| FullText URL | fulltext20250519-02.pdf suppl20250519-02.pdf fig1_20250519-02.pdf fig2_20250519-02.pdf fig3_20250519-02.pdf fig4_20250519-02.pdf fig5_20250519-02.pdf |
|---|---|
| Author | Takeda, Tatsuaki| Matsumoto, Jun| Sakai, Tomonori| Iwata, Naohiro| Hamano, Hirofumi| Koyama, Toshihiro| Ariyoshi, Noritaka| Zamami, Yoshito| |
| Keywords | adverse event breast cancer pertuzumab trastuzumab VigiBase |
| Note | This is the peer reviewed version of the following article: [Takeda T, Matsumoto J, Sakai T, et al. Comprehensive analysis of adverse event profile changes with pertuzumab addition to trastuzumab-based breast cancer therapy: Disproportionality analysis using VigiBase. Br J Clin Pharmacol. 2025;91(9):2659-2671. doi:10.1002/bcp.70094], which has been published in final form at [https://doi.org/10.1002/bcp.70094]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May. 2026.| |
| Published Date | 2025-05-08 |
| Publication Title | British Journal of Clinical Pharmacology |
| Volume | volume91 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | 2659 |
| End Page | 2671 |
| ISSN | 0306-5251 |
| NCID | AA00574388 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 British Pharmacological Society. |
| File Version | author |
| PubMed ID | 40344285 |
| DOI | 10.1002/bcp.70094 |
| Web of Science KeyUT | 001483932800001 |
| Related Url | isVersionOf https://doi.org/10.1002/bcp.70094 |
| Title Alternative | Drug interaction (62. Drug interactions of potassium absorption agents) |
|---|---|
| Author | Ariki, Saori| Hamano, Hirofumi| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-04-01 |
| Volume | volume137 |
| Issue | issue1 |
| Start Page | 30 |
| End Page | 32 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.30 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.30 |
| JaLCDOI | 10.18926/AMO/68362 |
|---|---|
| FullText URL | 79_1_051.pdf |
| Author | Miura, Taro| Kawasaki, Yoichi| Hamano, Hirofumi| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected in human serum. Here, we investigated the histamine-producing effects in HMC-1 cells and the inflammatory cytokine release effects in RAW264 cells for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; and 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All four promoted histamine production in HMC-1 cells; however, they did not significantly affect the release of inflammatory cytokines in RAW264 cells. These findings suggest that these four photoinitiators induce inflammatory cytokine-independent histamine production, potentially contributing to histamine-mediated chronic inflammation in vitro. |
| Keywords | photoinitiator ink injection histamine inflammation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-02 |
| Volume | volume79 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 51 |
| End Page | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40012160 |
| Web of Science KeyUT | 001440463800007 |
| Title Alternative | Drug interaction (61. Drug interactions of cancer cachexia therapeutics) |
|---|---|
| Author | Kawakami, Eiji| Okuda, Hiroto| Hamano, Hirofumi| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-12-02 |
| Volume | volume136 |
| Issue | issue3 |
| Start Page | 135 |
| End Page | 138 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.135 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.135 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okawa, Yasumasa| Ushio, Soichiro| Izushi, Yasuhisa| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Keywords | anxiolytic chotosan inflammation serotonin receptor Uncaria hook |
| Published Date | 2024-09-04 |
| Publication Title | Frontiers in Pharmacology |
| Volume | volume15 |
| Publisher | Frontiers Media |
| Start Page | 1471602 |
| ISSN | 1663-9812 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Okawa, Ushio, Izushi, Kitamura, Zamami and Sendo. |
| File Version | publisher |
| PubMed ID | 39295939 |
| DOI | 10.3389/fphar.2024.1471602 |
| Web of Science KeyUT | 001315388700001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphar.2024.1471602 |
| Title Alternative | mRNA-vaccine |
|---|---|
| Author | Tanaka, Yuta| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-08-01 |
| Volume | volume136 |
| Issue | issue2 |
| Start Page | 83 |
| End Page | 84 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.83 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.83 |
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| FullText URL | 78_3_227.pdf |
| Author | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| Keywords | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| Title Alternative | Drug interaction (59. Drug interaction of molecular targeted therapies for rare lung cancer) |
|---|---|
| Author | Okuda, Hiroto| Kuroda, Satoshi| Hamano, Hirofumi| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-04-01 |
| Volume | volume136 |
| Issue | issue1 |
| Start Page | 29 |
| End Page | 32 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.29 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.29 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takahashi, Tetta| Tomonobu, Nahoko| Kinoshita, Rie| Yamamoto, Ken-Ichi| Murata, Hitoshi| Komalasari, Ni Luh Gede Yoni| Chen, Youyi| Jiang, Fan| Gohara, Yuma| Ochi, Toshiki| Ruma, I. Made Winarsa| Sumardika, I. Wayan| Zhou, Jin| Honjo, Tomoko| Sakaguchi, Yoshihiko| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Inoue, Yusuke| Futami, Junichiro| Toyooka, Shinichi| Zamami, Yoshito| Sakaguchi, Masakiyo| |
| Keywords | breast cancer lysyl oxidase annexin A2 S100A11 plasmin cancer microenvironment |
| Published Date | 2024-03-26 |
| Publication Title | Frontiers in Oncology |
| Volume | volume14 |
| Publisher | Frontiers Media |
| Start Page | 1371342 |
| ISSN | 2234-943X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Takahashi, Tomonobu, Kinoshita, Yamamoto, Murata, Komalasari, Chen, Jiang, Gohara, Ochi, Ruma, Sumardika, Zhou, Honjo, Sakaguchi, Yamauchi, Kuribayashi, Kondo, Inoue, Futami, Toyooka, Zamami and Sakaguchi. |
| File Version | publisher |
| PubMed ID | 38595825 |
| DOI | 10.3389/fonc.2024.1371342 |
| Web of Science KeyUT | 001198366100001 |
| Related Url | isVersionOf https://doi.org/10.3389/fonc.2024.1371342 |
| FullText URL | fulltext20240206-02.pdf |
|---|---|
| Author | Takeda, Tatsuaki| Sugimoto, Shiho| Matsumoto, Jun| Iwata, Naohiro| Nakamoto, Akihiko| Ozaki, Aya Fukuma| Hamano, Hirofumi| Ariyoshi, Noritaka| Zamami, Yoshito| |
| Keywords | Abemaciclib Adverse event Breast cancer Cyclin-dependent kinase 4/6 inhibitor Palbociclib |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11096-023-01687-6| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-01-19 |
| Publication Title | International Journal of Clinical Pharmacy |
| Volume | volume46 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 536 |
| End Page | 541 |
| ISSN | 2210-7703 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024 |
| File Version | author |
| PubMed ID | 38240964 |
| DOI | 10.1007/s11096-023-01687-6 |
| Web of Science KeyUT | 001145361500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s11096-023-01687-6 |
| FullText URL | fulltext20240117-01.pdf fig1_20240117-01.pdf fig2_20240117-01.pdf fig3_20240117-01.pdf |
|---|---|
| Author | Koyama, Toshihiro| Iinuma, Shunya| Yamamoto, Michio| Niimura, Takahiro| Osaki, Yuka| Nishimura, Sayoko| Harada, Ko| Zamami, Yoshito| Hagiya, Hideharu| |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s40264-023-01387-0| This fulltext file will be available in Dec. 2024.| |
| Published Date | 2023-12-22 |
| Publication Title | Drug Safety |
| Volume | volume47 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 237 |
| End Page | 249 |
| ISSN | 0114-5916 |
| NCID | AA10748827 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG |
| File Version | author |
| PubMed ID | 38133735 |
| DOI | 10.1007/s40264-023-01387-0 |
| Web of Science KeyUT | 001132965700001 |
| Related Url | isVersionOf https://doi.org/10.1007/s40264-023-01387-0 |
| Title Alternative | Drug interaction (58. Drug interactions in tacrolimus) |
|---|---|
| Author | Kimura, Ikuya| Hamano, Hirofumi| Kajizono, Makoto| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2023-12-01 |
| Volume | volume135 |
| Issue | issue3 |
| Start Page | 167 |
| End Page | 171 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.135.167 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2023 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.135.167 |
| JaLCDOI | 10.18926/AMO/66151 |
|---|---|
| FullText URL | 77_6_595.pdf |
| Author | Bando, Takashi| Chuma, Masayuki| Hamano, Hirofumi| Niimura, Takahiro| Okada, Naoto| Kondo, Masateru| Izumi, Yuki| Ishida, Shunsuke| Yoshioka, Toshihiko| Asada, Mizuho| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Miyata, Koji| Yagi, Kenta| Izawa-Ishizawa, Yuki| Azuma, Momoyo| Yanagawa, Hiroaki| Tasaki, Yoshikazu| Ishizawa, Keisuke| |
| Abstract | There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN. |
| Keywords | vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 595 |
| End Page | 605 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145933 |
| Web of Science KeyUT | 001164631200004 |
| Title Alternative | Drug interaction (57. Drug interactions in renal failure) |
|---|---|
| Author | Hamano, Hirofumi| Kajizono, Makoto| Nishihara, Shigeki| Murakawa, Kiminaka| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2023-08-01 |
| Volume | volume135 |
| Issue | issue2 |
| Start Page | 89 |
| End Page | 91 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.135.89 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2023 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.135.89 |
| Title Alternative | Drug interaction (56. Interaction among antiarrhythmic drugs and other drugs) |
|---|---|
| FullText URL | 135_39.pdf |
| Author | Murao, Takuya| Esumi, Satoru| Hamano, Hirofumi| Murakawa, Kiminaka| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2023-04-01 |
| Volume | volume135 |
| Issue | issue1 |
| Start Page | 39 |
| End Page | 42 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.135.39 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2023 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.135.39 |
| Title Alternative | Drug interaction (55. Examples of drug interaction of great concern during pregnancy) |
|---|---|
| FullText URL | 134_185.pdf |
| Author | Shiromizu, Shoya| Esumi, Satoru| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2022-12-01 |
| Volume | volume134 |
| Issue | issue3 |
| Start Page | 185 |
| End Page | 186 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.134.185 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2022 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.134.185 |
| Title Alternative | Drug interaction (54. Drug interaction in the process of absorption and excretion of anticancer drugs) |
|---|---|
| FullText URL | 134_102.pdf |
| Author | Danzako, Minato| Esumi, Satoru| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2022-08-01 |
| Volume | volume134 |
| Issue | issue2 |
| Start Page | 102 |
| End Page | 107 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.134.102 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2022 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.134.102 |
| Title Alternative | Drug interaction (53. Interaction of traditional Japanese herbal medicines in chemotherapy) |
|---|---|
| FullText URL | 134_43.pdf |
| Author | Iwata, Naohiro| Esumi, Satoru| Zamami, Yoshito| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2022-04-01 |
| Volume | volume134 |
| Issue | issue1 |
| Start Page | 43 |
| End Page | 47 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.134.43 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2022 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.134.43 |
| FullText URL | fulltext20230207-1.pdf |
|---|---|
| Author | Matsumoto, Jun| Nishimoto, Anzu| Watari, Shogo| Ueki, Hideo| Shiromizu, Shoya| Iwata, Naohiro| Takeda, Tatsuaki| Ushio, Soichiro| Kajizono, Makoto| Fujiyoshi, Masachika| Koyama, Toshihiro| Araki, Motoo| Wada, Koichiro| Zamami, Yoshito| Nasu, Yasutomo| Ariyoshi, Noritaka| |
| Keywords | Genetic variant Polymorphism Renal cell carcinoma Survival UDP-glucuronosyltransferase |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11010-022-04637-4| |
| Published Date | 2022-12-26 |
| Publication Title | Molecular and Cellular Biochemistry |
| Volume | volume478 |
| Issue | issue8 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1779 |
| End Page | 1790 |
| ISSN | 0300-8177 |
| NCID | AA00745800 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 |
| File Version | author |
| PubMed ID | 36571650 |
| DOI | 10.1007/s11010-022-04637-4 |
| Web of Science KeyUT | 000904010400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11010-022-04637-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Esumi, Satoru| Ushio, Soichiro| Zamami, Yoshito| |
| Keywords | Alzheimer's disease polypharmacy drug interactions |
| Published Date | 2022-10-13 |
| Publication Title | Medicina-Lithuania |
| Volume | volume58 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 1445 |
| ISSN | 1010-660X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36295605 |
| DOI | 10.3390/medicina58101445 |
| Web of Science KeyUT | 000875259600001 |
| Related Url | isVersionOf https://doi.org/10.3390/medicina58101445 |
