| 著者 | Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu| |
|---|---|
| 発行日 | 2008-06 |
| 出版物タイトル | Tissue Engineering Part A |
| 巻 | 14巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/30972 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Endo, Hirosuke| Asaumi, Koji| Mitani, Shigeru| Noda, Tomoyuki| Minagawa, Hiroshi| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
| 抄録 | <p>A minimally invasive plate osteosynthesis technique using a locking compression plate (LCP) has been used widely in trauma cases. Its advantages are that the MIPO technique does not interfere with the fracture site and thus provides improved biological healing, and that the LCP has excellent angular stability. Its use in bone lengthening, however, has not been established. In such cases, it is desirable to shorten the external skeletal fixation period as much as possible. Here, the MIPO technique using an LCP was applied to femoral distraction osteogenesis in an attempt to shorten the external skeletal fixation period. For femoral lengthening, the MIPO technique was performed in 2 stages. Orthofix external fixators (Orthofix, England) were used to insert screws from the anterolateral side rather than from the lateral side of the femur for bone lengthening. When sufficient callus formation was detected postoperatively at the site of bone lengthening, and the absence of infection was ensured, limb draping was performed, including a whole external fixator, and then the MIPO technique was applied with an LCP. In 3 cases (5 limbs), the average duration of external skeletal fixation was 134days, the average external-fixation index was 24days/cm, and the average consolidation index was 22days/cm. The MIPO technique using an LCP made it possible to shorten the external skeletal fixation-wearing period in femoral lengthening.</p> |
| キーワード | femoral lengthening minimally invasive plate osteosynthesis locking compression plate external skeletal fixation external-fixation index |
| Amo Type | Original Article |
| 発行日 | 2008-10 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 62巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 339 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 18985094 |
| Web of Science KeyUT | 000260391300008 |
| 著者 | Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi| |
|---|---|
| 発行日 | 2009-05 |
| 出版物タイトル | The International Journal of Biochemistry & Cell Biology |
| 巻 | 41巻 |
| 号 | 5号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/31850 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Ohmori, Takao| Endo, Hirosuke| Mitani, Shigeru| Minagawa, Hiroshi| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
| 抄録 | <p>In 1957, Pavlik introduced the Pavlik harness as a useful treatment for developmental dislocation of the hip (DDH), and subsequent studies have documented favorable outcomes among patients treated with this device. However, there are only a few articles reporting how early radiographic measurements can be used to determine the prognosis after treatment with the Pavlik harness. In this study, 217 hips from 192 patients whose DDH treatment with the Pavlik harness was initiated before they were 6 months old and whose follow-up lasted at least 14 years (rate, 63.8%) were analyzed using measurements from radiographs taken immediately before and after harness treatment, and at 1, 2, and 3 years of age. Severin's classification at the final follow-up was I or II in 71.9% and III or IV in 28.1% of the hips, respectively. Avascular necrosis of the femoral head (AVN) was seen in 10% of the hips. Stepwise multiple regression analysis was performed to retrospectively determine whether any radiographic factors were related to the final classification as Severin I/II or III/IV. Receiver opera-ting characteristic (ROC) curves were drawn for these factors, and a Wiberg OE angle (Point O was the middle point of the proximal metaphyseal border of the femur) of 2 degrees on the 3-year radiographs was found to be the most useful screening value for judging the acetabular development of DDH cases after treatment with a Pavlik harness, with a sensitivity of 71% a specificity of 93%, and a likelihood ratio of 10.1.</p> |
| キーワード | developmental dislocation of the hip long-term follow up radiographic measurement stepwise multiple regression analysis acetabular development |
| Amo Type | Original Article |
| 発行日 | 2009-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 128 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19571898 |
| Web of Science KeyUT | 000267388200001 |
