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Author Ouddoud, Hanane| Lescano, Judah Israel Ong| Belangoy, Keith Pardillada| Nishimura, Yoshito| Harada, Ko| Hagiya, Hideharu| Vu, Quynh Thi| Iwata, Naohiro| Takeda, Tatsuaki| Zamami, Yoshito| Koyama, Toshihiro|
Keywords cardiovascular diseases global burden of disease North Africa and Middle East risk factors joinpoint regression
Published Date 2026-06-23
Publication Title Journal of Clinical Medicine
Volume volume15
Issue issue13
Publisher MDPI AG
Start Page 4866
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 by the authors.
File Version publisher
PubMed ID 42452328
DOI 10.3390/jcm15134866
Related Url isVersionOf https://doi.org/10.3390/jcm15134866
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Author Ouddoud, Hanane| Lescano, Judah Israel Ong| Belangoy, Keith Pardillada| Nishimura, Yoshito| Harada, Ko| Hagiya, Hideharu| Vu, Quynh Thi| Iwata, Naohiro| Higashionna, Tsukasa| Takeda, Tatsuaki| Zamami, Yoshito| Koyama, Toshihiro|
Keywords GBD 2023 diabetes mellitus Middle East and North Africa joinpoint regression cardiovascular risk factors epidemiology public health
Published Date 2026-07-13
Publication Title Medicina
Volume volume62
Issue issue7
Publisher MDPI AG
Start Page 1352
ISSN 1648-9144
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 by the authors.
File Version publisher
PubMed ID 42512894
DOI 10.3390/medicina62071352
Web of Science KeyUT 001832560800001
Related Url isVersionOf https://doi.org/10.3390/medicina62071352
JaLCDOI 10.18926/AMO/71066
FullText URL 80_4_233.pdf
Author Ogawa, Sakura| Fukushima, Shinnosuke| Akazawa, Hidemasa| Namba, Sachie| Hirota, Chiyoko| Kishiue, Tomoyoshi| Ibara, Shohei| Kondo, Takayuki| Fukuda, Genshi| Iio, Koji| Tsuji, Shuma| Gotoh, Kazuyoshi| Otsuka, Fumio| Hagiya, Hideharu|
Abstract Carbapenemase-producing Enterobacterales (CPE) and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-E) are representative antimicrobial-resistant pathogens. We investigated the prevalence of CPE and ESBL-E in Okayama, Japan to clarify their current epidemiology and potential clinical burden. Active surveillance for CPE and ESBL-E was performed first, using stool samples submitted to the Okayama Medical Laboratory (Japan) in the years 2024-2025. Screening was performed using a selective agar (CHROMagar mSuper CARBA/ESBL). Phenotypic identification was conducted with the use of a modified carbapenem inactivation method and double-disk phenotypic confirmatory tests. Clinical information including patient age, sex, sampling date, and hospital address were collected, and the data were analyzed according to specimen origin (hospitals, clinics, and health checkups). A total of 2,000 stool samples were screened, of which two CPE isolates (0.1%) and 285 ESBL-E isolates (14.3%) were identified. By specimen origin, the ESBL-E positivity rate was significantly higher in hospitals (17.4%) than in clinics (11.8%). By age category, the late elderly (> 75 years) exhibited the highest ESBL-E positivity rate (22.6%) compared to other age groups. In the clinics and health checkups, infants (0 years) demonstrated high ESBL-E positivity rates (18.2% and 14.3%, respectively). Escherichia coli was the most common ESBL-E organism in the hospitals (77.2%), clinics (88.8%), and health checkups (87.5%). Our active screening demonstrated that the prevalences of CPE and ESBL-E were within the reported ranges; however, in this era of increasing internationalization, continuous surveillance of these notifiable pathogens is warranted.
Keywords antimicrobial resistance carbapenem-resistant Enterobacteriaceae extended-spectrum β-lactamase infection prevention and control Okayama Medical Laboratory
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2026-08
Volume volume80
Issue issue4
Publisher Okayama University Medical School
Start Page 233
End Page 240
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2026 by Okayama University Medical School
File Version publisher
Refereed True
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Author Ichihara, Eiki| Mitsuhashi, Toshiharu| Tsuge, Mitsuru| Hasegawa, Kou| Kudo, Kenichiro| Tanimoto, Yasushi| Nouso, Kazuhiro| Oda, Naohiro| Mitsumune, Sho| Kimura, Goro| Yamada, Haruto| Takata, Ichiro| Hagiya, Hideharu| Taniguchi, Akihiko| Tsukahara, Kohei| Aokage, Toshiyuki| Toyooka, Shinichi| Tsukahara, Hirokazu| Maeda, Yoshinobu|
Keywords clinical outcome covid-19 localized respiratory symptom severe disease risk systemic symptom
Published Date 2025-05-27
Publication Title Cureus
Volume volume17
Issue issue5
Publisher Springer Science and Business Media LLC
Start Page e84919
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Copyright 2025 Ichihara et al.
File Version publisher
PubMed ID 40575188
DOI 10.7759/cureus.84919
Related Url isVersionOf https://doi.org/10.7759/cureus.84919
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Author Oguni, Kohei| Hagiya, Hideharu| Yamamoto, Yukichika| Ishida, Tomoharu| Ohki, Tomoka| Otsuka, Fumio|
Keywords autopsy cytomegalovirus cutaneous cytomegalovirus virus-associated hemophagocytic syndrome rheumatoid vasculitis
Published Date 2026-04-15
Publication Title Internal Medicine
Volume volume65
Issue issue8
Publisher Japanese Society of Internal Medicine
Start Page 1172
End Page 1177
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 40903227
DOI 10.2169/internalmedicine.5990-25
Web of Science KeyUT 001564005800001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.5990-25
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Author Akiyama, Hiroshi| Otsuka, Yuki| Masuda, Yohei| Soejima, Yoshiaki| Nakamoto, Kenta| Katayama, Yu| Sato, Aki| Hagiya, Hideharu| Otsuka, Fumio|
Keywords Behçet's disease nasal mucosal manifestation apremilast colchicine prednisolone
Published Date 2026-04-01
Publication Title Internal Medicine
Volume volume65
Issue issue7
Publisher Japanese Society of Internal Medicine
Start Page 1069
End Page 1073
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 40866267
DOI 10.2169/internalmedicine.6014-25
CRID 1390870696577092992
Web of Science KeyUT 001559836000001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6014-25
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Author Harada, Ko| Fujii, Mariko| Sako, Nanami| Vu, Quynh Thi| Nishimura, Yoshito| Belangoy, Keith Pardillada| Ouddoud, Hanane| Takeda, Tatsuaki| Zamami, Yoshito| Hagiya, Hideharu| Koyama, Toshihiro|
Published Date 2026-02-15
Publication Title Annals of the American Thoracic Society
Volume volume23
Issue issue5
Publisher Oxford University Press (OUP)
Start Page 823
End Page 827
ISSN 2329-6933
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2026.
File Version publisher
PubMed ID 41691480
DOI 10.1093/annalsats/aaoag026
Web of Science KeyUT 001758847900006
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Author Akazawa, Hidemasa| Hagiya, Hideharu| Fukushima, Shinnosuke| Nakamoto, Kenta| Oguni, Kohei| Manabe, Yohei| Kokubo-Tanaka, Mio| Maruyama, Haruhiko| Otsuka, Fumio|
Published Date 2026-03-04
Publication Title The American Journal of Tropical Medicine and Hygiene
Volume volume114
Issue issue3
Publisher American Society of Tropical Medicine and Hygiene
Start Page 486
End Page 489
ISSN 0002-9637
NCID AA00521439
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The author(s)
File Version publisher
PubMed ID 41666460
DOI 10.4269/ajtmh.25-0392
Web of Science KeyUT 001715134600019
Related Url isVersionOf https://doi.org/10.4269/ajtmh.25-0392
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Author Miyahara, Tomoyuki| Fukushima, Shinnosuke| Matsuo, Toshihiko| Hagiya, Hideharu|
Keywords abscess endophthalmitis orbital cellulitis Staphylococcus aureus
Published Date 2026-06-01
Publication Title Internal Medicine
Volume volume65
Issue issue11
Publisher Japanese Society of Internal Medicine
Start Page 1578
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 41125378
DOI 10.2169/internalmedicine.6260-25
Web of Science KeyUT 001602699700001
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Author Hagiya, Hideharu| Soejima, Yoshiaki| Tokumasu, Kazuki| Hirai, Yoji| Otsuka, Yuki| Kawaguchi, Marina| Fukushima, Shinnosuke| Nakamoto, Kenta| Oguni, Kohei| Shiode, Yusuke| Uda, Kazuhiro| Yashiro, Masato| Hasegawa, Kousei| Iio, Koji| Otsuka, Fumio|
Keywords inborn errors of immunity Mycobacterium avium complex nontuberculous mycobacteria primary immunodeficiency syndrome signal transducer and activator of transcription-3
Published Date 2026-05-15
Publication Title Internal Medicine
Volume volume65
Issue issue10
Publisher Japanese Society of Internal Medicine
Start Page 1421
End Page 1430
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 41034003
DOI 10.2169/internalmedicine.6174-25
Web of Science KeyUT 001586962100001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6174-25
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Author Tsuji, Shuma| Hagiya, Hideharu| Fukushima, Shinnosuke| Urakami, Iori| Gotoh, Kazuyoshi|
Keywords Enterobacteriaceae carbapenems
Published Date 2026-04-09
Publication Title Microbiology Resource Announcements
Volume volume15
Issue issue4
Publisher American Society for Microbiology
Start Page e0087625
ISSN 2576-098X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 Tsuji et al.
File Version publisher
PubMed ID 41817432
DOI 10.1128/mra.00876-25
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Author Fukushima, Shinnosuke| Sunami, Hiroshi| Nakano, Yasuhiro| Nakamoto, Kenta| Akazawa, Hidemasa| Hidani, Yoshimi| Kida, Kouji| Tsurumi, Go| Hagiya, Hideharu|
Keywords Epidemiology Japanese spotted fever Rickettsia species Tick bite Tick-borne disease
Published Date 2026-05
Publication Title Ticks and Tick-borne Diseases
Volume volume17
Issue issue3
Publisher Elsevier BV
Start Page 102635
ISSN 1877-959X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The Authors.
File Version publisher
PubMed ID 41889057
DOI 10.1016/j.ttbdis.2026.102635
Web of Science KeyUT 001730158000001
Related Url isVersionOf https://doi.org/10.1016/j.ttbdis.2026.102635
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Author Okunobu, Hiroki| Fukushima, Shinnosuke| Hagiya, Hideharu| Otsuka, Fumio|
Keywords 16S rRNA abscess calcium pyrophosphate deposition disease culture-negative direct sequencing analysis
Published Date 2026-05-25
Publication Title Clinical Case Reports
Volume volume14
Issue issue6
Publisher Wiley
Start Page e72814
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The Author(s).
File Version publisher
PubMed ID 42256962
DOI 10.1002/ccr3.72814
Web of Science KeyUT 001775651200001
Related Url isVersionOf https://doi.org/10.1002/ccr3.72814
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Author Higuchi, Chigusa| Ogawa, Chikako| Iwasaki, Yoshiaki| Hagiya, Hideharu| Masuyama, Hisashi|
Keywords anxiety human papillomavirus vaccine Japanese youth questionnaire survey
Published Date 2026-05
Publication Title Journal of Obstetrics and Gynaecology Research
Volume volume52
Issue issue5
Publisher Wiley
Start Page e70314
ISSN 1341-8076
NCID AA11082002
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The Author(s).
File Version publisher
PubMed ID 42144280
DOI 10.1111/jog.70314
Web of Science KeyUT 001775347200027
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Author Hagiya, Hideharu| Fukushima, Shinnosuke| Akazawa, Hidemasa| Nakamoto, Kenta| Oguni, Kohei|
Keywords Electronic consultation (eConsult) Telehealth Infectious diseases Antimicrobial stewardship Primary care Remote consultation
Published Date 2026-05
Publication Title International Journal of Infectious Diseases
Volume volume166
Publisher Elsevier BV
Start Page 108524
ISSN 1201-9712
NCID AA11238338
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The Authors.
