| ID | 64358 |
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| Author |
Yamamoto, Shusei
Academic Field of Health Sciences, Okayama University
Sato, Ikumi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Fujii, Moe
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Kakimoto, Mai
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Honma, Koki
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Akiyama, Natsumi
Department of Medical Technology, Faculty of Health Sciences, Okayama University
Sakai, Miku
Department of Medical Technology, Faculty of Health Sciences, Okayama University
Fukuhama, Natsuki
Department of Medical Technology, Faculty of Health Sciences, Okayama University
Kumazaki, Shota
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Hirohata, Satoshi
Academic Field of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Kitamori, Kazuya
College of Human Life and Environment, Kinjo Gakuin University
Yamori, Yukio
Institute for World Health Development, Mukogawa Women's University
Watanabe, Shogo
Academic Field of Health Sciences, Okayama University
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| Abstract | The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.
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| Keywords | SHRSP5/Dmc
nonalcoholic steatohepatitis
cardiovascular disease
glycine-conjugated bile acids
unconjugated bile acids
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| Amo Type | Original Article
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2023-02
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| Volume | volume77
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| Issue | issue1
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| Publisher | Okayama University Medical School
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| Start Page | 29
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| End Page | 36
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