| JaLCDOI | 10.18926/AMO/31849 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yasuo| Kunisada, Toshiyuki| Misawa, Haruo| Koshimune, Koichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Surgical treatment of metastatic spinal cord compression is controversial. The purpose of this study was to investigate the effectiveness of our current surgical treatments and the use of spinal instrumentation. In this retrospective study covering the years between 1990 and 2006, 100 patients with spinal metastases which were secondary to various cancers underwent posterior and/or anterior decompression with spinal stabilization for the purposes of reduction of pain, and/or to help correct or improve neurological deficits. The group was made up of 60 men and 40 women whose ages ranged from 16 to 83 years (average of 60 years), and the average follow-up period was 14 months. The effect of treatment upon pain relief and neural deficits was assessed, and the cumulative survival rate was calculated by the Kaplan-Meier method. The average surgical time was 185min. This was calculated based on the following times, listed here with the surgery type:178min for posterior surgery;245min for anterior surgery;465 min for combined surgery;and 475min for total en bloc spondylectomy. Average blood loss during surgery was 1,630 ml for posterior surgery, 1,760 ml for anterior surgery, 1,930 ml for combined surgery, and 3,640 ml for total en bloc spondylectomy. Preoperative pain and paralysis were improved by 88% and 53%, respectively. In regards to surgical complications, postoperative epidural hematoma was observed in 2 patients, and instrumentation-related infection was observed in 1. Only 2 patients died within 2 months of surgery. In conclusion, posterior and/or anterior decompression with spinal stabilization is a safe and effective treatment for patients with spinal metastases, and can improve their quality of life.</p> |
| キーワード | spinal metastasis spinal surgery instrumentation |
| Amo Type | Original Article |
| 発行日 | 2009-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 145 |
| 終了ページ | 150 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19571901 |
| Web of Science KeyUT | 000267388200004 |
| JaLCDOI | 10.18926/AMO/31814 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Minagawa, Hiroshi| Aiga, Ayako| Endo, Hirosuke| Mitani, Shigeru| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
| 抄録 | <p>This retrospective study assessed the radiographic results of 16 patients with avascular necrosis following treatment for developmental dislocation of the hip (DDH) who were subsequently treated between 1991 and 2005 by rotation acetabular osteotomy (RAO) combined with femoral intertrochan-teric osteotomy (FIO). Initial treatment was by Pavlik harness, cast fixation, or overhead traction. The parameters that showed consistent improvement were the index of centralization, the index of acetabular coverage, adequate reduction of the greater trochanter, and abductor sufficiency. The combined procedure appears to be effective in cases in which preoperative planning shows a reasonable expectation of congruency and osteoarthritis is limited to the early stages.</p> |
| キーワード | rotation acetabular osteotomy femoral intertrochanteric osteotomy combined procedure developmental dysplasia of hip avascular necrosis |
| Amo Type | Original Article |
| 発行日 | 2009-08 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 169 |
| 終了ページ | 175 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 19727201 |
| Web of Science KeyUT | 000269228400002 |
| 著者 | Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2009-09-18 |
| 出版物タイトル | Journal of Biomechanics |
| 巻 | 42巻 |
| 号 | 13号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/31823 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Tanaka, Masato| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Misawa, Haruo| Takigawa, Tomoyuki| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | <p>Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.</p> |
| キーワード | Rett syndrome scoliosis computer navigation-assisted surgery segmental pedicle screw fixation |
| Amo Type | Case Report |
| 発行日 | 2009-12 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 63巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 373 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20035294 |
| Web of Science KeyUT | 000273145900009 |
| 著者 | Furumatsu, Takayuki| Shukunami, Chisa| Amemiya-Kudo, Michiyo| Shimano, Hitoshi| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-01 |
| 出版物タイトル | The International Journal of Biochemistry & Cell Biology |
| 巻 | 42巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Furumatsu, Takayuki| Hachioji, Motomi| Saiga, Kenta| Takata, Naoki| Yokoyama, Yusuke| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-01-01 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 391巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/32851 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Shintani, Mai| Senda, Masuo| Takayanagi, Tomoko| Katayama, Yoshimi| Furusawa, Kazunari| Okutani, Tamami| Kataoka, Masaki| Ozaki, Toshifumi| |
| 抄録 | <p>To assess the effects of service dogs on health-related quality of life (HRQOL), we conducted a survey of 10 service dog owners using SF-36v2 (Medical Outcomes Study 36 Item Short-Form Health Survey Version 2.0) and compared it with a matched control group of people with physical disabilities who did not have service dogs but were eligible for one. The scores for mental health and role emotional of service dog owners were relatively high, and their mental component summary was higher than the general population norm. These results indicate that service dogs affect the mentality of their owners. The comparison with the control group indicated that service dogs alleviate the mental burden of daily activities, and subjectively improved the physical functioning of their owners. This study showed that service dogs have positive functional and mental effects on their disabled owners.</p> |
| キーワード | service dog HRQOL SF-36v2 people with physical disability |
| Amo Type | Original Article |
| 発行日 | 2010-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 109 |
| 終了ページ | 113 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20424665 |
| Web of Science KeyUT | 000276996900004 |
| JaLCDOI | 10.18926/AMO/32855 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Shimamura, Yasunori| Nishida, Keiichiro| Imatani, Junya| Noda, Tomoyuki| Hashizume, Hiroyuki| Ohtsuka, Aiji| Ozaki, Toshifumi| |
| 抄録 | <p>We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods:an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were:Group I, 98.9+/-32.6;Group II, 108.5+/-27.2;Group III, 50.0+/-7.5;and Group IV, 34.5+/-12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p0.05). In the extension loading test, the mean failure loads were:Group I, 34.0+/-12.4;Group II, 51.0+/-14.8;Group III, 19.3+/-6.0;and Group IV, 14.7+/-3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.</p> |
| キーワード | distal humerus fracture biomechanics internal fixation elderly |
| Amo Type | Original Article |
| 発行日 | 2010-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 120 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20424666 |
| Web of Science KeyUT | 000276996900005 |
| JaLCDOI | 10.18926/AMO/32853 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Endo, Hirosuke| Noda, Tomoyuki| Mitani, Shigeru| Nakahara, Ryuichi| Tetsunaga, Tomonori| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | <p>Femoroacetabular impingement (FAI) is a condition characterized by the impingement of the femur and acetabulum. In Japan, this disorder has become recognized gradually. Here we report a rare case of surgically treated FAI, associated with an osseous protrusion on the acetabulum of a 30-year-old female. Plain computed tomography (CT) and reconstructive 3D-CT images clearly demonstrated an anterolateral bony protrusion. Hip arthroscopy showed no degeneration of the cartilage on either the femoral or acetabular side, but degeneration at the edge of labrum was observed in the region of the bony protrusion. The complete removal of the bony protrusion under hip arthroscopy was thus considered impracticable, and a small skin incision was therefore made anteriorly to approach the acetabulum. The Short-Form 36-Item Health Survey (SF-36) revealed improvement in all scores.</p> |
| キーワード | femoroacetabular impingement bony protrusion Pincer type hip arthroscopy SF36 |
| Amo Type | Case Report |
| 発行日 | 2010-04 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 149 |
| 終了ページ | 154 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20424671 |
| Web of Science KeyUT | 000276996900010 |
| 著者 | 三村 秀文| 藤原 寛康| 平木 隆夫| 郷原 英夫| 芝本 健太郎| 木股 敬裕| 尾﨑 敏文| 佐々木 了| 金澤 右| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 田中 雅人| 杉本 佳久| 三澤 治夫| 高畑 智宏| 尾﨑 敏文| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/40011 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Honda, Mitsugi| Arita, Seizaburo| Mitani, Shigeru| Takeda, Yoshihiro| Ozaki, Toshifumi| Inamura, Keiji| Kanazawa, Susumu| |
| 抄録 | Plain X-ray radiography is frequently used for the diagnosis of developmental dislocation of the hip (DDH). The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The data for these subjects were divided into 2 groups. The Min-Max method of nonlinear analysis was applied to the data from Group 1 to construct the diagnostic support system based on the measurement of 4 items in X-ray images:the outward displacement rate, upward displacement rate, OE angle, and alpha angle. This system was then applied to the data from Group 2, and the results were compared between the 2 groups to verify the reliability of the system. We obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%. |
| キーワード | X-ray image developmental dislocation of the hip acetabular dysplasia radiographic findings nonlinear multivariate analysis infant hip joint diagnostic support system |
| Amo Type | Original Article |
| 発行日 | 2010-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 189 |
| 終了ページ | 196 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596130 |
| Web of Science KeyUT | 000279094300005 |
| JaLCDOI | 10.18926/AMO/40007 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Furumatsu, Takayuki| Ozaki, Toshifumi| |
| 抄録 | Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis. |
| キーワード | epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis |
| Amo Type | Review |
| 発行日 | 2010-06 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 64巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 155 |
| 終了ページ | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 著作権者 | Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 20596126 |
| Web of Science KeyUT | 000279094300001 |
| 著者 | 古松 毅之| 尾﨑 敏文| 浅原 弘嗣| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 藤原 一夫| 遠藤 裕介| 三宅 由晃| 尾﨑 敏文| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2010-11-12 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 402巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |