心停止蘇生後の脳障害に関する実験的研究 第1編 髄液腔エラスタンスの経時的変化について

Volume changes in the central nervous system after cardiac arrest and cardiopulmonary resuscitation were observed by the measurement of cerebro-spinal fluid space elastic compliance (CSFS-EC). Two catheters were placed in the lumbar subarachnoidal space, normal saline solution was injected from one catheter, constantly, and pressure changes were measured with the other. Mongrel dogs, weighing about 10 kg, had cardiac fibrillation induced electrically and maintained for 3 minutes before resuscitation was started. CSFS-EC was measured 30 minutes, one hour, 2 hours, 4 hours and 24 hours after reestablishment of the circulation. In the dogs resuscitated successfully in a short period of time, CSFS-EC decreased gradually and constantly. On the other hand, when the resuscitation took longer, CSFS-EC increased initially, and decreased later. The CSFS-EC at 30 minutes had a good correlation with the time needed for resuscitation. In other words, the longer the time needed for resuscitation the higher the CSFS-EC. One hour after resuscitation, the difference of the CSFS-EC between the long and the short became satistically insignificant. Although 24 hours after resuscitation, all dogs behaved as normal, CSFS-EC were significantly lower than that of control. Even after a short period of cardiac arrest, the recovery of the central nervous system takes longer than expected.