フルテキストURL J_Orthop_Sci_22_4_731.pdf fig.pdf tbl.pdf
著者 Furumatsu, Takayuki| Fujii, Masataka| Kodama, Yuya| Ozaki, Toshifumi|
備考 This is an Accepted Manuscript of an article published by Elsevier|
発行日 2017-07
出版物タイトル Journal of Orthopaedic Science
22巻
4号
出版者 Elsevier
開始ページ 731
終了ページ 736
ISSN 0949-2658
NCID AA11052566
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28416188
DOI 10.1016/j.jos.2017.03.013
Web of Sience KeyUT 000407394700025
関連URL isVersionOf https://doi.org/10.1016/j.jos.2017.03.013
著者 Hino, Tomohito| Furumatsu, Takayuki| Miyazawa, Shinichi| Fujii, Masataka| Kodama, Yuya| Kamatsuki, Yusuke| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Ozaki, Toshifumi|
キーワード Medial meniscus posterior insertion histological analysis knee osteoarthritis medial meniscus posterior root tear transtibial pullout repair
備考 This fulltext will be available in Jul 2020|
発行日 2019-07-09
出版物タイトル Connective Tissue Research
出版者 TAYLOR & FRANCIS
開始ページ 1
終了ページ 8
ISSN 0300-8207
NCID AA00615033
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31181971
DOI 10.1080/03008207.2019.1631298
Web of Science KeyUT 000478374800001
関連URL isVersionOf https://doi.org/10.1080/03008207.2019.1631298
著者 Furumatsu, Takayuki| Hachioji, Motomi| Saiga, Kenta| Takata, Naoki| Yokoyama, Yusuke| Ozaki, Toshifumi|
発行日 2010-01-01
出版物タイトル Biochemical and Biophysical Research Communications
391巻
1号
資料タイプ 学術雑誌論文
フルテキストURL IntOrthop_43_5_1239.pdf Tables.pdf Fig.pdf
著者 Furumatsu, Takayuki| Miyazawa, Shinichi| Fujii, Masataka| Tanaka, Takaaki| Kodama, Yuya| Ozaki, Toshifumi|
キーワード Arthroscopic scoring Medial meniscus Meniscal healing Posterior root tear Transtibial pullout repair
発行日 2018-08-01
出版物タイトル International Orthopaedics
43巻
5号
出版者 Springer
開始ページ 1239
終了ページ 1245
ISSN 03412695
NCID AA0068148X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 30069591
DOI 10.1007/s00264-018-4071-z
Web of Science KeyUT 000466730800024
関連URL isVersionOf https://doi.org/10.1007/s00264-018-4071-z
JaLCDOI 10.18926/AMO/57717
フルテキストURL 73_6_523.pdf
著者 Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yoshiki| Kamatsuki, Yusuke| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi|
抄録 The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined with a medial meniscus (MM) posterior root tear is described. A 34-year-old Japanese man with bilateral ACL rupture that occurred > 10 years earlier was diagnosed with bilateral ACL tear combined with MM posterior root tear (MMPRT). We performed a transtibial pullout repair of the MMPRT with ACL reconstruction. The tibial tunnels for the MM posterior root repair and ACL reconstruction were created separately. Postoperatively, a good clinical outcome and meniscal healing were obtained. Our surgical technique may thus contribute to anatomical MM posterior root repair and ACL reconstruction.
キーワード bilateral anterior cruciate ligament tear medial meniscus posterior root tear pullout repair case report
Amo Type Case Report
発行日 2019-12
出版物タイトル Acta Medica Okayama
73巻
6号
出版者 Okayama University Medical School
開始ページ 523
終了ページ 528
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31871335
Web of Science KeyUT 000503431400008
著者 Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi|
発行日 2010-11-12
出版物タイトル Biochemical and Biophysical Research Communications
402巻
2号
資料タイプ 学術雑誌論文
著者 Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi|
発行日 2013-01
出版物タイトル International Orthopaedics
37巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54806
フルテキストURL 70_6_441.pdf
著者 Kashihara, Naoko| Furumatsu, Takayuki| Kodama, Yuya| Tanaka, Takaaki| Ozaki, Toshifumi|
抄録 Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability. The length and width of the lateral tibial plateau were determined by radiographic images. The length, width, body width, extrusion, and height of the LM were measured in magnetic resonance images and compared between the preoperative and postoperative measurements. Our analysis revealed that concurrent LM repair with ACL reconstruction improved the shortterm clinical outcomes. Although the body width and height of the LM did not change, the postoperative LM extrusion and LM width were significantly increased after the surgery. The post-traumatic transposition of the LM may not be completely prevented by LM repair concomitant with ACL reconstruction.
