020-63824-9 |
| Web of Science KeyUT | 000560329100004 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-63824-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Hatipoglu, Omer F.| Asano, Keiichi| Inagaki, Junko| Nishida, Keiichiro| Hirohata, Satoshi| |
| Keywords | cell migration-inducing hyaluronidase 1 (CEMIP) chondrocyte hyaluronan mechanical strain nuclear factor kappa B (NF-kappa B) osteoarthritis |
| Published Date | 2020-04-29 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 3140 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32365591 |
| DOI | 10.3390/ijms21093140 |
| Web of Science KeyUT | 000535581700111 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21093140 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Shinaoka, Akira| Kumagishi-Shinaoka, Kanae| Asano, Keiichi| Hatipoglu, Omer Faruk| Inagaki, Junko| Takahashi, Ken| Oohashi, Toshitaka| Nishida, Keiichiro| Naruse, Keiji| Hirohata, Satoshi| |
| Published Date | 2019-10-15 |
| Publication Title | Experimental Cell Research |
| Volume | volume383 |
| Issue | issue2 |
| Publisher | Elsevier |
| Start Page | 111556 |
| ISSN | 00144827 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier Inc. |
| File Version | publisher |
| PubMed ID | 31415758 |
| DOI | 10.1016/j.yexcr.2019.111556 |
| Web of Science KeyUT | 000488145400017 |
| Related Url | isVersionOf https://doi.org/10.1016/j.yexcr.2019.111556 |
| JaLCDOI | 10.18926/AMO/53521 |
|---|---|
| FullText URL | 69_3_145.pdf |
| Author | Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi| |
| Abstract | Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis. |
| Keywords | ECP reactive oxygen species Akt ERK |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 153 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101190 |
| Web of Science KeyUT | 000356903000003 |
| Author | Toeda, Kenichi| Nakamura, Keigo| Hirohata, Satoshi| Hatipoglu, Omer F.| Demircan, Kadir| Yamawaki, Hitoshi| Ogawa, Hiroko| Kusachi, Shozo| Shiratori, Yasushi| Ninomiya, Yoshifumi| |
|---|---|
| Published Date | 2005-12 |
| Publication Title | Molecular and Cellular Biochemistry |
| Volume | volume280 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Demircan, Kadir| Hirohata, Satoshi| Nishida, Keiichiro| Hatipoglu, Omer F.| Oohashi, Toshitaka| Yonezawa, Tomoko| Apte, Suneel S.| Ninomiya, Yoshifumi| |
|---|---|
| Published Date | 2005-5 |
| Publication Title | Arthritis & Rheumatism |
| Volume | volume52 |
| Issue | issue5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31831 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hatipoglu, Omer Faruk| Hirohata, Satoshi| Yaykasli, Kursat Oguz| Cilek, Mehmet Zeynel| Demircan, Kadir| Shinohata, Ryoko| Yonezawa, Tomoko| Oohashi, Toshitaka| Kusachi, Shozo| Ninomiya, Yoshifumi| |
| Abstract | ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene. When stimulated with tissue necrosis factor (TNF)-alpha, the expression level of ADAMTS1 mRNA rapidly increased, but the induction of ADAMTS1 mRNA peaked at 6h after stimulation, after which the expression levels of ADAMTS1 mRNA decreased. The 3'-UTR ADAMTS1 mRNA contains multiple adenine and uridine-rich elements, suggesting that the 3'-UTR may regulate gene stability. The addition of actinomycin D, an RNA synthesis inhibitor, demonstrated the decay of induced ADAMTS1 mRNA by TNF-alpha. Furthermore, a region containing multiple AUUUA motifs within the ADAMTS1 3'-UTR destabilized transfected Enhanced Green Fluorescence Protein (EGFP) mRNA expression. These results demonstrated that the ADAMTS1 3'-UTR may regulate the expression of ADAMTS1 mRNA. |
| Keywords | ADAMTS1 gene regulation metalloproteinase |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2009-04 |
| Volume | volume63 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 85 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 19404339 |
| Web of Science KeyUT | 000265457600002 |
| Author | 廣畑 聡| |
|---|---|
| Published Date | 1997-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
