ID | 30749 |
JaLCDOI | |
フルテキストURL | |
著者 |
Komiyama, Takamitsu
Okayama University
Yorimitsu, Masanori
Okayama University
Doi, Hideyuki
Okayama University
Miyazawa, Shinichi
Okayama University
Kitamura, Ai
Okayama University
Yoshida, Aki
Okayama University
Nasu, Yoshihisa
Okayama University
|
抄録 | Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR.
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キーワード | spontaneous hypertensive rats
insulin like growth factor-1
vascular endothelial growth factor
ossification disturbance
osteonecrosis
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Amo Type | Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2006-06
|
巻 | 60巻
|
号 | 3号
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出版者 | Okayama University Medical School
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開始ページ | 141
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終了ページ | 148
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |