| JaLCDOI | 10.18926/AMO/70450 |
|---|---|
| FullText URL | 80_2_075.pdf |
| Author | Lin, Deting| Horita, Masahiro| Watanabe, Masahito| Hasei, Joe| Ohtsuki, Takashi| Otsuka, Noriaki| Ichikawa, Chinatsu| Shimizu, Noriyuki| Naniwa, Shuichi| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Abstract | A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA. |
| Keywords | rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 75 |
| End Page | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 42025429 |
| Web of Science KeyUT | 001761342100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hakim, Taufik Fatwa Nur| Kitamatsu, Mizuki| Fujimoto, Shoumu| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Keywords | Peptide nanomicelles siRNA Near infrared light Targeted delivery Photosensitizer |
| Published Date | 2026-06 |
| Publication Title | Results in Chemistry |
| Volume | volume25 |
| Publisher | Elsevier BV |
| Start Page | 103265 |
| ISSN | 2211-7156 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.rechem.2026.103265 |
| Related Url | isVersionOf https://doi.org/10.1016/j.rechem.2026.103265 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bando, Akinari| Kitamatsu, Mizuki| Kanazaki, Yuuki| Tojo, Rika| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Keywords | Caged coacervating peptide Liquid–liquid phase separation Light |
| Published Date | 2026-02-25 |
| Publication Title | Scientific Reports |
| Volume | volume16 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 10464 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2026 |
| File Version | publisher |
| PubMed ID | 41735469 |
| DOI | 10.1038/s41598-026-40774-2 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-026-40774-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Furutani, Yuji| Shimasaki, Natsuki| Yamada, Riko| Ohtsuki, Takashi| Watanabe, Kazunori| |
| Published Date | 2026-02-18 |
| Publication Title | Journal of Medicinal Chemistry |
| Volume | volume69 |
| Issue | issue5 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 5944 |
| End Page | 5955 |
| ISSN | 0022-2623 |
| NCID | AA00702411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Authors. |
| File Version | publisher |
| PubMed ID | 41708292 |
| DOI | 10.1021/acs.jmedchem.5c03361 |
| Web of Science KeyUT | 001696231500001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.5c03361 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhou, Shengli| Furutani, Yuji| Yamashita, Kei| Kako, Sakuya| Watanabe, Kazunori| Kiwa, Toshihiko| Ohtsuki, Takashi| |
| Keywords | magnetic nanoparticle tumor-homing peptide superconducting quantum interference devices |
| Published Date | 2026-01-05 |
| Publication Title | Biosensors |
| Volume | volume16 |
| Issue | issue1 |
| Publisher | MDPI AG |
| Start Page | 45 |
| ISSN | 2079-6374 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 by the authors. |
| File Version | publisher |
| DOI | 10.3390/bios16010045 |
| Related Url | isVersionOf https://doi.org/10.3390/bios16010045 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ishii, Koki| Shigeto, Hajime| Yamamura, Shohei| Imai, Yoshitane| Ohtsuki, Takashi| Kitamatsu, Mizuki| |
| Published Date | 2025 |
| Publication Title | Organic & Biomolecular Chemistry |
| Volume | volume23 |
| Issue | issue27 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 6557 |
| End Page | 6563 |
| ISSN | 1477-0520 |
| NCID | AA1168650X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2025 |
| File Version | publisher |
| PubMed ID | 40534431 |
| DOI | 10.1039/d5ob00873e |
| Web of Science KeyUT | 001511108300001 |
| Related Url | isVersionOf https://doi.org/10.1039/d5ob00873e |
| FullText URL | fulltext.pdf suppl.pdf |
|---|---|
| Author | Maemoto, Hayaki| Suzaki, Ryohei| Watanabe, Kazunori| Itaka, Keiji| Ohtsuki, Takashi| |
| Keywords | mRNA Photochemical internalization Photosensitizer |
| Published Date | 2025-04 |
| Publication Title | European Journal of Medicinal Chemistry Reports |
| Volume | volume13 |
| Publisher | Elsevier BV |
| Start Page | 100242 |
| ISSN | 2772-4174 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.ejmcr.2024.100242 |
| Web of Science KeyUT | 001385949000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejmcr.2024.100242 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naniwa, Shuichi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Ohtsuki, Takashi| Hotta, Yoshifumi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Otsuka, Noriaki| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress LRP4 Agrin β-catenin SOX9 |
| Published Date | 2025-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1007 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39940775 |
| DOI | 10.3390/ijms26031007 |
| Web of Science KeyUT | 001418599900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26031007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fithroni, Abdul Basith| Inoue, Haruki| Zhou, Shengli| Hakim, Taufik Fatwa Nur| Tada, Takashi| Suzuki, Minoru| Sakurai, Yoshinori| Ishimoto, Manabu| Yamada, Naoyuki| Sauriasari, Rani| Sauerwein, Wolfgang A. G.| Watanabe, Kazunori| Ohtsuki, Takashi| Matsuura, Eiji| |
| Keywords | boron neutron capture therapy (BNCT) dual therapeutic effects Lactosome ® hydrophobic boron compound neutron irradiation theranostics |
| Published Date | 2025-01-06 |
| Publication Title | Cells |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 60 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39791761 |
| DOI | 10.3390/cells14010060 |
| Web of Science KeyUT | 001394869200001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells14010060 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Sato, Ikumi| Takashita, Ren| Kodama, Shintaro| Ikemura, Kentaro| Opoku, Gabriel| Watanabe, Shogo| Furumatsu, Takayuki| Yamada, Hiroshi| Ando, Mitsuru| Akiyoshi, Kazunari| Nishida, Keiichiro| Hirohata, Satoshi| |
| Keywords | extracellular vesicles (EVs) chondrocytes synoviocytes osteoarthritis (OA) |
| Published Date | 2024-11-06 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue22 |
| Publisher | MDPI |
| Start Page | 11942 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| DOI | 10.3390/ijms252211942 |
| Web of Science KeyUT | 001365437300001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms252211942 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhou, Shengli| Tsutsumiuchi, Kaname| Imai, Ritsuko| Miki, Yukiko| Kondo, Anna| Nakagawa, Hiroshi| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Keywords | tumor-homing peptide magnetic hyperthermia magnetic nanoparticles ferroptosis tumor-specific delivery |
| Published Date | 2024-06-03 |
| Publication Title | Molecules |
| Volume | volume29 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 2632 |
| ISSN | 1420-3049 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38893510 |
| DOI | 10.3390/molecules29112632 |
| Web of Science KeyUT | 001245732000001 |
| Related Url | isVersionOf https://doi.org/10.3390/molecules29112632 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Maekawa, Yuhi| Sakura, Sora| Furutani, Yuji| Fujihara, Rento| Sugime, Hisashi| Ohtsuki, Takashi| Kitamatsu, Mizuki| |
| Keywords | peptide pyrene metal ion fluorescence |
| Published Date | 2024-04-07 |
| Publication Title | Processes |
| Volume | volume12 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 746 |
| ISSN | 2227-9717 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| DOI | 10.3390/pr12040746 |
| Web of Science KeyUT | 001211366700001 |
| Related Url | isVersionOf https://doi.org/10.3390/pr12040746 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ikawa, Yuka| Wakai, Takuya| Funahashi, Hiroaki| Soe, Tet Htut| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-40361-9| |
| Published Date | 2023-08-11 |
| Publication Title | Scientific Reports |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | nature portfolio |
| Start Page | 13050 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37567923 |
| DOI | 10.1038/s41598-023-40361-9 |
| Web of Science KeyUT | 001068298400054 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-023-40361-9 |
| FullText URL | fulltext20230619-02.pdf |
|---|---|
| Author | Thu, Myat| Yanai, Kouta| Shigeto, Hajime| Yamamura, Shohei| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Published Date | 2023 |
| Publication Title | Analyst |
| Volume | volume148 |
| Issue | issue11 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 2626 |
| End Page | 2632 |