File Version publisher
PubMed ID 41796793
DOI 10.1016/j.ijid.2026.108524
Web of Science KeyUT 001732174400001
Related Url isVersionOf https://doi.org/10.1016/j.ijid.2026.108524
JaLCDOI 10.18926/AMO/70456
FullText URL 80_2_141.pdf
Author Sakamoto-Tokunaga, Moe| Katsuyama, Takayuki| Matoba, Masaki| Tamura, Tomokazu| Kubota, Natsuki| Terajima, Yuya| Shidahara, Kenta| Hirose, Kei| Matsumoto, Kazuya| Nawachi, Shoichi| Nakadoi, Takato| Katayama, Yu| Hayashi, Keigo| Miyawaki, Yoshia| Katsuyama, Eri| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Sada, Ken-Ei| Tsuji, Shuma| Gotoh, Kazuyoshi| Fukushima, Shinnosuke| Hagiya, Hideharu| Wada, Jun|
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals.
Keywords necrotizing fasciitis Raoultella ornithinolytica VEXAS syndrome whole-genome sequence
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2026-04
Volume volume80
Issue issue2
Publisher Okayama University Medical School
Start Page 141
End Page 145
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2026 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 42025435
Web of Science KeyUT 001761342100007
FullText URL fulltext.pdf
Author Belangoy, Keith Pardillada| Nishimura, Yoshito| Harada, Ko| Hagiya, Hideharu| Vu, Quynh Thi| Ouddoud, Hanane| Lescano, Judah Israel Ong| Yamamoto, Michio| Takeda, Tatsuaki| Hamano, Hirofumi| Koyama, Toshihiro| Zamami, Yoshito|
Keywords Age-standardized mortality rate Global health Mortality trends Sociodemographic index Systemic sclerosis
Published Date 2026-03-06
Publication Title Clinical Rheumatology
Volume volume45
Issue issue5
Publisher Springer Science and Business Media LLC
Start Page 2741
End Page 2748
ISSN 0770-3198
NCID AA10623843
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2026
File Version publisher
PubMed ID 41790357
DOI 10.1007/s10067-026-07995-2
Web of Science KeyUT 001712341500001
Related Url isVersionOf https://doi.org/10.1007/s10067-026-07995-2
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Author Fukushima, Shinnosuke| Tsuji, Shuma| Gotoh, Kazuyoshi| Iio, Koji| Ogawa, Sakura| Koyanagi, Norihito| Ito, Yuji| Koganemaru, Hiroshi| Yoshida, Atsushi| Hagiya, Hideharu|
Keywords blaZ Cefazolin inoculum effect Methicillin-susceptible Staphylococcus aureus Nitrocefin rapid test β-lactamase
Published Date 2026-07
Publication Title Diagnostic Microbiology and Infectious Disease
Volume volume115
Issue issue3
Publisher Elsevier BV
Start Page 117345
ISSN 0732-8893
NCID AA10623322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The Author(s).
File Version publisher
PubMed ID 41785539
DOI 10.1016/j.diagmicrobio.2026.117345
Related Url isVersionOf https://doi.org/10.1016/j.diagmicrobio.2026.117345
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Author Hagiya, Hideharu| Nishimura, Yoshito| Harada, Ko| Yamamoto, Maki| Takeda, Tatsuaki| Vu, Quynh Thi| Belangoy, Keith Pardillada| Ouddoud, Hanane| Zamami, Yoshito| Koyama, Toshihiro|
Keywords Aging Locally weighted regression model Infection Clostridioides difficile Disparity
Published Date 2026-03
Publication Title International Journal of Infectious Diseases
Volume volume164
Publisher Elsevier BV
Start Page 108315
ISSN 1201-9712
NCID AA11238338
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 41456768
DOI 10.1016/j.ijid.2025.108315
Web of Science KeyUT 001678827200001
Related Url isVersionOf https://doi.org/10.1016/j.ijid.2025.108315
Author Fukushima, Shinnosuke| Sumida, Takaomi| Kawamata, Osamu| Hidani, Yoshimi| Hagiya, Hideharu|
Keywords Epidemiology Japanese spotted fever Spotted fever group rickettsiae Tick bite Tick-borne disease
Note © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.|
Published Date 2026-03
Publication Title Journal of Infection and Chemotherapy
Volume volume32
Issue issue3
Publisher Elsevier BV
Start Page 102931
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 41720337
DOI 10.1016/j.jiac.2026.102931
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2026.102931