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ID 32287
JaLCDOI
フルテキストURL
著者
Shibahara, Motomi Okayama University
Nishida, Keiichiro Okayama University Kaken ID
Asahara, Hiroshi Okayama University
Yoshikawa, Takeshi Okayama University
Mitani, Shigeru Okayama University
Kondo, Yoichi Okayama University
Inoue, Hajime Okayama University
抄録

We investigated the presence of osteocyte apoptosis in the necrotic trabeculae of the femoral head of spontaneously hypertensive rat (SHR) using the in situ nick end labeling (TUNEL) method and transmission electron microscopy. The occurrence of osteonecrosis and ossification disturbance was significantly higher in SHR compared with Wistar Kyoto (WKY) rats, and Wistar (WT) rats used as control animals (P < 0.01). A high population of TUNEL positive osteocytes was detected mainly in 10- and 15-week-old SHRs. Sectioned examination of the femoral head of SHRs and WKY rats by electron microscopy revealed apoptotic cell appearances such as aggregation of chromatin particles and lipid formation. In contrast, a positive reaction was significantly lower in osteocytes in the femoral heads of WT rats (P < 0.01). Our results indicate that apoptosis forms an important component of the global pathologic process affecting the femoral head of SHR, which leads to osteonecrosis in this region.

キーワード
apoptosis
spontaneously hypertensive rat
osteonecrosis of the femoral head
Amo Type
Article
発行日
2000-04
出版物タイトル
Acta Medica Okayama
54巻
2号
出版者
Okayama University Medical School
開始ページ
67
終了ページ
74
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT