| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tanaka, Masato| Kumawat, Chetan| Gunjotikar, Sharvari| Oda, Yoshiaki| Shinohara, Kensuke| Komatsubara, Tadashi| Arataki, Shinya| Ozaki, Toshifumi| |
| Keywords | navigation o-arm c-arm free mis-tlif spine surgery |
| Published Date | 2024-08-03 |
| Publication Title | Cureus |
| Volume | volume16 |
| Issue | issue8 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | e66070 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Copyright 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 39224725 |
| DOI | 10.7759/cureus.66070 |
| Web of Science KeyUT | 001285023200009 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.66070 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tetsunaga, Tomonori| Tetsunaga, Tomoko| Yamada, Kazuki| Koura, Takashi| Inoue, Tomohiro| Okuda, Ryuichiro| Masada, Yasutaka| Muguruma, Sho| Okazaki, Yuki| Ozaki, Toshifumi| |
| Keywords | hip navigation system portable navigation retrospective study total hip arthroplasty (tha) |
| Published Date | 2024-11-21 |
| Publication Title | Cureus |
| Volume | volume16 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | e74176 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Copyright 2024 Tetsunaga et al. |
| File Version | publisher |
| PubMed ID | 39575353 |
| DOI | 10.7759/cureus.74176 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.74176 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shitozawa, Hisakazu| Misawa, Haruo| Uotani, Koji| Tetsunaga, Tomoko| Shinohara, Kensuke| Oda, Yoshiaki| Ueda, Masataka| Takatori, Ryo| Yamashita, Kazutaka| Ozaki, Toshifumi| |
| Keywords | adolescent idiopathic scoliosis (ais) height growth proximal femur maturity index risser staging skeletal maturation |
| Published Date | 2024-11-10 |
| Publication Title | Cureus |
| Volume | volume16 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | e73395 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Copyright 2024 Shitozawa et al. |
| File Version | publisher |
| PubMed ID | 39659310 |
| DOI | 10.7759/cureus.73395 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.73395 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Kintaka, Keisuke| Yokoyama, Yusuke| Tamura, Masanori| Kawada, Koki| Hasegawa, Tsubasa| Ozaki, Toshifumi| |
| Keywords | magnetic resonance imaging medial meniscus extrusion posterior root tear pullout repair technique three-dimensional reconstruction |
| Published Date | 2024-11-15 |
| Publication Title | Cureus |
| Volume | volume16 |
| Issue | issue11 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | e73778 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Copyright 2024 Okazaki et al. |
| File Version | publisher |
| PubMed ID | 39687808 |
| DOI | 10.7759/cureus.73778 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.73778 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okuda, Ryuichiro| Tetsunaga, Tomonori| Yamada, Kazuki| Tetsunaga, Tomoko| Inoue, Tomohiro| Masada, Yasutaka| Yamamoto, Tetsuya| Matsumoto, Shin| Okazaki, Yuki| Ozaki, Toshifumi| |
| Keywords | Periprosthetic fracture Anterolateral approach Direct anterior approach Bone density Hip prosthesis |
| Published Date | 2026-05 |
| Publication Title | Orthopaedics & Traumatology: Surgery & Research |
| Volume | volume112 |
| Issue | issue3 |
| Publisher | Elsevier BV |
| Start Page | 104642 |
| ISSN | 1877-0568 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Authors. |
| File Version | publisher |
| PubMed ID | 41690548 |
| DOI | 10.1016/j.otsr.2026.104642 |
| Web of Science KeyUT | 001761394700001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.otsr.2026.104642 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Masada, Yasutaka| Tetsunaga, Tomonori| Fujiwara, Kazuo| Yamada, Kazuki| Inoue, Tomohiro| Okuda, Ryuichiro| Tetsunaga, Tomoko| Okazaki, Yuki| Ozaki, Toshifumi| |
| Keywords | total hip arthroplasty ACTIS CORAIL mid-term outcome retrospective study |
| Published Date | 2026-01 |
| Publication Title | Journal of Orthopaedic Surgery |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | SAGE Publications |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 1022-5536 |
| NCID | AA11004541 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2026 |
| File Version | publisher |
| PubMed ID | 41800908 |
| DOI | 10.1177/10225536261434671 |
| Web of Science KeyUT | 001709481100001 |
| Related Url | isVersionOf https://doi.org/10.1177/10225536261434671 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hiraga, Hiroaki| Machida, Ryunosuke| Kawai, Akira| Kunisada, Toshiyuki| Yonemoto, Tsukasa| Endo, Makoto| Nishida, Yoshihiro| Nagano, Akihito| Ae, Keisuke| Yoshida, Shinichirou| Asanuma, Kunihiro| Toguchida, Junya| Furuta, Taisuke| Nakayama, Robert| Akisue, Toshihiro| Hiruma, Toru| Morii, Takeshi| Nishimura, Hideki| Hiraoka, Koji| Takeyama, Masanobu| Emori, Makoto| Tsukushi, Satoshi| Hatano, Hiroshi| Kawashima, Hiroyuki| Isu, Kazuo| Tanaka, Kazuhiro| Kataoka, Tomoko| Fukuda, Haruhiko| Iwamoto, Yukihide| Ozaki, Toshifumi| |
| Published Date | 2025-06 |
| Publication Title | Journal of Clinical Oncology |
| Volume | volume43 |
| Issue | issue16 |
| Publisher | American Society of Clinical Oncology (ASCO) |
| Start Page | 1886 |
| End Page | 1897 |
| ISSN | 0732-183X |
| NCID | AA10638385 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by American Society of Clinical Oncology. |
| File Version | publisher |
| PubMed ID | 40138604 |
| DOI | 10.1200/jco-24-01281 |
| Web of Science KeyUT | 001496344700002 |
| Related Url | isVersionOf https://doi.org/10.1200/jco-24-01281 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kohara, Toshiki| Okazaki, Yuki| Miyazawa, Shinichi| Furumatsu, Takayuki| Yokoyama, Yusuke| Tamura, Masanori| Kawada, Koki| Hasegawa, Tsubasa| Tetsunaga, Tomonori| Yamada, Kazuki| Ozaki, Toshifumi| |
| Published Date | 2026-01 |
| Publication Title | Case Reports in Orthopedics |
| Publisher | Wiley |
| Start Page | 5671446 |
| ISSN | 2090-6749 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 Toshiki Kohara et al. |
| File Version | publisher |
| PubMed ID | 41523742 |
| DOI | 10.1155/cro/5671446 |
| Web of Science KeyUT | 001658114800001 |
| Related Url | isVersionOf https://doi.org/10.1155/cro/5671446 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujiwara, Tomohiro| Mitsuhashi, Toshiharu| Nezu, Yutaka| Tajima, Takashi| Miwa, Shinji| Kojima, Toshio| Fujiwara, Shuichi| Kawai, Akira| Tanaka, Kazuhiro| Ozaki, Toshifumi| |
| Keywords | Soft-tissue sarcoma High-risk Surgery Perioperative radiotherapy Elderly patients |
| Published Date | 2026-01-31 |
| Publication Title | BMC Cancer |
| Volume | volume26 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 329 |
| ISSN | 1471-2407 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2026. |
| File Version | publisher |
| PubMed ID | 41620674 |
| DOI | 10.1186/s12885-026-15629-8 |
| Web of Science KeyUT | 001712752100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-026-15629-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hanzawa, Mana| Hasei, Joe| Okada, Ayumi| Tanaka, Chie| Shigeyasu, Yoshie| Fujii, Chikako| Horiuchi, Makiko| Sugihara, Akiko| Takeuchi, Koichi| Nakahara, Ryuichi| Katayama, Hideki| Takahashi, Yasushi| Ozaki, Toshifumi| Tsukahara, Hirokazu| |
| Keywords | anorexia nervosa caregiver burden family support family-based treatment generative AI agent large language model retrieval-augmented generation |
| Published Date | 2026-03-09 |
| Publication Title | Frontiers in Digital Health |
| Volume | volume8 |
| Publisher | Frontiers Media SA |
| Start Page | 1759690 |
| ISSN | 2673-253X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 Hanzawa, Hasei, Okada, Tanaka, Shigeyasu, Fujii, Horiuchi, Sugihara, Takeuchi, Nakahara, Katayama, Takahashi, Ozaki and Tsukahara. |
| File Version | publisher |
| PubMed ID | 41878376 |
| DOI | 10.3389/fdgth.2026.1759690 |
| Web of Science KeyUT | 001720251900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fdgth.2026.1759690 |
| JaLCDOI | 10.18926/AMO/70452 |
|---|---|
| FullText URL | 80_2_099.pdf |
| Author | Nguyen Trung Thanh| Nakamichi, Ryo| Shimamura, Yasunori| Saito, Taichi| Ishihara, Takeshi| Furutani, Tomoki| Shitozawa, Hisakazu| Noda, Tomoyuki| Ozaki, Toshifumi| |
| Abstract | Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction −1.0±2.2 mm [B1], −0.5±2.0 mm [B2], −0.6±1.8 mm [B3]; p=0.825; angulation −0.8±3.4°, −1.1±3.1°, −0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures. |
| Keywords | clavicle fracture minimally invasive plate osteosynthesis anteroinferior plating AO/OTA classification |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 99 |
| End Page | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 42025431 |
| Web of Science KeyUT | 001761342100003 |
| JaLCDOI | 10.18926/AMO/70450 |
|---|---|
| FullText URL | 80_2_075.pdf |
| Author | Lin, Deting| Horita, Masahiro| Watanabe, Masahito| Hasei, Joe| Ohtsuki, Takashi| Otsuka, Noriaki| Ichikawa, Chinatsu| Shimizu, Noriyuki| Naniwa, Shuichi| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Abstract | A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA. |
| Keywords | rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 75 |
| End Page | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 42025429 |
| Web of Science KeyUT | 001761342100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Furutani, Tomoki| Saito, Taichi| Ikeda, Asahi| Mashima, Kenta| Yukihiro, Natsumi| Kusakabe, Satoki| Nakamichi, Ryo| Yoshida, Aki| Nishida, Keiichiro| Ozaki, Toshifumi| |
| Keywords | enthesis psoriasis strenuous exercise |
| Published Date | 2026-03 |
| Publication Title | Health Science Reports |
| Volume | volume9 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | e72040 |
| ISSN | 2398-8835 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| PubMed ID | 41822761 |
| DOI | 10.1002/hsr2.72040 |
| Related Url | isVersionOf https://doi.org/10.1002/hsr2.72040 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shitozawa, Hisakazu| Nakamichi, Ryo| Yoshida, Aki| Ueda, Masataka| Saito, Taichi| Uotani, Koji| Oda, Yoshiaki| Takatori, Ryo| Yamashita, Kazutaka| Ozaki, Toshifumi| |
| Keywords | annulus fibrosus calcification ossification PIEZO1 |
| Published Date | 2026-03 |
| Publication Title | JOR SPINE |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e70168 |
| ISSN | 2572-1143 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| PubMed ID | 41783545 |
| DOI | 10.1002/jsp2.70168 |
| Web of Science KeyUT | 001705480300001 |
| Related Url | isVersionOf https://doi.org/10.1002/jsp2.70168 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naniwa, Shuichi| Yorimitsu, Masanori| Hasegawa, Tsubasa| Ando, Teruhiko| Okuda, Ryuichiro| Fukuoka, Shiro| Mochizuki, Yusuke| Yamakawa, Yasuaki| Nakahara, Ryuichi| Hanakawa, Shiro| Ozaki, Toshifumi| |
| Keywords | Fragility fractures of the pelvis Spinopelvic dissociation Finite element analysis Internal fixation |
| Published Date | 2026-02-27 |
| Publication Title | European Journal of Trauma and Emergency Surgery |
| Volume | volume52 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 72 |
| ISSN | 1863-9941 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2026 |
| File Version | publisher |
| PubMed ID | 41758241 |
| DOI | 10.1007/s00068-026-03087-7 |
| Web of Science KeyUT | 001705252200005 |
| Related Url | isVersionOf https://doi.org/10.1007/s00068-026-03087-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Horita, Masahiro| Kiso, Yohei| Nasu, Yoshihisa| Nakahara, Ryuichi| Saiga, Kenta| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Keywords | forefoot surgery foot length foot width rheumatoid arthritis |
| Published Date | 2026-02-28 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume15 |
| Issue | issue5 |
| Publisher | MDPI AG |
| Start Page | 1877 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 by the authors. |
| File Version | publisher |
| DOI | 10.3390/jcm15051877 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm15051877 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishida, Keiichiro| Nasu, Yoshihisa| Harada, Ryozo| Nakahara, Ryuichi| Horita, Masahiro| Natsumeda, Masamitsu| Naniwa, Shuichi| Ozaki, Toshifumi| |
| Keywords | delayed wound healing discontinuation ozoralizumab orthopaedic surgery perioperative management rheumatoid arthritis surgical site infection |
| Published Date | 2026-02-11 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume15 |
| Issue | issue4 |
| Publisher | MDPI AG |
| Start Page | 1422 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 by the authors. |
| File Version | publisher |
| DOI | 10.3390/jcm15041422 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm15041422 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Itano, Takuto| Huang, Rongsheng| Ozaki, Toshifumi| Nakata, Eiji| Fujimura, Atsushi| |
| Published Date | 2026-01-22 |
| Publication Title | Signal Transduction and Targeted Therapy |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 26 |
| ISSN | 2059-3635 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2026 |
| File Version | publisher |
| PubMed ID | 41565624 |
| DOI | 10.1038/s41392-025-02548-6 |
| Related Url | isVersionOf https://doi.org/10.1038/s41392-025-02548-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamazaki, Fumito| Nakano, Yoshiko| Sanada, Masashi| Kurahashi, Hiroki| Miyai, Shunsuke| Ueki, Arisa| Watanabe, Yuko| Hasegawa, Daisuke| Karakawa, Shuhei| Ozaki, Toshifumi| Hirasawa, Akira| Saito, Akiko M.| Inoue, Eisuke| Kato, Motohiro| Hattori, Hiroyoshi| |
| Keywords | cancer predisposition genotype–phenotype correlations hotspot variants Li–Fraumeni syndrome TP53 |
| Published Date | 2025-12-29 |
| Publication Title | Cancer Science |
| Publisher | Wiley |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 41457833 |
| DOI | 10.1111/cas.70302 |
| Web of Science KeyUT | 001649565500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.70302 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Sho| Ikeda, Tomohiro| Nakanishi, Nobuto| Katsukawa, Hajime| Nawa, Ricardo Kenji| Perme, Christiane| Ozaki, Toshifumi| Hamada, Masanori| Sato, Ikumi| Hirohata, Satoshi| |
| Keywords | critical illness intensive care unit outcome assessment physical function rehabilitation |
| Published Date | 2025 |
| Publication Title | Progress in Rehabilitation Medicine |
| Volume | volume10 |
| Publisher | Japanese Association of Rehabilitation Medicine |
| Start Page | 20250037 |
| ISSN | 2432-1354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Japanese Association of Rehabilitation Medicine |
| File Version | publisher |
| PubMed ID | 41341922 |
| DOI | 10.2490/prm.20250037 |
| Web of Science KeyUT | 001641295700001 |
| Related Url | isVersionOf https://doi.org/10.2490/prm.20250037 |