| ISSN | 0003-2654 |
| NCID | AA00524823 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2023 |
| File Version | publisher |
| PubMed ID | 37191032 |
| DOI | 10.1039/d3an00554b |
| Web of Science KeyUT | 000988019800001 |
| Related Url | isVersionOf https://doi.org/10.1039/D3AN00554B |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fithroni, Abdul Basith| Kobayashi, Kazuko| Uji, Hirotaka| Ishimoto, Manabu| Akehi, Masaru| Ohtsuki, Takashi| Matsuura, Eiji| |
| Keywords | boron neutron capture therapy (BNCT) biologically self-degradable amphipathic polymer (Lactosome) hydrophobic boron cluster carborane isomers or o-carborane alkylated derivatives molecular glue effect |
| Published Date | 2022-10-21 |
| Publication Title | CELLS |
| Volume | volume11 |
| Issue | issue20 |
| Publisher | MDPI |
| Start Page | 3307 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36291173 |
| DOI | 10.3390/cells11203307 |
| Web of Science KeyUT | 000872497500001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells11203307 |
| FullText URL | fulltext20220630-10.pdf |
|---|---|
| Author | Sumi, Nanako| Nagahiro, Shota| Nakata, Eiji| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Keywords | Ultrasound Sonosensitizer Rose Bengal RNAi RNA delivery |
| Note | © 2022 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.bmcl.2022.128767. This fulltext is available in May 2024. | |
| Published Date | 2022-07 |
| Publication Title | Bioorganic & Medicinal Chemistry Letters |
| Volume | volume68 |
| Publisher | Elsevier BV |
| Start Page | 128767 |
| ISSN | 0960-894X |
| NCID | AA1079577X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 35513220 |
| DOI | 10.1016/j.bmcl.2022.128767 |
| Web of Science KeyUT | 000800009100005 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bmcl.2022.128767 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Inagaki, Junko| Nakano, Airi| Hatipoglu, Omer Faruk| Ooka, Yuka| Tani, Yurina| Miki, Akane| Ikemura, Kentaro| Opoku, Gabriel| Ando, Ryosuke| Kodama, Shintaro| Ohtsuki, Takashi| Yamaji, Hirosuke| Yamamoto, Shusei| Katsuyama, Eri| Watanabe, Shogo| Hirohata, Satoshi| |
| Keywords | osteoarthritis matrix metalloproteinase MMP13 ADAMTS9 expression screening chondrocytes |
| Published Date | 2022-02-28 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 2681 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35269821 |
| DOI | 10.3390/ijms23052681 |
| Web of Science KeyUT | 000773522200001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms23052681 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Kazunori| Nawachi, Tomoko| Okutani, Ruriko| Ohtsuki, Takashi| |
| Published Date | 2021-07-22 |
| Publication Title | scientific reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 14936 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34294789 |
| DOI | 10.1038/s41598-021-94249-7 |
| Web of Science KeyUT | 000682800400009 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-94249-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hatipoglu, Omer Faruk| Uctepe, Eyyup| Opoku, Gabriel| Wake, Hidenori| Ikemura, Kentaro| Ohtsuki, Takashi| Inagaki, Junko| Gunduz, Mehmet| Gunduz, Esra| Watanabe, Shogo| Nishinaka, Takashi| Takahashi, Hideo| Hirohata, Satoshi| |
| Keywords | Pulmonary fibrosis Osteopontin Epithelial-mesenchymal transition |
| Published Date | 2021-07 |
| Publication Title | Biomedicine & Pharmacotherapy |
| Volume | volume139 |
| Publisher | Elsevier France-Editions Scientifiques Medicales e |
| Start Page | 111633 |
| ISSN | 0753-3322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.biopha.2021.111633 |
| Web of Science KeyUT | 000663683300007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biopha.2021.111633 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Watanabe, Kazunori| Ohtsuki, Takashi| |
| Keywords | heat shock response nuclear stress bodies HSF1 granules SAFB granules liquid-liquid phase separation |
| Published Date | 2021-05-07 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 4982 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34067147 |
| DOI | 10.3390/ijms22094982 |
| NAID | 120007042387 |
| Web of Science KeyUT | 000650646500001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22094982 |