キーワード lateral meniscus meniscal extrusion meniscal repair anterior cruciate ligament reconstruction
Amo Type Original Article
発行日 2016-12
出版物タイトル Acta Medica Okayama
70巻
6号
出版者 Okayama University Medical School
開始ページ 441
終了ページ 448
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28003668
JaLCDOI 10.18926/AMO/53910
フルテキストURL 69_6_355.pdf
著者 Okada, Yukimasa| Furumatsu, Takayuki| Miyazawa, Shinichi| Tanaka, Takaaki| Fujii, Masataka| Ozaki, Toshifumi| Abe, Nobuhiro|
抄録 Venous thromboembolism (VTE) is a potential complication occurring after total knee arthroplasty (TKA). We investigated the incidence of VTE after TKA using contrast-enhanced computed tomography (CT), and assessed the efficacy of VTE prophylaxis (fondaparinux and enoxaparin). At our hospital, 189 patients (225 knees) underwent TKA between April 2007 and October 2011. The 225 knees were divided into a control group with no VTE prophylaxis (31 cases), a fondaparinux group (107 cases), and an enoxaparin group (87 cases). Contrast-enhanced CT screening for VTE was performed in all cases on day 5 or 6 after TKA. D-dimer levels were measured on day 5 after TKA, and were significantly lower in the fondaparinux (9.8±3.8) and enoxaparin groups (9.4±4.9) than in the control group (15.6±9.8) (p<0.001). However, no statistically significant difference in the incidence of VTE was observed among the groups (control, 61.3%;fondaparinux, 49.5%;enoxaparin, 50.6%). Prophylaxis was not effective for the prevention of VTE as detected by contrast-enhanced CT after TKA. CT should be performed after TKA, even when VTE prophylaxis is used.
キーワード venous thromboembolism contrast-enhanced computed tomography total knee arthroplasty fondaparinux enoxaparin
Amo Type Original Article
発行日 2015-12
出版物タイトル Acta Medica Okayama
69巻
6号
出版者 Okayama University Medical School
開始ページ 355
終了ページ 359
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26690246
Web of Science KeyUT 000368434500005
著者 Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Kamatsuki| Sugiu, Kazuhisa| iyazawa, Shinichi| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Kodama, Yuya| Ozaki, Toshifumi|
キーワード Anterior cruciate ligament reconstruction Chondral damage Meniscal repair
備考 This fulltext is available in Feb. 2022.|
発行日 2020-04
出版物タイトル Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
20巻
出版者 Elsevier
開始ページ 1
終了ページ 5
ISSN 22146873
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32042596
DOI 10.1016/j.asmart.2020.01.001
Web of Science KeyUT 000526087700001
関連URL isVersionOf https://doi.org/10.1016/j.asmart.2020.01.001
JaLCDOI 10.18926/AMO/40007
フルテキストURL fulltext.pdf
著者 Furumatsu, Takayuki| Ozaki, Toshifumi|
抄録 Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
キーワード epigenetics DNA methylation histone acetylation and HAT histone deacetylation and HDAC chondrogenesis
Amo Type Review
発行日 2010-06
出版物タイトル Acta Medica Okayama
64巻
3号
出版者 Okayama University Medical School
開始ページ 155
終了ページ 161
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 20596126
Web of Sience KeyUT 000279094300001
フルテキストURL K002286.pdf
著者 古松 毅之|
発行日 2002-03-25
資料タイプ 学位論文
学位授与番号 甲第2286号
学位授与年月日 2002-03-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 Japanese
JaLCDOI 10.18926/AMO/49259
フルテキストURL 67_1_65.pdf
著者 Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi|
抄録 Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects.
キーワード bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair
Amo Type Case Report
発行日 2013-02
出版物タイトル Acta Medica Okayama
67巻
1号
出版者 Okayama University Medical School
開始ページ 65
終了ページ 74
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23439511
Web of Science KeyUT 000316829900009
JaLCDOI 10.18926/AMO/41320
フルテキストURL 64_6_351.pdf
著者 Furumatsu, Takayuki| Asahara, Hiroshi|
抄録 Chondrocyte differentiation is the fundamental process in skeletal development. From the mesenchymal condensation of chondroprogenitors to the hypertrophic maturation of chondrocytes, chondrogenesis is sequentially regulated by cross-talk among transcription factors, growth factors, and chromatin structure. The master transcription factor Sry-type HMG box (Sox) 9 has an essential role in the expression of chondrogenic genes through the association with Sox9-binding sites on its target genes. Several transcription factors and coactivators, such as Scleraxis/E47 and p300, cooperatively modulate the Sox9-dependent transcription by interacting with Sox9. The Sox9-related transcriptional apparatus activates its target gene expression through p300-mediated histone acetylation on chromatin. The transforming growth factor (TGF)-β superfamily also plays a key role in chondrocyte differentiation. The TGF-β-regulated Smad3/4 complex activates Sox9-dependent transcription on chromatin by associating with Sox9 itself, and by recruiting p300 onto Sox9. These findings suggest that the epigenetic status including histone modification and chromatin structure, directly influences Sox9-regulated chondrocyte differentiation. In this article, we review the regulators of Sox9 expression itself, modulators of posttranslational Sox9 function, and Sox9-associating factors in the Sox9-dependent epigenetic regulation during chondrogenesis.
キーワード Sox9 TGF-β-Smad3 coactivator p300 scleraxis/E47 chondrogenesis
Amo Type Review
発行日 2010-12
出版物タイトル Acta Medica Okayama
64巻
6号
出版者 Okayama University Medical School
開始ページ 351
終了ページ 357
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21173804
Web of Science KeyUT 000285664200001
JaLCDOI 10.18926/AMO/57957
フルテキストURL 74_1_77.pdf
著者 Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi|
抄録 Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.
キーワード idiopathic chondrolysis hip joint medication bump arthroscopy
Amo Type Case Report
発行日 2020-02
出版物タイトル Acta Medica Okayama
74巻
1号
出版者 Okayama University Medical School
開始ページ 77
終了ページ 81
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099253
フルテキストURL OTSR105_1_107.pdf Fig.pdf
著者 Furumatsu, Takayuki| Okazaki, Yuki| Okazaki, Yoshiki| Hino, Tomohito| Kamatsuki, Yusuke| Masuda, Shin| Miyazawa, Shinichi| Nakata, Eiji| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi|
キーワード Descending knee motion Injury pattern Medial meniscus Posterior root tear Squatting
発行日 2019-02-28
出版物タイトル Orthopaedics & Traumatology: Surgery & Research
105巻
1号
出版者 Elsevier
開始ページ 107
終了ページ 111
ISSN 18770568
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 30442555
DOI 10.1016/j.otsr.2018.10.001
Web of Science KeyUT 000456541300018
関連URL isVersionOf https://doi.org/10.1016/j.otsr.2018.10.001
著者 Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu|
発行日 2011-06-03
出版物タイトル Biochemical and Biophysical Research Communications
409巻
2号
資料タイプ 学術雑誌論文
著者 Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi|
発行日 2009-09-18
出版物タイトル Journal of Biomechanics
42巻
13号
資料タイプ 学術雑誌論文
著者 Okazaki, Yuki| Furumatsu, Takayuki| Okazaki, Yoshiki| Masuda, Shin| Hiranaka, Takaaki| Kodama, Yuya| Kamatsuki, Yusuke| Miyazawa, Shinichi| Tetsunaga, Tomonori| Ozaki, Toshifumi|
キーワード Magnetic resonance imaging Medial meniscus Meniscus extrusion Posterior root tear Three-dimensional assessment
備考 This fulltext is available in Feb. 2021.|
発行日 2020-01-01
出版物タイトル The Knee
27巻
1号
出版者 Elsevier
開始ページ 132
終了ページ 139
ISSN 09680160
NCID AA10996272
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31882388
DOI 10.1016/j.knee.2019.09.005
Web of Science KeyUT 000519666300017
関連URL isVersionOf https://doi.org/10.1016/j.knee.2019.09.005
著者 Okazaki, Yoshiki| Furumatsu, Takayuki| Yamauchi, Takatsugu| Okazaki, Yuki| Kamatsuki, Yusuke| Hiranaka, Takaaki| Kajiki, Yuya| Zhang, Ximing| Ozaki, Toshifumi|
キーワード medial meniscus posterior root tear transtibial repair meniscal volume medial extrusion three-dimensional magnetic resonance imaging
備考 This fulltext is available in Apr. 2021.|
発行日 2020-04-06
出版物タイトル Knee Surgery, Sports Traumatology, Arthroscopy
出版者 Springer
ISSN 09422056
NCID AA10973641
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32253480
DOI 10.1007/s00167-020-05953-2
Web of Science KeyUT 000525297800001
関連URL isVersionOf https://doi.org/10.1007/s00167-020-05953-2